Rps6kb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rps6kb2
Entrez Gene ID	361696
Full Name	ribosomal protein S6 kinase B2
General protein information	Preferred Names ribosomal protein S6 kinase B2 Names ribosomal protein S6 kinase beta-2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 ribosomal protein S6 kinase, polypeptide 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001010962.2	NP_001010962.2	ribosomal protein S6 kinase beta-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	RPS6KB2	NP_003943.2
Pan troglodytes (chimpanzee)	RPS6KB2	XP_001172909.1
	RPS6KB2	XP_001117937.1
Rattus norvegicus (Norway rat)	Rps6kb2	NP_001010962.2
Saccharomyces cerevisiae (baker's yeast)	SCH9	NP_012075.1
Eremothecium gossypii	AGOS_ADL389W	NP_983707.1
Bos taurus (cattle)	RPS6KB2	NP_001192511.1
Kluyveromyces lactis	KLLA0B03586g	XP_451694.1
Canis lupus familiaris (dog)	RPS6KB2	XP_851971.1
Mus musculus (house mouse)	Rps6kb2	NP_067460.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular mechanisms of mTOR-mediated translational control.
Ma XM, Blenis J
Nature reviews. Molecular cell biology10(5)307-18(2009 May)

Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.
Katta A, Karkala SK, Wu M, Meduru S, Desai DH, Rice KM, Blough ER
Muscle & nerve39(4)503-11(2009 Apr)

The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.
Zeniou-Meyer M, B?gl? A, Bader MF, Vitale N
Annals of the New York Academy of Sciences1152201-8(2009 Jan)

The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
Zeniou-Meyer M, Liu Y, B?gl? A, Olanich ME, Olanish M, Hanauer A, Becherer U, Rettig J, Bader MF, Vitale N
Proceedings of the National Academy of Sciences of the United States of America105(24)8434-9(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

insulin resistance is associated with alterations in the ability of muscle to activate p70S6k signaling following an acute bout of exercise
Title: Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.

RSK2 is a critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis
Title: The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.

RSK2 is an essential modulator of PLD1 activity in calcium-regulated exocytosis.
Title: The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.

Thus, proteins in the mTOR/p70S6K pathway are modulated in chronic MK-801 animal models.
Title: The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex.

p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context and is a substrate for protein kinase B and ribosomal S6 kinase
Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.

The following Rps6kb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rps6kb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01374	NM_001010962.2 Latest version!	Rattus norvegicus ribosomal protein S6 kinase B2 (Rps6kb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rps6kb2 ( NM_001010962.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001010962.2 Rattus norvegicus ribosomal protein S6 kinase B2 (Rps6kb2), mRNA.

Price & Availability↑

CloneID	ORa01374
Clone ID Related Accession (Same CDS sequence)	NM_001010962.2
Accession Version	NM_001010962.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	ribosomal protein S6 kinase beta-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DY315655.1, DY561917.1, AW144793.1 and CK843568.1. On Jan 25, 2008 this sequence version replaced NM_001010962.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCG TGTTTGATTT AGACTTGGAG ACCGAGGAAG GAAGTGAGGG CGAGGGCGAG 
CCGGAGTTCA ACCCTGCGGA CGTGTGTCCC CTTGGCGAGT TAAGGGCTGC TGGCCTGGAG 
ACAGTGGGAC ACTATGAGGA GGTGGAACTG ACAGAGAGCA GCGTCAACCT GGGTCCTGAG 
CGCATCGGAC CCCACTGCTT TGAGCTACTG AGTGTTCTGG GCAAGGGGGG TTATGGCAAG 
GTGTTCCAGG TGAGAAAAGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 
TTGAGAAAGG CCAAGATTGT ATGCAGTGCC AAGGACACAG CACATACCCG GGCTGAGCGG 
AACATTCTAG AATCGGTGAA GCACCCCTTC ATTGTAGAAC TGGCCTATGC TTTCCAGACA 
GGTGGCAAAC TCTACCTCAT CCTGGAGTGC CTCAGTGGTG GTGAGCTCTT CACACATCTT 
GAGCGAGAAG GCATCTTCCT GGAAGACACA GCCTGCTTCT ACCTGGCAGA GATCACACTA 
GCCCTGGGCC ATCTCCATTC CCAAGGCATC ATCTACCGGG ATCTCAAGCC CGAGAACATC 
ATGCTCAACA GCCAGGGCCA TATCAAACTG ACAGACTTTG GACTCTGCAA AGAGTCCATT 
CATGAGGGTG CTATCACTCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCAGAGATT 
CTAGTGCGCA TCGGTCACAA CCGGGCAGTG GACTGGTGGA GCCTGGGAGC CCTGATGTAC 
GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC TATGGATAAA 
ATCATTAAAG GGAAGCTGGT GCTGCCCCCC TACCTCACCC CGGATGCCCG GGACCTTGCC 
AAAAAGTTTC TGAAGCGGAA TCCCACTCAT CGAATTGGGG GTGGCCCAGG AGATGCTGCT 
GATGTGCAGA GGCACCCGTT TTTCCGGCAC ATCAATTGGG ATGACCTCTT GGCCCATCGT 
GTAGACCCTC CCTTCAGACC GAGTCTGCAA TCAGAAGAGG ACGTGAGCCA GTTTGATGTG 
CGATTCACAC GGCAGACGCC AGTAGATAGT CCAGATGACA CAGCCCTCAG TGAGAGTGCC 
AACCAAGCCT TCCTGGGCTT CACGTATGTG GCACCTTCTG TACTGGACAG CATCAAAGAG 
GGCTTCTCCT TCCAGCCTAA GCTGCGCTCC CCCAGACGCC TTAACAGCAG TCCCCGCACC 
CCTATCAGCC CCCTCAAGTT CTCTCCCTTT GAGGGGTTCC GGCCCAGTCC TGGCCCACCA 
GAGCCCATGG AGCCATCTCT ACCTCCACTC CTGCCACCAC CATCATCACC ACCACCCACA 
AGTACTGCCC CACTTCCCAT CCGTCCCCCC TCAGGAACCA AGAAGTCCAA GAAGGGACGG 
GGCCGCCCTG GGCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001010962.2
CDS	73..1530
Translation	MAAVFDLDLETEEGSEGEGEPEFNPADVCPLGELRAAGLETVGHYEEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHEGAITHTFCGTIEYMAPEILVRIGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTHRIGGGPGDAADVQRHPFFRHINWDDLLAHRVDPPFRPSLQSEEDVSQFDVRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRTPISPLKFSPFEGFRPSPGPPEPMEPSLPPLLPPPSSPPPTSTAPLPIRPPSGTKKSKKGRGRPGR

