Iqgap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Iqgap1
Entrez Gene ID	361598
Full Name	IQ motif containing GTPase activating protein 1
General protein information	Preferred Names IQ motif containing GTPase activating protein 1 Names ras GTPase-activating-like protein IQGAP1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108489.1	NP_001101959.2	ras GTPase-activating-like protein IQGAP1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IQGAP1	XP_523157.3
Xenopus tropicalis (tropical clawed frog)	iqgap1	XP_002932312.2
Homo sapiens (human)	IQGAP1	NP_003861.1
	IQGAP1	XP_002804991.1
Canis lupus familiaris (dog)	IQGAP1	XP_536199.2
Danio rerio (zebrafish)	iqgap1	XP_001920847.4
Mus musculus (house mouse)	Iqgap1	NP_057930.2
Rattus norvegicus (Norway rat)	Iqgap1	NP_001101959.2
Gallus gallus (chicken)	IQGAP1	XP_413959.4

Gene Ontology
Bibliography

Related articles in PubMed

The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding.
Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X
Cell stem cell21(5)635-649.e8(2017 Nov)

A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.
Vetterkind S, Lin QQ, Morgan KG
Scientific reports7(1)9302(2017 Aug)

Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization.
Nammalwar RC, Heil A, Gerke V
Biochimica et biophysica acta1853(9)2086-94(2015 Sep)

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
Cao D, Su Z, Wang W, Wu H, Liu X, Akram S, Qin B, Zhou J, Zhuang X, Adams G, Jin C, Wang X, Liu L, Hill DL, Wang D, Ding X, Yao X
The Journal of biological chemistry290(39)23766-80(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Caveolin-1 and IQGAP1 are required for phosphorylation of the actin associated pool of extracellular signal regulated kinase 1 and 2 (ERK1/2) in response to protein kinase C activation.
Title: Hierarchical scaffolding of an ERK1/2 activation pathway.

IQGAP1 protein domains actively participate in spine morphogenesis and differentially affect spine number and shape.
Title: Regulation of spine density and morphology by IQGAP1 protein domains.

IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 signaling protein
Title: IQGAP1 mediates angiotensin II-induced apoptosis of podocytes via the ERK1/2 MAPK signaling pathway.

These results suggest that Chlamydophila pneumoniae infection may promote the adhesion and migration of vascular smooth muscle cells possibly by upregulating the IQGAP1 expression.
Title: Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1.

We postulate that mTOR controls dendritic arbor morphology by enhancing cross talk between dynamic microtubules and actin through CLIP-170 and IQGAP1
Title: CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology.

The following Iqgap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Iqgap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12124	NM_001108489.1 Latest version!	Rattus norvegicus IQ motif containing GTPase activating protein 1 (Iqgap1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$1217.30 $1739.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Iqgap1 ( NM_001108489.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101959.2 Rattus norvegicus IQ motif containing GTPase activating protein 1 (Iqgap1), mRNA.

