Ulk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ulk1
Entrez Gene ID	360827
Full Name	unc-51 like autophagy activating kinase 1
General protein information	Preferred Names unc-51 like autophagy activating kinase 1 Names serine/threonine-protein kinase ULK1 unc-51-like kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q16
Summary	predicted to have similarity to C. elegans serine/threonine kinase UNC-51 [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006249565.3	XP_006249627.1	serine/threonine-protein kinase ULK1 isoform X1
NM_001108341.1	NP_001101811.1	serine/threonine-protein kinase ULK1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ULK1	XP_415091.2
Xenopus tropicalis (tropical clawed frog)	ulk1	NP_001106388.1
Homo sapiens (human)	ULK1	NP_003556.1
Pan troglodytes (chimpanzee)	ULK1	XP_001148902.3
	LOC709746	XP_001105326.2
Bos taurus (cattle)	ULK1	NP_001192856.1
Danio rerio (zebrafish)	ulk1b	XP_002665971.2
Rattus norvegicus (Norway rat)	Ulk1	NP_001101811.1
Canis lupus familiaris (dog)	ULK1	XP_534635.3
Mus musculus (house mouse)	Ulk1	NP_033495.2

Gene Ontology
Bibliography

Related articles in PubMed

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.
He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, Zhao Y, Mao Z
The Journal of cell biology217(1)315-328(2018 Jan)

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Hansen MD, Johnsen IB, Stiberg KA, Sherstova T, Wakita T, Richard GM, Kandasamy RK, Meurs EF, Anthonsen MW
Proceedings of the National Academy of Sciences of the United States of America114(17)E3462-E3471(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that EA protects against ischemic stroke through the inhibition of autophagosome formation and autophagy, which is mediated through the mTORC1-ULK complex-Beclin1 pathway
Title: Electroacupuncture protects against ischemic stroke by reducing autophagosome formation and inhibiting autophagy through the mTORC1-ULK1 complex-Beclin1 pathway.

Atg1/pULK and LC3 are key in the regulation of autophagy following cerebral ischemia reperfusion in the rat brain.
Title: Activation of autophagy in rat brain cells following focal cerebral ischemia reperfusion through enhanced expression of Atg1/pULK and LC3.

Data suggest Ulk1 has role in alcoholic cardiomyopathy; silencing Ulk1 in cardiac myoblasts down-regulates ethanol-induced autophagosome accumulation, expression of autophagy biomarker (microtubule-associated protein 1 light chain), and cell death.
Title: ULK1 plays a critical role in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge.

ULK1 knockdown inhibited rapamycin-induced autophagy consistent with a role downstream of mTOR
Title: siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.

The following Ulk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ulk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13915	NM_001108341.1 Latest version!	Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
ORa35179	XM_006249565.3 Latest version!	Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ulk1 ( NM_001108341.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101811.1 Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), mRNA.