Target ORF information:

RefSeq Version	NM_001010962.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ribosomal protein S6 kinase B2 (Rps6kb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001010962.2

ORF Insert Sequence:

ATGGCGGCCG TGTTTGATTT AGACTTGGAG ACCGAGGAAG GAAGTGAGGG CGAGGGCGAG 
CCGGAGTTCA ACCCTGCGGA CGTGTGTCCC CTTGGCGAGT TAAGGGCTGC TGGCCTGGAG 
ACAGTGGGAC ACTATGAGGA GGTGGAACTG ACAGAGAGCA GCGTCAACCT GGGTCCTGAG 
CGCATCGGAC CCCACTGCTT TGAGCTACTG AGTGTTCTGG GCAAGGGGGG TTATGGCAAG 
GTGTTCCAGG TGAGAAAAGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 
TTGAGAAAGG CCAAGATTGT ATGCAGTGCC AAGGACACAG CACATACCCG GGCTGAGCGG 
AACATTCTAG AATCGGTGAA GCACCCCTTC ATTGTAGAAC TGGCCTATGC TTTCCAGACA 
GGTGGCAAAC TCTACCTCAT CCTGGAGTGC CTCAGTGGTG GTGAGCTCTT CACACATCTT 
GAGCGAGAAG GCATCTTCCT GGAAGACACA GCCTGCTTCT ACCTGGCAGA GATCACACTA 
GCCCTGGGCC ATCTCCATTC CCAAGGCATC ATCTACCGGG ATCTCAAGCC CGAGAACATC 
ATGCTCAACA GCCAGGGCCA TATCAAACTG ACAGACTTTG GACTCTGCAA AGAGTCCATT 
CATGAGGGTG CTATCACTCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCAGAGATT 
CTAGTGCGCA TCGGTCACAA CCGGGCAGTG GACTGGTGGA GCCTGGGAGC CCTGATGTAC 
GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC TATGGATAAA 
ATCATTAAAG GGAAGCTGGT GCTGCCCCCC TACCTCACCC CGGATGCCCG GGACCTTGCC 
AAAAAGTTTC TGAAGCGGAA TCCCACTCAT CGAATTGGGG GTGGCCCAGG AGATGCTGCT 
GATGTGCAGA GGCACCCGTT TTTCCGGCAC ATCAATTGGG ATGACCTCTT GGCCCATCGT 
GTAGACCCTC CCTTCAGACC GAGTCTGCAA TCAGAAGAGG ACGTGAGCCA GTTTGATGTG 
CGATTCACAC GGCAGACGCC AGTAGATAGT CCAGATGACA CAGCCCTCAG TGAGAGTGCC 
AACCAAGCCT TCCTGGGCTT CACGTATGTG GCACCTTCTG TACTGGACAG CATCAAAGAG 
GGCTTCTCCT TCCAGCCTAA GCTGCGCTCC CCCAGACGCC TTAACAGCAG TCCCCGCACC 
CCTATCAGCC CCCTCAAGTT CTCTCCCTTT GAGGGGTTCC GGCCCAGTCC TGGCCCACCA 
GAGCCCATGG AGCCATCTCT ACCTCCACTC CTGCCACCAC CATCATCACC ACCACCCACA 
AGTACTGCCC CACTTCCCAT CCGTCCCCCC TCAGGAACCA AGAAGTCCAA GAAGGGACGG 
GGCCGCCCTG GGCGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular mechanisms of mTOR-mediated translational control.
Nature reviews. Molecular cell biology10(5)307-18(2009 May)
Ma XM,Blenis J

Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.
Muscle & nerve39(4)503-11(2009 Apr)
Katta A,Karkala SK,Wu M,Meduru S,Desai DH,Rice KM,Blough ER

The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.
Annals of the New York Academy of Sciences1152201-8(2009 Jan)
Zeniou-Meyer M,B?gl? A,Bader MF,Vitale N

The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
Proceedings of the National Academy of Sciences of the United States of America105(24)8434-9(2008 Jun)
Zeniou-Meyer M,Liu Y,B?gl? A,Olanich ME,Olanish M,Hanauer A,Becherer U,Rettig J,Bader MF,Vitale N

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Rps6kb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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