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CloneID	ORa12124
Clone ID Related Accession (Same CDS sequence)	NM_001108489.1
Accession Version	NM_001108489.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-16
Organism	Rattus norvegicus(Norway rat)
Product	ras GTPase-activating-like protein IQGAP1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473980.1. On or before Oct 4, 2007 this sequence version replaced XM_341877.3, XM_001066654.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCCGCCG CGGAGGAGGT CGATGGCCTG GGTGTGGTCC GGCCGCACTA TGGCTCTGTC 
CTGGATAATG AGAGACTCAC GGCAGAGGAG ATGGATGAGA GGAGGCGACA GAACGTGGCC 
TATGAGTACC TTTGTCATTT GGAAGAAGCA AAGAGGTGGA TGGAAGCATG CCTAGGGGAG 
GACCTGCCGC CCACCACAGA GCTGGAGGAG GGCCTTCGGA ATGGGGTCTA CCTTGCCAAG 
CTAGGGAACT TCTTCTCCCC CAAAGTGGTG TCCCTGAAGA AAATCTACGA TCGAGAGCAG 
ACCAGATACA AGGCTACCGG CCTACACTTC AGACACACGG ATAATGTGAT TCAGTGGCTG 
AATGCCATGG ATGAGATTGG ATTGCCTAAG ATTTTTTATC CAGAAACCAC AGATATCTAC 
GACCGGAAGA ACATGCCAAG ATGTATCTAC TGTATCCACG CCCTCAGTTT GTACCTGTTC 
AAACTGGGCC TGGCTCCTCA GATTCAAGAC CTGTATGGAA AGGTTGACTT CACAGAGGAA 
GAAATCAACA ACATGAAGAT TGAGCTTGAG AAGTACGGGA TCCAGATGCC TGCCTTCAGC 
AAGATAGGGG GCATCCTGGC TAACGAGCTC TCGGTGGATG AGGCTGCATT ACACGCTGCT 
GTCATTGCTA TTAATGAAGC TATTGATCAC AGAGTTGCAG CTGACACGTT TACGGCTCTG 
AAAAACCCCA ATGCCATGCT TGTCAATCTT GAAGAAGCGC TGGCTCCCAC CTACCAGGAT 
GTGCTTTACC AGGCCAAGCA GGACAAGATG ACAAATGCTA AAAACAGGAC GGAAAACTCT 
GACAGAGAAA GGGACGTTTA TGAGGAACTG CTCACACAAG CTGAAATCCA AGGGAATGTA 
AACAAAGTCA ACACATCATC TGCCCTGGCC AACATCAACC TGGCTTTAGA GCAGGGCTGT 
GCACTGACCC TGCTCAAGGC TCTGCAGTCA GTGGCTCTGG GCCTCCGAGG GTTGCAGACC 
CAGAACAGCG ACTGGTACCT GAAGCAGCTA CAGAGTGATC TGCAGCAAAA ACGACAGAGT 
GGCCAGACTG ACCCTCTGCA GAAGGAGGAG GTACAGGCCG GAGTGGATGC TGCCAACGGT 
GCTGCCCAAC AATACCAACG ACGGTTGGCA GCAGTGGCAG CGATCAATGC GGCGATCCAG 
AAGGGCATCG CCGAGAAGAC CGTTTTGGAG CTAATGAATC CTGAAGCCCA GCTGCCCCAG 
GTGTATCCAT TTGCAGCCGA TCTTTATCAG AAGGAGTTGG CCACCCTGCA GCAGCAGAGT 
CCTGAGCATA GCCTCACCCA TCCTGAACTC ACTGTTGCCG TGGAGATGCT GTCTTCTGTG 
GCCCTCATCA ACAGGGCGCT GGAGTCAGGA GACATGAACA CGGTGTGGAA GCAGCTGAGC 
AGCTCCGTTA CAGGCCTTAC CAATATCGAG GAAGAAAACT GTCAAAGGTA TCTGGATGAG 
CTGATGAAGC TGAAGGCGCA GGCACATGCA GAGAATAATG AATTTGTCAC GTGGAATGAC 
ATCCAGGCGT GTGTGGACCA CGTGAACCTG GTGGTCCACG AGGAACATGA GCGGATTTTG 
GCCATTGGTT TAATTAATGA AGCCCTGGAT GAAGGGGACG CTCAGAAGAC TCTGCAGGCC 
CTGCAGATCC CTGCAGCCAA GCTCGAGGGG GTCCTTCCAG AGGTGGCACA GCATTATCAA 
GACACGCTGA TCAGAGCAAA GAGAGAAAAG GCCCAGGAAA CCCAGGATGA GTCAGCTGTG 
TTATGGTTGG ATGAAATTCA AGGTGGAATC TGGCAGTCCA ACAAAGACAC CCAGGAAGCA 
