Abcb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb8
Entrez Gene ID	362302
Full Name	ATP binding cassette subfamily B member 8
General protein information	Preferred Names ATP binding cassette subfamily B member 8 Names ATP-binding cassette sub-family B member 8, mitochondrial ABC transporter 8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 ATP-binding cassette, sub-family B, member 8 ATP-binding cassette, subfamily B (MDR/TAP), member 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11

mRNA and Protein(s)

mRNA	Protein	Name
XM_006235946.2	XP_006236008.1	ATP-binding cassette sub-family B member 8, mitochondrial isoform X1
NM_001007796.1	NP_001007797.1	mitochondrial potassium channel ATP-binding subunit precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ABCB8	XP_519524.3
Canis lupus familiaris (dog)	ABCB8	XP_539916.2
Mus musculus (house mouse)	Abcb8	NP_083296.2
Bos taurus (cattle)	ABCB8	NP_001068994.2
Gallus gallus (chicken)	ABCB8	XP_004939090.1
Danio rerio (zebrafish)	abcb8	NP_001017544.1
Caenorhabditis elegans (roundworm)	haf-6	NP_490828.3
Drosophila melanogaster (fruit fly)	CG1824	NP_572810.1
Homo sapiens (human)	ABCB8	NP_009119.2
	ABCB8	XP_001101695.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006273	XP_316337.4
Xenopus tropicalis (tropical clawed frog)	abcb8	NP_001121515.1
Rattus norvegicus (Norway rat)	Abcb8	NP_001007797.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
Ichikawa Y, Bayeva M, Ghanefar M, Potini V, Sun L, Mutharasan RK, Wu R, Khechaduri A, Jairaj Naik T, Ardehali H
Proceedings of the National Academy of Sciences of the United States of America109(11)4152-7(2012 Mar)

Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis.
Melaine N, Satie AP, Lassurgu?re J, Desmots S, J?gou B, Samson M
International journal of andrology29(3)392-9(2006 Jun)

Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein.
Hogue DL, Liu L, Ling V
Journal of molecular biology285(1)379-89(1999 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins.
Title: Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.

In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes).
Title: Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis.

The following Abcb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12842	NM_001007796.1 Latest version!	Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$419.30 $599.00
ORa26930	XM_006235946.2 Latest version!	Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb8 ( NM_001007796.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007797.1 Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), mRNA.

