Trim2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trim2
Entrez Gene ID	361970
Full Name	tripartite motif-containing 2
General protein information	Preferred Names tripartite motif-containing 2 Names tripartite motif-containing protein 2 E3 ubiquitin-protein ligase TRIM2 RING-type E3 ubiquitin transferase TRIM2 tripartite motif protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108552.1	NP_001102022.1	tripartite motif-containing protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRIM2	NP_001123539.1
Gallus gallus (chicken)	TRIM2	NP_001244243.1
	TRIM2	XP_001086769.2
Bos taurus (cattle)	TRIM2	NP_001077204.1
Mus musculus (house mouse)	Trim2	NP_001258657.1
Rattus norvegicus (Norway rat)	Trim2	NP_001102022.1
Danio rerio (zebrafish)	trim2a	NP_001014393.1
Xenopus tropicalis (tropical clawed frog)	trim2	NP_001005680.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
Thompson S, Pearson AN, Ashley MD, Jessick V, Murphy BM, Gafken P, Henshall DC, Morris KT, Simon RP, Meller R
The Journal of biological chemistry286(22)19331-9(2011 Jun)

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, Russo T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.
Balastik M, Ferraguti F, Pires-da Silva A, Lee TH, Alvarez-Bolado G, Lu KP, Gruss P
Proceedings of the National Academy of Sciences of the United States of America105(33)12016-21(2008 Aug)

The tripartite motif family identifies cell compartments.
Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A
The EMBO journal20(9)2140-51(2001 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a role for TRIM2 in mediating the p42/p44 MAPK-dependent ubiquitination of Bim in rapid ischemic tolerance.
Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

The following Trim2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trim2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42728	NM_001108552.1 Latest version!	Rattus norvegicus tripartite motif-containing 2 (Trim2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trim2 ( NM_001108552.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102022.1 Rattus norvegicus tripartite motif-containing 2 (Trim2), mRNA.

Price & Availability↑

CloneID	ORa42728
Clone ID Related Accession (Same CDS sequence)	NM_001108552.1
Accession Version	NM_001108552.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-09
Organism	Rattus norvegicus(Norway rat)
Product	tripartite motif-containing protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473976.2. On or before Oct 4, 2007 this sequence version replaced XM_342268.3, XM_001065758.1, XM_001065860.1.

