Eif4g2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif4g2
Entrez Gene ID	361628
Full Name	eukaryotic translation initiation factor 4, gamma 2
General protein information	Preferred Names eukaryotic translation initiation factor 4, gamma 2 Names eukaryotic translation initiation factor 4 gamma 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q33
Summary	Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse and rat. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001017374.2	NP_001017374.2	eukaryotic translation initiation factor 4 gamma 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EIF4G2	XP_003951884.1
	EIF4G2	XP_001093873.2
Mus musculus (house mouse)	Eif4g2	NP_038535.2
Homo sapiens (human)	EIF4G2	NP_001409.3
Gallus gallus (chicken)	EIF4G2	NP_001093330.1
Xenopus tropicalis (tropical clawed frog)	eif4g2	NP_001004992.1
Bos taurus (cattle)	EIF4G2	NP_001093329.1
Rattus norvegicus (Norway rat)	Eif4g2	NP_001017374.2
Canis lupus familiaris (dog)	EIF4G2	XP_005633865.1

Gene Ontology
Bibliography

Related articles in PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Distler U, Schmeisser MJ, Pelosi A, Reim D, Kuharev J, Weiczner R, Baumgart J, Boeckers TM, Nitsch R, Vogt J, Tenzer S
Proteomics14(21-22)2607-13(2014 Nov)

The scanning mechanism of eukaryotic translation initiation.
Hinnebusch AG
Annual review of biochemistry83779-812(2014)

Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
Kar AN, MacGibeny MA, Gervasi NM, Gioio AE, Kaplan BB
The Journal of neuroscience : the official journal of the Society for Neuroscience33(17)7165-74(2013 Apr)

The mechanism of eukaryotic translation initiation: new insights and challenges.
Hinnebusch AG, Lorsch JR
Cold Spring Harbor perspectives in biology4(10)(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Local protein synthesis was found to be regulated by Eif4g2 (and Eif2b2) in the axon.
Title: Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.

At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.
Title: Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.

The following Eif4g2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif4g2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05658	NM_001017374.2 Latest version!	Rattus norvegicus eukaryotic translation initiation factor 4, gamma 2 (Eif4g2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif4g2 ( NM_001017374.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001017374.2 Rattus norvegicus eukaryotic translation initiation factor 4, gamma 2 (Eif4g2), mRNA.

Price & Availability↑

CloneID	ORa05658
Clone ID Related Accession (Same CDS sequence)	NM_001017374.2
Accession Version	NM_001017374.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2721bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	eukaryotic translation initiation factor 4 gamma 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB730161.1, BC099117.1 and AB256044.1. On or before Jul 25, 2007 this sequence version replaced XM_341907.3, NM_001017374.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC099117.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 9049310, 15718103 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