CAGAGGTTTG CCCTAGGAAT CTTCGCCATC AACGAAGCAG TAGAGAGTGG TGATGTTGGC 
AGAACCCTGA GTGCCCTTCG TTCTCCGGAC GTTGGCTTAT ATGGAGTGAT CCCTGAGTGT 
GGGGAAACAT ACCAGAGTGA CCTTGCTGAA GCCAAGAAGA AAAGACTAGC AGCAGGAGAC 
AATAACAGCA AGTGGGTGAA GCACTGGGTG AAAGGCGGGT ACCATTACTA CCACAATCTG 
GAGACGCAAG CAGGAGGATG GGCTGAACCC CCAGACTTCG TGCAGAATTC TGTGCAGCTT 
TCTCGAGAGG AAATCCAGAG CTCCATCTCT GGAGTGACCG CTGCGTATAA CCGAGAGCAG 
CTTTGGCTGG CCAACGAAGG CTTGATTACC AAGCTGCAAG CCTGCTGCCG TGGGTACCTT 
GTTCGACAGG AATTCCGATC CCGGATGAAC TTTCTGAAGA AACAGATCCC CGCCATCACC 
TGCATTCAGT CACAGTGGAG AGGATACAAA CAGAAGAAGG CATATCAAGA TCGGCTGGCT 
TACCTGCACT CCCATAAAGA CGAAGTTGTG AAGATTCAGT CCCTTGCCAG GATGCATCAA 
GCCAGAAAGC GCTATAGAGA TCGCCTACAG TATTTCCGAG ACCACATAAA TGACATTATC 
AAAATCCAGG CTTTCATTCG GGCAAACAAA GCTCGCGATG ACTACAAGAC TCTCATCAAT 
GCTGAGGATC CGCCTATGAT TGTGGTCCGA AAGTTTGTCC ACCTCCTGGA CCAAAGTGAT 
CAGGACTTTC AGGAAGAGCT TGATCTTATG AAGATGCGGG AGGAGGTCAT CACCCTCATC 
CGTTCCAACC AGCAGCTGGA GAATGACCTC AATCTCATGG ATATCAAAAT CGGCCTGCTG 
GTAAAGAACA AGATCACCCT GCAGGATGTG GTTTCCCATA GTAAAAAACT TACCAAAAAG 
AATAAGGAGC AGTTGTCTGA CATGATGATG ATAAACAAGC AGAAGGGCGG GCTCAAGGCC 
CTGAGCAAGG AGAAGAGGGA GAAGCTGGAA GCCTATCAGC ATCTCTTCTA TCTGCTACAG 
ACCAACCCTA CCTATCTGGC CAAGCTGATT TTTCAGATGC CACAGAACAA GTCCACCAAG 
TTCATGGACT CTGTGATCTT CACGCTCTAC AACTATGCAT CCAACCAGCG GGAGGAGTAC 
CTGCTGCTCC GACTCTTCCA GACGGCACTG CAGGAGGAGA TCAAGTCAAA GGTGGATCAG 
ATTCAAGAAA TCGTGACAGG AAACCCTACA GTTATTAAGA TGGTTGTAAG CTTCAACCGT 
GGTGCCCGGG GCCAGAATGC CCTCCGGCAG ATCTTGGCTC CTGTTGTGAA GGAAATTATG 
GATGACAAGT CTCTCAACAT CAAAACCGAC CCCGTGGACA TTTACAAGTC TTGGGTTAAT 
CAGATGGAGT CTCAGACAGG AGAAGCGAGC AAACTGCCTT ATGATGTGAC CCCTGAGCAA 
GCCTTGTCTC ATGAAGAAGT GAAGACGAGG TTAGACAACT CCATCAGGAA CATGAGGGCT 
GTGACAGACA AGTTCCTTTC AGCCATCGTC AGCTCTGTGG ACAAAATCCC TTACGGGATG 
CGCTTCATTG CCAAAGTGCT GAAGGACTCT TTGCACGAGA AGTTCCCGGA TGCTGCCGAG 
GACGAGCTGC TGAAGATTAT TGGTAACCTG CTTTACTACC GATACATGAA CCCGGCCATC 
GTTGCTCCTG ATGCCTTCGA CATTATTGAC CTGTCAGCAG GAGGCCAGCT CACCACAGAC 
CAGCGTAGAA ATCTGGGCTC CATTGCAAAG ATGCTGCAGC ACGCGGCTTC CAACAAGATG 
TTTCTGGGTG ATAATGCTCA CCTAAGCATC ATTAATGAAT ATCTCTCTCA GTCCTACCAG 
AAATTCAGAC GGTTTTTCCA AGCCGCTTGC GACGTCCCAG AGCTACAGGA TAAGTTTAAT 
GTGGATGAGT ATTCCGATCT AGTCACCCTC ACCAAGCCGG TTATCTACAT TTCCATTGGT 
GAGATCATCA ACACCCACAC TCTCCTGTTG GACCATCAGG ACGCCATTGC TCCAGAGCAT 
AACGACCCCA TCCATGAACT GCTGGATGAC CTTGGAGAGG TGCCCACCAT TGAGTCCCTT 
ATAGGAGAAA GCTGTGGTAA TTCAAATGAC CCCAGCAAGG AGGCGCTGGC TAAGACTGAA 
GTGTCTCTCA CACTGACCAA CAAGTTTGAC GTGCCTGGTG ATGAGAACGC AGAGATGGAT 
