Rps6ka4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rps6ka4
Entrez Gene ID	361715
Full Name	ribosomal protein S6 kinase A4
Synonyms	Ccdc88b
General protein information	Preferred Names ribosomal protein S6 kinase A4 Names ribosomal protein S6 kinase alpha-4 coiled-coil domain containing 88B ribosomal protein S6 kinase, polypeptide 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108517.2	NP_001101987.2	ribosomal protein S6 kinase alpha-4

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPS6KA4	NP_003933.1
Danio rerio (zebrafish)	rps6ka4	NP_001119875.1
Rattus norvegicus (Norway rat)	Rps6ka4	NP_001101987.2
	RPS6KA4	XP_001114877.1
Bos taurus (cattle)	RPS6KA4	NP_001178329.1
Pan troglodytes (chimpanzee)	RPS6KA4	XP_508900.3
Canis lupus familiaris (dog)	RPS6KA4	XP_854926.1
Mus musculus (house mouse)	Rps6ka4	NP_064308.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006094	XP_316151.4
Xenopus tropicalis (tropical clawed frog)	LOC100486973	XP_004919265.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.
Wang B, Chen J, Santiago FS, Janes M, Kavurma MM, Chong BH, Pimanda JE, Khachigian LM
Arteriosclerosis, thrombosis, and vascular biology30(3)536-45(2010 Mar)

MAPKAP kinases - MKs - two's company, three's a crowd.
Gaestel M
Nature reviews. Molecular cell biology7(2)120-30(2006 Feb)

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.
Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS
The EMBO journal22(11)2788-97(2003 Jun)

C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB).
Tom?s-Zuber M, Mary JL, Lamour F, Bur D, Lesslauer W
The Journal of biological chemistry276(8)5892-9(2001 Feb)

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
Pierrat B, Correia JS, Mary JL, Tom?s-Zuber M, Lesslauer W
The Journal of biological chemistry273(45)29661-71(1998 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rps6ka4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rps6ka4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07660	NM_001108517.2 Latest version!	Rattus norvegicus ribosomal protein S6 kinase A4 (Rps6ka4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$412.30 $589.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rps6ka4 ( NM_001108517.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101987.2 Rattus norvegicus ribosomal protein S6 kinase A4 (Rps6ka4), mRNA.