ATGCAGCGTG CAGGGTCGAG GACAGCCGGC CCCACATGTC AGTGGTCTAG GATGGCCAGT 
GAGGGCGCCA GCATCCCGAG TCCTGTGGTA CGCCAGATTG ACAAGCAGTT TCTGATCTGC 
AGTATATGCC TGGAACGGTA CAAGAACCCC AAGGTCCTGC CCTGTCTGCA CACTTTCTGC 
GAGAGGTGCC TGCAGAACTA CATTCCAGCC CACAGTTTAA CCCTCTCCTG CCCAGTGTGT 
CGTCAGACCT CCATCCTGCC TGAGAAAGGG GTGGCTGCAC TCCAGAACAA CTTTTTTATC 
ACAAACCTCA TGGATGTGCT GCAGCGAACG CCAGGCAGCA ACGGCGAGGA CCCTTCCATC 
CTGCAGACGG TCACCGCTGT GGCTGCAGGA AAGCCTCTAT CATGCCCGAA CCACGATGGA 
AATGTGATGG AATTTTACTG CCAGTCCTGT GAGACCGCCA TGTGTCGGGA GTGCACGGAG 
GGGGAGCACG CAGAGCACCC CACAGTCCCG CTGAAGGACG TGGTGGAGCA GCATAAGGCC 
TCACTCCAGG TCCAGCTGGA TGCAGTCAAC AAAAGACTCC CAGAAATAGA TTCTGCTCTT 
CAGTTCATCT CAGAAATCAT CCATCAGTTA ACCAACCAAA AGGCCAGCAT TGTGGACGAC 
ATCCACTCCA CCTTTGATGA ACTGCAGAAG ACTTTAAATG TTCGCAAGAG CGTGCTGCTC 
ATGGAGCTTG AGGTCAACTA TGGCCTCAAA CACAAAGTGC TGCAGTCGCA GCTGGATACC 
CTGCTCCAAG GCCAGGAAAG CATTAAGAGC TGCAGCAACT TCACAGCGCA AGCCCTCAAC 
CATGGCACGG AGACGGAGGT GCTGCTGGTG AAGAAGCAGA TGAGCGAGAA GCTCAACGAA 
CTGGCGGACC AAGACTTCCC ACTGCACCCG CGCGAGAACG ATCAGCTGGA TTTTATCGTG 
GAAACTGAGG GATTGAAAAA GTCTATCCAC AACCTGGGGA CCATCCTCAC CACTAACGCG 
GTCGCCTCTG AGACGGTGGC CACGGGCGAG GGGCTTCGGC AGACCATCAT CGGGCAGCCC 
ATGTCCGTTA CTATAACCAC CAAGGACAAA GACGGAGAGC TGTGCAAGAC AGGCAACGCA 
TACCTCACCG CTGAGCTCAG CACCCCCGAC GGCAGCGTGG CGGACGGAGA GATCCTGGAC 
AACAAGAACG GCACCTACGA GTTCCTGTAT ACTGTGCAGA AGGAGGGGGA CTTCACCCTG 
TCTCTCAGGC TCTACGACCA ACACATCCGA GGCAGTCCGT TTAAGCTCAA GGTCATCCGC 
TCGGCGGACG TGTCCCCCAC CACCGAGGGC GTGAAGCGAC GAGTCAAGTC CCCAGGGAGC 
GGGCACGTCA AGCAGAAGGC TGTAAAGAGA CCGGCCAGCA TGTACAGCAC CGGCAAGCGA 
AAAGAGAACC CCATCGAGGA CGACTTGATC TTCCGAGTGG GTACCAAAGG AAGAAACAAA 
GGAGAATTTA CAAACCTGCA GGGTGTGGCT GCATCTACGA GTGGAAAGAT ATTAATTGCA 
GATAGTAACA ACCAGTGTGT GCAGATCTTT TCCAATGACG GACAGTTCAA AAGTCGTTTC 
GGCATCCGAG GTCGATCCCC AGGACAGCTC CAGCGTCCCA CAGGGGTAGC GGTGCACCCC 
AGTGGGGACA TCATCATCGC AGATTATGAC AACAAGTGGG TCAGCATTTT CTCCAATGAT 
GGGAAGTTTA AGACAAAAAT TGGATCAGGA AAACTGATGG GGCCCAAAGG AGTTTCTGTG 
GACCGCAATG GGCACATTAT TGTGGTGGAC AACAAGGCAT GCTGCGTGTT CATCTTTCAG 
CCCAACGGGA AAATAGTCAC CAGGTTTGGT AGCCGAGGAA ACGGCGACAG GCAGTTTGCA 
GGTCCCCATT TTGCAGCTGT GAATAGCAGT AATGAGATCA TCATTACAGA TTTCCATAAT 
CATTCTGTCA AGGTATTTAA TCAGGAAGGA GAATTCATGT TGAAGTTCGG CTCAAATGGA 
GAAGGAAATG GGCAGTTTAA TGCACCAACA GGTGTAGCCG TGGACTCGAA TGGAAACATC 
ATTGTGGCTG ACTGGGGGAA CAGCAGGATC CAGGTTTTTG ATGGGAGTGG ATCATTTTTG 
TCCTATATCA ACACATCTGC TGACCCGCTG TATGGCCCCC AAGGCCTGGC TCTAACTTCG 
GATGGCCACG TCGTGGTTGC AGACTCCGGA AACCACTGCT TCAAGGTCTA TCGGTACTTA 
CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102022.1
CDS	231..2516
Translation	MQRAGSRTAGPTCQWSRMASEGASIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNGEDPSILQTVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSSNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ

Target ORF information:

RefSeq Version	NM_001108552.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tripartite motif-containing 2 (Trim2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108552.1

ORF Insert Sequence:

