Akap7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akap7
Entrez Gene ID	361458
Full Name	A-kinase anchoring protein 7
Synonyms	AKAP-18,AKAP18d,Akap15,Akap18
General protein information	Preferred Names A-kinase anchoring protein 7 Names A-kinase anchor protein 7 isoforms delta and gamma A kinase (PRKA) anchor protein 7 A-kinase anchor protein 18 A-kinase anchoring protein 18 ,isoform delta AKAP-7 isoforms delta and gamma PRKA7 isoforms delta and gamma protein kinase A-anchoring protein 7 isoforms delta and gamma
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p12
Summary	member of the A-kinase anchoring protein (AKAP) family; binds to the regulatory subunit (RII) of cAMP-dependent protein kinase A [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001001801.3	NP_001001801.1	A-kinase anchor protein 7 isoforms delta and gamma

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	AKAP7	XP_004940277.1
Xenopus tropicalis (tropical clawed frog)	akap7	XP_002936351.2
Homo sapiens (human)	AKAP7	NP_057461.2
Pan troglodytes (chimpanzee)	AKAP7	XP_518739.2
	AKAP7	XP_001103953.2
Mus musculus (house mouse)	Akap7	NP_061217.3
Rattus norvegicus (Norway rat)	Akap7	NP_001001801.1
Canis lupus familiaris (dog)	AKAP7	XP_005615711.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of plasma membrane-associated AKAPs for the regulation of cardiac I
Seyler C, Scherer D, K?pple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E
Naunyn-Schmiedeberg's archives of pharmacology390(5)493-503(2017 May)

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
Jones BW, Deem J, Younts TJ, Weisenhaus M, Sanford CA, Slack MC, Chin J, Nachmanson D, McKennon A, Castillo PE, McKnight GS
eLife5(2016 12)

Phosphorylation state-dependent interaction between AKAP7?/? and phospholamban increases phospholamban phosphorylation.
Rigatti M, Le AV, Gerber C, Moraru II, Dodge-Kafka KL
Cellular signalling27(9)1807-15(2015 Sep)

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.
Burgers PP, van der Heyden MA, Kok B, Heck AJ, Scholten A
Biochemistry54(1)11-21(2015 Jan)

AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells.
Josefsen K, Lee YC, Thams P, Efendic S, Nielsen JH
FEBS letters584(1)81-5(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Title: Role of plasma membrane-associated AKAPs for the regulation of cardiac I

results confirm that AKAP7gamma/delta binding to PLB is important for phosphorylation of PLB.
Title: Phosphorylation state-dependent interaction between AKAP7?/? and phospholamban increases phospholamban phosphorylation.

The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.
Title: AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells.

Akap18 contains a phosphodiesterase domain that binds AMP.
Title: AKAP18 contains a phosphoesterase domain that binds AMP.

Data show that AKAP18delta acts as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca(2+) re-uptake.
Title: AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

The following Akap7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akap7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09738	NM_001001801.3 Latest version!	Rattus norvegicus A-kinase anchoring protein 7 (Akap7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akap7 ( NM_001001801.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001001801.1 Rattus norvegicus A-kinase anchoring protein 7 (Akap7), mRNA.

Price & Availability↑

CloneID	ORa09738
Clone ID Related Accession (Same CDS sequence)	NM_001001801.3
Accession Version	NM_001001801.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	A-kinase anchor protein 7 isoforms delta and gamma
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY350741.1. On Jun 10, 2007 this sequence version replaced NM_001001801.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY350741.1, BC098632.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689603 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCGCC CCGCCGCGGG AGAAATAGAT GCCAATAAGT GTGATCATTT ATCAAGAGGA 
GAGGAAGGGA CGGGGGACCT GGAGACCAGC CCTGTAGGTT CTCTGGCAGA CCTGCCGTTT 
GCTGCCGTAG ACATTCAAGA TGACTGTGGA CTCCCTGATG TACCTCAAGG AAATGTACCT 
CAAGGAAACC CAAAGAGAAG CAAAGAAAAT AGAGGCGACA GGAATGATCA CGTGAAGAAG 
AGGAAGAAGG CCAAGAAAGA TTATCAACCC AACTATTTCC TGTCCATTCC AATCACCAAC 
AAAAAGATTA CAGCTGGAAT TAAAGTCTTG CAAAATTCGA TACTGAGACA GGATAATCGA 
TTGACCAAAG CCATGGTCGG CGACGGCTCC TTTCACATCA CCTTGCTAGT GATGCAGCTA 
TTAAACGAAG ATGAAGTAAA CATAGGTACC GACGCGCTTT TGGAACTGAA GCCGTTCGTT 
GAGGAGATCC TTGAGGGGAA GCATCTGACT TTGCCCTTCC ACGGGATTGG CACTTTCCAA 
GGTCAGGTTG GCTTTGTGAA GCTGGCAGAC GGAGATCACG TCAGTGCCCT CCTGGAGATA 
GCAGAGACTG CAAAAAGGAC ATTTCAGGAA AAAGGCATCC TGGCTGGAGA AAGCAGAACT 
TTTAAGCCTC ACCTGACCTT TATGAAGCTG TCCAAAGCAC CAATGCTCTG GAAGAAGGGA 
GTGAGAAAAA TAGAGCCTGG ATTGTATGAG CAATTTATCG ACCACAGATT TGGAGAAGAA 
ATACTGTACC AAATAGATCT CTGCTCCATG CTGAAGAAAA AACAGAGCAA TGGTTATTAC 
CACTGCGAGT CTTCGATCGT GATCGGTGAG AAGGACCGAA AGGAGCCTGA GGATGCTGAA 
CTGGTCAGGC TCAGTAAGAG GCTGGTGGAG AACGCCGTGC TCAAGGCTGT CCAGCAGTAC 
CTAGAAGAGA CACAGAACAA AAAGCAGCCG GGGGAGGGGA ACTCCGTCAA AGCTGAGGAG 
GGAGATCGGA ATGGCGATGG CAGTGATAAC AACCGGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001001801.1
CDS	1..1062
Translation	MERPAAGEIDANKCDHLSRGEEGTGDLETSPVGSLADLPFAAVDIQDDCGLPDVPQGNVPQGNPKRSKENRGDRNDHVKKRKKAKKDYQPNYFLSIPITNKKITAGIKVLQNSILRQDNRLTKAMVGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKHLTLPFHGIGTFQGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGESRTFKPHLTFMKLSKAPMLWKKGVRKIEPGLYEQFIDHRFGEEILYQIDLCSMLKKKQSNGYYHCESSIVIGEKDRKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSVKAEEGDRNGDGSDNNRK

