Parn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Parn
Entrez Gene ID	360464
Full Name	poly(A)-specific ribonuclease
Synonyms	RGD1565449
General protein information	Preferred Names poly(A)-specific ribonuclease Names poly(A)-specific ribonuclease PARN poly(A)-specific ribonuclease (deadenylation nuclease)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270415.1	NP_001257344.1	poly(A)-specific ribonuclease PARN

Pathways from BioSystems

Homologies

Homo sapiens (human)	PARN	NP_002573.1
Canis lupus familiaris (dog)	PARN	XP_536966.2
Rattus norvegicus (Norway rat)	Parn	NP_001257344.1
Arabidopsis thaliana (thale cress)	AHG2	NP_175983.5
	LOC712984	XP_002808334.1
Bos taurus (cattle)	PARN	NP_001094588.1
Danio rerio (zebrafish)	parn	NP_957382.1
Anopheles gambiae (African malaria mosquito)	PARN	XP_308433.4
Caenorhabditis elegans (roundworm)	K10C8.1	NP_506169.2
Schizosaccharomyces pombe (fission yeast)	SPBC29A10.09c	NP_596054.1
Gallus gallus (chicken)	PARN	NP_001025800.1
Pan troglodytes (chimpanzee)	PARN	XP_510832.3
Mus musculus (house mouse)	Parn	NP_083037.1
Xenopus tropicalis (tropical clawed frog)	parn	NP_001184102.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R
Nature structural & molecular biology23(4)286-92(2016 Apr)

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
Moon DH, Segal M, Boyraz B, Guinan E, Hofmann I, Cahan P, Tai AK, Agarwal S
Nature genetics47(12)1482-8(2015 Dec)

PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
Boele J, Persson H, Shin JW, Ishizu Y, Newie IS, S?kilde R, Hawkins SM, Coarfa C, Ikeda K, Takayama K, Horie-Inoue K, Ando Y, Burroughs AM, Sasaki C, Suzuki C, Sakai M, Aoki S, Ogawa A, Hasegawa A, Lizio M, Kaida K, Teusink B, Carninci P, Suzuki H, Inoue S, Gunaratne PH, Rovira C, Hayashizaki Y, de Hoon MJ
Proceedings of the National Academy of Sciences of the United States of America111(31)11467-72(2014 Aug)

Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Udagawa T, Swanger SA, Takeuchi K, Kim JH, Nalavadi V, Shin J, Lorenz LJ, Zukin RS, Bassell GJ, Richter JD
Molecular cell47(2)253-66(2012 Jul)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.

The following Parn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Parn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09252	NM_001270415.1 Latest version!	Rattus norvegicus poly(A)-specific ribonuclease (Parn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Parn ( NM_001270415.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257344.1 Rattus norvegicus poly(A)-specific ribonuclease (Parn), mRNA.