Price & Availability↑

CloneID	ORa12842
Clone ID Related Accession (Same CDS sequence)	NM_001007796.1
Accession Version	NM_001007796.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2145bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial potassium channel ATP-binding subunit precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085781.1. On Dec 15, 2004 this sequence version replaced XM_342614.1. ##Evidence-Data-START## Transcript exon combination :: BC085781.1, DQ233644.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTTGGTGC ACTTATTTCG GGTCGGAATT CGGGGTGGCC CAGTTCCAAG ATGGTCGCTA 
CAATCCCTGC GCTTCCAGAC GTTCTCAGCC GCCAGGTCCT CAGATGACCA GTTCAGCTCA 
TGCCTCCTGC GGGCTGTAGC CCAGCTCCGG TCACAACTCC GCGCTCACCT CCCTCGATCC 
CCACCAGCTT CCCACCGGAG TACCTCTGCC TGGTGTTGGG TTGGGGGGAC TTTGGTGGTC 
CCCGCTGTGC TGTGGCAGCA TCCCCGTTTC TGCCTTATAG CACTATGTGA GGCCAAAGGG 
TCCCCTCCTG CCCAGCCCAC ACGTGCCCGG GAGCTGCGCT TTAAGTGGAA GCTATTCTGG 
CATTTCCTTC ACCCCCACCT GCTGGCCCTG GGGCTAGCCA TTGTGCTGGC CTTGGGTGCG 
GCACTAGTGA ATGTGCAGAT CCCCTTGCTC CTCGGCCAAC TGGTGGAGAT CGTCGCCAAG 
TACACGAGGG AGCATGTGGG GAGTTTCGTG TCTGAGTCCC GTAGGCTCAG TATCCAGCTG 
CTCCTACTCT ATGGTGTTCA GGGACTACTG ACCTTTGGAT ACCTAGTGCT GCTGTCCCAC 
ATGGGTGAGC GCATGGCCAT GGACATGCGG AAAGCCCTTT TCAGCTCCCT GCTCCGGCAA 
GACATTGCTT TCTTTGATGC CAAAAAGACA GGGCAGCTAG TGAGCCGCTT GACTACTGAT 
GTGCAAGAGT TCAAGTCATC CTTCAAGCTT GTCATCTCCC AGGGACTGCG CAGCTCCACC 
CAGGTGATCG GTAGCCTGAT GACCCTGTCT ATTCTGTCCC CGCGCCTTAC ACTGATGCTG 
GCTGTTGTCA CACCTGCCCT CATGGGAGTG GGCACCCTGA TGGGCTCAGG CCTCCGAAAG 
CTTTCTCGAC AGTGTCAGGA GCAGATTGCC AGGGCGACAG GTGTAGCAGA CGAGGCCCTT 
GGCAGTGTTC GGACTGTTCG GGCCTTCGCA ATGGAGAAGA GGGAGGAGGA ACGCTATCAA 
GCAGAACTGG AGTCATGCTG CTGTAAAGCA GAGGAGCTGG GCAGGGGCAT CGCCTTGTTC 
CAGGGGCTCT CAAACATCGC TTTCAACTGT ATGGTCTTGG GCACCCTGTT CATTGGAGGC 
TCCCTTGTGG CTGGACAGCA GCTGAAAGGG GGAGACCTCA TGTCCTTCCT GGTGGCTTCC 
CAGACAGTAC AGAGGTCTAT GGCCAGCCTC TCTGTCCTGT TTGGTCAGGT GGTGCGTGGG 
CTGAGTGCAG GAGCCCGAGT CTTTGAGTAC ATGTCCCTGA GCCCCGTCAT CCCCTTGACC 
GGGGGCTACT CTATCCCCAG CAAGGACCTT CGTGGTTCTA TCACCTTCCA GAATGTCAGC 
TTCAGCTACC CCTGCCGACC TGGCTTCAAT GTGCTCAAGA ACTTCACCCT GAAGCTGCCC 
CCTGGCAAGA TTGTGGCTCT CGTTGGCCAG TCTGGGGGAG GAAAGACCAC AGTTGCTTCC 
CTGCTGGAAC GCTTCTATGA CCCCACAGCT GGCGTGGTGA CGCTGGATGG GCATGACCTG 
CGTACTCTCG ACCCCTCCTG GCTCCGGGGC CAGGTCATAG GTTTCATCAG CCAGGAGCCA 
GTCCTGTTTG CAACAACCAT CATGGAGAAT ATCCGATTTG GGAAGCTAGA TGCTTCCGAT 
GAAGAGGTGT ATACAGCTGC ACGGAAAGCC AATGCCCACG AGTTCATCAG CAGCTTCCCT 
GATGGCTACA GCACTGTGGT TGGTGAACGG GGCACAACCT TGTCCGGTGG TCAGAAGCAG 
CGCCTAGCCA TCGCACGTGC CCTCATCAAG AGGCCCACAG TGTTGATCCT GGATGAAGCC 
ACCAGTGCGC TGGACGCAGA GTCTGAGAGG ATAGTACAGG AGGCACTGGA CCGGGCCAGT 
GCTGGTCGCA CCGTGTTGGT CATTGCCCAC CGGCTCAGTA CTGTTCGTGC CGCCCACTCC 
ATCATCGTCA TGGCCAATGG CCAAGTCTGT GAGGCTGGGA CCCACGAAGA ACTCCTTCAA 
AAAGGCGGGC TCTACGCAGA GCTTATCCGG AGACAAGCCC TGGATGCCTC ACTGCCCTCA 
GCCCCACCTG CAGAGAAGCC TGAAGACCAC AGAAGCTGCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007797.1
CDS	1..2145
Translation	MLVHLFRVGIRGGPVPRWSLQSLRFQTFSAARSSDDQFSSCLLRAVAQLRSQLRAHLPRSPPASHRSTSAWCWVGGTLVVPAVLWQHPRFCLIALCEAKGSPPAQPTRARELRFKWKLFWHFLHPHLLALGLAIVLALGAALVNVQIPLLLGQLVEIVAKYTREHVGSFVSESRRLSIQLLLLYGVQGLLTFGYLVLLSHMGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSSTQVIGSLMTLSILSPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMSLSPVIPLTGGYSIPSKDLRGSITFQNVSFSYPCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVTLDGHDLRTLDPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARKANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKRPTVLILDEATSALDAESERIVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLQKGGLYAELIRRQALDASLPSAPPAEKPEDHRSCQ