Price & Availability↑

CloneID	ORa13915
Clone ID Related Accession (Same CDS sequence)	NM_001108341.1
Accession Version	NM_001108341.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3156bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase ULK1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473973.1. On or before Oct 4, 2007 this sequence version replaced XM_341100.3, XM_001080656.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCGG GCCGCGGCGG CGTCGAGACC GTGGGCAAGT TCGAGTTCTC TCGCAAAGAC 
CTGATTGGAC ACGGCGCCTT CGCGGTGGTC TTCAAGGGTC GACACCGCGA GAAGCACGAC 
CTGGAGGTGG CCGTCAAATG CATTAACAAG AAGAACCTTG CCAAGTCCCA GACACTGCTA 
GGAAAGGAAA TCAAAATCCT GAAGGAACTA AAGCACGAAA ACATTGTGGC GTTGTATGAC 
TTCCAGGAGA TGGCCAATTC TGTCTACCTG GTCATGGAGT ATTGTAATGG TGGAGACCTG 
GCTGACTACC TGCACACTAT GCGCACACTG AGTGAAGACA CTGTCAGGCT GTTCCTACAA 
CAGATTGCAG GTGCCATGCA GCTGCTACAC AGCAAGGGCA TCATTCACCG TGATTTGAAG 
CCCCAGAACA TCCTGCTGTC CAATCCCGGG GGTCGACGTG CCAACCCCAG CAACATCCGA 
GTCAAGATTG CTGACTTTGG ATTTGCCCGG TACCTCCAGA GCAACATGAT GGCGGCCACG 
CTCTGTGGCT CTCCTATGTA CATGGCCCCT GAGGTTATCA TGTCCCAGCA CTACGATGGG 
AAGGCTGACC TGTGGAGCAT TGGCACCATT GTCTACCAGT GTCTGACAGG GAAGGCCCCT 
TTTCAGGCCA GCAGCCCTCA GGATTTGCGC CTGTTTTATG AGAAGAACAA GACACTAGTT 
CCTGCCATCC CACGGGAGAC ATCAGCTCCC CTGCGGCAGT TGCTTCTGGC TCTATTGCAG 
CGTAACCACA AGGACCGCAT GGACTTTGAT GAATTTTTCC ACCACCCTTT CTTAGATGCC 
AGCACCCCCA TCAAGAAATC CCCACCTGTG CCTGTGCCCT CATATCCAAG CTCAGGGTCC 
GGCAGCAGCT CCAGCAGCAG CTCTGCCTCC CACCTGGCAT CTCCCCCGTC CCTGGGGGAG 
ATGCCGCAAC TGCAGAAGAC CCTTACCTCC CCAGCTGATG CTGCTGGCTT TCTGCAGGGG 
TCCCGGGACT CTGGTGGCAG TAGCAAAGAC TCCTGTGACA CAGATGACTT TGTCATGGTC 
CCAGCCCAGT TTCCAGGTGA TCTAGTCCCT GAGGCAGCCA GTGCCAAGCC CCCACCTGAC 
AGTCTGCTGT GTAGTGGGAG CTCACTGGTG GCCTCTGCTG GCCTAGAGAG CCATGGCCGT 
ACCCCATCTC CCTCTCCGAC CTGCAGCAGC TCTCCCAGCC CCTCTGGCCG GCCTGGCCCC 
TTCTCCAGCA ACAGGTACGG TGCCTCGGTC CCCATTCCTG TCCCCACTCA GGTGCACAAC 
TACCAGCGCA TCGAGCAGAA CCTGCAGTCA CCTACTCAAC AGCAGACAGC CCGGTCTTCT 
GCCATCCGAA GGTCAGGTAG CACCAGCCCC CTGGGCTTTG GTCGGGCCAG CCCATCACCT 
CCCTCGCACA CTGATGGAGC CATGCTGGCC AGGAAGCTGT CACTAGGAGG TGGCCGTCCC 
TACACACCCT CTCCCCAAGT GGGAACCATC CCAGAGCGGC CCAGCTGGAG CAGAGTACCC 
TCCCCACAAG GAGCTGATGT GCGGGCTGGC AGGTCACCAC GACCAGGCTC CTCTGTGCCT 
GAGCACTCTC CACGAACCAC CGGGCTGGGC TGCCGCCTGC ACAGTGCCCC CAACCTTTCG 
