Kdsr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kdsr
Entrez Gene ID	360833
Full Name	3-ketodihydrosphingosine reductase
Synonyms	Fvt1
General protein information	Preferred Names 3-ketodihydrosphingosine reductase Names 3-ketodihydrosphingosine reductase follicular lymphoma variant translocation 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108342.1	NP_001101812.1	3-ketodihydrosphingosine reductase

Pathways from BioSystems

Homologies

	KDSR	XP_001089855.1
Danio rerio (zebrafish)	kdsr	NP_957433.1
Drosophila melanogaster (fruit fly)	CG10425	NP_651363.1
Homo sapiens (human)	KDSR	NP_002026.1
Bos taurus (cattle)	KDSR	NP_001039384.1
Arabidopsis thaliana (thale cress)	AT3G06060	NP_187257.2
Canis lupus familiaris (dog)	KDSR	XP_852048.2
Mus musculus (house mouse)	Kdsr	NP_081810.1
Xenopus tropicalis (tropical clawed frog)	kdsr	NP_001072722.1
Rattus norvegicus (Norway rat)	Kdsr	NP_001101812.1
Pan troglodytes (chimpanzee)	KDSR	XP_001146230.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003984	XP_318434.3
Arabidopsis thaliana (thale cress)	AT5G19200	NP_197421.1
Oryza sativa (rice)	Os02g0701900	NP_001047846.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma.
Boyden LM, Vincent NG, Zhou J, Hu R, Craiglow BG, Bayliss SJ, Rosman IS, Lucky AW, Diaz LA, Goldsmith LA, Paller AS, Lifton RP, Baserga SJ, Choate KA
American journal of human genetics100(6)978-984(2017 Jun)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane.
Kihara A, Igarashi Y
The Journal of biological chemistry279(47)49243-50(2004 Nov)

Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites.
Fukatsu K, Bannai H, Zhang S, Nakamura H, Inoue T, Mikoshiba K
The Journal of biological chemistry279(47)48976-82(2004 Nov)

FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma.
Rimokh R, Gadoux M, Berth?as MF, Berger F, Garoscio M, Del?age G, Germain D, Magaud JP
Blood81(1)136-42(1993 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kdsr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdsr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07169	NM_001108342.1 Latest version!	Rattus norvegicus 3-ketodihydrosphingosine reductase (Kdsr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kdsr ( NM_001108342.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101812.1 Rattus norvegicus 3-ketodihydrosphingosine reductase (Kdsr), mRNA.

Price & Availability↑

CloneID	ORa07169
Clone ID Related Accession (Same CDS sequence)	NM_001108342.1
Accession Version	NM_001108342.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	3-ketodihydrosphingosine reductase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474000.1. On or before Oct 25, 2007 this sequence version replaced XM_001064145.1, XM_341106.3. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00632250, SAMN00632253 [ECO:0000348] ##Evidence-Data-END##

ATGTTGCTGC TGGCCGCCGC CGGCCTCGTG GCCTTCGTGC TACTCCTCTA CATGGTGTCG 
CCGCTCATCA GCCCCAAGCC CCTCGCGCTG CCCGGCGCGC ACGTAGTGGT CACAGGAGGT 
TCCAGTGGCA TCGGGAAGTG CATTGCTATT GAGTGCTACA AACAGGGAGC GTTTATAACT 
CTGGTTGCAC GGAATGAGGA CAAGCTACTG CAGGCGAAGA AAGAGATTGA AAAGTACTCC 
ATTAACGACA AACAGGTGGT GCTGTGTATC TCAGTTGATG TGTCCCAAGA CTATAACCAA 
GTAGAGAATG TCATAAAGCA GGCACAGGAG AAGCTGGGTC CTGTGGACAT GCTGGTCAAC 
TGTGCAGGCA CCTCTAAGTC AGGAAAGTTT GAAGAACTTG AAGTTAGTAG TTTTGAGAAA 
TTAATGAGCA TAAATTACCT GGGCAGCGTG TACCCCAGCA GGGCGGTAAT CACCACCATG 
AAGGAGCGCC GGGTGGGCAG GATCGTGTTT GTGTCCTCTC AGGCAGGACA GCTGGGGCTG 
TTTGGCTTCA CCGCCTACTC TTCATCCAAG TTTGCCATAA GAGGATTGGC AGAAGCTCTG 
CAAATGGAGG TGAAGCCGTA TAATGTGTAC GTCACTGTGG CCTACCCACC AGACACTGAC 
ACTCCGGGGC TGGCGGAGGA AAACAAAACG AAGCCCCTGG AGACCCGGCT TATCTCAGAG 
ACCACAGCTG TTTGCAAACC AGAGCAGGTG GCCAAACAAA TTGTCAAGGA TGCCATACAA 
GGGAATTTTA ATAGTTCTAT TGGCTCAGAT GGGTACATGC TGTCCTCCCT GACCTGTGGG 
ATGGCCCCGG TGACTTCCAT CACTGAAGGA CTCCAGCAGG TGGTCACCAT GGGCCTTTTC 
CGAACAATCG CTTTGTTTTA CCTTGGAAGT TTTGATAATA TAATTCGCCG CTGCATGGTG 
CAGAAAAGAA AGCCTGAAGT CGGAGACAAA ACTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101812.1
CDS	75..1073
Translation	MLLLAAAGLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEKYSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGTSKSGKFEELEVSSFEKLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSSSKFAIRGLAEALQMEVKPYNVYVTVAYPPDTDTPGLAEENKTKPLETRLISETTAVCKPEQVAKQIVKDAIQGNFNSSIGSDGYMLSSLTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDNIIRRCMVQKRKPEVGDKTA