Price & Availability↑

CloneID	ORa07660
Clone ID Related Accession (Same CDS sequence)	NM_001108517.2
Accession Version	NM_001108517.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2322bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	ribosomal protein S6 kinase alpha-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN932052.1, BU671341.1, FM059731.1, CB700259.1, FM035808.1, BF407559.1, CB737401.1, AW251264.1 and BQ194971.1. On Jun 23, 2009 this sequence version replaced NM_001108517.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGACG AGGATGAGGA TGAGGGCTGC GCCGTGGAGC TGCAGATCAC CGAAGCCAAC 
CTGACCGGGC ATGAGGAGAA GGTGAGCGTG GAGAACTTCG CGCTGCTCAA GGTGCTGGGC 
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCGG GTGGGCACGA TGCGGGCAAG 
CTCTATGCCA TGAAGGTGCT TCGCAAGGCG GCGTTGGTGC AGCGCGCCAA GACGCAGGAG 
CATACCCGCA CCGAACGCTC AGTGCTGGAG CTGGTACGCC AGGCACCCTT CCTGGTCACA 
CTGCACTACG CCTTCCAGAC GGACGCCAAA CTGCACCTCA TCCTGGACTA TGTGAGCGGT 
GGTGAGATGT TCACTCACCT GTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGAGTG 
TACGGGGGAG AGATTGTGCT GGCCCTAGAG CACCTGCACA AGTTGGGCAT CATCTACAGG 
GACCTGAAGC TGGAGAACGT CTTACTTGAC TCTGAAGGTC ACATTGTCCT CACAGACTTT 
GGTTTGAGCA AGGAGTTCCT GACTGAGGAG AAAGAGCGAA CCTTCTCCTT CTGTGGCACC 
ATCGAGTACA TGGCTCCCGA AATCATCCGA AGCAAGGCTG GACATGGCAA GGCTGTGGAC 
TGGTGGAGCC TGGGTATCCT GCTCTTCGAG CTGCTGACAG GAGCCTCACC CTTCACACTG 
GAGGGAGAAA GGAACACTCA GGCTGAGGTG TCTCGACGGA TCTTGAAGTG CTCCCCTCCC 
TTCCCTCCCC GGATTGGGCC TGTGGCACAG GACCTGCTAC AGCGCCTGCT GTGCAAGGAC 
CCTAAGAAGA GGTTGGGCGC AGGTCCCCAG GGTGCACAGG AAGTCAAGAG TCACCTCTTT 
TTCCAGGGTC TGGATTGGGT TGCTCTGGCT GCCAGAAAGA TCCCAGCCCC ATTCCGGCCC 
CAGATCCGCT CAGAGCTGGA TGTGGGGAAT TTTGCAGAGG AATTCACTCG GCTGGAGCCT 
GTCTACTCCC CTGCTGGCAG CCCTCCACCT GGGGACCCTA GGATCTTTCA GGGATACTCC 
TTCGTGGCTC CTTCCATACT CTTTGACCAC AACAACGCAG TGATGGCTGA TGTGCTGGCG 
GCACCTGGTG CTGGATACAG GCCTGGCAGG GCAGCAGTTG CCAGGAGTGC CATGATGCAG 
GACTCGCCTT TCTTCCAGCA GTATGAGCTG GACCTTCGGG AGCCAGCGCT GGGGCAGGGC 
AGCTTCTCTG TGTGTAGGCG ATGTCGCCAG CGCCAGAGTG GTCAGGAATT TGCCGTCAAG 
ATCCTCAGCC GCAGGCTGGA GGAGAACACT CAGCGCGAGG TAGCTGCCCT TCGCTTGTGC 
CAGTCACACC CCAACGTGGT GAACCTGCAT GAGGTGCTTC ACGACCAGTT ACACACTTAT 
CTGGTCCTGG AGTTGCTGCG GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGACTC 
TTCAGCGAGT CCGAGGCTAG CCAGATCCTT CGGAGCTTGG TGTCAGCCGT GAGCTTCATG 
CATGAGGAGG CGGGCGTGGT GCACCGTGAC CTGAAACCCG AGAACATCTT GTACGCAGAC 
GACACTCCTG GGGCCCCGGT GAAGATCATC GACTTTGGGT TCGCGAGACT GCGGCCCCAG 
AGCCCGGCGG GGCCCATGCA GACGCCTTGC TTCACCCTGC AGTACGCTGC ACCCGAGCTG 
CTGGCACAGC AGGGGTACGA CGAGTCCTGT GATCTTTGGA GCCTGGGTGT CATTCTGTAC 
ATGATGCTGT CTGGACAGGT TCCCTTCCAA GGGGCCTCTG GCCAGGGTGG ACAGAGCCAG 
GCAGCTGAGA TCATGTGCAA GATCCGTGAA GGGCGCTTCT CTCTGGACGG GGAAGCCTGG 
CAAGGTGTTT CGGAGGAAGC CAAGGAGCTG GTCCGAGGGC TACTGACAGT GGACCCCGCC 
AAGCGGCTGA AGCTGGAGGG GCTGCGTAGC AGCTCGTGGC TTCAGGACGG CAGTGCGCGC 
TCCTCGCCCC CGCTCCGCAC GCCGGATGTG CTGGAGTCCT CTGGGCCAGC AGTGCGCTCC 
GGGCTCAATG CCACTTTCAT GGCGTTTAAC CGAGGAAAGC GCGAGGGCTT CTTTTTGAAG 
AGTGTGGAGA ACGCGCCGCT GGCCAAAAGG CGCAAGCAGA AGCTCCGGAG CGCGGCCGCC 
TCCCGCCGCG GCTCCCCGGT GCCTGCCTCC TCGGGTCGCC TACCAGCCTC TGCCTCCAAG 
GGGACAACTC GCCGAGCCAA CGGCCCCTTG TCCCCTTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101987.2
CDS	49..2370
Translation	MGDEDEDEGCAVELQITEANLTGHEEKVSVENFALLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHLFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPAGSPPPGDPRIFQGYSFVAPSILFDHNNAVMADVLAAPGAGYRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENTQREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAGPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSAAASRRGSPVPASSGRLPASASKGTTRRANGPLSPS

Target ORF information:

RefSeq Version	NM_001108517.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ribosomal protein S6 kinase A4 (Rps6ka4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108517.2

ORF Insert Sequence:

