Mllt10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mllt10
Entrez Gene ID	361285
Full Name	MLLT10, histone lysine methyltransferase DOT1L cofactor
General protein information	Preferred Names MLLT10, histone lysine methyltransferase DOT1L cofactor Names protein AF-10 myeloid/lymphoid or mixed lineage-leukemia translocation to 10 homolog myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 translocated to, 10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001012162.1	NP_001012162.1	protein AF-10

Pathways from BioSystems

Homologies

Homo sapiens (human)	MLLT10	NP_001182555.1
	LOC709083	XP_001097577.2
Danio rerio (zebrafish)	mllt10	XP_005162679.1
Pan troglodytes (chimpanzee)	MLLT10	XP_003312528.2
Canis lupus familiaris (dog)	MLLT10	XP_544224.3
Gallus gallus (chicken)	MLLT10	XP_004939300.1
Mus musculus (house mouse)	Mllt10	NP_001239489.1
Xenopus tropicalis (tropical clawed frog)	mllt10	XP_002933195.2
Bos taurus (cattle)	LOC519864	XP_003586813.2
Rattus norvegicus (Norway rat)	Mllt10	NP_001012162.1

Gene Ontology
Bibliography

Related articles in PubMed

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Chen S, Yang Z, Wilkinson AW, Deshpande AJ, Sidoli S, Krajewski K, Strahl BD, Garcia BA, Armstrong SA, Patel DJ, Gozani O
Molecular cell60(2)319-27(2015 Oct)

AF10-dependent transcription is enhanced by its interaction with FLRG.
Forissier S, Razanajaona D, Ay AS, Martel S, Bartholin L, Rimokh R
Biology of the cell99(10)563-71(2007 Oct)

hDOT1L links histone methylation to leukemogenesis.
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y
Cell121(2)167-78(2005 Apr)

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD
Blood86(6)2073-6(1995 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mllt10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mllt10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41980	NM_001012162.1 Latest version!	Rattus norvegicus MLLT10, histone lysine methyltransferase DOT1L cofactor (Mllt10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mllt10 ( NM_001012162.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012162.1 Rattus norvegicus MLLT10, histone lysine methyltransferase DOT1L cofactor (Mllt10), mRNA.