GCGCGGACCA TCTTACTGAA TACAAAACGT TTAATTGTGG ATGTCATCCG GTTCCAGCCA 
GGAGAGACCT TGACTGAAAT CCTAGAAACC CCAGCCACCA ATGAACAGGA AGCTGAACAT 
CAGAGGGCCA TGCAGAGACG GGCTATCCGC GATGCCAAAA CCCCTGACAA GATGAAAAAA 
TCAAAGCCCA TGAAGGAGGA TAACAACCTC AGCCTCCAGG AGAAGAAAGA GAAGATCCAG 
ACTGGCCTAA AGAAGCTAAC GGAACTTGGG ACGGTGGACC CAAAGAACAG ATACCAGGAA 
CTCATCAACG ACATTGCTAA GGATATCCGG AATCAGCGGC GATACAGGCA GAGGAGGAAG 
GCTGAGCTGG TAAAGCTGCA GCAGACCTAC TCGGCGCTGA ACTCGAAGGC CACCTTTTAC 
GGAGAGCAGG TGGATTACTA CAAGAGCTAC ATCAAGACCT GCTTGGATAA CTTGGCCAGC 
AAGGGCAAGG TCTCCAAAAA ACCTAGGGAA ATGAAAGGCA AAAAAAGCAA AAAGATTTCT 
CTGAAGTACA CAGCAGCAAG ACTGCATGAG AAGGGAGTGC TTCTGGAAAT TGAGGACCTT 
CAAGCAAACC AATTTAAAAA TGTTATCTTC GAAATTGGTC CAACAGAAGA AGTTGGAGAC 
TTTGAAGTGA AGGCCAAGTT CATGGGCGTT CAGATGGAGA CTTTCATGCT GCATTATCAG 
GACTTGCTGC AGCTACAGTA TGAAGGGGTT GCGGTCATGA AGTTGTTTGA TAGAGCTAAA 
GTGAATGTCA ACCTCCTGAT CTTCCTTCTC AACAAAAAGT TCTATGGGAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101959.2
CDS	100..5073
Translation	MSAAEEVDGLGVVRPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEEEINNMKIELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDHRVAADTFTALKNPNAMLVNLEEALAPTYQDVLYQAKQDKMTNAKNRTENSDRERDVYEELLTQAEIQGNVNKVNTSSALANINLALEQGCALTLLKALQSVALGLRGLQTQNSDWYLKQLQSDLQQKRQSGQTDPLQKEEVQAGVDAANGAAQQYQRRLAAVAAINAAIQKGIAEKTVLELMNPEAQLPQVYPFAADLYQKELATLQQQSPEHSLTHPELTVAVEMLSSVALINRALESGDMNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFVTWNDIQACVDHVNLVVHEEHERILAIGLINEALDEGDAQKTLQALQIPAAKLEGVLPEVAQHYQDTLIRAKREKAQETQDESAVLWLDEIQGGIWQSNKDTQEAQRFALGIFAINEAVESGDVGRTLSALRSPDVGLYGVIPECGETYQSDLAEAKKKRLAAGDNNSKWVKHWVKGGYHYYHNLETQAGGWAEPPDFVQNSVQLSREEIQSSISGVTAAYNREQLWLANEGLITKLQACCRGYLVRQEFRSRMNFLKKQIPAITCIQSQWRGYKQKKAYQDRLAYLHSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLINAEDPPMIVVRKFVHLLDQSDQDFQEELDLMKMREEVITLIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEYLLLRLFQTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIMDDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALSHEEVKTRLDNSIRNMRAVTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAAEDELLKIIGNLLYYRYMNPAIVAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQKFRRFFQAACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEHNDPIHELLDDLGEVPTIESLIGESCGNSNDPSKEALAKTEVSLTLTNKFDVPGDENAEMDARTILLNTKRLIVDVIRFQPGETLTEILETPATNEQEAEHQRAMQRRAIRDAKTPDKMKKSKPMKEDNNLSLQEKKEKIQTGLKKLTELGTVDPKNRYQELINDIAKDIRNQRRYRQRRKAELVKLQQTYSALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKISLKYTAARLHEKGVLLEIEDLQANQFKNVIFEIGPTEEVGDFEVKAKFMGVQMETFMLHYQDLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK

Target ORF information:

RefSeq Version	NM_001108489.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus IQ motif containing GTPase activating protein 1 (Iqgap1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108489.1

ORF Insert Sequence:

ATGTCCGCCG CGGAGGAGGT CGATGGCCTG GGTGTGGTCC GGCCGCACTA TGGCTCTGTC 
CTGGATAATG AGAGACTCAC GGCAGAGGAG ATGGATGAGA GGAGGCGACA GAACGTGGCC 
TATGAGTACC TTTGTCATTT GGAAGAAGCA AAGAGGTGGA TGGAAGCATG CCTAGGGGAG 
GACCTGCCGC CCACCACAGA GCTGGAGGAG GGCCTTCGGA ATGGGGTCTA CCTTGCCAAG 
CTAGGGAACT TCTTCTCCCC CAAAGTGGTG TCCCTGAAGA AAATCTACGA TCGAGAGCAG 
ACCAGATACA AGGCTACCGG CCTACACTTC AGACACACGG ATAATGTGAT TCAGTGGCTG 
AATGCCATGG ATGAGATTGG ATTGCCTAAG ATTTTTTATC CAGAAACCAC AGATATCTAC 
GACCGGAAGA ACATGCCAAG ATGTATCTAC TGTATCCACG CCCTCAGTTT GTACCTGTTC 
AAACTGGGCC TGGCTCCTCA GATTCAAGAC CTGTATGGAA AGGTTGACTT CACAGAGGAA 
GAAATCAACA ACATGAAGAT TGAGCTTGAG AAGTACGGGA TCCAGATGCC TGCCTTCAGC 
AAGATAGGGG GCATCCTGGC TAACGAGCTC TCGGTGGATG AGGCTGCATT ACACGCTGCT 
GTCATTGCTA TTAATGAAGC TATTGATCAC AGAGTTGCAG CTGACACGTT TACGGCTCTG 
AAAAACCCCA ATGCCATGCT TGTCAATCTT GAAGAAGCGC TGGCTCCCAC CTACCAGGAT 
GTGCTTTACC AGGCCAAGCA GGACAAGATG ACAAATGCTA AAAACAGGAC GGAAAACTCT 
GACAGAGAAA GGGACGTTTA TGAGGAACTG CTCACACAAG CTGAAATCCA AGGGAATGTA 
AACAAAGTCA ACACATCATC TGCCCTGGCC AACATCAACC TGGCTTTAGA GCAGGGCTGT 
GCACTGACCC TGCTCAAGGC TCTGCAGTCA GTGGCTCTGG GCCTCCGAGG GTTGCAGACC 
CAGAACAGCG ACTGGTACCT GAAGCAGCTA CAGAGTGATC TGCAGCAAAA ACGACAGAGT 
GGCCAGACTG ACCCTCTGCA GAAGGAGGAG GTACAGGCCG GAGTGGATGC TGCCAACGGT 
GCTGCCCAAC AATACCAACG ACGGTTGGCA GCAGTGGCAG CGATCAATGC GGCGATCCAG 
AAGGGCATCG CCGAGAAGAC CGTTTTGGAG CTAATGAATC CTGAAGCCCA GCTGCCCCAG 
GTGTATCCAT TTGCAGCCGA TCTTTATCAG AAGGAGTTGG CCACCCTGCA GCAGCAGAGT 
CCTGAGCATA GCCTCACCCA TCCTGAACTC ACTGTTGCCG TGGAGATGCT GTCTTCTGTG 
GCCCTCATCA ACAGGGCGCT GGAGTCAGGA GACATGAACA CGGTGTGGAA GCAGCTGAGC 
AGCTCCGTTA CAGGCCTTAC CAATATCGAG GAAGAAAACT GTCAAAGGTA TCTGGATGAG 
CTGATGAAGC TGAAGGCGCA GGCACATGCA GAGAATAATG AATTTGTCAC GTGGAATGAC 
ATCCAGGCGT GTGTGGACCA CGTGAACCTG GTGGTCCACG AGGAACATGA GCGGATTTTG 
GCCATTGGTT TAATTAATGA AGCCCTGGAT GAAGGGGACG CTCAGAAGAC TCTGCAGGCC 
CTGCAGATCC CTGCAGCCAA GCTCGAGGGG GTCCTTCCAG AGGTGGCACA GCATTATCAA 