GTGGAGAGTG CGATTGCAGA AGGGGGTGCT TCTCGTTTCA GTGCTTCTTC GGGCGGAGGA 
GGAAGTAGGG GTGCACCTCA GCACTATCCC AAGACTGCTG GCAACAGCGA GTTCCTGGGG 
AAAACCCCAG GGCAAAACGC TCAGAAATGG ATTCCTGCAC GAAGCACTAG ACGAGATGAC 
AACTCCGCAG CAAACAACTC CGCAAATGAA AAAGAACGAC ATGATGCAAT CTTCAGGAAA 
GTAAGAGGCA TACTAAATAA GCTTACTCCT GAAAAGTTTG ACAAGCTATG CCTTGAGCTC 
CTCAATGTGG GTGTAGAGTC TAAACTCATC CTTAAAGGGG TCATACTGCT GATTGTGGAC 
AAAGCCCTAG AAGAGCCAAA GTATAGCTCA CTGTATGCTC AGCTATGTCT GCGATTGGCA 
GAAGATGCAC CAAACTTTGA TGGCCCAGCA GCAGAGGGTC AACCAGGACA GAAGCAAAGC 
ACAACATTCA GACGCCTCTT GATTTCCAAA TTGCAAGATG AATTTGAAAA CCGAACCAGA 
AATGTTGATG TCTATGATAA GCGTGAAAAT CCCCTCCTCC CTGAGGAGGA GGAACAGAGA 
GCCATTGCTA AGATCAAGAT GTTGGGGAAC ATCAAATTCA TTGGAGAACT TGGCAAGCTT 
GATCTTATTC ATGAATCTAT CCTTCATAAG TGCATCAAAA CACTTTTGGA AAAGAAGAAG 
AGAGTCCAAC TCAAAGATAT GGGAGAGGAT TTGGAGTGCC TCTGTCAGAT AATGAGGACA 
GTGGGACCTC GATTAGACCA TGAACGAGCC AAGTCCTTAA TGGATCAGTA CTTTGCCAGA 
ATGTGTTCCT TAATGTTAAG TAAGGAATTG CCAGCCAGGA TTCGTTTCCT ACTGCAGGAT 
ACCGTAGAGT TGCGAGAGCA CCATTGGGTT CCTCGCAAGG CTTTTCTTGA CAATGGACCA 
AAGACGATCA ATCAAATCCG TCAAGATGCA GTAAAAGATC TAGGAGTGTT TATTCCTGCT 
CCTATGGCTC AAGGGAGGAA TGACTTCTTC CTGGAGGGAC CGTTCATGCC GCCAAGGATG 
AAAATGGATA GGGACCCACT TGGGGGACTC GCTGATATGT TTGGACAAAT GCCAGGTAGT 
GGAATTGGTA CTGGTCCAGG AGTTATCCAG GATAGATTTT CACCCACAAT GGGACGTCAT 
CGTTCAAATC AGCTCTTCAA TGGCCATGGG GGACACATCA TGCCTCCCAC GCAATCGCAG 
TTTGGAGAGA TGGGGGGCAA GTTTATGAAA AGCCAGGGGC TAAGCCAGCT CTACCATAAC 
CAGAGTCAGG GACTCTTATC CCAGCTGCAA GGACAGTCGA AGGATATGCC ACCTCGGTTT 
TCTAAGAAAG GACAGCTTAA TGCAGATGAG ATTAGTTTGA GGCCTGCTCA GTCGTTTCTA 
ATGAATAAAA ATCAGGTGCC AAAGCTTCAG CCCCAGATAA CTATGATTCC TCCCAGTGCA 
CAGCCACCAC GCACTCAAAC ACCACCTCTG GGACAGACAC CTCAACTTGG TCTCAAAACT 
AATCCACCAC TTATTCAGGA AAAGCCTGCC AAGACTAGCA AAAAGCCACC ACCATCAAAG 
GAAGAACTAC TTAAACTGAC CGAAGCTGTT GTAACTGAGT ATCTGAACAG TGGAAATGCC 
AACGACGCTG TCAGTGGTGT GAGAGAAATG AGAGCTCCAA AACACTTTCT TCCTGAGATG 
TTAAGCAAAG TGATCATCCT GTCACTTGAT AGAAGTGATG AAGATAAAGA AAAAGCAAGC 