Target ORF information:

RefSeq Version	NM_001007796.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007796.1

ORF Insert Sequence:

ATGTTGGTGC ACTTATTTCG GGTCGGAATT CGGGGTGGCC CAGTTCCAAG ATGGTCGCTA 
CAATCCCTGC GCTTCCAGAC GTTCTCAGCC GCCAGGTCCT CAGATGACCA GTTCAGCTCA 
TGCCTCCTGC GGGCTGTAGC CCAGCTCCGG TCACAACTCC GCGCTCACCT CCCTCGATCC 
CCACCAGCTT CCCACCGGAG TACCTCTGCC TGGTGTTGGG TTGGGGGGAC TTTGGTGGTC 
CCCGCTGTGC TGTGGCAGCA TCCCCGTTTC TGCCTTATAG CACTATGTGA GGCCAAAGGG 
TCCCCTCCTG CCCAGCCCAC ACGTGCCCGG GAGCTGCGCT TTAAGTGGAA GCTATTCTGG 
CATTTCCTTC ACCCCCACCT GCTGGCCCTG GGGCTAGCCA TTGTGCTGGC CTTGGGTGCG 
GCACTAGTGA ATGTGCAGAT CCCCTTGCTC CTCGGCCAAC TGGTGGAGAT CGTCGCCAAG 
TACACGAGGG AGCATGTGGG GAGTTTCGTG TCTGAGTCCC GTAGGCTCAG TATCCAGCTG 
CTCCTACTCT ATGGTGTTCA GGGACTACTG ACCTTTGGAT ACCTAGTGCT GCTGTCCCAC 
ATGGGTGAGC GCATGGCCAT GGACATGCGG AAAGCCCTTT TCAGCTCCCT GCTCCGGCAA 
GACATTGCTT TCTTTGATGC CAAAAAGACA GGGCAGCTAG TGAGCCGCTT GACTACTGAT 
GTGCAAGAGT TCAAGTCATC CTTCAAGCTT GTCATCTCCC AGGGACTGCG CAGCTCCACC 
CAGGTGATCG GTAGCCTGAT GACCCTGTCT ATTCTGTCCC CGCGCCTTAC ACTGATGCTG 
GCTGTTGTCA CACCTGCCCT CATGGGAGTG GGCACCCTGA TGGGCTCAGG CCTCCGAAAG 
CTTTCTCGAC AGTGTCAGGA GCAGATTGCC AGGGCGACAG GTGTAGCAGA CGAGGCCCTT 
GGCAGTGTTC GGACTGTTCG GGCCTTCGCA ATGGAGAAGA GGGAGGAGGA ACGCTATCAA 
GCAGAACTGG AGTCATGCTG CTGTAAAGCA GAGGAGCTGG GCAGGGGCAT CGCCTTGTTC 
CAGGGGCTCT CAAACATCGC TTTCAACTGT ATGGTCTTGG GCACCCTGTT CATTGGAGGC 
TCCCTTGTGG CTGGACAGCA GCTGAAAGGG GGAGACCTCA TGTCCTTCCT GGTGGCTTCC 
CAGACAGTAC AGAGGTCTAT GGCCAGCCTC TCTGTCCTGT TTGGTCAGGT GGTGCGTGGG 
CTGAGTGCAG GAGCCCGAGT CTTTGAGTAC ATGTCCCTGA GCCCCGTCAT CCCCTTGACC 
GGGGGCTACT CTATCCCCAG CAAGGACCTT CGTGGTTCTA TCACCTTCCA GAATGTCAGC 
TTCAGCTACC CCTGCCGACC TGGCTTCAAT GTGCTCAAGA ACTTCACCCT GAAGCTGCCC 
CCTGGCAAGA TTGTGGCTCT CGTTGGCCAG TCTGGGGGAG GAAAGACCAC AGTTGCTTCC 
CTGCTGGAAC GCTTCTATGA CCCCACAGCT GGCGTGGTGA CGCTGGATGG GCATGACCTG 
