Cul4a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cul4a
Entrez Gene ID	361181
Full Name	cullin 4A
Synonyms	RGD1563853
General protein information	Preferred Names cullin 4A Names cullin-4A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5

mRNA and Protein(s)

mRNA	Protein	Name
XM_008771401.2	XP_008769623.1	cullin-4A isoform X1
NM_001127301.1	NP_001120773.1	cullin-4A

Pathways from BioSystems

Homologies

	LOC714302	XP_002808198.1
Rattus norvegicus (Norway rat)	Cul4a	NP_001120773.1
Canis lupus familiaris (dog)	CUL4A	XP_849542.3
Bos taurus (cattle)	CUL4A	XP_002692061.2
Homo sapiens (human)	CUL4A	NP_001008895.1
Pan troglodytes (chimpanzee)	CUL4A	XP_003314265.1
Mus musculus (house mouse)	Cul4a	NP_666319.2
Gallus gallus (chicken)	CUL4A	XP_003640577.1
Xenopus tropicalis (tropical clawed frog)	cul4a	NP_001015893.1

Gene Ontology
Bibliography

Related articles in PubMed

Selective degradation of splicing factor CAPER? by anticancer sulfonamides.
Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M, Yokoi A, Inoue A, Yoshida T, Mabuchi M, Tanaka A, Owa T
Nature chemical biology13(6)675-680(2017 Jun)

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Badertscher L, Wild T, Montellese C, Alexander LT, Bammert L, Sarazova M, Stebler M, Csucs G, Mayer TU, Zamboni N, Zemp I, Horvath P, Kutay U
Cell reports13(12)2879-91(2015 Dec)

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1.
Tong X, Zhang D, Guha A, Arthurs B, Cazares V, Gupta N, Yin L
PloS one10(10)e0139725(2015)

Identification of a primary target of thalidomide teratogenicity.
Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H
Science (New York, N.Y.)327(5971)1345-50(2010 Mar)