TCTTTGATCA GTTTACTCAA ACAGGAAGGG ATAGCCACAA GTGACAACTT TATGCAGGCT 
TTCCTGAATG TATTGGAGCA GTGCCCCAAA CTGGAGGTTG ACATCCCCTT GGTGAAATCT 
TACTTGGCAC AGTTTGCGGC TCGTGCTATA ATTTCAGAGT TGGTGAGCAT TTCAGAACTA 
GCTCAACCAC TGGAGAGTGG CACCCACTTC CCTCTCTTCT TACTTTGTCT TCAACAATTA 
GCTAAATTAC AAGACCGAGA ATGGTTAACC GAACTTTTTC AACAAAGCAA GGTCAATATG 
CAGAAAATGC TGCCAGAAAT TGATCAGAAT AAGGATCGAA TGTTGGAGAT TTTGGAAGGA 
AAGGGACTGA GTTTCTTATT CCCACTCCTT AAATTGGAGA AGGAACTATT GAAGCAAATT 
AAGCTGGATC CATCCCCTCA AACTATATAT AAATGGATTA AAGATAACAT CTCTCCCAAA 
CTTCATGTAG ATAAAGGATT TGTGAACATC TTAATGACCA GCTTCTTACA GTACATTTCT 
AGTGAAGTTA GCCCACCCAG CGATGAAACA GATTCTTCCT CTGCTCCTTC CAAAGAACAG 
TTAGAGCAGG AAAAACAGCT GCTGCTCTCT TTTAAGCCAG TGATGCAGAA GTTTCTTCAT 
GATCATGTGG ATCTACAGGT CAGTGCCCTG TATGCTTTGC AGGTGCACTG TTACAACAGC 
AGCTTCCCAA AAGGCATGTT ACTTCGATTT TTTGTTCATT TCTATGACAT GGAAATTATT 
GAAGAGGAAG CTTTCTTAGC TTGGAAGGAA GACATAACTC AAGAGTTTCC AGGAAAAGGC 
AAGGCTTTGT TCCAGGTGAA TCAGTGGCTA ACCTGGCTAG AAACTGCTGA AGAAGAAGAA 
TCAGAGGAAG AAGCTGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001017374.2
CDS	302..3022
Translation	VESAIAEGGASRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHDAIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPAAEGQPGQKQSTTFRRLLISKLQDEFENRTRNVDVYDKRENPLLPEEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGPRLDHERAKSLMDQYFARMCSLMLSKELPARIRFLLQDTVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRNDFFLEGPFMPPRMKMDRDPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGEMGGKFMKSQGLSQLYHNQSQGLLSQLQGQSKDMPPRFSKKGQLNADEISLRPAQSFLMNKNQVPKLQPQITMIPPSAQPPRTQTPPLGQTPQLGLKTNPPLIQEKPAKTSKKPPPSKEELLKLTEAVVTEYLNSGNANDAVSGVREMRAPKHFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCPKLEVDIPLVKSYLAQFAARAIISELVSISELAQPLESGTHFPLFLLCLQQLAKLQDREWLTELFQQSKVNMQKMLPEIDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIKLDPSPQTIYKWIKDNISPKLHVDKGFVNILMTSFLQYISSEVSPPSDETDSSSAPSKEQLEQEKQLLLSFKPVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFLAWKEDITQEFPGKGKALFQVNQWLTWLETAEEEESEEEAD