ATGCAGCGTG CAGGGTCGAG GACAGCCGGC CCCACATGTC AGTGGTCTAG GATGGCCAGT 
GAGGGCGCCA GCATCCCGAG TCCTGTGGTA CGCCAGATTG ACAAGCAGTT TCTGATCTGC 
AGTATATGCC TGGAACGGTA CAAGAACCCC AAGGTCCTGC CCTGTCTGCA CACTTTCTGC 
GAGAGGTGCC TGCAGAACTA CATTCCAGCC CACAGTTTAA CCCTCTCCTG CCCAGTGTGT 
CGTCAGACCT CCATCCTGCC TGAGAAAGGG GTGGCTGCAC TCCAGAACAA CTTTTTTATC 
ACAAACCTCA TGGATGTGCT GCAGCGAACG CCAGGCAGCA ACGGCGAGGA CCCTTCCATC 
CTGCAGACGG TCACCGCTGT GGCTGCAGGA AAGCCTCTAT CATGCCCGAA CCACGATGGA 
AATGTGATGG AATTTTACTG CCAGTCCTGT GAGACCGCCA TGTGTCGGGA GTGCACGGAG 
GGGGAGCACG CAGAGCACCC CACAGTCCCG CTGAAGGACG TGGTGGAGCA GCATAAGGCC 
TCACTCCAGG TCCAGCTGGA TGCAGTCAAC AAAAGACTCC CAGAAATAGA TTCTGCTCTT 
CAGTTCATCT CAGAAATCAT CCATCAGTTA ACCAACCAAA AGGCCAGCAT TGTGGACGAC 
ATCCACTCCA CCTTTGATGA ACTGCAGAAG ACTTTAAATG TTCGCAAGAG CGTGCTGCTC 
ATGGAGCTTG AGGTCAACTA TGGCCTCAAA CACAAAGTGC TGCAGTCGCA GCTGGATACC 
CTGCTCCAAG GCCAGGAAAG CATTAAGAGC TGCAGCAACT TCACAGCGCA AGCCCTCAAC 
CATGGCACGG AGACGGAGGT GCTGCTGGTG AAGAAGCAGA TGAGCGAGAA GCTCAACGAA 
CTGGCGGACC AAGACTTCCC ACTGCACCCG CGCGAGAACG ATCAGCTGGA TTTTATCGTG 
GAAACTGAGG GATTGAAAAA GTCTATCCAC AACCTGGGGA CCATCCTCAC CACTAACGCG 
GTCGCCTCTG AGACGGTGGC CACGGGCGAG GGGCTTCGGC AGACCATCAT CGGGCAGCCC 
ATGTCCGTTA CTATAACCAC CAAGGACAAA GACGGAGAGC TGTGCAAGAC AGGCAACGCA 
TACCTCACCG CTGAGCTCAG CACCCCCGAC GGCAGCGTGG CGGACGGAGA GATCCTGGAC 
AACAAGAACG GCACCTACGA GTTCCTGTAT ACTGTGCAGA AGGAGGGGGA CTTCACCCTG 
TCTCTCAGGC TCTACGACCA ACACATCCGA GGCAGTCCGT TTAAGCTCAA GGTCATCCGC 
TCGGCGGACG TGTCCCCCAC CACCGAGGGC GTGAAGCGAC GAGTCAAGTC CCCAGGGAGC 
GGGCACGTCA AGCAGAAGGC TGTAAAGAGA CCGGCCAGCA TGTACAGCAC CGGCAAGCGA 
AAAGAGAACC CCATCGAGGA CGACTTGATC TTCCGAGTGG GTACCAAAGG AAGAAACAAA 
GGAGAATTTA CAAACCTGCA GGGTGTGGCT GCATCTACGA GTGGAAAGAT ATTAATTGCA 
GATAGTAACA ACCAGTGTGT GCAGATCTTT TCCAATGACG GACAGTTCAA AAGTCGTTTC 
GGCATCCGAG GTCGATCCCC AGGACAGCTC CAGCGTCCCA CAGGGGTAGC GGTGCACCCC 
AGTGGGGACA TCATCATCGC AGATTATGAC AACAAGTGGG TCAGCATTTT CTCCAATGAT 
GGGAAGTTTA AGACAAAAAT TGGATCAGGA AAACTGATGG GGCCCAAAGG AGTTTCTGTG 
GACCGCAATG GGCACATTAT TGTGGTGGAC AACAAGGCAT GCTGCGTGTT CATCTTTCAG 
CCCAACGGGA AAATAGTCAC CAGGTTTGGT AGCCGAGGAA ACGGCGACAG GCAGTTTGCA 
GGTCCCCATT TTGCAGCTGT GAATAGCAGT AATGAGATCA TCATTACAGA TTTCCATAAT 
CATTCTGTCA AGGTATTTAA TCAGGAAGGA GAATTCATGT TGAAGTTCGG CTCAAATGGA 
GAAGGAAATG GGCAGTTTAA TGCACCAACA GGTGTAGCCG TGGACTCGAA TGGAAACATC 
ATTGTGGCTG ACTGGGGGAA CAGCAGGATC CAGGTTTTTG ATGGGAGTGG ATCATTTTTG 
TCCTATATCA ACACATCTGC TGACCCGCTG TATGGCCCCC AAGGCCTGGC TCTAACTTCG 
GATGGCCACG TCGTGGTTGC AGACTCCGGA AACCACTGCT TCAAGGTCTA TCGGTACTTA 
CAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.
The Journal of biological chemistry286(22)19331-9(2011 Jun)
Thompson S,Pearson AN,Ashley MD,Jessick V,Murphy BM,Gafken P,Henshall DC,Morris KT,Simon RP,Meller R

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(9)3255-63(2010 Sep)
Tarantino C,Paolella G,Cozzuto L,Minopoli G,Pastore L,Parisi S,Russo T

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America105(33)12016-21(2008 Aug)
Balastik M,Ferraguti F,Pires-da Silva A,Lee TH,Alvarez-Bolado G,Lu KP,Gruss P

The tripartite motif family identifies cell compartments.
The EMBO journal20(9)2140-51(2001 May)
Reymond A,Meroni G,Fantozzi A,Merla G,Cairo S,Luzi L,Riganelli D,Zanaria E,Messali S,Cainarca S,Guffanti A,Minucci S,Pelicci PG,Ballabio A

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Trim2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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