Fes cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fes
Entrez Gene ID	361597
Full Name	FES proto-oncogene, tyrosine kinase
Synonyms	RGD1564385
General protein information	Preferred Names FES proto-oncogene, tyrosine kinase Names tyrosine-protein kinase Fes/Fps feline sarcoma oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108488.1	NP_001101958.1	tyrosine-protein kinase Fes/Fps

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Fes	NP_034324.2
Danio rerio (zebrafish)	fes	NP_001186798.1
Caenorhabditis elegans (roundworm)	ZK622.1	NP_494994.1
Xenopus tropicalis (tropical clawed frog)	LOC100489191	XP_002932286.2
	FES	XP_001093848.1
Bos taurus (cattle)	FES	NP_001027471.1
Gallus gallus (chicken)	FES	XP_003641916.2
Pan troglodytes (chimpanzee)	FES	XP_001169472.1
Canis lupus familiaris (dog)	FES	XP_851836.1
Rattus norvegicus (Norway rat)	Fes	NP_001101958.1
Homo sapiens (human)	FES	NP_001996.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes.
Hu J, Zheng L, Shen X, Zhang Y, Li C, Xi T
Gene6201-9(2017 Jul)

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.
McPherson VA, Everingham S, Karisch R, Smith JA, Udell CM, Zheng J, Jia Z, Craig AW
Molecular and cellular biology29(2)389-401(2009 Jan)

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.
Naba A, Reverdy C, Louvard D, Arpin M
The EMBO journal27(1)38-50(2008 Jan)

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.
Laurent CE, Delfino FJ, Cheng HY, Smithgall TE
Molecular and cellular biology24(21)9351-8(2004 Nov)

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Laurent CE, Smithgall TE
Experimental cell research299(1)188-98(2004 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Fes and Bcr cooperate to activate Rho family GTPases as part of a novel pathway regulating neurite extension in PC12 cells, and provide more evidence for an emerging role for Fes in neuronal differentiation.
Title: The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.

A 95 kDa Fes protein was purified from the rat brain CRMP-CRAM complex and shown to be involved in Sema3A signaling [Fes].
Title: Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.

The following Fes gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fes cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07499	NM_001108488.1 Latest version!	Rattus norvegicus FES proto-oncogene, tyrosine kinase (Fes), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fes ( NM_001108488.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101958.1 Rattus norvegicus FES proto-oncogene, tyrosine kinase (Fes), mRNA.