Price & Availability↑

CloneID	ORa41980
Clone ID Related Accession (Same CDS sequence)	NM_001012162.1
Accession Version	NM_001012162.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2940bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	protein AF-10
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC087128.1. On Feb 11, 2005 this sequence version replaced XM_341570.1. ##Evidence-Data-START## Transcript exon combination :: BC087128.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGAGAT GTGAGCTGTG TCCCCATAAA GATGGAGCTT TAAAAAGAAC AGATAATGGG 
GGTTGGGCTC ATGTGGTTTG TGCCCTCTAT ATCCCAGAGG TACAATTTGC CAATGTTTCT 
ACAATGGAGC CAATCGTTTT ACAGTCTGTC CCACATGATC GTTATAATAA GACTTGCTAC 
ATATGTGATG AGCAAGGACG AGAGAGCAAA GCGGCCACTG GCGCCTGCAT GACATGCAAT 
AAACATGGAT GTCGACAGGC CTTCCATGTA ACATGTGCTC AGTTTGCCGG GCTGCTTTGT 
GAAGAAGAAG GGAATGGCGC GGACAACGTC CAGTACTGTG GCTACTGTAA ATACCACTTT 
AGTAAGCTGA AAAAGAGCAA ACGGGGATCT AATAGGTCAT ATGATCAAAG TTTAAGTGAT 
TCTTCCTCTC ACTCTCAGGA TAAACATCAT GAGAAAGAGA AAAAAAAATA TAAAGAAAAG 
GACAAACACA AACCAAAACA CAAGAAGCAA CCCGAGCCAT CACCCGCCTT GGTTCCTTCT 
TTGACTGTTA CTACAGAAAA GACATATACA AGCACTAGCA ACAACTCCAT ATCTGGATCG 
TTGAAGTGCT TGGAAGATAC CGCAGCAAGA TTTACAAATG CAAATTTCCA GGAAGTGTCT 
GCCCACACCT CTAGTGGGAA AGATGTGTCA GAGGCAAGGT CAGAGGGCAA AGGGAAGAAA 
TCTTCAGCTC ACAGCTCAGG TCAAAGGGGA AGGAAGCCTG GTGGTGGAAG AAATCCAGGA 
ACAACGGTGT CAGCATCTAG CCCCTTTCCA CAAGGCAGTT TTTCAGGAAC TCCAGGCAGT 
GTAAAGTCAT CTTCTGGAAG TTCAGTGCAG TCTCCCCAGG ATTTCCTCAG CTTCACTGAC 
TCGGACCTGC GGAATGACAG TTACACTCAC ACGCAGCCGC CACCGTCAAC CAAAGATGTA 
CATAAAGGGG AGCCTGGCAG CCAGGATGCA GGGGTGAACA GCTTTAGCTC TCTAGTTGGT 
CACCCTGGGA CCTCAGGTGC GACTTCACAG CCGAAAAGCT TTGACAGCTC TCCTGGGGAG 
TTGGGCAGCT CCAGCCTTCC TACAGCAGGG TATAAGCGGG CTCAGACTTC TGGGGTAGAA 
GAGGAGGAAG CCGTGAAGGA AAAGAAACGG AAAGGGAATA AACAAAGCAA GCATGGCCCT 
GGCCGACCCA AAGGAAACAA GAACCAAGAA AATGTTTCTC ACCTCTCGGT TTCTTCTGCT 
TCACCGACAT CATCCGTGGC ATCGGCTGCG GGGAGTGTGA CAAGCTGTAG CCTTCAGAAG 
TCCCCCACGC TGCTCAGGAA TGGAAGTATG CAGAGTCTCA GCGTGGGCTC GTCCCCGCTT 
GGCTCAGAAA TTTCCATGCA GTATCGACAT GATGGAGCTT GTCCAACAAC TAGTATTTAT 
AACAGCAATG ATGTAGCCGT TTCCTTCCCA AACGTGGTGT CTGGCTCAGG ATCGAGCACT 
CCCGTCTCCA GCTCTCATAT ACCTCAGCAG TCGTCTGGGC ATTTGCAACA GGTGGGAGCT 
CTCTCCCCCT CGGCTGCGTC ATCTGTAACC CCCGCTGCTG CTACAACTCA GGCAAACACC 
GCTCCTGGAT CTTCTCTGAG TCAGGCACCG GCCCATGTGT ATGGCAGTAG ATTAAATCAG 
AATCCATCCA TGGCCGTTCT TATAGCTCAG TCTGAGAGCA GCCAAACAGA TCAAGATCTC 