GACTTCCATG TCGTTCGTCC CAAGCTGCCT AAGCCTCCAA CAGACCCACT GGGAGCTACC 
TTCAGCCCAC CCCAGACCAG CGCACCCCAG CCATGCCCAG GGCTACAGTC TTGCCGGCCA 
CTGCGTGGCT CACCTAAGCT GCCTGACTTC CTACAGCGGA GTCCCCTACC CCCCATCCTA 
GGCTCTCCTA CTAAGGCTGG ACCCTCGTTT GACTTCCCCA AAGCCCCCAG CTCTCAGAGT 
TTGCTGACCC TGTTGGCTAG GCAGGGTGTA GTAATGACAC CACCTCGGAA CCGTACACTG 
CCTGACCTCT CAGAGGCGGG TCCTTTCCAG GGCCAGCAGC TGGGCTCTGG CCTACGGCCC 
GCCGAAGACA CAAGGGGCCC CTTTGGCCGG TCCTTCAGCA CCAGCCGCCT TACGGACCTG 
CTGCTTAAGG CTGCATTTGG GACACAGGCC TCTGACTCAG GCAGCACTGA CAGCCTACAG 
GAGAAACCTA TGGAGATTGC TCCCTCTGCT GGTTTTGGAG GGACTCTGCA TCCAGGAGCT 
CGTGCTGGAG GGGCAAGCAG CCCAGCACCT GTGGTATTTA CTGTGGGCTC CCCACCCAGT 
GGTACCACCC CACCCCAGAG TACCCGCACC AGAATGTTCT CAGTGGGCTC TTCCAGCTCC 
CTGGGCTCGA CTGGCTCCTC CTCTGCCCGC CACTTAGTGC CTGGGGCTTG TGCAGAGGCC 
CCGGAGCTTT CTGCCCCAGG CTACTGCTGT AGCCTTGCTG ACCCCCTTGC TGCCAACTTG 
GAGGGGGCTG TGACCTTCGA GGCTCCTGAC CTCCCAGAGG AGACCCTCAT GGAGCAAGAG 
CACACGGAAA CCCTACACAG CCTGCGCTTC ACACTAGCGT TTGCACAGCA AGTTCTGGAG 
ATTGCAGCCC TGAAGGGCAG TGCCAGTGAG GCAGCCGGGG GCCCTGAGTA CCAGCTTCAG 
GAAAGTGTGG TGGCTGACCA GATCAGTCAG TTGAGCCGAG AGTGGGGCTT TGCAGAGCAA 
CTGGTTCTGT ACTTGAAGGT GGCTGAGCTG CTCTCTTCAG GCTTACAGAC TGCCATTGAC 
CAGATTCGAG CTGGCAAGCT CTGCCTTTCG TCTACTGTGA AGCAGGTGGT ACGCAGACTA 
AATGAGCTGT ATAAGGCCAG CGTGGTATCC TGCCAGGGCC TCAGTCTGCG GCTTCAGCGC 
TTCTTTCTGG ACAAGCAACG GCTGCTGGAT GGGATCCATG GTGTCACTGC AGAGCGGCTT 
ATCCTCAGCC ATGCTGTGCA GATGGTACAA TCAGCTGCAC TCGATGAGAT GTTCCAGCAC 
CGAGAGAGCT GTGTACCTCG ATATCACAAA GCCCTGCTGT TGTTGGAGGG GCTGCAGCAC 
ACTCTCACGG ACCAGGCAGA CATTGAGAAC ATTGCCAAAT GCAAGCTGTG CATTGAGAGG 
AGACTCTCGG CCCTGCTGAG TGGCGTCTAT GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101811.1
CDS	40..3195
Translation	MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPSSGSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFVMVPAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQVGTIPERPSWSRVPSPQGADVRAGRSPRPGSSVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRPLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGSGLRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGSTDSLQEKPMEIAPSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQSTRTRMFSVGSSSSLGSTGSSSARHLVPGACAEAPELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLLLEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA

Target ORF information:

RefSeq Version	NM_001108341.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108341.1

ORF Insert Sequence:

ATGGAGCCGG GCCGCGGCGG CGTCGAGACC GTGGGCAAGT TCGAGTTCTC TCGCAAAGAC 
CTGATTGGAC ACGGCGCCTT CGCGGTGGTC TTCAAGGGTC GACACCGCGA GAAGCACGAC 
CTGGAGGTGG CCGTCAAATG CATTAACAAG AAGAACCTTG CCAAGTCCCA GACACTGCTA 
GGAAAGGAAA TCAAAATCCT GAAGGAACTA AAGCACGAAA ACATTGTGGC GTTGTATGAC 
TTCCAGGAGA TGGCCAATTC TGTCTACCTG GTCATGGAGT ATTGTAATGG TGGAGACCTG 
GCTGACTACC TGCACACTAT GCGCACACTG AGTGAAGACA CTGTCAGGCT GTTCCTACAA 
CAGATTGCAG GTGCCATGCA GCTGCTACAC AGCAAGGGCA TCATTCACCG TGATTTGAAG 
CCCCAGAACA TCCTGCTGTC CAATCCCGGG GGTCGACGTG CCAACCCCAG CAACATCCGA 
GTCAAGATTG CTGACTTTGG ATTTGCCCGG TACCTCCAGA GCAACATGAT GGCGGCCACG 
CTCTGTGGCT CTCCTATGTA CATGGCCCCT GAGGTTATCA TGTCCCAGCA CTACGATGGG 
AAGGCTGACC TGTGGAGCAT TGGCACCATT GTCTACCAGT GTCTGACAGG GAAGGCCCCT 
TTTCAGGCCA GCAGCCCTCA GGATTTGCGC CTGTTTTATG AGAAGAACAA GACACTAGTT 
CCTGCCATCC CACGGGAGAC ATCAGCTCCC CTGCGGCAGT TGCTTCTGGC TCTATTGCAG 
CGTAACCACA AGGACCGCAT GGACTTTGAT GAATTTTTCC ACCACCCTTT CTTAGATGCC 
AGCACCCCCA TCAAGAAATC CCCACCTGTG CCTGTGCCCT CATATCCAAG CTCAGGGTCC 
GGCAGCAGCT CCAGCAGCAG CTCTGCCTCC CACCTGGCAT CTCCCCCGTC CCTGGGGGAG 
ATGCCGCAAC TGCAGAAGAC CCTTACCTCC CCAGCTGATG CTGCTGGCTT TCTGCAGGGG 
TCCCGGGACT CTGGTGGCAG TAGCAAAGAC TCCTGTGACA CAGATGACTT TGTCATGGTC 
CCAGCCCAGT TTCCAGGTGA TCTAGTCCCT GAGGCAGCCA GTGCCAAGCC CCCACCTGAC 
AGTCTGCTGT GTAGTGGGAG CTCACTGGTG GCCTCTGCTG GCCTAGAGAG CCATGGCCGT 
ACCCCATCTC CCTCTCCGAC CTGCAGCAGC TCTCCCAGCC CCTCTGGCCG GCCTGGCCCC 
TTCTCCAGCA ACAGGTACGG TGCCTCGGTC CCCATTCCTG TCCCCACTCA GGTGCACAAC 
TACCAGCGCA TCGAGCAGAA CCTGCAGTCA CCTACTCAAC AGCAGACAGC CCGGTCTTCT 
GCCATCCGAA GGTCAGGTAG CACCAGCCCC CTGGGCTTTG GTCGGGCCAG CCCATCACCT 
CCCTCGCACA CTGATGGAGC CATGCTGGCC AGGAAGCTGT CACTAGGAGG TGGCCGTCCC 
TACACACCCT CTCCCCAAGT GGGAACCATC CCAGAGCGGC CCAGCTGGAG CAGAGTACCC 
TCCCCACAAG GAGCTGATGT GCGGGCTGGC AGGTCACCAC GACCAGGCTC CTCTGTGCCT 
GAGCACTCTC CACGAACCAC CGGGCTGGGC TGCCGCCTGC ACAGTGCCCC CAACCTTTCG 
GACTTCCATG TCGTTCGTCC CAAGCTGCCT AAGCCTCCAA CAGACCCACT GGGAGCTACC 
TTCAGCCCAC CCCAGACCAG CGCACCCCAG CCATGCCCAG GGCTACAGTC TTGCCGGCCA 
CTGCGTGGCT CACCTAAGCT GCCTGACTTC CTACAGCGGA GTCCCCTACC CCCCATCCTA 
GGCTCTCCTA CTAAGGCTGG ACCCTCGTTT GACTTCCCCA AAGCCCCCAG CTCTCAGAGT 
TTGCTGACCC TGTTGGCTAG GCAGGGTGTA GTAATGACAC CACCTCGGAA CCGTACACTG 
CCTGACCTCT CAGAGGCGGG TCCTTTCCAG GGCCAGCAGC TGGGCTCTGG CCTACGGCCC 
GCCGAAGACA CAAGGGGCCC CTTTGGCCGG TCCTTCAGCA CCAGCCGCCT TACGGACCTG 
CTGCTTAAGG CTGCATTTGG GACACAGGCC TCTGACTCAG GCAGCACTGA CAGCCTACAG 
GAGAAACCTA TGGAGATTGC TCCCTCTGCT GGTTTTGGAG GGACTCTGCA TCCAGGAGCT 
CGTGCTGGAG GGGCAAGCAG CCCAGCACCT GTGGTATTTA CTGTGGGCTC CCCACCCAGT 
GGTACCACCC CACCCCAGAG TACCCGCACC AGAATGTTCT CAGTGGGCTC TTCCAGCTCC 
CTGGGCTCGA CTGGCTCCTC CTCTGCCCGC CACTTAGTGC CTGGGGCTTG TGCAGAGGCC 
CCGGAGCTTT CTGCCCCAGG CTACTGCTGT AGCCTTGCTG ACCCCCTTGC TGCCAACTTG 
