Lat2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lat2
Entrez Gene ID	317676
Full Name	linker for activation of T cells family, member 2
Synonyms	Ntal,Wbscr5
General protein information	Preferred Names linker for activation of T cells family, member 2 Names linker for activation of T-cells family member 2 LAT-2 like Williams-Beuren syndrome chromosome region 5 homolog Williams-Beuren syndrome chromosome region 5-like protein linker for activation of B-cells non-T cell activation linker
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12q12
Summary	human homolog maps to the microdeletion region in Williams syndrome and may act as an adaptor for non T-cell immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598358.1	XP_017453847.1	linker for activation of T-cells family member 2 isoform X2
XM_017598359.1	XP_017453848.1	linker for activation of T-cells family member 2 isoform X4
XM_017598357.1	XP_017453846.1	linker for activation of T-cells family member 2 isoform X1
NM_173840.1	NP_776212.1	linker for activation of T-cells family member 2 precursor
XM_006249160.3	XP_006249222.1	linker for activation of T-cells family member 2 isoform X3

Pathways from BioSystems

Homologies

Homo sapiens (human)	LAT2	NP_054865.2
	LAT2	XP_001082644.1
Bos taurus (cattle)	LAT2	NP_001068651.2
Mus musculus (house mouse)	Lat2	NP_064428.1
Rattus norvegicus (Norway rat)	Lat2	NP_776212.1
Gallus gallus (chicken)	LOC100857708	XP_003643276.2
Pan troglodytes (chimpanzee)	LAT2	XP_003318629.1
Canis lupus familiaris (dog)	LAT2	XP_005621012.1
Gallus gallus (chicken)	LOC100857800	XP_004950582.1
Gallus gallus (chicken)	LAT2	NP_001007483.1
Gallus gallus (chicken)	LOC100857709	XP_004950578.1

Gene Ontology
Bibliography

Related articles in PubMed

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y?LAT2 Carrier-Mediated Loss.
Milewski K, Bogaci?ska-Kara? M, Fr??ko I, Hilgier W, Ja?wiec R, Albrecht J, Zieli?ska M
International journal of molecular sciences18(11)(2017 Nov)

Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.
Zieli?ska M, Milewski K, Skowro?ska M, Gajos A, Ziemi?ska E, Ber?sewicz A, Albrecht J
Journal of neurochemistry135(6)1272-81(2015 Dec)

Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
H?lov? I, Dr?berov? L, Bambouskov? M, Machyna M, Stegurov? L, Smrz D, Dr?ber P
The Journal of biological chemistry288(14)9801-14(2013 Apr)

Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
Kurayama R, Ito N, Nishibori Y, Fukuhara D, Akimoto Y, Higashihara E, Ishigaki Y, Sai Y, Miyamoto K, Endou H, Kanai Y, Yan K
Laboratory investigation; a journal of technical methods and pathology91(7)992-1006(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression
Title: Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.

chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.

The Saturday night forecast called for possible showers or thunderstorms, with winds of 20 to 26 mph. The expected total rainfall Saturday ranges from six-tenths of an inch to an inch, with more possible in thunderstorms, the weather service said.
Title: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.

Regulates Fc epsilon type I (IgE) receptor-mediated signaling at multiple steps and by different mechanisms in mast cells.
Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.

LAT2 colocalizes with Thy-1 (CD90); their colocalization is enhanced following Thy-1 aggregation.
Title: Topography of plasma membrane microdomains and its consequences for mast cell signaling.

The following Lat2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lat2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12865	NM_173840.1 Latest version!	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa34773	XM_006249160.3 Latest version!	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa57831	XM_017598357.1 Latest version!	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa57832	XM_017598358.1 Latest version!	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa57833	XM_017598359.1 Latest version!	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lat2 ( NM_173840.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_776212.1 Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), mRNA.