GGAGACAATA CCCGCAGCCT GGTTGGTCGG GGCAGCTCCC CCCGAGGAAG CCTCTCTCCA 
AGATCCCCTG TGAGCAACTT GCAGATTCGA TATGATCAGC CAAGCAGCAG TGGTTTGGAA 
AGCCTGCCTC CAGTGGCAGT GAGTATTGAG CAGCTCTTGG AGAGGCAATG GAGCGAAGGG 
CAGCAGTTTT TATTAGAGCA GGGCACTCCG AGTGACATTT TAGGAATGTT AAAGTCATTA 
CATCAACTTC AAGTTGAAAA TCGAAGATTA GAAGAACAGA TTAAAAACTT GACTGCCAAA 
AAAGAACGTC TTCAGTTGTT GAACGCACAG CTTTCAGTGC CTTTCCCAGC AATAACGACA 
AACCCTAGTC CATCTCATCA GATACACACA TACACAGCAC AGACTGCTCC TACTACTGAC 
TCTCTGAACA GCAGTAAGAG CCCGCATATA GGAAACAGCT TTGTACCCGA CAATTCTCTT 
CCTGTATTAA ATCAGGACCT GACTTCCAGT GGGCAAAGCA CCAGCAGCTC TTCTGCTCTT 
TCCACTCCCC CGCCTGCTGG GCAGAGTCCA GCCCAGCAGG GCTCTGGAGT TAGTGGGGTT 
CAGCAGGTGA ACGGCGTGAC AGTGGGGCCA CTAGCTAGTG GAATGCAGAC TGTCACATCC 
ACCATTCCTG CTGTGTCTGC AGTGGGTGGA ATAATTGGAG CTTTGCCAGG TAACCAGCTG 
GCAATCAATG GCATTGTAGG AGCGTTAAAT GGTGTTATTC AGACGCCGGT CACAATATCC 
CAGAACCCTG CCCCGCTCAC CCACACCAGT GTGCCACCTA ATGCAGCACA TCCCATGCCA 
GCCGCCGCCC TGACTAACAG TGCCTCGGGC CTGGGGCTGC TGTCGGACCA GCAGCGACAG 
ATGTTCCTCC AGCAGCAGCA GTTCCAGCAG CTCTTGAACT CCCAGCAGCT CACGCCGGAG 
CAGCACCAGG CCTTCCTGTA CCAGCTGATG CAGCAGCAGC ACCATCCCCC CGAGCTTCAG 
CAGATGCAGC TCCCAGGGCC CACGCAGATC CCCATCAACA ACCTCCTGGC AGGCCCTCCG 
GCGCCCCCAC TCCACACGGC GACCACCAAC CCCTTCCTCA CCATCCACGG GGACAGCACA 
AGCCAGAAAG TCACAAGACT TAGTGATAAG ACTGGGCCTG TAGCTCAAGA GAAAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012162.1
CDS	369..3308
Translation	MKRCELCPHKDGALKRTDNGGWAHVVCALYIPEVQFANVSTMEPIVLQSVPHDRYNKTCYICDEQGRESKAATGACMTCNKHGCRQAFHVTCAQFAGLLCEEEGNGADNVQYCGYCKYHFSKLKKSKRGSNRSYDQSLSDSSSHSQDKHHEKEKKKYKEKDKHKPKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKCLEDTAARFTNANFQEVSAHTSSGKDVSEARSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSASSPFPQGSFSGTPGSVKSSSGSSVQSPQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNSFSSLVGHPGTSGATSQPKSFDSSPGELGSSSLPTAGYKRAQTSGVEEEEAVKEKKRKGNKQSKHGPGRPKGNKNQENVSHLSVSSASPTSSVASAAGSVTSCSLQKSPTLLRNGSMQSLSVGSSPLGSEISMQYRHDGACPTTSIYNSNDVAVSFPNVVSGSGSSTPVSSSHIPQQSSGHLQQVGALSPSAASSVTPAAATTQANTAPGSSLSQAPAHVYGSRLNQNPSMAVLIAQSESSQTDQDLGDNTRSLVGRGSSPRGSLSPRSPVSNLQIRYDQPSSSGLESLPPVAVSIEQLLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPAITTNPSPSHQIHTYTAQTAPTTDSLNSSKSPHIGNSFVPDNSLPVLNQDLTSSGQSTSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGPLASGMQTVTSTIPAVSAVGGIIGALPGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLSDQQRQMFLQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQHHPPELQQMQLPGPTQIPINNLLAGPPAPPLHTATTNPFLTIHGDSTSQKVTRLSDKTGPVAQEKS