GAGGGGGCTG TGACCTTCGA GGCTCCTGAC CTCCCAGAGG AGACCCTCAT GGAGCAAGAG 
CACACGGAAA CCCTACACAG CCTGCGCTTC ACACTAGCGT TTGCACAGCA AGTTCTGGAG 
ATTGCAGCCC TGAAGGGCAG TGCCAGTGAG GCAGCCGGGG GCCCTGAGTA CCAGCTTCAG 
GAAAGTGTGG TGGCTGACCA GATCAGTCAG TTGAGCCGAG AGTGGGGCTT TGCAGAGCAA 
CTGGTTCTGT ACTTGAAGGT GGCTGAGCTG CTCTCTTCAG GCTTACAGAC TGCCATTGAC 
CAGATTCGAG CTGGCAAGCT CTGCCTTTCG TCTACTGTGA AGCAGGTGGT ACGCAGACTA 
AATGAGCTGT ATAAGGCCAG CGTGGTATCC TGCCAGGGCC TCAGTCTGCG GCTTCAGCGC 
TTCTTTCTGG ACAAGCAACG GCTGCTGGAT GGGATCCATG GTGTCACTGC AGAGCGGCTT 
ATCCTCAGCC ATGCTGTGCA GATGGTACAA TCAGCTGCAC TCGATGAGAT GTTCCAGCAC 
CGAGAGAGCT GTGTACCTCG ATATCACAAA GCCCTGCTGT TGTTGGAGGG GCTGCAGCAC 
ACTCTCACGG ACCAGGCAGA CATTGAGAAC ATTGCCAAAT GCAAGCTGTG CATTGAGAGG 
AGACTCTCGG CCCTGCTGAG TGGCGTCTAT GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ulk1 ( XM_006249565.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249627.1 Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa35179
Clone ID Related Accession (Same CDS sequence)	XM_006249565.3
Accession Version	XM_006249565.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3174bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase ULK1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249565.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGG GCCGCGGCGG CGTCGAGACC GTGGGCAAGT TCGAGTTCTC TCGCAAAGAC 
CTGATTGGAC ACGGCGCCTT CGCGGTGGTC TTCAAGGGTC GACACCGCGA GAAGCACGAC 
CTGGAGGTGG CCGTCAAATG CATTAACAAG AAGAACCTTG CCAAGTCCCA GACACTGCTA 
GGAAAGGAAA TCAAAATCCT GAAGGAACTA AAGCACGAAA ACATTGTGGC GTTGTATGAC 
TTCCAGGAGA TGGCCAATTC TGTCTACCTG GTCATGGAGT ATTGTAATGG TGGAGACCTG 
GCTGACTACC TGCACACTAT GCGCACACTG AGTGAAGACA CTGTCAGGCT GTTCCTACAA 
CAGATTGCAG GTGCCATGCA GCTGCTACAC AGCAAGGGCA TCATTCACCG TGATTTGAAG 
CCCCAGAACA TCCTGCTGTC CAATCCCGGG GGTCGACGTG CCAACCCCAG CAACATCCGA 
GTCAAGATTG CTGACTTTGG ATTTGCCCGG TACCTCCAGA GCAACATGAT GGCGGCCACG 
CTCTGTGGCT CTCCTATGTA CATGGCCCCT GAGGTTATCA TGTCCCAGCA CTACGATGGG 
AAGGCTGACC TGTGGAGCAT TGGCACCATT GTCTACCAGT GTCTGACAGG GAAGGCCCCT 
TTTCAGGCCA GCAGCCCTCA GGATTTGCGC CTGTTTTATG AGAAGAACAA GACACTAGTT 
CCTGCCATCC CACGGGAGAC ATCAGCTCCC CTGCGGCAGT TGCTTCTGGC TCTATTGCAG 
CGTAACCACA AGGACCGCAT GGACTTTGAT GAATTTTTCC ACCACCCTTT CTTAGATGCC 
AGCACCCCCA TCAAGAAATC CCCACCTGTG CCTGTGCCCT CATATCCAAG CTCAGGGTCC 
GGCAGCAGCT CCAGCAGCAG CTCTGCCTCC CACCTGGCAT CTCCCCCGTC CCTGGGGGAG 
ATGCCGCAAC TGCAGAAGAC CCTTACCTCC CCAGCTGATG CTGCTGGCTT TCTGCAGGGG 
TCCCGGGACT CTGGTGGCAG TAGCAAAGAC TCCTGTGACA CAGATGACTT TGTCATGGTC 
CCAGCCCAGT TTCCAGGTGA TCTAGTCCCT GAGGCAGCCA GTGCCAAGCC CCCACCTGAC 
AGTCTGCTGT GTAGTGGGAG CTCACTGGTG GCCTCTGCTG GCCTAGAGAG CCATGGCCGT 
ACCCCATCTC CCTCTCCGAC CTGCAGCAGC TCTCCCAGCC CCTCTGGCCG GCCTGGCCCC 
TTCTCCAGCA ACAGGTACGG TGCCTCGGTC CCCATTCCTG TCCCCACTCA GGTGCACAAC 
TACCAGCGCA TCGAGCAGAA CCTGCAGTCA CCTACTCAAC AGCAGACAGC CCGGTCTTCT 
GCCATCCGAA GGTCAGGTAG CACCAGCCCC CTGGGCTTTG GTCGGGCCAG CCCATCACCT 
CCCTCGCACA CTGATGGAGC CATGCTGGCC AGGAAGCTGT CACTAGGAGG TGGCCGTCCC 