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.
Terai K, Abbas T, Jazaeri AA, Dutta A
Molecular cell37(1)143-9(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cul4a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cul4a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa47870	XM_008771401.2 Latest version!	Rattus norvegicus cullin 4A (Cul4a), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa01559	NM_001127301.1 Latest version!	Rattus norvegicus cullin 4A (Cul4a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cul4a ( XM_008771401.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008769623.1 Rattus norvegicus cullin 4A (Cul4a), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa47870
Clone ID Related Accession (Same CDS sequence)	XM_008771401.2
Accession Version	XM_008771401.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cullin-4A isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008771401.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATCATGA TCAGAAGCAT CTTCCTGTTT CTGGACCGCA CCTACGTCCT CCAGAACTCC 
ATGCTGCCTT CCATCTGGGA CATGGGCCTA GAGCTGTTTA GGAACCATAT CATCAGTGAC 
AGGATGGTGC AAAGCAAGAC CATTGATGGG ATCCTGCTGC TGATTGGGCG TGAACGAAGT 
GGTGAGGCTG TGGACAGGAG TCTGCTTCGC AGTCTGTTGA GCATGCTCTC AGATCTCCAG 
GTCTACAAAG ACTCATTCGA ACTGAAGTTC TTGGAAGAGA CTAACTGTCT GTACGCTGCT 
GAAGGCCAGC GGCTGATGCA AGACAGGGAG GTTCCAGAAT ACCTTAACCA TGTGAGTAAA 
CGTCTAGAAG AGGAAGCAGA CCGAGTGATC ACTTACTTAG ACCACAGCAC ACAAAAACCG 
TTGATTGCCT GTGTGGAGAA ACAGTTGTTA GGAGAACATT TGACAGCAAT TCTTCAGAAA 
GGGCTTGAGC AGCTGCTGGA TGAGAACAGG GTGCCCGACC TCACACAGAT GTACCAGCTC 
TTCAGCCGGG TGAAAGGGGG CCAGCACGCA CTGCTGCAGC ACTGGAGCGA GTACATCAAG 
ACCTTTGGGA CAACCATTGT CATCAATCCT GAGAAAGACA AAGACATGGT CCAAGACCTG 
CTGGACTTTA AGGACAAAGT GGACCACGTG GTGGAGGTGT GCTTCCAGAG GAACGAGCGC 
TTCATCAACC TGATGAAGGA GTCCTTTGAG ACGTTCATAA ACAAGAGACC AAACAAGCCG 
GCAGAGCTCA TTGCCAAGCA CGTGGATTCA AAGTTACGAG CAGGCAACAA GGAAGCAACA 
GACGAGGAGC TGGAGAGGAT CCTGGACAAG ATCATGATTC TGTTCCGATT CATCCACGGT 
AAAGATGTCT TTGAAGCATT TTATAAGAAA GACTTAGCAA AAAGGCTGCT AGTGGGGAAG 
AGCGCGTCGG TGGACGCGGA GAAGTCCATG CTGTCCAAGC TGAAGCATGA GTGTGGAGCA 
GCTTTTACCA GCAAGCTGGA GGGCATGTTC AAGGACATGG AGCTGTCCAA AGACATCATG 
GTTCACTTCA AGCAGCATAT GCAGAACCAA AGTGCACCAG GCCCCATCGA CCTCACGGTG 
AACATCCTCA CCATGGGCTA CTGGCCTACA TACACACCCA TGGAAGTGCA CCTCCCTCCA 
GAGATGGTCA GACTTCAGGA AGTATTCAAG ACGTTCTACC TGGGCAAGCA CAGTGGCCGG 
AAGCTGCAGT GGCAGACGAC GCTGGGACAC GCTGTGTTGA AGGCGGACTT TAAGGAGGGG 
AAGAAGGAGT TCCAGGTGTC CCTGTTCCAG ACGCTCGTGC TGCTCATGTT CAACGAGGGC 
GACGGGTTCA GCTTCGAAGA AATCAAAATG GCCACCGGCA TAGAGGACAG TGAGTTGCGA 
AGAACACTGC AGTCTCTCGC CTGTGGTAAA GCCCGGGTCC TGATTAAAAG TCCCAAAGGG 
AAGGAGGTGG AAGACGGAGA TAAGTTCATC TTCAATGCAG ACTTCAAACA CAAGTTGTTC 
AGAATAAAGA TCAATCAAAT CCAGATGAAG GAAACCGTTG AAGAACAGGT TAGCACCACA 
GAGAGAGTGT TCCAGGACAG ACAGTACCAG ATCGACGCTG CTATAGTCAG AATAATGAAA 
ATGAGGAAGA CACTTGGTCA TAATCTTCTA GTTTCTGAAT TATACAATCA GCTGAAATTT 
CCAGTAAAGC CTGGAGATTT GAAAAAGAGG ATTGAGTCAC TTATAGACAG AGACTATATG 
GAACGAGACA AAGACAGTCC AAATCAGTAC CACTACGTGG CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008769623.1
CDS	1338..3182
Translation	MIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA

Target ORF information:

RefSeq Version	XM_008771401.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cullin 4A (Cul4a), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008771401.2

ORF Insert Sequence:

ATGATCATGA TCAGAAGCAT CTTCCTGTTT CTGGACCGCA CCTACGTCCT CCAGAACTCC 
ATGCTGCCTT CCATCTGGGA CATGGGCCTA GAGCTGTTTA GGAACCATAT CATCAGTGAC 
AGGATGGTGC AAAGCAAGAC CATTGATGGG ATCCTGCTGC TGATTGGGCG TGAACGAAGT 
GGTGAGGCTG TGGACAGGAG TCTGCTTCGC AGTCTGTTGA GCATGCTCTC AGATCTCCAG 
GTCTACAAAG ACTCATTCGA ACTGAAGTTC TTGGAAGAGA CTAACTGTCT GTACGCTGCT 
GAAGGCCAGC GGCTGATGCA AGACAGGGAG GTTCCAGAAT ACCTTAACCA TGTGAGTAAA 
CGTCTAGAAG AGGAAGCAGA CCGAGTGATC ACTTACTTAG ACCACAGCAC ACAAAAACCG 
TTGATTGCCT GTGTGGAGAA ACAGTTGTTA GGAGAACATT TGACAGCAAT TCTTCAGAAA 
GGGCTTGAGC AGCTGCTGGA TGAGAACAGG GTGCCCGACC TCACACAGAT GTACCAGCTC 
TTCAGCCGGG TGAAAGGGGG CCAGCACGCA CTGCTGCAGC ACTGGAGCGA GTACATCAAG 
ACCTTTGGGA CAACCATTGT CATCAATCCT GAGAAAGACA AAGACATGGT CCAAGACCTG 
CTGGACTTTA AGGACAAAGT GGACCACGTG GTGGAGGTGT GCTTCCAGAG GAACGAGCGC 
TTCATCAACC TGATGAAGGA GTCCTTTGAG ACGTTCATAA ACAAGAGACC AAACAAGCCG 
GCAGAGCTCA TTGCCAAGCA CGTGGATTCA AAGTTACGAG CAGGCAACAA GGAAGCAACA 
GACGAGGAGC TGGAGAGGAT CCTGGACAAG ATCATGATTC TGTTCCGATT CATCCACGGT 
AAAGATGTCT TTGAAGCATT TTATAAGAAA GACTTAGCAA AAAGGCTGCT AGTGGGGAAG 
AGCGCGTCGG TGGACGCGGA GAAGTCCATG CTGTCCAAGC TGAAGCATGA GTGTGGAGCA 
GCTTTTACCA GCAAGCTGGA GGGCATGTTC AAGGACATGG AGCTGTCCAA AGACATCATG 
GTTCACTTCA AGCAGCATAT GCAGAACCAA AGTGCACCAG GCCCCATCGA CCTCACGGTG 
AACATCCTCA CCATGGGCTA CTGGCCTACA TACACACCCA TGGAAGTGCA CCTCCCTCCA 
GAGATGGTCA GACTTCAGGA AGTATTCAAG ACGTTCTACC TGGGCAAGCA CAGTGGCCGG 
AAGCTGCAGT GGCAGACGAC GCTGGGACAC GCTGTGTTGA AGGCGGACTT TAAGGAGGGG 
AAGAAGGAGT TCCAGGTGTC CCTGTTCCAG ACGCTCGTGC TGCTCATGTT CAACGAGGGC 
GACGGGTTCA GCTTCGAAGA AATCAAAATG GCCACCGGCA TAGAGGACAG TGAGTTGCGA 
AGAACACTGC AGTCTCTCGC CTGTGGTAAA GCCCGGGTCC TGATTAAAAG TCCCAAAGGG 
AAGGAGGTGG AAGACGGAGA TAAGTTCATC TTCAATGCAG ACTTCAAACA CAAGTTGTTC 
AGAATAAAGA TCAATCAAAT CCAGATGAAG GAAACCGTTG AAGAACAGGT TAGCACCACA 
GAGAGAGTGT TCCAGGACAG ACAGTACCAG ATCGACGCTG CTATAGTCAG AATAATGAAA 
ATGAGGAAGA CACTTGGTCA TAATCTTCTA GTTTCTGAAT TATACAATCA GCTGAAATTT 
CCAGTAAAGC CTGGAGATTT GAAAAAGAGG ATTGAGTCAC TTATAGACAG AGACTATATG 
GAACGAGACA AAGACAGTCC AAATCAGTAC CACTACGTGG CGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cul4a ( NM_001127301.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001120773.1 Rattus norvegicus cullin 4A (Cul4a), mRNA.

