Tmprss6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmprss6
Entrez Gene ID	315388
Full Name	transmembrane protease, serine 6
General protein information	Preferred Names transmembrane protease, serine 6 Names transmembrane protease serine 6 transmembrane serine protease 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34

mRNA and Protein(s)

mRNA	Protein	Name
XM_006241996.3	XP_006242058.1	transmembrane protease serine 6 isoform X2
XM_006241995.3	XP_006242057.1	transmembrane protease serine 6 isoform X1
NM_001130556.1	NP_001124028.1	transmembrane protease serine 6

Pathways from BioSystems

Homologies

	TMPRSS6	XP_001085203.1
Mus musculus (house mouse)	Tmprss6	NP_082178.2
Gallus gallus (chicken)	TMPRSS6	XP_004937823.1
Homo sapiens (human)	TMPRSS6	NP_001275929.1
Pan troglodytes (chimpanzee)	TMPRSS6	XP_003317294.2
Bos taurus (cattle)	TMPRSS6	XP_002687735.2
Canis lupus familiaris (dog)	TMPRSS6	XP_850550.2
Rattus norvegicus (Norway rat)	Tmprss6	NP_001124028.1
Xenopus tropicalis (tropical clawed frog)	tmprss6	XP_002934284.1

Gene Ontology
Bibliography

Related articles in PubMed

Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats.
Gurieva I, Fr?dlov? J, Rychtar??kov? Z, Vokurka M, Truksa J, Krijt J
Blood cells, molecules & diseases641-7(2017 May)

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
Rausa M, Pagani A, Nai A, Campanella A, Gilberti ME, Apostoli P, Camaschella C, Silvestri L
PloS one10(4)e0122696(2015)

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.
De Falco L, Silvestri L, Kannengiesser C, Mor?n E, Oudin C, Rausa M, Bruno M, Aranda J, Argiles B, Yenicesu I, Falcon-Rodriguez M, Yilmaz-Keskin E, Kocak U, Beaumont C, Camaschella C, Iolascon A, Grandchamp B, Sanchez M
Human mutation35(11)1321-9(2014 Nov)

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
Maxson JE, Chen J, Enns CA, Zhang AS
The Journal of biological chemistry285(50)39021-8(2010 Dec)

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
Truksa J, Gelbart T, Peng H, Beutler E, Beutler B, Lee P
British journal of haematology147(4)571-81(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression
Title: Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.

identification, structural features, enzymology, expression pattern and potential roles of TMPRSS6 [review]
Title: The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles.

The following Tmprss6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmprss6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa41661	NM_001130556.1 Latest version!	Rattus norvegicus transmembrane serine protease 6 (Tmprss6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa30567	XM_006241995.3 Latest version!	Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa30568	XM_006241996.3 Latest version!	Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmprss6 ( NM_001130556.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001124028.1 Rattus norvegicus transmembrane serine protease 6 (Tmprss6), mRNA.

Price & Availability↑

CloneID	ORa41661
Clone ID Related Accession (Same CDS sequence)	NM_001130556.1
Accession Version	NM_001130556.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2319bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Rattus norvegicus(Norway rat)
Product	transmembrane protease serine 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473950.2. On or before Jul 28, 2008 this sequence version replaced XM_235768.4, XM_001074604.1, XM_001074630.1.