Target ORF information:

RefSeq Version	NM_001012162.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MLLT10, histone lysine methyltransferase DOT1L cofactor (Mllt10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012162.1

ORF Insert Sequence:

ATGAAGAGAT GTGAGCTGTG TCCCCATAAA GATGGAGCTT TAAAAAGAAC AGATAATGGG 
GGTTGGGCTC ATGTGGTTTG TGCCCTCTAT ATCCCAGAGG TACAATTTGC CAATGTTTCT 
ACAATGGAGC CAATCGTTTT ACAGTCTGTC CCACATGATC GTTATAATAA GACTTGCTAC 
ATATGTGATG AGCAAGGACG AGAGAGCAAA GCGGCCACTG GCGCCTGCAT GACATGCAAT 
AAACATGGAT GTCGACAGGC CTTCCATGTA ACATGTGCTC AGTTTGCCGG GCTGCTTTGT 
GAAGAAGAAG GGAATGGCGC GGACAACGTC CAGTACTGTG GCTACTGTAA ATACCACTTT 
AGTAAGCTGA AAAAGAGCAA ACGGGGATCT AATAGGTCAT ATGATCAAAG TTTAAGTGAT 
TCTTCCTCTC ACTCTCAGGA TAAACATCAT GAGAAAGAGA AAAAAAAATA TAAAGAAAAG 
GACAAACACA AACCAAAACA CAAGAAGCAA CCCGAGCCAT CACCCGCCTT GGTTCCTTCT 
TTGACTGTTA CTACAGAAAA GACATATACA AGCACTAGCA ACAACTCCAT ATCTGGATCG 
TTGAAGTGCT TGGAAGATAC CGCAGCAAGA TTTACAAATG CAAATTTCCA GGAAGTGTCT 
GCCCACACCT CTAGTGGGAA AGATGTGTCA GAGGCAAGGT CAGAGGGCAA AGGGAAGAAA 
TCTTCAGCTC ACAGCTCAGG TCAAAGGGGA AGGAAGCCTG GTGGTGGAAG AAATCCAGGA 
ACAACGGTGT CAGCATCTAG CCCCTTTCCA CAAGGCAGTT TTTCAGGAAC TCCAGGCAGT 
GTAAAGTCAT CTTCTGGAAG TTCAGTGCAG TCTCCCCAGG ATTTCCTCAG CTTCACTGAC 
TCGGACCTGC GGAATGACAG TTACACTCAC ACGCAGCCGC CACCGTCAAC CAAAGATGTA 
CATAAAGGGG AGCCTGGCAG CCAGGATGCA GGGGTGAACA GCTTTAGCTC TCTAGTTGGT 
CACCCTGGGA CCTCAGGTGC GACTTCACAG CCGAAAAGCT TTGACAGCTC TCCTGGGGAG 
TTGGGCAGCT CCAGCCTTCC TACAGCAGGG TATAAGCGGG CTCAGACTTC TGGGGTAGAA 
GAGGAGGAAG CCGTGAAGGA AAAGAAACGG AAAGGGAATA AACAAAGCAA GCATGGCCCT 
GGCCGACCCA AAGGAAACAA GAACCAAGAA AATGTTTCTC ACCTCTCGGT TTCTTCTGCT 
TCACCGACAT CATCCGTGGC ATCGGCTGCG GGGAGTGTGA CAAGCTGTAG CCTTCAGAAG 
TCCCCCACGC TGCTCAGGAA TGGAAGTATG CAGAGTCTCA GCGTGGGCTC GTCCCCGCTT 
GGCTCAGAAA TTTCCATGCA GTATCGACAT GATGGAGCTT GTCCAACAAC TAGTATTTAT 
AACAGCAATG ATGTAGCCGT TTCCTTCCCA AACGTGGTGT CTGGCTCAGG ATCGAGCACT 
CCCGTCTCCA GCTCTCATAT ACCTCAGCAG TCGTCTGGGC ATTTGCAACA GGTGGGAGCT 
CTCTCCCCCT CGGCTGCGTC ATCTGTAACC CCCGCTGCTG CTACAACTCA GGCAAACACC 
GCTCCTGGAT CTTCTCTGAG TCAGGCACCG GCCCATGTGT ATGGCAGTAG ATTAAATCAG 
AATCCATCCA TGGCCGTTCT TATAGCTCAG TCTGAGAGCA GCCAAACAGA TCAAGATCTC 