Price & Availability↑

CloneID	ORa01559
Clone ID Related Accession (Same CDS sequence)	NM_001127301.1
Accession Version	NM_001127301.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2280bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	cullin-4A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC166799.1. On or before May 11, 2008 this sequence version replaced XM_341464.3, XM_001066808.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC166799.1, FQ210009.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGACG AGGGCCCTCG GAAGGGCAGC GTCTCGGCTC TCATGGGCCG CACCAACGGC 
CTCACCAAGC CCGCGGCGTT GGCCAGTGGC CCCGCCAAAC CGGGAGGCAC GGGCGGCTCC 
AGGAAGCTGG TCATCAAGAA CTTCCGAGAC AGGCCGCGGC TGCCTGACAA CTACACTCAG 
GACACGTGGC GGAAGCTTCA CGAAGCGGTC AAGGCCATCC AGAGCAGCAC ATCCATCAGG 
TACAACCTGG AGGAACTGTA CCAGGCTGTT GAGAATCTGT GCTCTCACAA AGTCTCCCCC 
ACGCTCTACA AGCAGCTGCG GCAGGTCTGT GAAGACCATG TCCAGGCCCA GATCCTCCCC 
TTCAGAGAAG ACTCACTAGA CAGCGTTTTG TTTCTGAAGA AGATTAACAC ATGCTGGCAA 
GATCACTGCA GACAAATGAT CATGATCAGA AGCATCTTCC TGTTTCTGGA CCGCACCTAC 
GTCCTCCAGA ACTCCATGCT GCCTTCCATC TGGGACATGG GCCTAGAGCT GTTTAGGAAC 
CATATCATCA GTGACAGGAT GGTGCAAAGC AAGACCATTG ATGGGATCCT GCTGCTGATT 
GGGCGTGAAC GAAGTGGTGA GGCTGTGGAC AGGAGTCTGC TTCGCAGTCT GTTGAGCATG 
CTCTCAGATC TCCAGGTCTA CAAAGACTCA TTCGAACTGA AGTTCTTGGA AGAGACTAAC 
TGTCTGTACG CTGCTGAAGG CCAGCGGCTG ATGCAAGACA GGGAGGTTCC AGAATACCTT 
AACCATGTGA GTAAACGTCT AGAAGAGGAA GCAGACCGAG TGATCACTTA CTTAGACCAC 
AGCACACAAA AACCGTTGAT TGCCTGTGTG GAGAAACAGT TGTTAGGAGA ACATTTGACA 
GCAATTCTTC AGAAAGGGCT TGAGCAGCTG CTGGATGAGA ACAGGGTGCC CGACCTCACA 
CAGATGTACC AGCTCTTCAG CCGGGTGAAA GGGGGCCAGC ACGCACTGCT GCAGCACTGG 
AGCGAGTACA TCAAGACCTT TGGGACAACC ATTGTCATCA ATCCTGAGAA AGACAAAGAC 
ATGGTCCAAG ACCTGCTGGA CTTTAAGGAC AAAGTGGACC ACGTGGTGGA GGTGTGCTTC 
CAGAGGAACG AGCGCTTCAT CAACCTGATG AAGGAGTCCT TTGAGACGTT CATAAACAAG 
AGACCAAACA AGCCGGCAGA GCTCATTGCC AAGCACGTGG ATTCAAAGTT ACGAGCAGGC 
AACAAGGAAG CAACAGACGA GGAGCTGGAG AGGATCCTGG ACAAGATCAT GATTCTGTTC 
CGATTCATCC ACGGTAAAGA TGTCTTTGAA GCATTTTATA AGAAAGACTT AGCAAAAAGG 
CTGCTAGTGG GGAAGAGCGC GTCGGTGGAC GCGGAGAAGT CCATGCTGTC CAAGCTGAAG 
CATGAGTGTG GAGCAGCTTT TACCAGCAAG CTGGAGGGCA TGTTCAAGGA CATGGAGCTG 
TCCAAAGACA TCATGGTTCA CTTCAAGCAG CATATGCAGA ACCAAAGTGC ACCAGGCCCC 
ATCGACCTCA CGGTGAACAT CCTCACCATG GGCTACTGGC CTACATACAC ACCCATGGAA 
GTGCACCTCC CTCCAGAGAT GGTCAGACTT CAGGAAGTAT TCAAGACGTT CTACCTGGGC 
AAGCACAGTG GCCGGAAGCT GCAGTGGCAG ACGACGCTGG GACACGCTGT GTTGAAGGCG 
GACTTTAAGG AGGGGAAGAA GGAGTTCCAG GTGTCCCTGT TCCAGACGCT CGTGCTGCTC 
ATGTTCAACG AGGGCGACGG GTTCAGCTTC GAAGAAATCA AAATGGCCAC CGGCATAGAG 
GACAGTGAGT TGCGAAGAAC ACTGCAGTCT CTCGCCTGTG GTAAAGCCCG GGTCCTGATT 
AAAAGTCCCA AAGGGAAGGA GGTGGAAGAC GGAGATAAGT TCATCTTCAA TGCAGACTTC 
AAACACAAGT TGTTCAGAAT AAAGATCAAT CAAATCCAGA TGAAGGAAAC CGTTGAAGAA 
CAGGTTAGCA CCACAGAGAG AGTGTTCCAG GACAGACAGT ACCAGATCGA CGCTGCTATA 
GTCAGAATAA TGAAAATGAG GAAGACACTT GGTCATAATC TTCTAGTTTC TGAATTATAC 
AATCAGCTGA AATTTCCAGT AAAGCCTGGA GATTTGAAAA AGAGGATTGA GTCACTTATA 
GACAGAGACT ATATGGAACG AGACAAAGAC AGTCCAAATC AGTACCACTA CGTGGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001120773.1
CDS	18..2297
Translation	MADEGPRKGSVSALMGRTNGLTKPAALASGPAKPGGTGGSRKLVIKNFRDRPRLPDNYTQDTWRKLHEAVKAIQSSTSIRYNLEELYQAVENLCSHKVSPTLYKQLRQVCEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEQLLDENRVPDLTQMYQLFSRVKGGQHALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSAPGPIDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKADFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA

Target ORF information:

RefSeq Version	NM_001127301.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cullin 4A (Cul4a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127301.1

ORF Insert Sequence:

ATGGCGGACG AGGGCCCTCG GAAGGGCAGC GTCTCGGCTC TCATGGGCCG CACCAACGGC 
CTCACCAAGC CCGCGGCGTT GGCCAGTGGC CCCGCCAAAC CGGGAGGCAC GGGCGGCTCC 
AGGAAGCTGG TCATCAAGAA CTTCCGAGAC AGGCCGCGGC TGCCTGACAA CTACACTCAG 
GACACGTGGC GGAAGCTTCA CGAAGCGGTC AAGGCCATCC AGAGCAGCAC ATCCATCAGG 
TACAACCTGG AGGAACTGTA CCAGGCTGTT GAGAATCTGT GCTCTCACAA AGTCTCCCCC 
ACGCTCTACA AGCAGCTGCG GCAGGTCTGT GAAGACCATG TCCAGGCCCA GATCCTCCCC 
TTCAGAGAAG ACTCACTAGA CAGCGTTTTG TTTCTGAAGA AGATTAACAC ATGCTGGCAA 
GATCACTGCA GACAAATGAT CATGATCAGA AGCATCTTCC TGTTTCTGGA CCGCACCTAC 
GTCCTCCAGA ACTCCATGCT GCCTTCCATC TGGGACATGG GCCTAGAGCT GTTTAGGAAC 
CATATCATCA GTGACAGGAT GGTGCAAAGC AAGACCATTG ATGGGATCCT GCTGCTGATT 
GGGCGTGAAC GAAGTGGTGA GGCTGTGGAC AGGAGTCTGC TTCGCAGTCT GTTGAGCATG 
CTCTCAGATC TCCAGGTCTA CAAAGACTCA TTCGAACTGA AGTTCTTGGA AGAGACTAAC 
TGTCTGTACG CTGCTGAAGG CCAGCGGCTG ATGCAAGACA GGGAGGTTCC AGAATACCTT 
AACCATGTGA GTAAACGTCT AGAAGAGGAA GCAGACCGAG TGATCACTTA CTTAGACCAC 
AGCACACAAA AACCGTTGAT TGCCTGTGTG GAGAAACAGT TGTTAGGAGA ACATTTGACA 
GCAATTCTTC AGAAAGGGCT TGAGCAGCTG CTGGATGAGA ACAGGGTGCC CGACCTCACA 
CAGATGTACC AGCTCTTCAG CCGGGTGAAA GGGGGCCAGC ACGCACTGCT GCAGCACTGG 
AGCGAGTACA TCAAGACCTT TGGGACAACC ATTGTCATCA ATCCTGAGAA AGACAAAGAC 
ATGGTCCAAG ACCTGCTGGA CTTTAAGGAC AAAGTGGACC ACGTGGTGGA GGTGTGCTTC 
CAGAGGAACG AGCGCTTCAT CAACCTGATG AAGGAGTCCT TTGAGACGTT CATAAACAAG 
AGACCAAACA AGCCGGCAGA GCTCATTGCC AAGCACGTGG ATTCAAAGTT ACGAGCAGGC 
AACAAGGAAG CAACAGACGA GGAGCTGGAG AGGATCCTGG ACAAGATCAT GATTCTGTTC 
CGATTCATCC ACGGTAAAGA TGTCTTTGAA GCATTTTATA AGAAAGACTT AGCAAAAAGG 
CTGCTAGTGG GGAAGAGCGC GTCGGTGGAC GCGGAGAAGT CCATGCTGTC CAAGCTGAAG 
CATGAGTGTG GAGCAGCTTT TACCAGCAAG CTGGAGGGCA TGTTCAAGGA CATGGAGCTG 
TCCAAAGACA TCATGGTTCA CTTCAAGCAG CATATGCAGA ACCAAAGTGC ACCAGGCCCC 