TACACACCCT CTCCCCAAGC CACCCTTTTC CTACCAGTGG GAACCATCCC AGAGCGGCCC 
AGCTGGAGCA GAGTACCCTC CCCACAAGGA GCTGATGTGC GGGCTGGCAG GTCACCACGA 
CCAGGCTCCT CTGTGCCTGA GCACTCTCCA CGAACCACCG GGCTGGGCTG CCGCCTGCAC 
AGTGCCCCCA ACCTTTCGGA CTTCCATGTC GTTCGTCCCA AGCTGCCTAA GCCTCCAACA 
GACCCACTGG GAGCTACCTT CAGCCCACCC CAGACCAGCG CACCCCAGCC ATGCCCAGGG 
CTACAGTCTT GCCGGCCACT GCGTGGCTCA CCTAAGCTGC CTGACTTCCT ACAGCGGAGT 
CCCCTACCCC CCATCCTAGG CTCTCCTACT AAGGCTGGAC CCTCGTTTGA CTTCCCCAAA 
GCCCCCAGCT CTCAGAGTTT GCTGACCCTG TTGGCTAGGC AGGGTGTAGT AATGACACCA 
CCTCGGAACC GTACATTGCC TGACCTCTCA GAGGCGGGTC CTTTCCAGGG CCAGCAGCTG 
GGCTCTGGCC TACGGCCCGC CGAAGACACA AGGGGCCCCT TTGGCCGGTC CTTCAGCACC 
AGCCGCCTTA CGGACCTGCT GCTTAAGGCT GCATTTGGGA CACAGGCCTC TGACTCAGGC 
AGCACTGACA GCCTACAGGA GAAACCTATG GAGATTGCTC CCTCTGCTGG TTTTGGAGGG 
ACTCTGCATC CAGGAGCTCG TGCTGGAGGG GCAAGCAGCC CAGCACCTGT GGTATTTACT 
GTGGGCTCCC CACCCAGTGG TACCACCCCA CCCCAGAGTA CCCGCACCAG AATGTTCTCA 
GTGGGCTCTT CCAGCTCCCT GGGCTCGACT GGCTCCTCCT CTGCCCGCCA CTTAGTGCCT 
GGGGCTTGTG CAGAGGCCCC GGAGCTTTCT GCCCCAGGCT ACTGCTGTAG CCTTGCTGAC 
CCCCTTGCTG CCAACTTGGA GGGGGCTGTG ACCTTCGAGG CTCCTGACCT CCCAGAGGAG 
ACCCTCATGG AGCAAGAGCA CACGGAAACC CTACACAGCC TGCGCTTCAC ACTAGCGTTT 
GCACAGCAAG TTCTGGAGAT TGCAGCCCTG AAGGGCAGTG CCAGTGAGGC AGCCGGGGGC 
CCTGAGTACC AGCTTCAGGA AAGTGTGGTG GCTGACCAGA TCAGTCAGTT GAGCCGAGAG 
TGGGGCTTTG CAGAGCAACT GGTTCTGTAC TTGAAGGTGG CTGAGCTGCT CTCTTCAGGC 
TTACAGACTG CCATTGACCA GATTCGAGCT GGCAAGCTCT GCCTTTCGTC TACTGTGAAG 
CAGGTGGTAC GCAGACTAAA TGAGCTGTAT AAGGCCAGCG TGGTATCCTG CCAGGGCCTC 
AGTCTGCGGC TTCAGCGCTT CTTTCTGGAC AAGCAACGGC TGCTGGATGG GATCCATGGT 
GTCACTGCAG AGCGGCTTAT CCTCAGCCAT GCTGTGCAGA TGGTACAATC AGCTGCACTC 
GATGAGATGT TCCAGCACCG AGAGAGCTGT GTACCTCGAT ATCACAAAGC CCTGCTGTTG 
TTGGAGGGGC TGCAGCACAC TCTCACGGAC CAGGCAGACA TTGAGAACAT TGCCAAATGC 
AAGCTGTGCA TTGAGAGGAG ACTCTCGGCC CTGCTGAGTG GCGTCTATGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249627.1
CDS	383..3556
Translation	MEPGRGGVETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQIAGAMQLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASTPIKKSPPVPVPSYPSSGSGSSSSSSSASHLASPPSLGEMPQLQKTLTSPADAAGFLQGSRDSGGSSKDSCDTDDFVMVPAQFPGDLVPEAASAKPPPDSLLCSGSSLVASAGLESHGRTPSPSPTCSSSPSPSGRPGPFSSNRYGASVPIPVPTQVHNYQRIEQNLQSPTQQQTARSSAIRRSGSTSPLGFGRASPSPPSHTDGAMLARKLSLGGGRPYTPSPQATLFLPVGTIPERPSWSRVPSPQGADVRAGRSPRPGSSVPEHSPRTTGLGCRLHSAPNLSDFHVVRPKLPKPPTDPLGATFSPPQTSAPQPCPGLQSCRPLRGSPKLPDFLQRSPLPPILGSPTKAGPSFDFPKAPSSQSLLTLLARQGVVMTPPRNRTLPDLSEAGPFQGQQLGSGLRPAEDTRGPFGRSFSTSRLTDLLLKAAFGTQASDSGSTDSLQEKPMEIAPSAGFGGTLHPGARAGGASSPAPVVFTVGSPPSGTTPPQSTRTRMFSVGSSSSLGSTGSSSARHLVPGACAEAPELSAPGYCCSLADPLAANLEGAVTFEAPDLPEETLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGGPEYQLQESVVADQISQLSREWGFAEQLVLYLKVAELLSSGLQTAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRFFLDKQRLLDGIHGVTAERLILSHAVQMVQSAALDEMFQHRESCVPRYHKALLLLEGLQHTLTDQADIENIAKCKLCIERRLSALLSGVYA