ATGGGAGACG AGGATGAGGA TGAGGGCTGC GCCGTGGAGC TGCAGATCAC CGAAGCCAAC 
CTGACCGGGC ATGAGGAGAA GGTGAGCGTG GAGAACTTCG CGCTGCTCAA GGTGCTGGGC 
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCGG GTGGGCACGA TGCGGGCAAG 
CTCTATGCCA TGAAGGTGCT TCGCAAGGCG GCGTTGGTGC AGCGCGCCAA GACGCAGGAG 
CATACCCGCA CCGAACGCTC AGTGCTGGAG CTGGTACGCC AGGCACCCTT CCTGGTCACA 
CTGCACTACG CCTTCCAGAC GGACGCCAAA CTGCACCTCA TCCTGGACTA TGTGAGCGGT 
GGTGAGATGT TCACTCACCT GTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGAGTG 
TACGGGGGAG AGATTGTGCT GGCCCTAGAG CACCTGCACA AGTTGGGCAT CATCTACAGG 
GACCTGAAGC TGGAGAACGT CTTACTTGAC TCTGAAGGTC ACATTGTCCT CACAGACTTT 
GGTTTGAGCA AGGAGTTCCT GACTGAGGAG AAAGAGCGAA CCTTCTCCTT CTGTGGCACC 
ATCGAGTACA TGGCTCCCGA AATCATCCGA AGCAAGGCTG GACATGGCAA GGCTGTGGAC 
TGGTGGAGCC TGGGTATCCT GCTCTTCGAG CTGCTGACAG GAGCCTCACC CTTCACACTG 
GAGGGAGAAA GGAACACTCA GGCTGAGGTG TCTCGACGGA TCTTGAAGTG CTCCCCTCCC 
TTCCCTCCCC GGATTGGGCC TGTGGCACAG GACCTGCTAC AGCGCCTGCT GTGCAAGGAC 
CCTAAGAAGA GGTTGGGCGC AGGTCCCCAG GGTGCACAGG AAGTCAAGAG TCACCTCTTT 
TTCCAGGGTC TGGATTGGGT TGCTCTGGCT GCCAGAAAGA TCCCAGCCCC ATTCCGGCCC 
CAGATCCGCT CAGAGCTGGA TGTGGGGAAT TTTGCAGAGG AATTCACTCG GCTGGAGCCT 
GTCTACTCCC CTGCTGGCAG CCCTCCACCT GGGGACCCTA GGATCTTTCA GGGATACTCC 
TTCGTGGCTC CTTCCATACT CTTTGACCAC AACAACGCAG TGATGGCTGA TGTGCTGGCG 
GCACCTGGTG CTGGATACAG GCCTGGCAGG GCAGCAGTTG CCAGGAGTGC CATGATGCAG 
GACTCGCCTT TCTTCCAGCA GTATGAGCTG GACCTTCGGG AGCCAGCGCT GGGGCAGGGC 
AGCTTCTCTG TGTGTAGGCG ATGTCGCCAG CGCCAGAGTG GTCAGGAATT TGCCGTCAAG 
ATCCTCAGCC GCAGGCTGGA GGAGAACACT CAGCGCGAGG TAGCTGCCCT TCGCTTGTGC 
CAGTCACACC CCAACGTGGT GAACCTGCAT GAGGTGCTTC ACGACCAGTT ACACACTTAT 
CTGGTCCTGG AGTTGCTGCG GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGACTC 
TTCAGCGAGT CCGAGGCTAG CCAGATCCTT CGGAGCTTGG TGTCAGCCGT GAGCTTCATG 
CATGAGGAGG CGGGCGTGGT GCACCGTGAC CTGAAACCCG AGAACATCTT GTACGCAGAC 
GACACTCCTG GGGCCCCGGT GAAGATCATC GACTTTGGGT TCGCGAGACT GCGGCCCCAG 
AGCCCGGCGG GGCCCATGCA GACGCCTTGC TTCACCCTGC AGTACGCTGC ACCCGAGCTG 
CTGGCACAGC AGGGGTACGA CGAGTCCTGT GATCTTTGGA GCCTGGGTGT CATTCTGTAC 
ATGATGCTGT CTGGACAGGT TCCCTTCCAA GGGGCCTCTG GCCAGGGTGG ACAGAGCCAG 
GCAGCTGAGA TCATGTGCAA GATCCGTGAA GGGCGCTTCT CTCTGGACGG GGAAGCCTGG 
CAAGGTGTTT CGGAGGAAGC CAAGGAGCTG GTCCGAGGGC TACTGACAGT GGACCCCGCC 
AAGCGGCTGA AGCTGGAGGG GCTGCGTAGC AGCTCGTGGC TTCAGGACGG CAGTGCGCGC 
TCCTCGCCCC CGCTCCGCAC GCCGGATGTG CTGGAGTCCT CTGGGCCAGC AGTGCGCTCC 
GGGCTCAATG CCACTTTCAT GGCGTTTAAC CGAGGAAAGC GCGAGGGCTT CTTTTTGAAG 
AGTGTGGAGA ACGCGCCGCT GGCCAAAAGG CGCAAGCAGA AGCTCCGGAG CGCGGCCGCC 
TCCCGCCGCG GCTCCCCGGT GCCTGCCTCC TCGGGTCGCC TACCAGCCTC TGCCTCCAAG 
GGGACAACTC GCCGAGCCAA CGGCCCCTTG TCCCCTTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription.
Arteriosclerosis, thrombosis, and vascular biology30(3)536-45(2010 Mar)
Wang B,Chen J,Santiago FS,Janes M,Kavurma MM,Chong BH,Pimanda JE,Khachigian LM

MAPKAP kinases - MKs - two's company, three's a crowd.
Nature reviews. Molecular cell biology7(2)120-30(2006 Feb)
Gaestel M

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.
The EMBO journal22(11)2788-97(2003 Jun)
Soloaga A,Thomson S,Wiggin GR,Rampersaud N,Dyson MH,Hazzalin CA,Mahadevan LC,Arthur JS

C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB).
The Journal of biological chemistry276(8)5892-9(2001 Feb)
Tom?s-Zuber M,Mary JL,Lamour F,Bur D,Lesslauer W

RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
The Journal of biological chemistry273(45)29661-71(1998 Nov)
Pierrat B,Correia JS,Mary JL,Tom?s-Zuber M,Lesslauer W

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Rps6ka4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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