GACACGCTGA TCAGAGCAAA GAGAGAAAAG GCCCAGGAAA CCCAGGATGA GTCAGCTGTG 
TTATGGTTGG ATGAAATTCA AGGTGGAATC TGGCAGTCCA ACAAAGACAC CCAGGAAGCA 
CAGAGGTTTG CCCTAGGAAT CTTCGCCATC AACGAAGCAG TAGAGAGTGG TGATGTTGGC 
AGAACCCTGA GTGCCCTTCG TTCTCCGGAC GTTGGCTTAT ATGGAGTGAT CCCTGAGTGT 
GGGGAAACAT ACCAGAGTGA CCTTGCTGAA GCCAAGAAGA AAAGACTAGC AGCAGGAGAC 
AATAACAGCA AGTGGGTGAA GCACTGGGTG AAAGGCGGGT ACCATTACTA CCACAATCTG 
GAGACGCAAG CAGGAGGATG GGCTGAACCC CCAGACTTCG TGCAGAATTC TGTGCAGCTT 
TCTCGAGAGG AAATCCAGAG CTCCATCTCT GGAGTGACCG CTGCGTATAA CCGAGAGCAG 
CTTTGGCTGG CCAACGAAGG CTTGATTACC AAGCTGCAAG CCTGCTGCCG TGGGTACCTT 
GTTCGACAGG AATTCCGATC CCGGATGAAC TTTCTGAAGA AACAGATCCC CGCCATCACC 
TGCATTCAGT CACAGTGGAG AGGATACAAA CAGAAGAAGG CATATCAAGA TCGGCTGGCT 
TACCTGCACT CCCATAAAGA CGAAGTTGTG AAGATTCAGT CCCTTGCCAG GATGCATCAA 
GCCAGAAAGC GCTATAGAGA TCGCCTACAG TATTTCCGAG ACCACATAAA TGACATTATC 
AAAATCCAGG CTTTCATTCG GGCAAACAAA GCTCGCGATG ACTACAAGAC TCTCATCAAT 
GCTGAGGATC CGCCTATGAT TGTGGTCCGA AAGTTTGTCC ACCTCCTGGA CCAAAGTGAT 
CAGGACTTTC AGGAAGAGCT TGATCTTATG AAGATGCGGG AGGAGGTCAT CACCCTCATC 
CGTTCCAACC AGCAGCTGGA GAATGACCTC AATCTCATGG ATATCAAAAT CGGCCTGCTG 
GTAAAGAACA AGATCACCCT GCAGGATGTG GTTTCCCATA GTAAAAAACT TACCAAAAAG 
AATAAGGAGC AGTTGTCTGA CATGATGATG ATAAACAAGC AGAAGGGCGG GCTCAAGGCC 
CTGAGCAAGG AGAAGAGGGA GAAGCTGGAA GCCTATCAGC ATCTCTTCTA TCTGCTACAG 
ACCAACCCTA CCTATCTGGC CAAGCTGATT TTTCAGATGC CACAGAACAA GTCCACCAAG 
TTCATGGACT CTGTGATCTT CACGCTCTAC AACTATGCAT CCAACCAGCG GGAGGAGTAC 
CTGCTGCTCC GACTCTTCCA GACGGCACTG CAGGAGGAGA TCAAGTCAAA GGTGGATCAG 
ATTCAAGAAA TCGTGACAGG AAACCCTACA GTTATTAAGA TGGTTGTAAG CTTCAACCGT 
GGTGCCCGGG GCCAGAATGC CCTCCGGCAG ATCTTGGCTC CTGTTGTGAA GGAAATTATG 
GATGACAAGT CTCTCAACAT CAAAACCGAC CCCGTGGACA TTTACAAGTC TTGGGTTAAT 
CAGATGGAGT CTCAGACAGG AGAAGCGAGC AAACTGCCTT ATGATGTGAC CCCTGAGCAA 
GCCTTGTCTC ATGAAGAAGT GAAGACGAGG TTAGACAACT CCATCAGGAA CATGAGGGCT 
GTGACAGACA AGTTCCTTTC AGCCATCGTC AGCTCTGTGG ACAAAATCCC TTACGGGATG 
CGCTTCATTG CCAAAGTGCT GAAGGACTCT TTGCACGAGA AGTTCCCGGA TGCTGCCGAG 
GACGAGCTGC TGAAGATTAT TGGTAACCTG CTTTACTACC GATACATGAA CCCGGCCATC 
GTTGCTCCTG ATGCCTTCGA CATTATTGAC CTGTCAGCAG GAGGCCAGCT CACCACAGAC 
CAGCGTAGAA ATCTGGGCTC CATTGCAAAG ATGCTGCAGC ACGCGGCTTC CAACAAGATG 
TTTCTGGGTG ATAATGCTCA CCTAAGCATC ATTAATGAAT ATCTCTCTCA GTCCTACCAG 