Target ORF information:

RefSeq Version	NM_001001801.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus A-kinase anchoring protein 7 (Akap7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001001801.3

ORF Insert Sequence:

ATGGAGCGCC CCGCCGCGGG AGAAATAGAT GCCAATAAGT GTGATCATTT ATCAAGAGGA 
GAGGAAGGGA CGGGGGACCT GGAGACCAGC CCTGTAGGTT CTCTGGCAGA CCTGCCGTTT 
GCTGCCGTAG ACATTCAAGA TGACTGTGGA CTCCCTGATG TACCTCAAGG AAATGTACCT 
CAAGGAAACC CAAAGAGAAG CAAAGAAAAT AGAGGCGACA GGAATGATCA CGTGAAGAAG 
AGGAAGAAGG CCAAGAAAGA TTATCAACCC AACTATTTCC TGTCCATTCC AATCACCAAC 
AAAAAGATTA CAGCTGGAAT TAAAGTCTTG CAAAATTCGA TACTGAGACA GGATAATCGA 
TTGACCAAAG CCATGGTCGG CGACGGCTCC TTTCACATCA CCTTGCTAGT GATGCAGCTA 
TTAAACGAAG ATGAAGTAAA CATAGGTACC GACGCGCTTT TGGAACTGAA GCCGTTCGTT 
GAGGAGATCC TTGAGGGGAA GCATCTGACT TTGCCCTTCC ACGGGATTGG CACTTTCCAA 
GGTCAGGTTG GCTTTGTGAA GCTGGCAGAC GGAGATCACG TCAGTGCCCT CCTGGAGATA 
GCAGAGACTG CAAAAAGGAC ATTTCAGGAA AAAGGCATCC TGGCTGGAGA AAGCAGAACT 
TTTAAGCCTC ACCTGACCTT TATGAAGCTG TCCAAAGCAC CAATGCTCTG GAAGAAGGGA 
GTGAGAAAAA TAGAGCCTGG ATTGTATGAG CAATTTATCG ACCACAGATT TGGAGAAGAA 
ATACTGTACC AAATAGATCT CTGCTCCATG CTGAAGAAAA AACAGAGCAA TGGTTATTAC 
CACTGCGAGT CTTCGATCGT GATCGGTGAG AAGGACCGAA AGGAGCCTGA GGATGCTGAA 
CTGGTCAGGC TCAGTAAGAG GCTGGTGGAG AACGCCGTGC TCAAGGCTGT CCAGCAGTAC 
CTAGAAGAGA CACAGAACAA AAAGCAGCCG GGGGAGGGGA ACTCCGTCAA AGCTGAGGAG 
GGAGATCGGA ATGGCGATGG CAGTGATAAC AACCGGAAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of plasma membrane-associated AKAPs for the regulation of cardiac I
Naunyn-Schmiedeberg's archives of pharmacology390(5)493-503(2017 May)
Seyler C,Scherer D,K?pple C,Kulzer M,Korkmaz S,Xynogalos P,Thomas D,Kaya Z,Scholz E,Backs J,Karle C,Katus HA,Zitron E

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
eLife5(2016 12)
Jones BW,Deem J,Younts TJ,Weisenhaus M,Sanford CA,Slack MC,Chin J,Nachmanson D,McKennon A,Castillo PE,McKnight GS

Phosphorylation state-dependent interaction between AKAP7?/? and phospholamban increases phospholamban phosphorylation.
Cellular signalling27(9)1807-15(2015 Sep)
Rigatti M,Le AV,Gerber C,Moraru II,Dodge-Kafka KL

A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs.
Biochemistry54(1)11-21(2015 Jan)
Burgers PP,van der Heyden MA,Kok B,Heck AJ,Scholten A

AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells.
FEBS letters584(1)81-5(2010 Jan)
Josefsen K,Lee YC,Thams P,Efendic S,Nielsen JH

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Akap7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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