Price & Availability↑

CloneID	ORa12865
Clone ID Related Accession (Same CDS sequence)	NM_173840.1
Accession Version	NM_173840.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	linker for activation of T-cells family member 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY170849.1. On or before Dec 17, 2003 this sequence version replaced XM_346432.1, XM_347351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY170849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END##

ATGAATGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AGAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCATC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGTC CTGAGTCCCC TAGGTACCAG 
AACTTCTACA AAGGAAGCAG ACGGGAGTCT GATGCTGCCT ATGTAGATCC CATCCCCACA 
GACTACTACA ACTGGGGATG TTTCCAGAAG CCCCCAGAAG ACAATGATTC CAACTCCTAC 
GAGAATGTGC TCATCTGCAA GCCCAGCACC CCCGAGTCAG GTACTGAGGA ATCCGAGGAT 
TACCAGAACT CGGTATCCAT CCTTCAGTGG CGAGAATCCA AGAGGACTAT GGGTGCACGC 
ACGTCCCCAT CAGGAAGCCC AGACGAGGAG CCAGATTACG TGAATGGGGA TGTGGCCACG 
ACGGAGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776212.1
CDS	1..615
Translation	MNAELELLWPLSGLLLLLLLGTTAWLCVQCSRPGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGPESPRYQNFYKGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI

Target ORF information:

RefSeq Version	NM_173840.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_173840.1

ORF Insert Sequence:

ATGAATGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AGAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCATC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGTC CTGAGTCCCC TAGGTACCAG 
AACTTCTACA AAGGAAGCAG ACGGGAGTCT GATGCTGCCT ATGTAGATCC CATCCCCACA 
GACTACTACA ACTGGGGATG TTTCCAGAAG CCCCCAGAAG ACAATGATTC CAACTCCTAC 
GAGAATGTGC TCATCTGCAA GCCCAGCACC CCCGAGTCAG GTACTGAGGA ATCCGAGGAT 
TACCAGAACT CGGTATCCAT CCTTCAGTGG CGAGAATCCA AGAGGACTAT GGGTGCACGC 
ACGTCCCCAT CAGGAAGCCC AGACGAGGAG CCAGATTACG TGAATGGGGA TGTGGCCACG 
ACGGAGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lat2 ( XM_006249160.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006249222.1 Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa34773
Clone ID Related Accession (Same CDS sequence)	XM_006249160.3
Accession Version	XM_006249160.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	linker for activation of T-cells family member 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006249160.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AAAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCGTC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGTC CTGAGTCCCC TAGGTACCAG 
AACTTCTACA AAGGAAGCAG ACGGGAGTCT GATGCTGCCT ATGTAGATCC CATCCCCACG 
GACTACTACA ACTGGGGATG TTTCCAGAAG CCCCCAGAAG ACAATGATTC CAACTCCTAC 
GAGAATGTGC TCATCTGCAA GCCCAGCACC CCCGAGTCAG GTACTGAGGA ATCCGAGGAT 
TACCAGAACT CGGTATCCAT CCTTCAGTGG CGAGAATCCA AGAGGACTAT GGGTGCACGC 
ACGTCCCCAT CAGGAAGCCC AGACGAGGAG CCAGATTACG TGAATGGGGA TGTGGCCACG 
ACGGAGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006249222.1
CDS	177..791
Translation	MSAELELLWPLSGLLLLLLLGTTAWLCVQCSRPGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGPESPRYQNFYKGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI

Target ORF information:

RefSeq Version	XM_006249160.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006249160.3

ORF Insert Sequence:

ATGAGTGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AAAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCGTC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGTC CTGAGTCCCC TAGGTACCAG 
AACTTCTACA AAGGAAGCAG ACGGGAGTCT GATGCTGCCT ATGTAGATCC CATCCCCACG 
GACTACTACA ACTGGGGATG TTTCCAGAAG CCCCCAGAAG ACAATGATTC CAACTCCTAC 
GAGAATGTGC TCATCTGCAA GCCCAGCACC CCCGAGTCAG GTACTGAGGA ATCCGAGGAT 
TACCAGAACT CGGTATCCAT CCTTCAGTGG CGAGAATCCA AGAGGACTAT GGGTGCACGC 
ACGTCCCCAT CAGGAAGCCC AGACGAGGAG CCAGATTACG TGAATGGGGA TGTGGCCACG 
ACGGAGAAAA TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lat2 ( XM_017598357.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453846.1 Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57831
Clone ID Related Accession (Same CDS sequence)	XM_017598357.1
Accession Version	XM_017598357.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	linker for activation of T-cells family member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCCTGC CCTCTGGCCT CAGCTTCCTG AGCCCTGGGA TCACAGACCT GTGTCACCAC 
ACCCAGCTGA CAAGAACCCT CTCAGTGACA GGCAGCTGGA AGGGACAGCC TGGTGGAGTT 
ACAAAGGGGA GGAGGGGTTC CAGACTTCAG CCCTCCCCCA CTGCACCCCC TGAGTTCAGG 
GACACTAGCT ACGCCATTTC TGTTCTTGCA GGGGTGAAGA GAAATGAGAA AATCTACGAG 
CAAAGGAACC AGCAAGAAAA TGAACAGAGC GTAGCCTCGT CTCAGACGTA CTCCCTGGCC 
AGGCCGGTGC GGACAGGACT CCAGATGGAC GCAGCCTCAA ACAAGTCATT TGAGAGGAAG 
AACAAGCTGC TTTTCTCCCA CCTGGAGGGT CCTGAGTCCC CTAGGTACCA GAACTTCTAC 
AAAGGAAGCA GACGGGAGTC TGATGCTGCC TATGTAGATC CCATCCCCAC GGACTACTAC 
AACTGGGGAT GTTTCCAGAA GCCCCCAGAA GACAATGATT CCAACTCCTA CGAGAATGTG 
CTCATCTGCA AGCCCAGCAC CCCCGAGTCA GGTACTGAGG AATCCGAGGA TTACCAGAAC 
TCGGTATCCA TCCTTCAGTG GCGAGAATCC AAGAGGACTA TGGGTGCACG CACGTCCCCA 
TCAGGAAGCC CAGACGAGGA GCCAGATTAC GTGAATGGGG ATGTGGCCAC GACGGAGAAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453846.1
CDS	3..728
Translation	MFLPSGLSFLSPGITDLCHHTQLTRTLSVTGSWKGQPGGVTKGRRGSRLQPSPTAPPEFRDTSYAISVLAGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGPESPRYQNFYKGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI

Target ORF information:

RefSeq Version	XM_017598357.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598357.1

ORF Insert Sequence:

ATGTTCCTGC CCTCTGGCCT CAGCTTCCTG AGCCCTGGGA TCACAGACCT GTGTCACCAC 
ACCCAGCTGA CAAGAACCCT CTCAGTGACA GGCAGCTGGA AGGGACAGCC TGGTGGAGTT 
ACAAAGGGGA GGAGGGGTTC CAGACTTCAG CCCTCCCCCA CTGCACCCCC TGAGTTCAGG 
GACACTAGCT ACGCCATTTC TGTTCTTGCA GGGGTGAAGA GAAATGAGAA AATCTACGAG 
CAAAGGAACC AGCAAGAAAA TGAACAGAGC GTAGCCTCGT CTCAGACGTA CTCCCTGGCC 
AGGCCGGTGC GGACAGGACT CCAGATGGAC GCAGCCTCAA ACAAGTCATT TGAGAGGAAG 
AACAAGCTGC TTTTCTCCCA CCTGGAGGGT CCTGAGTCCC CTAGGTACCA GAACTTCTAC 
AAAGGAAGCA GACGGGAGTC TGATGCTGCC TATGTAGATC CCATCCCCAC GGACTACTAC 
AACTGGGGAT GTTTCCAGAA GCCCCCAGAA GACAATGATT CCAACTCCTA CGAGAATGTG 
CTCATCTGCA AGCCCAGCAC CCCCGAGTCA GGTACTGAGG AATCCGAGGA TTACCAGAAC 
TCGGTATCCA TCCTTCAGTG GCGAGAATCC AAGAGGACTA TGGGTGCACG CACGTCCCCA 
TCAGGAAGCC CAGACGAGGA GCCAGATTAC GTGAATGGGG ATGTGGCCAC GACGGAGAAA 
ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lat2 ( XM_017598358.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453847.1 Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa57832
Clone ID Related Accession (Same CDS sequence)	XM_017598358.1
Accession Version	XM_017598358.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 690bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	linker for activation of T-cells family member 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTCCTGC CCTCTGGCCT CAGCTTCCTG AGCCCTGGGA TCACAGACCT GTGTCACCAC 
ACCCAGCTGA CAAGAACCCT CTCAGTGACA GGCAGCTGGA AGGGACAGCC TGGTGGAGTT 
ACAAAGGGGA GGAGGGGTTC CAGACTTCAG CCCTCCCCCA CTGCACCCCC TGAGTTCAGG 
GACACTAGCT ACGCCATTTC TGTTCTTGCA GGGGTGAAGA GAAATGAGAA AATCTACGAG 
CAAAGGAACC AGCAAGAAAA TGAACAGAGC GTAGCCTCGT CTCAGACGTA CTCCCTGGCC 
AGGCCGGTGC GGACAGGACT CCAGATGGAC GCAGCCTCAA ACAAGTCATT TGAGAGGAAG 
AACAAGCTGC TTTTCTCCCA CCTGGAGGGA AGCAGACGGG AGTCTGATGC TGCCTATGTA 
GATCCCATCC CCACGGACTA CTACAACTGG GGATGTTTCC AGAAGCCCCC AGAAGACAAT 
GATTCCAACT CCTACGAGAA TGTGCTCATC TGCAAGCCCA GCACCCCCGA GTCAGGTACT 
GAGGAATCCG AGGATTACCA GAACTCGGTA TCCATCCTTC AGTGGCGAGA ATCCAAGAGG 
ACTATGGGTG CACGCACGTC CCCATCAGGA AGCCCAGACG AGGAGCCAGA TTACGTGAAT 
GGGGATGTGG CCACGACGGA GAAAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453847.1
CDS	3..692
Translation	MFLPSGLSFLSPGITDLCHHTQLTRTLSVTGSWKGQPGGVTKGRRGSRLQPSPTAPPEFRDTSYAISVLAGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI

Target ORF information:

RefSeq Version	XM_017598358.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598358.1

ORF Insert Sequence:

ATGTTCCTGC CCTCTGGCCT CAGCTTCCTG AGCCCTGGGA TCACAGACCT GTGTCACCAC 
ACCCAGCTGA CAAGAACCCT CTCAGTGACA GGCAGCTGGA AGGGACAGCC TGGTGGAGTT 
ACAAAGGGGA GGAGGGGTTC CAGACTTCAG CCCTCCCCCA CTGCACCCCC TGAGTTCAGG 
GACACTAGCT ACGCCATTTC TGTTCTTGCA GGGGTGAAGA GAAATGAGAA AATCTACGAG 
CAAAGGAACC AGCAAGAAAA TGAACAGAGC GTAGCCTCGT CTCAGACGTA CTCCCTGGCC 
AGGCCGGTGC GGACAGGACT CCAGATGGAC GCAGCCTCAA ACAAGTCATT TGAGAGGAAG 
AACAAGCTGC TTTTCTCCCA CCTGGAGGGA AGCAGACGGG AGTCTGATGC TGCCTATGTA 
GATCCCATCC CCACGGACTA CTACAACTGG GGATGTTTCC AGAAGCCCCC AGAAGACAAT 
GATTCCAACT CCTACGAGAA TGTGCTCATC TGCAAGCCCA GCACCCCCGA GTCAGGTACT 
GAGGAATCCG AGGATTACCA GAACTCGGTA TCCATCCTTC AGTGGCGAGA ATCCAAGAGG 
ACTATGGGTG CACGCACGTC CCCATCAGGA AGCCCAGACG AGGAGCCAGA TTACGTGAAT 
GGGGATGTGG CCACGACGGA GAAAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lat2 ( XM_017598359.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453848.1 Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa57833
Clone ID Related Accession (Same CDS sequence)	XM_017598359.1
Accession Version	XM_017598359.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	linker for activation of T-cells family member 2 isoform X4
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGTGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AAAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCGTC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGAA GCAGACGGGA GTCTGATGCT 
GCCTATGTAG ATCCCATCCC CACGGACTAC TACAACTGGG GATGTTTCCA GAAGCCCCCA 
GAAGACAATG ATTCCAACTC CTACGAGAAT GTGCTCATCT GCAAGCCCAG CACCCCCGAG 
TCAGGTACTG AGGAATCCGA GGATTACCAG AACTCGGTAT CCATCCTTCA GTGGCGAGAA 
TCCAAGAGGA CTATGGGTGC ACGCACGTCC CCATCAGGAA GCCCAGACGA GGAGCCAGAT 
TACGTGAATG GGGATGTGGC CACGACGGAG AAAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453848.1
CDS	177..755
Translation	MSAELELLWPLSGLLLLLLLGTTAWLCVQCSRPGVKRNEKIYEQRNQQENEQSVASSQTYSLARPVRTGLQMDAASNKSFERKNKLLFSHLEGSRRESDAAYVDPIPTDYYNWGCFQKPPEDNDSNSYENVLICKPSTPESGTEESEDYQNSVSILQWRESKRTMGARTSPSGSPDEEPDYVNGDVATTEKI