Price & Availability↑

CloneID	ORa07499
Clone ID Related Accession (Same CDS sequence)	NM_001108488.1
Accession Version	NM_001108488.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2469bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase Fes/Fps
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473980.1. On or before Oct 4, 2007 this sequence version replaced XM_341876.3, XM_001066375.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA ACAGATGCAA 
GAAGCTGAGC TTCGTTTATT GGAAGGGATG AGGAAGTGGA TGGCGCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AAGACAGCGG GGGCCAGAGC 
TGGAGCAGTG GCCCTGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACG 
GAGAACTTGA GCCGGGTACT GCGGCAGCAT GCAGAAGATC TGAACTCAGG GCCCCTGAGC 
AAGCTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACTTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTAAAGAGC 
CAGTACCGGA CCCTGACACG AGATAGTGCC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGCGACAA GGCCAAAGAC AAGTATGTAC GAAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT ACTGGGTGTG AGGGCCGCGC AGCTGCACCA CCAGCACTAC 
CACCAATTCA TGCTGCCTGG CCTGCTGCAG TCACTACAGG ACTTGCACGA AGAGATGGCA 
GGCATCCTGA AGGACATCCT GCAGGAATAC CTAGAGATCA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GCATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA GTACGGATCT GCCCCTGATG TCCCACCTTG TGTCACTTTT 
GATGTGTCAC TTCTTGAAGA GGGCGAACAG CTGGAACCTG GGGACCTGCA GCTGAACGAG 
CTGACCTTGG AGAGCGTGCA GCACACGCTG ACCTCTGTGA CAGACGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGGGA GCTCCAGTGC 
GAGGAGCAGA ACACCCACCC CCGAGAACGG GTGCAGCTTC TGGGCAAGAG GCAGGTGCTG 
CAAGAGGCGA TGCAGGGGTT GCAGGTAGCA CTGTGCAATC AGGACAAGCT TCAGGCTCAG 
CAGGAACTTC TACAGAGCAA GATGGAGCAG CTCGGGACAG GCGAGCCCCC AGCCGTACCA 
CTCCTTCAGG ATGACCGTCA TTCCACCTCT TCCACGGAGC AGGAGCGAGA TGGGGGAAGG 
ACACCCACCC TGGAGATCAT TAAAAGCCAC TTCTCTGGAA TCTTCCGCCC CAAGTTCTCC 
ATCCCTCCTC CGCTGCAGCT CGTTCCAGAG GTGCAGAAGC CCCTCCACGA GCAGCTGTGG 
TACCATGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTTCTGT CTGTGCTGTG GGATGGCCAG 
CCCCGACACT TCATCATCCA ATCCTCAGAT AACCTGTACC GGCTGGAAGG GGACGGCTTT 
CCCAGCATCC CTTTGCTCAT CACTCACCTG CTGTCCTCCC AGCAGCCCCT TACAAAGAAG 
AGTGGTGTTG TCTTGTTCAG GGCGGTACCC AAGGACAAGT GGGTACTGAA GCATGAGGAT 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGACGTCTT 
CGTGCAGACA ACACCCCGGT GGCTGTGAAG TCTTGTCGAG AGACGCTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCGAGGATC CTGAAACAGT ACAACCACCC CAACATTGTA 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCCATCTACA TTGTCATGGA GCTGGTTCAA 
GGGGGCGACT TTCTCACCTT TCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACCCTG 
CTGCAGATGG TAGGGGATGC AGCTGCTGGC ATGGAGTACT TGGAAAGCAA GTGCTGTATC 
CACCGGGATC TGGCTGCTCG CAACTGCCTG GTGACAGAGA AGAATGTTCT GAAGATCAGT 
GACTTCGGGA TGTCTCGAGA AGAGGCTGAC GGGATCTACG CGGCCTCAGC CGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAA GCTCTTAATT ATGGACGCTA CTCCTCAGAA 
AGTGACGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTAGG GGCCTCACCT 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTCG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCAGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCGGGGCAGA GGCCTAGCTT CAGCACCATC TGCCAGGAGC TACAGAGTAT CCGAAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101958.1
CDS	135..2603
Translation	MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKSQYRTLTRDSAQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHQHYHQFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSAPDVPPCVTFDVSLLEEGEQLEPGDLQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQCEEQNTHPRERVQLLGKRQVLQEAMQGLQVALCNQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQERDGGRTPTLEIIKSHFSGIFRPKFSIPPPLQLVPEVQKPLHEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTICQELQSIRKRHR

Target ORF information:

RefSeq Version	NM_001108488.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FES proto-oncogene, tyrosine kinase (Fes), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108488.1

ORF Insert Sequence:

ATGGGCTTCT CTTCAGAGCT GTGCAGCCCC CAGGGCCACG GGGCAGTGCA ACAGATGCAA 
GAAGCTGAGC TTCGTTTATT GGAAGGGATG AGGAAGTGGA TGGCGCAGAG GGTCAAGAGT 
GACCGGGAAT ATGCAGGATT GCTTCACCAC ATGTCCTTGC AAGACAGCGG GGGCCAGAGC 
TGGAGCAGTG GCCCTGACAG CCCTGTCAGC CAGTCCTGGG CAGAGATAAC AAGCCAGACG 
GAGAACTTGA GCCGGGTACT GCGGCAGCAT GCAGAAGATC TGAACTCAGG GCCCCTGAGC 
AAGCTGAGCG TGCTGATCCG GGAGCGGCAG CACCTGAGAA AGACTTACAA CGAGCAGTGG 
CAGCAGCTGC AGCAGGAGCT CACCAAGACC CACAGCCAGG ACATTGAGAA GCTAAAGAGC 
CAGTACCGGA CCCTGACACG AGATAGTGCC CAGGCCAGGC GCAAGTACCA GGAAGCCAGC 
AAAGACAAGG ATCGCGACAA GGCCAAAGAC AAGTATGTAC GAAGCCTGTG GAAGCTCTTT 
GCCCACCACA ACCGCTACGT ACTGGGTGTG AGGGCCGCGC AGCTGCACCA CCAGCACTAC 
CACCAATTCA TGCTGCCTGG CCTGCTGCAG TCACTACAGG ACTTGCACGA AGAGATGGCA 
GGCATCCTGA AGGACATCCT GCAGGAATAC CTAGAGATCA GCAGTCTGGT GCAGGACGAT 
GTGGCATCCA TTCACCGTGA GCTGGCTGCA GCTGCTGCTC GCATCCAGCC TGAGTTTGAG 
TACCTAGGCT TCCTGCGACA GTACGGATCT GCCCCTGATG TCCCACCTTG TGTCACTTTT 
GATGTGTCAC TTCTTGAAGA GGGCGAACAG CTGGAACCTG GGGACCTGCA GCTGAACGAG 
CTGACCTTGG AGAGCGTGCA GCACACGCTG ACCTCTGTGA CAGACGAACT GGCTGTGGCC 
ACCAAAGAGG TGCTGAGCCG GCAGGAGATG GTCAGTCAGC TGCAGCGGGA GCTCCAGTGC 
GAGGAGCAGA ACACCCACCC CCGAGAACGG GTGCAGCTTC TGGGCAAGAG GCAGGTGCTG 
CAAGAGGCGA TGCAGGGGTT GCAGGTAGCA CTGTGCAATC AGGACAAGCT TCAGGCTCAG 
CAGGAACTTC TACAGAGCAA GATGGAGCAG CTCGGGACAG GCGAGCCCCC AGCCGTACCA 
CTCCTTCAGG ATGACCGTCA TTCCACCTCT TCCACGGAGC AGGAGCGAGA TGGGGGAAGG 
ACACCCACCC TGGAGATCAT TAAAAGCCAC TTCTCTGGAA TCTTCCGCCC CAAGTTCTCC 
ATCCCTCCTC CGCTGCAGCT CGTTCCAGAG GTGCAGAAGC CCCTCCACGA GCAGCTGTGG 
TACCATGGGG CTATCCCTCG GGCAGAGGTA GCTGAGCTGC TAACACACTC CGGGGACTTC 
CTGGTTCGGG AGAGCCAGGG CAAGCAGGAG TATGTTCTGT CTGTGCTGTG GGATGGCCAG 
CCCCGACACT TCATCATCCA ATCCTCAGAT AACCTGTACC GGCTGGAAGG GGACGGCTTT 
CCCAGCATCC CTTTGCTCAT CACTCACCTG CTGTCCTCCC AGCAGCCCCT TACAAAGAAG 
AGTGGTGTTG TCTTGTTCAG GGCGGTACCC AAGGACAAGT GGGTACTGAA GCATGAGGAT 
CTGGTGCTGG GAGAGCAGAT CGGAAGGGGG AACTTCGGAG AGGTGTTTAG TGGACGTCTT 
CGTGCAGACA ACACCCCGGT GGCTGTGAAG TCTTGTCGAG AGACGCTCCC ACCTGACCTC 
AAGGCCAAGT TTCTGCAAGA AGCGAGGATC CTGAAACAGT ACAACCACCC CAACATTGTA 
CGTCTCATCG GGGTCTGCAC ACAGAAACAG CCCATCTACA TTGTCATGGA GCTGGTTCAA 
GGGGGCGACT TTCTCACCTT TCTGCGGACA GAGGGAGCCC GCCTGCGGGT GAAGACCCTG 
CTGCAGATGG TAGGGGATGC AGCTGCTGGC ATGGAGTACT TGGAAAGCAA GTGCTGTATC 
CACCGGGATC TGGCTGCTCG CAACTGCCTG GTGACAGAGA AGAATGTTCT GAAGATCAGT 
GACTTCGGGA TGTCTCGAGA AGAGGCTGAC GGGATCTACG CGGCCTCAGC CGGCCTCAGA 
CAAGTCCCTG TTAAGTGGAC TGCCCCTGAA GCTCTTAATT ATGGACGCTA CTCCTCAGAA 
AGTGACGTGT GGAGCTTTGG CATTTTGCTG TGGGAGACCT TCAGCCTAGG GGCCTCACCT 
TATCCCAACC TCACCAATCA GCAGACACGG GAGTTTGTCG AAAAGGGGCA TCGTCTGCCT 
TGCCCAGAGC TGTGCCCTGA TGCAGTCTTC AGGCTCATGG AGCAGTGCTG GGCCTATGAG 
CCGGGGCAGA GGCCTAGCTT CAGCACCATC TGCCAGGAGC TACAGAGTAT CCGAAAGCGG 
CATCGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes.
Gene6201-9(2017 Jul)
Hu J,Zheng L,Shen X,Zhang Y,Li C,Xi T

Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.
Molecular and cellular biology29(2)389-401(2009 Jan)
McPherson VA,Everingham S,Karisch R,Smith JA,Udell CM,Zheng J,Jia Z,Craig AW

Spatial recruitment and activation of the Fes kinase by ezrin promotes HGF-induced cell scattering.
The EMBO journal27(1)38-50(2008 Jan)
Naba A,Reverdy C,Louvard D,Arpin M

The human c-Fes tyrosine kinase binds tubulin and microtubules through separate domains and promotes microtubule assembly.
Molecular and cellular biology24(21)9351-8(2004 Nov)
Laurent CE,Delfino FJ,Cheng HY,Smithgall TE

The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Experimental cell research299(1)188-98(2004 Sep)
Laurent CE,Smithgall TE

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Fes cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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