ATCGACCTCA CGGTGAACAT CCTCACCATG GGCTACTGGC CTACATACAC ACCCATGGAA 
GTGCACCTCC CTCCAGAGAT GGTCAGACTT CAGGAAGTAT TCAAGACGTT CTACCTGGGC 
AAGCACAGTG GCCGGAAGCT GCAGTGGCAG ACGACGCTGG GACACGCTGT GTTGAAGGCG 
GACTTTAAGG AGGGGAAGAA GGAGTTCCAG GTGTCCCTGT TCCAGACGCT CGTGCTGCTC 
ATGTTCAACG AGGGCGACGG GTTCAGCTTC GAAGAAATCA AAATGGCCAC CGGCATAGAG 
GACAGTGAGT TGCGAAGAAC ACTGCAGTCT CTCGCCTGTG GTAAAGCCCG GGTCCTGATT 
AAAAGTCCCA AAGGGAAGGA GGTGGAAGAC GGAGATAAGT TCATCTTCAA TGCAGACTTC 
AAACACAAGT TGTTCAGAAT AAAGATCAAT CAAATCCAGA TGAAGGAAAC CGTTGAAGAA 
CAGGTTAGCA CCACAGAGAG AGTGTTCCAG GACAGACAGT ACCAGATCGA CGCTGCTATA 
GTCAGAATAA TGAAAATGAG GAAGACACTT GGTCATAATC TTCTAGTTTC TGAATTATAC 
AATCAGCTGA AATTTCCAGT AAAGCCTGGA GATTTGAAAA AGAGGATTGA GTCACTTATA 
GACAGAGACT ATATGGAACG AGACAAAGAC AGTCCAAATC AGTACCACTA CGTGGCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selective degradation of splicing factor CAPER? by anticancer sulfonamides.
Nature chemical biology13(6)675-680(2017 Jun)
Uehara T,Minoshima Y,Sagane K,Sugi NH,Mitsuhashi KO,Yamamoto N,Kamiyama H,Takahashi K,Kotake Y,Uesugi M,Yokoi A,Inoue A,Yoshida T,Mabuchi M,Tanaka A,Owa T

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Cell reports13(12)2879-91(2015 Dec)
Badertscher L,Wild T,Montellese C,Alexander LT,Bammert L,Sarazova M,Stebler M,Csucs G,Mayer TU,Zamboni N,Zemp I,Horvath P,Kutay U

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1.
PloS one10(10)e0139725(2015)
Tong X,Zhang D,Guha A,Arthurs B,Cazares V,Gupta N,Yin L

Identification of a primary target of thalidomide teratogenicity.
Science (New York, N.Y.)327(5971)1345-50(2010 Mar)
Ito T,Ando H,Suzuki T,Ogura T,Hotta K,Imamura Y,Yamaguchi Y,Handa H

CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.
Molecular cell37(1)143-9(2010 Jan)
Terai K,Abbas T,Jazaeri AA,Dutta A

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Cul4a cDNA ORF clone, Rattus norvegicus(Norway rat)

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