Target ORF information:

RefSeq Version	XM_006249565.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-51 like autophagy activating kinase 1 (Ulk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249565.3

ORF Insert Sequence:

ATGGAGCCGG GCCGCGGCGG CGTCGAGACC GTGGGCAAGT TCGAGTTCTC TCGCAAAGAC 
CTGATTGGAC ACGGCGCCTT CGCGGTGGTC TTCAAGGGTC GACACCGCGA GAAGCACGAC 
CTGGAGGTGG CCGTCAAATG CATTAACAAG AAGAACCTTG CCAAGTCCCA GACACTGCTA 
GGAAAGGAAA TCAAAATCCT GAAGGAACTA AAGCACGAAA ACATTGTGGC GTTGTATGAC 
TTCCAGGAGA TGGCCAATTC TGTCTACCTG GTCATGGAGT ATTGTAATGG TGGAGACCTG 
GCTGACTACC TGCACACTAT GCGCACACTG AGTGAAGACA CTGTCAGGCT GTTCCTACAA 
CAGATTGCAG GTGCCATGCA GCTGCTACAC AGCAAGGGCA TCATTCACCG TGATTTGAAG 
CCCCAGAACA TCCTGCTGTC CAATCCCGGG GGTCGACGTG CCAACCCCAG CAACATCCGA 
GTCAAGATTG CTGACTTTGG ATTTGCCCGG TACCTCCAGA GCAACATGAT GGCGGCCACG 
CTCTGTGGCT CTCCTATGTA CATGGCCCCT GAGGTTATCA TGTCCCAGCA CTACGATGGG 
AAGGCTGACC TGTGGAGCAT TGGCACCATT GTCTACCAGT GTCTGACAGG GAAGGCCCCT 
TTTCAGGCCA GCAGCCCTCA GGATTTGCGC CTGTTTTATG AGAAGAACAA GACACTAGTT 
CCTGCCATCC CACGGGAGAC ATCAGCTCCC CTGCGGCAGT TGCTTCTGGC TCTATTGCAG 
CGTAACCACA AGGACCGCAT GGACTTTGAT GAATTTTTCC ACCACCCTTT CTTAGATGCC 
AGCACCCCCA TCAAGAAATC CCCACCTGTG CCTGTGCCCT CATATCCAAG CTCAGGGTCC 
GGCAGCAGCT CCAGCAGCAG CTCTGCCTCC CACCTGGCAT CTCCCCCGTC CCTGGGGGAG 
ATGCCGCAAC TGCAGAAGAC CCTTACCTCC CCAGCTGATG CTGCTGGCTT TCTGCAGGGG 
TCCCGGGACT CTGGTGGCAG TAGCAAAGAC TCCTGTGACA CAGATGACTT TGTCATGGTC 
CCAGCCCAGT TTCCAGGTGA TCTAGTCCCT GAGGCAGCCA GTGCCAAGCC CCCACCTGAC 
AGTCTGCTGT GTAGTGGGAG CTCACTGGTG GCCTCTGCTG GCCTAGAGAG CCATGGCCGT 
ACCCCATCTC CCTCTCCGAC CTGCAGCAGC TCTCCCAGCC CCTCTGGCCG GCCTGGCCCC 
TTCTCCAGCA ACAGGTACGG TGCCTCGGTC CCCATTCCTG TCCCCACTCA GGTGCACAAC 
TACCAGCGCA TCGAGCAGAA CCTGCAGTCA CCTACTCAAC AGCAGACAGC CCGGTCTTCT 
GCCATCCGAA GGTCAGGTAG CACCAGCCCC CTGGGCTTTG GTCGGGCCAG CCCATCACCT 
CCCTCGCACA CTGATGGAGC CATGCTGGCC AGGAAGCTGT CACTAGGAGG TGGCCGTCCC 
TACACACCCT CTCCCCAAGC CACCCTTTTC CTACCAGTGG GAACCATCCC AGAGCGGCCC 
AGCTGGAGCA GAGTACCCTC CCCACAAGGA GCTGATGTGC GGGCTGGCAG GTCACCACGA 
CCAGGCTCCT CTGTGCCTGA GCACTCTCCA CGAACCACCG GGCTGGGCTG CCGCCTGCAC 
AGTGCCCCCA ACCTTTCGGA CTTCCATGTC GTTCGTCCCA AGCTGCCTAA GCCTCCAACA 