Target ORF information:

RefSeq Version	NM_001017374.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus eukaryotic translation initiation factor 4, gamma 2 (Eif4g2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001017374.2

ORF Insert Sequence:

GTGGAGAGTG CGATTGCAGA AGGGGGTGCT TCTCGTTTCA GTGCTTCTTC GGGCGGAGGA 
GGAAGTAGGG GTGCACCTCA GCACTATCCC AAGACTGCTG GCAACAGCGA GTTCCTGGGG 
AAAACCCCAG GGCAAAACGC TCAGAAATGG ATTCCTGCAC GAAGCACTAG ACGAGATGAC 
AACTCCGCAG CAAACAACTC CGCAAATGAA AAAGAACGAC ATGATGCAAT CTTCAGGAAA 
GTAAGAGGCA TACTAAATAA GCTTACTCCT GAAAAGTTTG ACAAGCTATG CCTTGAGCTC 
CTCAATGTGG GTGTAGAGTC TAAACTCATC CTTAAAGGGG TCATACTGCT GATTGTGGAC 
AAAGCCCTAG AAGAGCCAAA GTATAGCTCA CTGTATGCTC AGCTATGTCT GCGATTGGCA 
GAAGATGCAC CAAACTTTGA TGGCCCAGCA GCAGAGGGTC AACCAGGACA GAAGCAAAGC 
ACAACATTCA GACGCCTCTT GATTTCCAAA TTGCAAGATG AATTTGAAAA CCGAACCAGA 
AATGTTGATG TCTATGATAA GCGTGAAAAT CCCCTCCTCC CTGAGGAGGA GGAACAGAGA 
GCCATTGCTA AGATCAAGAT GTTGGGGAAC ATCAAATTCA TTGGAGAACT TGGCAAGCTT 
GATCTTATTC ATGAATCTAT CCTTCATAAG TGCATCAAAA CACTTTTGGA AAAGAAGAAG 
AGAGTCCAAC TCAAAGATAT GGGAGAGGAT TTGGAGTGCC TCTGTCAGAT AATGAGGACA 
GTGGGACCTC GATTAGACCA TGAACGAGCC AAGTCCTTAA TGGATCAGTA CTTTGCCAGA 
ATGTGTTCCT TAATGTTAAG TAAGGAATTG CCAGCCAGGA TTCGTTTCCT ACTGCAGGAT 
ACCGTAGAGT TGCGAGAGCA CCATTGGGTT CCTCGCAAGG CTTTTCTTGA CAATGGACCA 
AAGACGATCA ATCAAATCCG TCAAGATGCA GTAAAAGATC TAGGAGTGTT TATTCCTGCT 
CCTATGGCTC AAGGGAGGAA TGACTTCTTC CTGGAGGGAC CGTTCATGCC GCCAAGGATG 
AAAATGGATA GGGACCCACT TGGGGGACTC GCTGATATGT TTGGACAAAT GCCAGGTAGT 
GGAATTGGTA CTGGTCCAGG AGTTATCCAG GATAGATTTT CACCCACAAT GGGACGTCAT 
CGTTCAAATC AGCTCTTCAA TGGCCATGGG GGACACATCA TGCCTCCCAC GCAATCGCAG 
TTTGGAGAGA TGGGGGGCAA GTTTATGAAA AGCCAGGGGC TAAGCCAGCT CTACCATAAC 
CAGAGTCAGG GACTCTTATC CCAGCTGCAA GGACAGTCGA AGGATATGCC ACCTCGGTTT 
TCTAAGAAAG GACAGCTTAA TGCAGATGAG ATTAGTTTGA GGCCTGCTCA GTCGTTTCTA 
ATGAATAAAA ATCAGGTGCC AAAGCTTCAG CCCCAGATAA CTATGATTCC TCCCAGTGCA 
CAGCCACCAC GCACTCAAAC ACCACCTCTG GGACAGACAC CTCAACTTGG TCTCAAAACT 
AATCCACCAC TTATTCAGGA AAAGCCTGCC AAGACTAGCA AAAAGCCACC ACCATCAAAG 
GAAGAACTAC TTAAACTGAC CGAAGCTGTT GTAACTGAGT ATCTGAACAG TGGAAATGCC 
AACGACGCTG TCAGTGGTGT GAGAGAAATG AGAGCTCCAA AACACTTTCT TCCTGAGATG 
TTAAGCAAAG TGATCATCCT GTCACTTGAT AGAAGTGATG AAGATAAAGA AAAAGCAAGC 
TCTTTGATCA GTTTACTCAA ACAGGAAGGG ATAGCCACAA GTGACAACTT TATGCAGGCT 
TTCCTGAATG TATTGGAGCA GTGCCCCAAA CTGGAGGTTG ACATCCCCTT GGTGAAATCT 
TACTTGGCAC AGTTTGCGGC TCGTGCTATA ATTTCAGAGT TGGTGAGCAT TTCAGAACTA 
GCTCAACCAC TGGAGAGTGG CACCCACTTC CCTCTCTTCT TACTTTGTCT TCAACAATTA 
GCTAAATTAC AAGACCGAGA ATGGTTAACC GAACTTTTTC AACAAAGCAA GGTCAATATG 
CAGAAAATGC TGCCAGAAAT TGATCAGAAT AAGGATCGAA TGTTGGAGAT TTTGGAAGGA 
AAGGGACTGA GTTTCTTATT CCCACTCCTT AAATTGGAGA AGGAACTATT GAAGCAAATT 
AAGCTGGATC CATCCCCTCA AACTATATAT AAATGGATTA AAGATAACAT CTCTCCCAAA 
CTTCATGTAG ATAAAGGATT TGTGAACATC TTAATGACCA GCTTCTTACA GTACATTTCT 
AGTGAAGTTA GCCCACCCAG CGATGAAACA GATTCTTCCT CTGCTCCTTC CAAAGAACAG 
TTAGAGCAGG AAAAACAGCT GCTGCTCTCT TTTAAGCCAG TGATGCAGAA GTTTCTTCAT 
GATCATGTGG ATCTACAGGT CAGTGCCCTG TATGCTTTGC AGGTGCACTG TTACAACAGC 
AGCTTCCCAA AAGGCATGTT ACTTCGATTT TTTGTTCATT TCTATGACAT GGAAATTATT 
GAAGAGGAAG CTTTCTTAGC TTGGAAGGAA GACATAACTC AAGAGTTTCC AGGAAAAGGC 
AAGGCTTTGT TCCAGGTGAA TCAGTGGCTA ACCTGGCTAG AAACTGCTGA AGAAGAAGAA 
TCAGAGGAAG AAGCTGACTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics.
Proteomics14(21-22)2607-13(2014 Nov)
Distler U,Schmeisser MJ,Pelosi A,Reim D,Kuharev J,Weiczner R,Baumgart J,Boeckers TM,Nitsch R,Vogt J,Tenzer S

The scanning mechanism of eukaryotic translation initiation.
Annual review of biochemistry83779-812(2014)
Hinnebusch AG

Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience33(17)7165-74(2013 Apr)
Kar AN,MacGibeny MA,Gervasi NM,Gioio AE,Kaplan BB

The mechanism of eukaryotic translation initiation: new insights and challenges.
Cold Spring Harbor perspectives in biology4(10)(2012 Oct)
Hinnebusch AG,Lorsch JR

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Eif4g2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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