Cdnf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdnf
Entrez Gene ID	361276
Full Name	cerebral dopamine neurotrophic factor
Synonyms	Armetl1
General protein information	Preferred Names cerebral dopamine neurotrophic factor Names cerebral dopamine neurotrophic factor ARMET-like protein 1 arginine-rich protein mutated in early stage tumors-like 1 arginine-rich, mutated in early stage tumors-like 1 conserved dopamine neurotrophic factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037543.1	NP_001032632.1	cerebral dopamine neurotrophic factor precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CDNF	NP_001025125.2
Canis lupus familiaris (dog)	CDNF	XP_848954.2
Mus musculus (house mouse)	Cdnf	NP_808315.1
	CDNF	XP_001088321.1
Pan troglodytes (chimpanzee)	CDNF	XP_507666.2
Bos taurus (cattle)	CDNF	NP_001192698.1
Danio rerio (zebrafish)	cdnf	NP_001116753.1
Rattus norvegicus (Norway rat)	Cdnf	NP_001032632.1
Xenopus tropicalis (tropical clawed frog)	cdnf	XP_002935290.1

Gene Ontology
Bibliography

Related articles in PubMed

Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity.
Wang L, Wang Z, Xu X, Zhu R, Bi J, Liu W, Feng X, Wu H, Zhang H, Wu J, Kong W, Yu B, Yu X
International journal of medical sciences14(4)340-347(2017)

Key subdomains in the C-terminal of cerebral dopamine neurotrophic factor regulate the protein secretion.
Liu H, Zhao C, Zhong L, Liu J, Zhang S, Cheng B, Gong L
Biochemical and biophysical research communications465(3)427-32(2015 Sep)

Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion.
Cheng L, Zhao H, Zhang W, Liu B, Liu Y, Guo Y, Nie L
Biochemical and biophysical research communications435(1)34-9(2013 May)

Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells.
Sun ZP, Gong L, Huang SH, Geng Z, Cheng L, Chen ZY
Journal of neurochemistry117(1)121-32(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In all, these findings suggest that helix-7 in the C-terminal is important for CDNF secretion, which maybe potential affect CDNF function in ER stress.
Title: Key subdomains in the C-terminal of cerebral dopamine neurotrophic factor regulate the protein secretion.

Data show that overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviated cell damage and proinflammatory cytokine secretion, which may represent a promising strategy for neuroprotection in the central nervous system (CNS).
Title: Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion.

Disruption of the helix-1 domain of cerebral dopamine neurotrophic factor significantly reduces its secretion in endoplasmic reticulum.
Title: Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells.

The following Cdnf gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdnf cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09425	NM_001037543.1 Latest version!	Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdnf ( NM_001037543.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032632.1 Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf), mRNA.

Price & Availability↑

CloneID	ORa09425
Clone ID Related Accession (Same CDS sequence)	NM_001037543.1
Accession Version	NM_001037543.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-23
Organism	Rattus norvegicus(Norway rat)
Product	cerebral dopamine neurotrophic factor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC128960.4, AABR07072569.1 and AABR07028640.1. On Dec 1, 2005 this sequence version replaced XM_341561.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: FQ121633.1, FQ128463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGGTGCA CCAGTCCGGC TGCCCTGGTG ACTTTTTGCG CCGGGCTTTG GATCTCCAAC 
CATGTGCTGG CACAGGGCCT GGAGGCCGGT GTGCGATCGA GGGCTGACTG TGAAGTATGC 
AAAGAGTTCT TAAACCGATT CTACAACTCC TTGCTAACCA GAGGAATAGA CTTTTCTGTG 
GATACCATAG AGGAAGAGCT GATCAGCTTT TGCGCGGACA CCAAGGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC TACCAAAGAC TCGGCCACCA AGATCCTAGG TGAAGTCACT 
CGTCCCATGA GTGTACACAT GCCCACGGTG AAGATTTGTG AGAAGCTGAA GAAGATGGAC 
AGCCAGATCT GCGAGCTGAA ATATGAGAAG AAATTGGACT TGGAATCTGT GGACCTGTGG 
AAAATGAGGG TTGCAGAGCT GAAGCAGATC CTTCACAGCT GGGGGGAAGA GTGCAGGGCC 
TGCGCGGAGA AGCATGACTA CGTGAACCTC ATTAAAGAAC TGGCCCCCAA ATACGTAGAG 
ACGCGCCCCC AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032632.1
CDS	61..624
Translation	MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFLNRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRPMSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRACAEKHDYVNLIKELAPKYVETRPQTEL

Target ORF information:

RefSeq Version	NM_001037543.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037543.1

ORF Insert Sequence:

ATGCGGTGCA CCAGTCCGGC TGCCCTGGTG ACTTTTTGCG CCGGGCTTTG GATCTCCAAC 
CATGTGCTGG CACAGGGCCT GGAGGCCGGT GTGCGATCGA GGGCTGACTG TGAAGTATGC 
AAAGAGTTCT TAAACCGATT CTACAACTCC TTGCTAACCA GAGGAATAGA CTTTTCTGTG 
GATACCATAG AGGAAGAGCT GATCAGCTTT TGCGCGGACA CCAAGGGAAA AGAAAACCGC 
CTGTGCTATT ATCTAGGAGC TACCAAAGAC TCGGCCACCA AGATCCTAGG TGAAGTCACT 
CGTCCCATGA GTGTACACAT GCCCACGGTG AAGATTTGTG AGAAGCTGAA GAAGATGGAC 
AGCCAGATCT GCGAGCTGAA ATATGAGAAG AAATTGGACT TGGAATCTGT GGACCTGTGG 
AAAATGAGGG TTGCAGAGCT GAAGCAGATC CTTCACAGCT GGGGGGAAGA GTGCAGGGCC 
TGCGCGGAGA AGCATGACTA CGTGAACCTC ATTAAAGAAC TGGCCCCCAA ATACGTAGAG 
ACGCGCCCCC AAACAGAGCT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity.
International journal of medical sciences14(4)340-347(2017)
Wang L,Wang Z,Xu X,Zhu R,Bi J,Liu W,Feng X,Wu H,Zhang H,Wu J,Kong W,Yu B,Yu X

Key subdomains in the C-terminal of cerebral dopamine neurotrophic factor regulate the protein secretion.
Biochemical and biophysical research communications465(3)427-32(2015 Sep)
Liu H,Zhao C,Zhong L,Liu J,Zhang S,Cheng B,Gong L

Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion.
Biochemical and biophysical research communications435(1)34-9(2013 May)
Cheng L,Zhao H,Zhang W,Liu B,Liu Y,Guo Y,Nie L

Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells.
Journal of neurochemistry117(1)121-32(2011 Apr)
Sun ZP,Gong L,Huang SH,Geng Z,Cheng L,Chen ZY

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Cdnf cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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