Target ORF information:

RefSeq Version	XM_017598359.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus linker for activation of T cells family, member 2 (Lat2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598359.1

ORF Insert Sequence:

ATGAGTGCCG AGTTGGAGCT GCTGTGGCCA CTGTCAGGAC TGTTGCTGCT GCTGCTCTTG 
GGGACCACAG CTTGGCTGTG TGTCCAGTGC TCCCGCCCAG GGGTGAAGAG AAATGAGAAA 
ATCTACGAGC AAAGGAACCA GCAAGAAAAT GAACAGAGCG TAGCCTCGTC TCAGACGTAC 
TCCCTGGCCA GGCCGGTGCG GACAGGACTC CAGATGGACG CAGCCTCAAA CAAGTCATTT 
GAGAGGAAGA ACAAGCTGCT TTTCTCCCAC CTGGAGGGAA GCAGACGGGA GTCTGATGCT 
GCCTATGTAG ATCCCATCCC CACGGACTAC TACAACTGGG GATGTTTCCA GAAGCCCCCA 
GAAGACAATG ATTCCAACTC CTACGAGAAT GTGCTCATCT GCAAGCCCAG CACCCCCGAG 
TCAGGTACTG AGGAATCCGA GGATTACCAG AACTCGGTAT CCATCCTTCA GTGGCGAGAA 
TCCAAGAGGA CTATGGGTGC ACGCACGTCC CCATCAGGAA GCCCAGACGA GGAGCCAGAT 
TACGTGAATG GGGATGTGGC CACGACGGAG AAAATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y?LAT2 Carrier-Mediated Loss.
International journal of molecular sciences18(11)(2017 Nov)
Milewski K,Bogaci?ska-Kara? M,Fr??ko I,Hilgier W,Ja?wiec R,Albrecht J,Zieli?ska M

Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.
Journal of neurochemistry135(6)1272-81(2015 Dec)
Zieli?ska M,Milewski K,Skowro?ska M,Gajos A,Ziemi?ska E,Ber?sewicz A,Albrecht J

Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
The Journal of biological chemistry288(14)9801-14(2013 Apr)
H?lov? I,Dr?berov? L,Bambouskov? M,Machyna M,Stegurov? L,Smrz D,Dr?ber P

Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
Laboratory investigation; a journal of technical methods and pathology91(7)992-1006(2011 Jul)
Kurayama R,Ito N,Nishibori Y,Fukuhara D,Akimoto Y,Higashihara E,Ishigaki Y,Sai Y,Miyamoto K,Endou H,Kanai Y,Yan K

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

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Lat2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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