ATGCCAAGAT GTTTCCAGCT CCCCTGTTCT ACCAGGATGC CCACCGCTGA GGTTCCCCAA 
GCAGCTGGTG GTCAGGGTGA TGGAGGTGAT GGAGAGGAAG CTGCAGAGCC AGAGGGGGTG 
TTCAAGGCCC CCAGAAACGC CAAGAGAAAA GACAGGGACT ACGTCCGCTT CACACCACTG 
TTGCTGGTCT TGGCTGCGTT GGCTTCGGCA GGAGTCATGC TCTGGTATTT CCTAGGGTAC 
AAGGCGGAAG TGACCATAAG CCAGGTGTAC TCTGGCAGCC TCCGGGTGCT CAACCGCCAT 
TTTTCACAGG ACTTGGCCCG ACGGGAGTCT ATTGCTTTCC GCACTGAAAC TGCCAAAGCC 
CAGAAGATGT TCCAAGAGCT GGTTGCCAGC ACCCGCTTGG GTACTTACTA CAACTCCAGT 
TCCATCTACG CCTTTGGGGA GGGACCCCTT ATCTGCTTCT TCTGGTTCAT CCTTGACATC 
CCCGAGTACC AGCGACTGAC CCTGAGCCCT GAGGTGGTGC GCGAGCTCCT GGTGGGTGAG 
CTACTGTCCA ACAGCTCAGC CTTGGCTTCC TATAGGACCG AATATGAGGT GGACCCGGAA 
GGCCTGGTGA TACTAGAAGC CAGCGTGAAC GACATAGTCG TACTGAATTC CACGCTGGGC 
TGTTACCGCT ACAGCTACGT GAACCCGGGC CAGGTCCTCC GGTTGAGGGG GCCCGACCAG 
CAGACCACTA GCTGCCTGTG GCACCTGCAG GGGCCCGAGG ACCTCATGCT CAAAGTGCAG 
CTAGAGTGGA CTCGGGTTGA TTGCAGAGAC AGGGTGGCGA TGTACGACGC AGCTGGGCCC 
CTGGAGAAGA GACTTATCAC CTCGGTCTAT GGGTGCAGCC GCCAGGAACC CGTGATGGAG 
GTGCTGGCGT CGGGCTCTGT CATGGCCGTG GTGTGGAAGA AGGGCTTGCA TAGCTTCTAT 
GACCCTTTTC TGCTCTCAGT GAAGTCTGTG GCCTTCCAGG ACTGCCAGGT GAACCTGACC 
CTGGAAGGCC GGCTGGATCC ACAGGGCTTC CTCCGTACAC CCTACTACCC CAGTTACTAC 
TCGCCCAGTA CCCACTGCTC CTGGCATCTC ACGGTTCCCT CTCTGGACTA TGGCTTGGCA 
CTCTGGTTTG ACGCCTATGC ACTGAGGAGG CAGAAGTACA ACCTACTATG TACTCAGGGC 
CAGTGGATGA TCCAGAACAG GAGGCTATGT GGCTTCCGTA CCCTGCAGCC ATATGCTGAG 
AGGATCCCCG TGGTGGCCTC GGATGGTATC ACCATCAACT TCACCTCCCA GATCTCCCTC 
ACAGGCCCGG GTGTGCAAGT GTACTACAGC TTGTACAACC AATCAGACCC CTGCCCTGGA 
GAGTTCCTCT GCTCTGTGAA TGGATTGTGT GTCCCTGCTT GTGACGGAAT CAAGGACTGC 
CCCAACGGCC TGGATGAGAG GAACTGTGTC TGCAGAGCCA TGTTCCAGTG CCAAGAGGAC 
AGCACGTGCA TCTCACTGCC GAGAGTCTGT GACCGGCAGC CCGACTGTCT CAATGGTAGC 
GACGAAGAGC AGTGCCAAGA AGGAGTGCCC TGTGGGACAT TCACTTTCCA GTGTGAGGAC 
CGGAGCTGTG TGAAGAAGCC CAACCCCGAG TGTGACGGGC AGGCAGACTG CAGGGATGGC 
TCGGATGAGG AGCACTGTGA CTGTGGCCTC CAGGGCCCCT CCAGCCGCAT TGTGGGCGGG 
GCCATGTCCT CGGAGGGTGA GTGGCCCTGG CAGGCCAGTC TCCAGATTCG GGGTCGACAC 
ATCTGTGGGG GGGCTCTCAT CGCTGACCGC TGGGTCATAA CAGCCGCTCA CTGCTTCCAG 
GAGGACAGCA TGGCCTCCCC GAGGCTGTGG ACCGTGTTTC TGGGAAAGAT GCGGCAGAAT 
TCACGCTGGC CGGGCGAGGT GTCCTTCAAG GTGAGCCGCC TGTTCCTGCA CCCGTATCAT 
GAGGAGGACA GCCATGACTA CGACGTGGCC CTGCTGCAGC TGGACCACCC TGTGGTGTAC 
TCGGCCACCG TGCGCCCCGT CTGCCTGCCC GCACGCTCTC ACTTCTTTGA GCCAGGCCAG 
CACTGCTGGA TCACAGGCTG GGGAGCCCAG CGAGAGGGTG GTCCTGGTAG CAGCACCCTT 
CAGAAGGTGG ATGTGCAACT GATCCCTCAG GACCTGTGCA ATGAGGCCTA CCGTTACCAG 
GTGACCCCAC GCATGCTCTG TGCTGGTTAT CGCAAGGGCA AGAAAGATGC CTGCCAGGGC 
GACTCTGGAG GCCCACTGGT TTGCAAGGAG CCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001124028.1
CDS	203..2521
Translation	MPRCFQLPCSTRMPTAEVPQAAGGQGDGGDGEEAAEPEGVFKAPRNAKRKDRDYVRFTPLLLVLAALASAGVMLWYFLGYKAEVTISQVYSGSLRVLNRHFSQDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYAFGEGPLICFFWFILDIPEYQRLTLSPEVVRELLVGELLSNSSALASYRTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQDCQVNLTLEGRLDPQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGFRTLQPYAERIPVVASDGITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPR

Target ORF information:

RefSeq Version	NM_001130556.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane serine protease 6 (Tmprss6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130556.1

ORF Insert Sequence:

ATGCCAAGAT GTTTCCAGCT CCCCTGTTCT ACCAGGATGC CCACCGCTGA GGTTCCCCAA 
GCAGCTGGTG GTCAGGGTGA TGGAGGTGAT GGAGAGGAAG CTGCAGAGCC AGAGGGGGTG 
TTCAAGGCCC CCAGAAACGC CAAGAGAAAA GACAGGGACT ACGTCCGCTT CACACCACTG 
TTGCTGGTCT TGGCTGCGTT GGCTTCGGCA GGAGTCATGC TCTGGTATTT CCTAGGGTAC 
AAGGCGGAAG TGACCATAAG CCAGGTGTAC TCTGGCAGCC TCCGGGTGCT CAACCGCCAT 
TTTTCACAGG ACTTGGCCCG ACGGGAGTCT ATTGCTTTCC GCACTGAAAC TGCCAAAGCC 
CAGAAGATGT TCCAAGAGCT GGTTGCCAGC ACCCGCTTGG GTACTTACTA CAACTCCAGT 
TCCATCTACG CCTTTGGGGA GGGACCCCTT ATCTGCTTCT TCTGGTTCAT CCTTGACATC 
CCCGAGTACC AGCGACTGAC CCTGAGCCCT GAGGTGGTGC GCGAGCTCCT GGTGGGTGAG 
CTACTGTCCA ACAGCTCAGC CTTGGCTTCC TATAGGACCG AATATGAGGT GGACCCGGAA 
GGCCTGGTGA TACTAGAAGC CAGCGTGAAC GACATAGTCG TACTGAATTC CACGCTGGGC 
TGTTACCGCT ACAGCTACGT GAACCCGGGC CAGGTCCTCC GGTTGAGGGG GCCCGACCAG 
CAGACCACTA GCTGCCTGTG GCACCTGCAG GGGCCCGAGG ACCTCATGCT CAAAGTGCAG 
CTAGAGTGGA CTCGGGTTGA TTGCAGAGAC AGGGTGGCGA TGTACGACGC AGCTGGGCCC 
CTGGAGAAGA GACTTATCAC CTCGGTCTAT GGGTGCAGCC GCCAGGAACC CGTGATGGAG 
GTGCTGGCGT CGGGCTCTGT CATGGCCGTG GTGTGGAAGA AGGGCTTGCA TAGCTTCTAT 
GACCCTTTTC TGCTCTCAGT GAAGTCTGTG GCCTTCCAGG ACTGCCAGGT GAACCTGACC 
CTGGAAGGCC GGCTGGATCC ACAGGGCTTC CTCCGTACAC CCTACTACCC CAGTTACTAC 
TCGCCCAGTA CCCACTGCTC CTGGCATCTC ACGGTTCCCT CTCTGGACTA TGGCTTGGCA 
CTCTGGTTTG ACGCCTATGC ACTGAGGAGG CAGAAGTACA ACCTACTATG TACTCAGGGC 
CAGTGGATGA TCCAGAACAG GAGGCTATGT GGCTTCCGTA CCCTGCAGCC ATATGCTGAG 
AGGATCCCCG TGGTGGCCTC GGATGGTATC ACCATCAACT TCACCTCCCA GATCTCCCTC 
ACAGGCCCGG GTGTGCAAGT GTACTACAGC TTGTACAACC AATCAGACCC CTGCCCTGGA 
GAGTTCCTCT GCTCTGTGAA TGGATTGTGT GTCCCTGCTT GTGACGGAAT CAAGGACTGC 
CCCAACGGCC TGGATGAGAG GAACTGTGTC TGCAGAGCCA TGTTCCAGTG CCAAGAGGAC 