Target ORF information:

RefSeq Version	NM_001108342.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 3-ketodihydrosphingosine reductase (Kdsr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108342.1

ORF Insert Sequence:

ATGTTGCTGC TGGCCGCCGC CGGCCTCGTG GCCTTCGTGC TACTCCTCTA CATGGTGTCG 
CCGCTCATCA GCCCCAAGCC CCTCGCGCTG CCCGGCGCGC ACGTAGTGGT CACAGGAGGT 
TCCAGTGGCA TCGGGAAGTG CATTGCTATT GAGTGCTACA AACAGGGAGC GTTTATAACT 
CTGGTTGCAC GGAATGAGGA CAAGCTACTG CAGGCGAAGA AAGAGATTGA AAAGTACTCC 
ATTAACGACA AACAGGTGGT GCTGTGTATC TCAGTTGATG TGTCCCAAGA CTATAACCAA 
GTAGAGAATG TCATAAAGCA GGCACAGGAG AAGCTGGGTC CTGTGGACAT GCTGGTCAAC 
TGTGCAGGCA CCTCTAAGTC AGGAAAGTTT GAAGAACTTG AAGTTAGTAG TTTTGAGAAA 
TTAATGAGCA TAAATTACCT GGGCAGCGTG TACCCCAGCA GGGCGGTAAT CACCACCATG 
AAGGAGCGCC GGGTGGGCAG GATCGTGTTT GTGTCCTCTC AGGCAGGACA GCTGGGGCTG 
TTTGGCTTCA CCGCCTACTC TTCATCCAAG TTTGCCATAA GAGGATTGGC AGAAGCTCTG 
CAAATGGAGG TGAAGCCGTA TAATGTGTAC GTCACTGTGG CCTACCCACC AGACACTGAC 
ACTCCGGGGC TGGCGGAGGA AAACAAAACG AAGCCCCTGG AGACCCGGCT TATCTCAGAG 
ACCACAGCTG TTTGCAAACC AGAGCAGGTG GCCAAACAAA TTGTCAAGGA TGCCATACAA 
GGGAATTTTA ATAGTTCTAT TGGCTCAGAT GGGTACATGC TGTCCTCCCT GACCTGTGGG 
ATGGCCCCGG TGACTTCCAT CACTGAAGGA CTCCAGCAGG TGGTCACCAT GGGCCTTTTC 
CGAACAATCG CTTTGTTTTA CCTTGGAAGT TTTGATAATA TAATTCGCCG CTGCATGGTG 
CAGAAAAGAA AGCCTGAAGT CGGAGACAAA ACTGCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma.
American journal of human genetics100(6)978-984(2017 Jun)
Boyden LM,Vincent NG,Zhou J,Hu R,Craiglow BG,Bayliss SJ,Rosman IS,Lucky AW,Diaz LA,Goldsmith LA,Paller AS,Lifton RP,Baserga SJ,Choate KA

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane.
The Journal of biological chemistry279(47)49243-50(2004 Nov)
Kihara A,Igarashi Y

Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites.
The Journal of biological chemistry279(47)48976-82(2004 Nov)
Fukatsu K,Bannai H,Zhang S,Nakamura H,Inoue T,Mikoshiba K

FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma.
Blood81(1)136-42(1993 Jan)
Rimokh R,Gadoux M,Berth?as MF,Berger F,Garoscio M,Del?age G,Germain D,Magaud JP