AAATTCAGAC GGTTTTTCCA AGCCGCTTGC GACGTCCCAG AGCTACAGGA TAAGTTTAAT 
GTGGATGAGT ATTCCGATCT AGTCACCCTC ACCAAGCCGG TTATCTACAT TTCCATTGGT 
GAGATCATCA ACACCCACAC TCTCCTGTTG GACCATCAGG ACGCCATTGC TCCAGAGCAT 
AACGACCCCA TCCATGAACT GCTGGATGAC CTTGGAGAGG TGCCCACCAT TGAGTCCCTT 
ATAGGAGAAA GCTGTGGTAA TTCAAATGAC CCCAGCAAGG AGGCGCTGGC TAAGACTGAA 
GTGTCTCTCA CACTGACCAA CAAGTTTGAC GTGCCTGGTG ATGAGAACGC AGAGATGGAT 
GCGCGGACCA TCTTACTGAA TACAAAACGT TTAATTGTGG ATGTCATCCG GTTCCAGCCA 
GGAGAGACCT TGACTGAAAT CCTAGAAACC CCAGCCACCA ATGAACAGGA AGCTGAACAT 
CAGAGGGCCA TGCAGAGACG GGCTATCCGC GATGCCAAAA CCCCTGACAA GATGAAAAAA 
TCAAAGCCCA TGAAGGAGGA TAACAACCTC AGCCTCCAGG AGAAGAAAGA GAAGATCCAG 
ACTGGCCTAA AGAAGCTAAC GGAACTTGGG ACGGTGGACC CAAAGAACAG ATACCAGGAA 
CTCATCAACG ACATTGCTAA GGATATCCGG AATCAGCGGC GATACAGGCA GAGGAGGAAG 
GCTGAGCTGG TAAAGCTGCA GCAGACCTAC TCGGCGCTGA ACTCGAAGGC CACCTTTTAC 
GGAGAGCAGG TGGATTACTA CAAGAGCTAC ATCAAGACCT GCTTGGATAA CTTGGCCAGC 
AAGGGCAAGG TCTCCAAAAA ACCTAGGGAA ATGAAAGGCA AAAAAAGCAA AAAGATTTCT 
CTGAAGTACA CAGCAGCAAG ACTGCATGAG AAGGGAGTGC TTCTGGAAAT TGAGGACCTT 
CAAGCAAACC AATTTAAAAA TGTTATCTTC GAAATTGGTC CAACAGAAGA AGTTGGAGAC 
TTTGAAGTGA AGGCCAAGTT CATGGGCGTT CAGATGGAGA CTTTCATGCT GCATTATCAG 
GACTTGCTGC AGCTACAGTA TGAAGGGGTT GCGGTCATGA AGTTGTTTGA TAGAGCTAAA 
GTGAATGTCA ACCTCCTGAT CTTCCTTCTC AACAAAAAGT TCTATGGGAA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding.
Cell stem cell21(5)635-649.e8(2017 Nov)
Liu J,Liu W,Yang L,Wu Q,Zhang H,Fang A,Li L,Xu X,Sun L,Zhang J,Tang F,Wang X

A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.
Scientific reports7(1)9302(2017 Aug)
Vetterkind S,Lin QQ,Morgan KG

Ezrin interacts with the scaffold protein IQGAP1 and affects its cortical localization.
Biochimica et biophysica acta1853(9)2086-94(2015 Sep)
Nammalwar RC,Heil A,Gerke V

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
The Journal of biological chemistry290(39)23766-80(2015 Sep)
Cao D,Su Z,Wang W,Wu H,Liu X,Akram S,Qin B,Zhou J,Zhuang X,Adams G,Jin C,Wang X,Liu L,Hill DL,Wang D,Ding X,Yao X

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Iqgap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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