GGAGACAATA CCCGCAGCCT GGTTGGTCGG GGCAGCTCCC CCCGAGGAAG CCTCTCTCCA 
AGATCCCCTG TGAGCAACTT GCAGATTCGA TATGATCAGC CAAGCAGCAG TGGTTTGGAA 
AGCCTGCCTC CAGTGGCAGT GAGTATTGAG CAGCTCTTGG AGAGGCAATG GAGCGAAGGG 
CAGCAGTTTT TATTAGAGCA GGGCACTCCG AGTGACATTT TAGGAATGTT AAAGTCATTA 
CATCAACTTC AAGTTGAAAA TCGAAGATTA GAAGAACAGA TTAAAAACTT GACTGCCAAA 
AAAGAACGTC TTCAGTTGTT GAACGCACAG CTTTCAGTGC CTTTCCCAGC AATAACGACA 
AACCCTAGTC CATCTCATCA GATACACACA TACACAGCAC AGACTGCTCC TACTACTGAC 
TCTCTGAACA GCAGTAAGAG CCCGCATATA GGAAACAGCT TTGTACCCGA CAATTCTCTT 
CCTGTATTAA ATCAGGACCT GACTTCCAGT GGGCAAAGCA CCAGCAGCTC TTCTGCTCTT 
TCCACTCCCC CGCCTGCTGG GCAGAGTCCA GCCCAGCAGG GCTCTGGAGT TAGTGGGGTT 
CAGCAGGTGA ACGGCGTGAC AGTGGGGCCA CTAGCTAGTG GAATGCAGAC TGTCACATCC 
ACCATTCCTG CTGTGTCTGC AGTGGGTGGA ATAATTGGAG CTTTGCCAGG TAACCAGCTG 
GCAATCAATG GCATTGTAGG AGCGTTAAAT GGTGTTATTC AGACGCCGGT CACAATATCC 
CAGAACCCTG CCCCGCTCAC CCACACCAGT GTGCCACCTA ATGCAGCACA TCCCATGCCA 
GCCGCCGCCC TGACTAACAG TGCCTCGGGC CTGGGGCTGC TGTCGGACCA GCAGCGACAG 
ATGTTCCTCC AGCAGCAGCA GTTCCAGCAG CTCTTGAACT CCCAGCAGCT CACGCCGGAG 
CAGCACCAGG CCTTCCTGTA CCAGCTGATG CAGCAGCAGC ACCATCCCCC CGAGCTTCAG 
CAGATGCAGC TCCCAGGGCC CACGCAGATC CCCATCAACA ACCTCCTGGC AGGCCCTCCG 
GCGCCCCCAC TCCACACGGC GACCACCAAC CCCTTCCTCA CCATCCACGG GGACAGCACA 
AGCCAGAAAG TCACAAGACT TAGTGATAAG ACTGGGCCTG TAGCTCAAGA GAAAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Molecular cell60(2)319-27(2015 Oct)
Chen S,Yang Z,Wilkinson AW,Deshpande AJ,Sidoli S,Krajewski K,Strahl BD,Garcia BA,Armstrong SA,Patel DJ,Gozani O

AF10-dependent transcription is enhanced by its interaction with FLRG.
Biology of the cell99(10)563-71(2007 Oct)
Forissier S,Razanajaona D,Ay AS,Martel S,Bartholin L,Rimokh R

hDOT1L links histone methylation to leukemogenesis.
Cell121(2)167-78(2005 Apr)
Okada Y,Feng Q,Lin Y,Jiang Q,Li Y,Coffield VM,Su L,Xu G,Zhang Y

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.
Blood86(6)2073-6(1995 Sep)
Chaplin T,Bernard O,Beverloo HB,Saha V,Hagemeijer A,Berger R,Young BD

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Mllt10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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