CGTACTCTCG ACCCCTCCTG GCTCCGGGGC CAGGTCATAG GTTTCATCAG CCAGGAGCCA 
GTCCTGTTTG CAACAACCAT CATGGAGAAT ATCCGATTTG GGAAGCTAGA TGCTTCCGAT 
GAAGAGGTGT ATACAGCTGC ACGGAAAGCC AATGCCCACG AGTTCATCAG CAGCTTCCCT 
GATGGCTACA GCACTGTGGT TGGTGAACGG GGCACAACCT TGTCCGGTGG TCAGAAGCAG 
CGCCTAGCCA TCGCACGTGC CCTCATCAAG AGGCCCACAG TGTTGATCCT GGATGAAGCC 
ACCAGTGCGC TGGACGCAGA GTCTGAGAGG ATAGTACAGG AGGCACTGGA CCGGGCCAGT 
GCTGGTCGCA CCGTGTTGGT CATTGCCCAC CGGCTCAGTA CTGTTCGTGC CGCCCACTCC 
ATCATCGTCA TGGCCAATGG CCAAGTCTGT GAGGCTGGGA CCCACGAAGA ACTCCTTCAA 
AAAGGCGGGC TCTACGCAGA GCTTATCCGG AGACAAGCCC TGGATGCCTC ACTGCCCTCA 
GCCCCACCTG CAGAGAAGCC TGAAGACCAC AGAAGCTGCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb8 ( XM_006235946.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006236008.1 Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26930
Clone ID Related Accession (Same CDS sequence)	XM_006235946.2
Accession Version	XM_006235946.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family B member 8, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006235946.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCGCTA CAATCCCTGC GCTTCCAGAC GTTCTCAGCC GCCAGCTGGC CTTGGGTGCG 
GCACTAGTGA ATGTGCAGAT CCCCTTGCTC CTCGGCCAAC TGGTGGAGAT CGTCGCCAAG 
TACACGAGGG AGCATGTGGG GAGTTTCGTG TCTGAGTCCC GTAGGCTCAG TATCCAGCTG 
CTCCTACTCT ATGGTGTTCA GGGACTACTG ACCTTTGGAT ACCTAGTGCT GCTGTCCCAC 
ATGGGTGAGC GCATGGCCAT GGACATGCGG AAAGCCCTTT TCAGCTCCCT GCTCCGGCAA 
GACATTGCTT TCTTTGATGC CAAAAAGACA GGGCAGCTAG TGAGCCGCTT GACTACTGAT 
GTGCAAGAGT TCAAGTCATC CTTCAAGCTT GTCATCTCCC AGGGACTGCG CAGCTCCACC 
CAGGTGATCG GTAGCCTGAT GACCCTGTCT ATTCTGTCCC CGCGCCTTAC ACTGATGCTG 
GCTGTTGTCA CACCTGCCCT CATGGGAGTG GGCACCCTGA TGGGCTCAGG CCTCCGAAAG 
CTTTCTCGAC AGTGTCAGGA GCAGATTGCC AGGGCGACAG GTGTAGCAGA CGAGGCCCTT 
GGCAGTGTTC GGACTGTTCG GGCCTTCGCA ATGGAGAAGA GGGAGGAGGA ACGCTATCAA 
GCAGAACTGG AGTCATGCTG CTGTAAAGCA GAGGAGCTGG GCAGGGGCAT CGCCTTGTTC 