GACCCACTGG GAGCTACCTT CAGCCCACCC CAGACCAGCG CACCCCAGCC ATGCCCAGGG 
CTACAGTCTT GCCGGCCACT GCGTGGCTCA CCTAAGCTGC CTGACTTCCT ACAGCGGAGT 
CCCCTACCCC CCATCCTAGG CTCTCCTACT AAGGCTGGAC CCTCGTTTGA CTTCCCCAAA 
GCCCCCAGCT CTCAGAGTTT GCTGACCCTG TTGGCTAGGC AGGGTGTAGT AATGACACCA 
CCTCGGAACC GTACATTGCC TGACCTCTCA GAGGCGGGTC CTTTCCAGGG CCAGCAGCTG 
GGCTCTGGCC TACGGCCCGC CGAAGACACA AGGGGCCCCT TTGGCCGGTC CTTCAGCACC 
AGCCGCCTTA CGGACCTGCT GCTTAAGGCT GCATTTGGGA CACAGGCCTC TGACTCAGGC 
AGCACTGACA GCCTACAGGA GAAACCTATG GAGATTGCTC CCTCTGCTGG TTTTGGAGGG 
ACTCTGCATC CAGGAGCTCG TGCTGGAGGG GCAAGCAGCC CAGCACCTGT GGTATTTACT 
GTGGGCTCCC CACCCAGTGG TACCACCCCA CCCCAGAGTA CCCGCACCAG AATGTTCTCA 
GTGGGCTCTT CCAGCTCCCT GGGCTCGACT GGCTCCTCCT CTGCCCGCCA CTTAGTGCCT 
GGGGCTTGTG CAGAGGCCCC GGAGCTTTCT GCCCCAGGCT ACTGCTGTAG CCTTGCTGAC 
CCCCTTGCTG CCAACTTGGA GGGGGCTGTG ACCTTCGAGG CTCCTGACCT CCCAGAGGAG 
ACCCTCATGG AGCAAGAGCA CACGGAAACC CTACACAGCC TGCGCTTCAC ACTAGCGTTT 
GCACAGCAAG TTCTGGAGAT TGCAGCCCTG AAGGGCAGTG CCAGTGAGGC AGCCGGGGGC 
CCTGAGTACC AGCTTCAGGA AAGTGTGGTG GCTGACCAGA TCAGTCAGTT GAGCCGAGAG 
TGGGGCTTTG CAGAGCAACT GGTTCTGTAC TTGAAGGTGG CTGAGCTGCT CTCTTCAGGC 
TTACAGACTG CCATTGACCA GATTCGAGCT GGCAAGCTCT GCCTTTCGTC TACTGTGAAG 
CAGGTGGTAC GCAGACTAAA TGAGCTGTAT AAGGCCAGCG TGGTATCCTG CCAGGGCCTC 
AGTCTGCGGC TTCAGCGCTT CTTTCTGGAC AAGCAACGGC TGCTGGATGG GATCCATGGT 
GTCACTGCAG AGCGGCTTAT CCTCAGCCAT GCTGTGCAGA TGGTACAATC AGCTGCACTC 
GATGAGATGT TCCAGCACCG AGAGAGCTGT GTACCTCGAT ATCACAAAGC CCTGCTGTTG 
TTGGAGGGGC TGCAGCACAC TCTCACGGAC CAGGCAGACA TTGAGAACAT TGCCAAATGC 
AAGCTGTGCA TTGAGAGGAG ACTCTCGGCC CTGCTGAGTG GCGTCTATGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.
The Journal of cell biology217(1)315-328(2018 Jan)
He Y,She H,Zhang T,Xu H,Cheng L,Yepes M,Zhao Y,Mao Z

Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Proceedings of the National Academy of Sciences of the United States of America114(17)E3462-E3471(2017 Apr)
Hansen MD,Johnsen IB,Stiberg KA,Sherstova T,Wakita T,Richard GM,Kandasamy RK,Meurs EF,Anthonsen MW

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Ulk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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