AGCACGTGCA TCTCACTGCC GAGAGTCTGT GACCGGCAGC CCGACTGTCT CAATGGTAGC 
GACGAAGAGC AGTGCCAAGA AGGAGTGCCC TGTGGGACAT TCACTTTCCA GTGTGAGGAC 
CGGAGCTGTG TGAAGAAGCC CAACCCCGAG TGTGACGGGC AGGCAGACTG CAGGGATGGC 
TCGGATGAGG AGCACTGTGA CTGTGGCCTC CAGGGCCCCT CCAGCCGCAT TGTGGGCGGG 
GCCATGTCCT CGGAGGGTGA GTGGCCCTGG CAGGCCAGTC TCCAGATTCG GGGTCGACAC 
ATCTGTGGGG GGGCTCTCAT CGCTGACCGC TGGGTCATAA CAGCCGCTCA CTGCTTCCAG 
GAGGACAGCA TGGCCTCCCC GAGGCTGTGG ACCGTGTTTC TGGGAAAGAT GCGGCAGAAT 
TCACGCTGGC CGGGCGAGGT GTCCTTCAAG GTGAGCCGCC TGTTCCTGCA CCCGTATCAT 
GAGGAGGACA GCCATGACTA CGACGTGGCC CTGCTGCAGC TGGACCACCC TGTGGTGTAC 
TCGGCCACCG TGCGCCCCGT CTGCCTGCCC GCACGCTCTC ACTTCTTTGA GCCAGGCCAG 
CACTGCTGGA TCACAGGCTG GGGAGCCCAG CGAGAGGGTG GTCCTGGTAG CAGCACCCTT 
CAGAAGGTGG ATGTGCAACT GATCCCTCAG GACCTGTGCA ATGAGGCCTA CCGTTACCAG 
GTGACCCCAC GCATGCTCTG TGCTGGTTAT CGCAAGGGCA AGAAAGATGC CTGCCAGGGC 
GACTCTGGAG GCCCACTGGT TTGCAAGGAG CCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss6 ( XM_006241995.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242057.1 Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30567
Clone ID Related Accession (Same CDS sequence)	XM_006241995.3
Accession Version	XM_006241995.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2436bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transmembrane protease serine 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006241995.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAAGAT GTTTCCAGCT CCCCTGTTCT ACCAGGATGC CCACCGCTGA GGTTCCCCAA 
GCAGCTGGTG GTCAGGGTGA TGGAGGTGAT GGAGAGGAAG CTGCAGAGCC AGAGGGGGTG 
TTCAAGGCCC CCAGAAACGC CAAGAGAAAA GACAGGGACT ACGTCCGCTT CACACCACTG 
TTGCTGGTCT TGGCTGCGTT GGCTTCGGCA GGAGTCATGC TCTGGTATTT CCTAGGGTAC 
AAGGCGGAAG TGACCATAAG CCAGGTGTAC TCTGGCAGCC TCCGGGTGCT CAACCGCCAT 
TTTTCACAGG ACTTGGCCCG ACGGGAGTCT ATTGCTTTCC GCACTGAAAC TGCCAAAGCC 
CAGAAGATGT TCCAAGAGCT GGTTGCCAGC ACCCGCTTGG GTACTTACTA CAACTCCAGT 