CAGGGGCTCT CAAACATCGC TTTCAACTGT ATGGTCTTGG GCACCCTGTT CATTGGAGGC 
TCCCTTGTGG CTGGACAGCA GCTGAAAGGG GGAGACCTCA TGTCCTTCCT GGTGGCTTCC 
CAGACAGTAC AGAGGTCTAT GGCCAGCCTC TCTGTCCTGT TTGGTCAGGT GGTGCGTGGG 
CTGAGTGCAG GAGCCCGAGT CTTTGAGTAC ATGTCCCTGA GCCCCGTCAT CCCCTTGACC 
GGGGGCTACT CTATCCCCAG CAAGGACCTT CGTGGTTCTA TCACCTTCCA GAATGTCAGC 
TTCAGCTACC CCTGCCGACC TGGCTTCAAT GTGCTCAAGA ACTTCACCCT GAAGCTGCCC 
CCTGGCAAGA TTGTGGCTCT CGTTGGCCAG TCTGGGGGAG GAAAGACCAC AGTTGCTTCC 
CTGCTGGAAC GCTTCTATGA CCCCACAGCT GGCGTGGTGA CGCTGGATGG GCATGACCTG 
CGTACTCTCG ACCCCTCCTG GCTCCGGGGC CAGGTCATAG GTTTCATCAG CCAGGAGCCA 
GTCCTGTTTG CAACAACCAT CATGGAGAAT ATCCGATTTG GGAAGCTAGA TGCTTCCGAT 
GAAGAGGTGT ATACAGCTGC ACGGAAAGCC AATGCCCACG AGTTCATCAG CAGCTTCCCT 
GATGGCTACA GCACTGTGGT TGGTGAACGG GGCACAACCT TGTCCGGTGG TCAGAAGCAG 
CGCCTAGCCA TCGCACGTGC CCTCATCAAG AGGCCCACAG TGTTGATCCT GGATGAAGCC 
ACCAGTGCGC TGGACGCAGA GTCTGAGAGG ATAGTACAGG AGGCACTGGA CCGGGCCAGT 
GCTGGTCGCA CCGTGTTGGT CATTGCCCAC CGGCTCAGTA CTGTTCGTGC CGCCCACTCC 
ATCATCGTCA TGGCCAATGG CCAAGTCTGT GAGGCTGGGA CCCACGAAGA ACTCCTTCAA 
AAAGGCGGGC TCTACGCAGA GCTTATCCGG AGACAAGCCC TGGATGCCTC ACTGCCCTCA 
GCCCCACCTG CAGAGAAGCC TGAAGACCAC AGAAGCTGCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006236008.1
CDS	157..1941
Translation	MVATIPALPDVLSRQLALGAALVNVQIPLLLGQLVEIVAKYTREHVGSFVSESRRLSIQLLLLYGVQGLLTFGYLVLLSHMGERMAMDMRKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSSTQVIGSLMTLSILSPRLTLMLAVVTPALMGVGTLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKREEERYQAELESCCCKAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMSLSPVIPLTGGYSIPSKDLRGSITFQNVSFSYPCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVTLDGHDLRTLDPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARKANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKRPTVLILDEATSALDAESERIVQEALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLQKGGLYAELIRRQALDASLPSAPPAEKPEDHRSCQ