Price & Availability↑

CloneID	ORa09252
Clone ID Related Accession (Same CDS sequence)	NM_001270415.1
Accession Version	NM_001270415.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1875bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	poly(A)-specific ribonuclease PARN
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from HQ123458.1. On or before Jul 7, 2012 this sequence version replaced XM_001075629.3, XM_340740.5. ##Evidence-Data-START## Transcript exon combination :: HQ123458.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGATAA TCCGGAGCAA TTTTAAGATT AATCTTCCCA AAGTGTACCA GGCCATAGAG 
GAGGCTGACT TCTTCGCCAT CGATGGGGAG TTTTCAGGAA TCAGTGATGG ACCCTCAGTA 
ACAGCATTAA CAAGTGGTTT TGACACCCCA GAAGAGAGAT ATCAGAAGCT TAAAAAGCAT 
TCCATGGACT TCTTGCTGTT TCAGTTTGGC CTCTGTGCTT TTAAGTATGA CCACGCCAAT 
TCCAAGCATG TAACGAAGTC GTTTAACTTC TATGTTTTCC CCAAGCCTTT CAGTAGGTCC 
TCACCAGATG TCAAGTTTGT TTGCCAGAGC TCCAGCATTG ACTTTCTGGC AAGCCAAGGA 
TTTGACTTTA ATAAAGTGTT TTGCAGTGGA ATTCCATATC TGAACCAGGA AGAAGAAAGA 
CAGCTGAGAG AGCAATTTGA TGAAAAACGT TCTCAGGCCA ATGGGGCCGG AGCTCTGACA 
AAATGTCCTG TGACAATTCC TGAGGATCAG AAGAAGTTTA TTGACCAAGT AATAGAGAAG 
ATAGAGGGTT TCCTACAGAG AGAAGAGAAG AGGACTCTGG AACTTAACCC ATGCACTGGG 
TTCCAAAGAA AACTTATTTA TCAGACTTTG AGTTGGAAGT ATCCCAAAGG CATTCATGTT 
GAGACATTAG AGACTGACAA GAAGGAAAGA CACATAGTTA TCAGCAAAGT GGATGAAGAA 
GAACGCAAAA GGAGAGAACA GGAGAAGTAC GCAAAGGAGC AGGAGGAACT GAATGATGCT 
GTAGGATTTT CAAGAGTCAT CCATGCGATT GCTAATTCGG GGAAGCTGGT TGTTGGACAC 
AACATGCTCT TGGATGTCAT GCACACTATT CACCAGTTCT ACTGCCCTCT GCCTGTGGAC 
CTGAATGAGT TTAAGGAGAT GACAACATGT GTCTTCCCCA GACTCTTGGA TACTAAATTG 
ATGGCCAGCA CCCAGCCCTT TAAGGATATC ATTAACAATA CATCCCTTGC AGAGTTGGAA 
AAGCGGTTGA AAGAGACACC TTTTGACCCT CCTAAAGTTG AGAGTGCGGA AGGCTTTCCA 
AGCTACGACA CAGCTTCTGA GCAGCTGCAT GAGGCAGGTT ATGATGCGTA CATCACAGGA 
CTCTGCTTCA TCTCCATGGC AAATTACTTA GGTTCTTTAC TCAGTCCTCC AAAAACGTGT 
GTGTCCGCCA GATCAAAGCT CATCGAACCC TTTTTTAACA AGTTATTTCT TATGAGGGTC 
ATGGATATTC CCTATTTAAA CTTGGAAGGG CCAGACTTGC AGCCTAAGCG GGATCATGTT 
CTCCATGTGA CCTTCCCTAA AGAATGGAAA ACCAGTGACC TGTACCAGCT CTTCAGCGCC 
TTTGGTAACA TTCAGATATC CTGGATTGAT GACACATCAG CCTTCGTTTC TCTCAGCCAA 
CCAGAACAAG TACAAATTGC TGTTAATACC AGTAAGTATG CTGAAAGTTA TCGGATCCAG 
ACCTACGCTG AGTATGTGGG AAAGAAGCAG GAAAGCAAGC AGGTCAAGAG GAAGTGGACA 
GAAGACAGTT GGAAGGAGGT GGACAGAAAG CGGCCCCACG TGCCGGGCCC CTGTTACCAC 
ACCAACAGCT TCACTGCAGC CGGCATAGTT GGAAAGAGAA CTCTGAGTCC CGACCCTCGG 
GAAGCTGGAG TGGTGGACAG AGAATCAGAG GGAATATCTG ACCCGGAACT TGAACAGACG 
GATTACTGTG CAGACCCCCT CCCAGAGGGA AGGAAAAAGG CCAAGAAGTT AAAAAGAATG 
AAGAAAGAGT TTTCCTTGGC AGGAAGTGCC TCAGATAGCC CTGCTGTGCT TTTTGAAGTC 
CCCGACACGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257344.1
CDS	1..1875
Translation	MEIIRSNFKINLPKVYQAIEEADFFAIDGEFSGISDGPSVTALTSGFDTPEERYQKLKKHSMDFLLFQFGLCAFKYDHANSKHVTKSFNFYVFPKPFSRSSPDVKFVCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLREQFDEKRSQANGAGALTKCPVTIPEDQKKFIDQVIEKIEGFLQREEKRTLELNPCTGFQRKLIYQTLSWKYPKGIHVETLETDKKERHIVISKVDEEERKRREQEKYAKEQEELNDAVGFSRVIHAIANSGKLVVGHNMLLDVMHTIHQFYCPLPVDLNEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFDPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSLLSPPKTCVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVQIAVNTSKYAESYRIQTYAEYVGKKQESKQVKRKWTEDSWKEVDRKRPHVPGPCYHTNSFTAAGIVGKRTLSPDPREAGVVDRESEGISDPELEQTDYCADPLPEGRKKAKKLKRMKKEFSLAGSASDSPAVLFEVPDTW

Target ORF information:

RefSeq Version	NM_001270415.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus poly(A)-specific ribonuclease (Parn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270415.1

ORF Insert Sequence:

ATGGAGATAA TCCGGAGCAA TTTTAAGATT AATCTTCCCA AAGTGTACCA GGCCATAGAG 
GAGGCTGACT TCTTCGCCAT CGATGGGGAG TTTTCAGGAA TCAGTGATGG ACCCTCAGTA 
ACAGCATTAA CAAGTGGTTT TGACACCCCA GAAGAGAGAT ATCAGAAGCT TAAAAAGCAT 
TCCATGGACT TCTTGCTGTT TCAGTTTGGC CTCTGTGCTT TTAAGTATGA CCACGCCAAT 
TCCAAGCATG TAACGAAGTC GTTTAACTTC TATGTTTTCC CCAAGCCTTT CAGTAGGTCC 
TCACCAGATG TCAAGTTTGT TTGCCAGAGC TCCAGCATTG ACTTTCTGGC AAGCCAAGGA 
TTTGACTTTA ATAAAGTGTT TTGCAGTGGA ATTCCATATC TGAACCAGGA AGAAGAAAGA 
CAGCTGAGAG AGCAATTTGA TGAAAAACGT TCTCAGGCCA ATGGGGCCGG AGCTCTGACA 
AAATGTCCTG TGACAATTCC TGAGGATCAG AAGAAGTTTA TTGACCAAGT AATAGAGAAG 
ATAGAGGGTT TCCTACAGAG AGAAGAGAAG AGGACTCTGG AACTTAACCC ATGCACTGGG 
TTCCAAAGAA AACTTATTTA TCAGACTTTG AGTTGGAAGT ATCCCAAAGG CATTCATGTT 
GAGACATTAG AGACTGACAA GAAGGAAAGA CACATAGTTA TCAGCAAAGT GGATGAAGAA 
GAACGCAAAA GGAGAGAACA GGAGAAGTAC GCAAAGGAGC AGGAGGAACT GAATGATGCT 
GTAGGATTTT CAAGAGTCAT CCATGCGATT GCTAATTCGG GGAAGCTGGT TGTTGGACAC 
AACATGCTCT TGGATGTCAT GCACACTATT CACCAGTTCT ACTGCCCTCT GCCTGTGGAC 
CTGAATGAGT TTAAGGAGAT GACAACATGT GTCTTCCCCA GACTCTTGGA TACTAAATTG 
ATGGCCAGCA CCCAGCCCTT TAAGGATATC ATTAACAATA CATCCCTTGC AGAGTTGGAA 
AAGCGGTTGA AAGAGACACC TTTTGACCCT CCTAAAGTTG AGAGTGCGGA AGGCTTTCCA 
AGCTACGACA CAGCTTCTGA GCAGCTGCAT GAGGCAGGTT ATGATGCGTA CATCACAGGA 
CTCTGCTTCA TCTCCATGGC AAATTACTTA GGTTCTTTAC TCAGTCCTCC AAAAACGTGT 
GTGTCCGCCA GATCAAAGCT CATCGAACCC TTTTTTAACA AGTTATTTCT TATGAGGGTC 
ATGGATATTC CCTATTTAAA CTTGGAAGGG CCAGACTTGC AGCCTAAGCG GGATCATGTT 
CTCCATGTGA CCTTCCCTAA AGAATGGAAA ACCAGTGACC TGTACCAGCT CTTCAGCGCC 
TTTGGTAACA TTCAGATATC CTGGATTGAT GACACATCAG CCTTCGTTTC TCTCAGCCAA 
CCAGAACAAG TACAAATTGC TGTTAATACC AGTAAGTATG CTGAAAGTTA TCGGATCCAG 
ACCTACGCTG AGTATGTGGG AAAGAAGCAG GAAAGCAAGC AGGTCAAGAG GAAGTGGACA 
GAAGACAGTT GGAAGGAGGT GGACAGAAAG CGGCCCCACG TGCCGGGCCC CTGTTACCAC 
ACCAACAGCT TCACTGCAGC CGGCATAGTT GGAAAGAGAA CTCTGAGTCC CGACCCTCGG 
GAAGCTGGAG TGGTGGACAG AGAATCAGAG GGAATATCTG ACCCGGAACT TGAACAGACG 
GATTACTGTG CAGACCCCCT CCCAGAGGGA AGGAAAAAGG CCAAGAAGTT AAAAAGAATG 
AAGAAAGAGT TTTCCTTGGC AGGAAGTGCC TCAGATAGCC CTGCTGTGCT TTTTGAAGTC 
CCCGACACGT GGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Nature structural & molecular biology23(4)286-92(2016 Apr)
Shukla S,Schmidt JC,Goldfarb KC,Cech TR,Parker R

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component.
Nature genetics47(12)1482-8(2015 Dec)
Moon DH,Segal M,Boyraz B,Guinan E,Hofmann I,Cahan P,Tai AK,Agarwal S

PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
Proceedings of the National Academy of Sciences of the United States of America111(31)11467-72(2014 Aug)
Boele J,Persson H,Shin JW,Ishizu Y,Newie IS,S?kilde R,Hawkins SM,Coarfa C,Ikeda K,Takayama K,Horie-Inoue K,Ando Y,Burroughs AM,Sasaki C,Suzuki C,Sakai M,Aoki S,Ogawa A,Hasegawa A,Lizio M,Kaida K,Teusink B,Carninci P,Suzuki H,Inoue S,Gunaratne PH,Rovira C,Hayashizaki Y,de Hoon MJ

Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Molecular cell47(2)253-66(2012 Jul)
Udagawa T,Swanger SA,Takeuchi K,Kim JH,Nalavadi V,Shin J,Lorenz LJ,Zukin RS,Bassell GJ,Richter JD

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

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Parn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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