Target ORF information:

RefSeq Version	XM_006235946.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily B member 8 (Abcb8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235946.2

ORF Insert Sequence:

ATGGTCGCTA CAATCCCTGC GCTTCCAGAC GTTCTCAGCC GCCAGCTGGC CTTGGGTGCG 
GCACTAGTGA ATGTGCAGAT CCCCTTGCTC CTCGGCCAAC TGGTGGAGAT CGTCGCCAAG 
TACACGAGGG AGCATGTGGG GAGTTTCGTG TCTGAGTCCC GTAGGCTCAG TATCCAGCTG 
CTCCTACTCT ATGGTGTTCA GGGACTACTG ACCTTTGGAT ACCTAGTGCT GCTGTCCCAC 
ATGGGTGAGC GCATGGCCAT GGACATGCGG AAAGCCCTTT TCAGCTCCCT GCTCCGGCAA 
GACATTGCTT TCTTTGATGC CAAAAAGACA GGGCAGCTAG TGAGCCGCTT GACTACTGAT 
GTGCAAGAGT TCAAGTCATC CTTCAAGCTT GTCATCTCCC AGGGACTGCG CAGCTCCACC 
CAGGTGATCG GTAGCCTGAT GACCCTGTCT ATTCTGTCCC CGCGCCTTAC ACTGATGCTG 
GCTGTTGTCA CACCTGCCCT CATGGGAGTG GGCACCCTGA TGGGCTCAGG CCTCCGAAAG 
CTTTCTCGAC AGTGTCAGGA GCAGATTGCC AGGGCGACAG GTGTAGCAGA CGAGGCCCTT 
GGCAGTGTTC GGACTGTTCG GGCCTTCGCA ATGGAGAAGA GGGAGGAGGA ACGCTATCAA 
GCAGAACTGG AGTCATGCTG CTGTAAAGCA GAGGAGCTGG GCAGGGGCAT CGCCTTGTTC 
CAGGGGCTCT CAAACATCGC TTTCAACTGT ATGGTCTTGG GCACCCTGTT CATTGGAGGC 
TCCCTTGTGG CTGGACAGCA GCTGAAAGGG GGAGACCTCA TGTCCTTCCT GGTGGCTTCC 
CAGACAGTAC AGAGGTCTAT GGCCAGCCTC TCTGTCCTGT TTGGTCAGGT GGTGCGTGGG 
CTGAGTGCAG GAGCCCGAGT CTTTGAGTAC ATGTCCCTGA GCCCCGTCAT CCCCTTGACC 
GGGGGCTACT CTATCCCCAG CAAGGACCTT CGTGGTTCTA TCACCTTCCA GAATGTCAGC 
TTCAGCTACC CCTGCCGACC TGGCTTCAAT GTGCTCAAGA ACTTCACCCT GAAGCTGCCC 
CCTGGCAAGA TTGTGGCTCT CGTTGGCCAG TCTGGGGGAG GAAAGACCAC AGTTGCTTCC 
CTGCTGGAAC GCTTCTATGA CCCCACAGCT GGCGTGGTGA CGCTGGATGG GCATGACCTG 
CGTACTCTCG ACCCCTCCTG GCTCCGGGGC CAGGTCATAG GTTTCATCAG CCAGGAGCCA 
GTCCTGTTTG CAACAACCAT CATGGAGAAT ATCCGATTTG GGAAGCTAGA TGCTTCCGAT 
GAAGAGGTGT ATACAGCTGC ACGGAAAGCC AATGCCCACG AGTTCATCAG CAGCTTCCCT 
GATGGCTACA GCACTGTGGT TGGTGAACGG GGCACAACCT TGTCCGGTGG TCAGAAGCAG 
CGCCTAGCCA TCGCACGTGC CCTCATCAAG AGGCCCACAG TGTTGATCCT GGATGAAGCC 
ACCAGTGCGC TGGACGCAGA GTCTGAGAGG ATAGTACAGG AGGCACTGGA CCGGGCCAGT 
GCTGGTCGCA CCGTGTTGGT CATTGCCCAC CGGCTCAGTA CTGTTCGTGC CGCCCACTCC 
ATCATCGTCA TGGCCAATGG CCAAGTCTGT GAGGCTGGGA CCCACGAAGA ACTCCTTCAA 
AAAGGCGGGC TCTACGCAGA GCTTATCCGG AGACAAGCCC TGGATGCCTC ACTGCCCTCA 
GCCCCACCTG CAGAGAAGCC TGAAGACCAC AGAAGCTGCC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
Proceedings of the National Academy of Sciences of the United States of America109(11)4152-7(2012 Mar)
Ichikawa Y,Bayeva M,Ghanefar M,Potini V,Sun L,Mutharasan RK,Wu R,Khechaduri A,Jairaj Naik T,Ardehali H

Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis.
International journal of andrology29(3)392-9(2006 Jun)
Melaine N,Satie AP,Lassurgu?re J,Desmots S,J?gou B,Samson M

Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein.
Journal of molecular biology285(1)379-89(1999 Jan)
Hogue DL,Liu L,Ling V

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Abcb8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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