TCCATCTACG CCTTTGGGGA GGGACCCCTT ATCTGCTTCT TCTGGTTCAT CCTTGACATC 
CCCGAGTACC AGCGACTGAC CCTGAGCCCT GAGGTGGTGC GCGAGCTCCT GGTGGGTGAG 
CTACTGTCCA ACAGCTCAGC CTTGGCTTCC TATAGGACCG AATATGAGGT GGACCCGGAA 
GGCCTGGTGA TACTAGAAGC CAGCGTGAAC GACATAGTCG TACTGAATTC CACGCTGGGC 
TGTTACCGCT ACAGCTACGT GAACCCGGGC CAGGTCCTCC GGTTGAGGGG GCCCGACCAG 
CAGACCACTA GCTGCCTGTG GCACCTGCAG GGGCCCGAGG ACCTCATGCT CAAAGTGCAG 
CTAGAGTGGA CTCGGGTTGA TTGCAGAGAC AGGGTGGCGA TGTACGACGC AGCTGGGCCC 
CTGGAGAAGA GACTTATCAC CTCGGTCTAT GGGTGCAGCC GCCAGGAACC CGTGATGGAG 
GTGCTGGCGT CGGGCTCTGT CATGGCCGTG GTGTGGAAGA AGGGCTTGCA TAGCTTCTAT 
GACCCTTTTC TGCTCTCAGT GAAGTCTGTG GCCTTCCAGG ACTGCCAGGT GAACCTGACC 
CTGGAAGGCC GGCTGGATCC ACAGGGCTTC CTCCGTACAC CCTACTACCC CAGTTACTAC 
TCGCCCAGTA CCCACTGCTC CTGGCATCTC ACGGTTCCCT CTCTGGACTA TGGCTTGGCA 
CTCTGGTTTG ACGCCTATGC ACTGAGGAGG CAGAAGTACA ACCTACTATG TACTCAGGGC 
CAGTGGATGA TCCAGAACAG GAGGCTATGT GGCTTCCGTA CCCTGCAGCC ATATGCTGAG 
AGGATCCCCG TGGTGGCCTC GGATGGTATC ACCATCAACT TCACCTCCCA GATCTCCCTC 
ACAGGCCCGG GTGTGCAAGT GTACTACAGC TTGTACAACC AATCAGACCC CTGCCCTGGA 
GAGTTCCTCT GCTCTGTGAA TGGATTGTGT GTCCCTGCTT GTGACGGAAT CAAGGACTGC 
CCCAACGGCC TGGATGAGAG GAACTGTGTC TGCAGAGCCA TGTTCCAGTG CCAAGAGGAC 
AGCACGTGCA TCTCACTGCC GAGAGTCTGT GACCGGCAGC CCGACTGTCT CAATGGTAGC 
GACGAAGAGC AGTGCCAAGA AGGAGTGCCC TGTGGGACAT TCACTTTCCA GTGTGAGGAC 
CGGAGCTGTG TGAAGAAGCC CAACCCCGAG TGTGACGGGC AGGCAGACTG CAGGGATGGC 
TCGGATGAGG AGCACTGTGA CTGTGGCCTC CAGGGCCCCT CCAGCCGCAT TGTGGGCGGG 
GCCATGTCCT CGGAGGGTGA GTGGCCCTGG CAGGCCAGTC TCCAGATTCG GGGTCGACAC 
ATCTGTGGGG GGGCTCTCAT CGCTGACCGC TGGGTCATAA CAGCCGCTCA CTGCTTCCAG 
GAGGACAGCA TGGCCTCCCC GAGGCTGTGG ACCGTGTTTC TGGGAAAGAT GCGGCAGAAT 
TCACGCTGGC CGGGCGAGGT GTCCTTCAAG GTGAGCCGCC TGTTCCTGCA CCCGTATCAT 
GAGGAGGACA GCCATGACTA CGACGTGGCC CTGCTGCAGC TGGACCACCC TGTGGTGTAC 
TCGGCCACCG TGCGCCCCGT CTGCCTGCCC GCACGCTCTC ACTTCTTTGA GCCAGGCCAG 
CACTGCTGGA TCACAGGCTG GGGAGCCCAG CGAGAGGGTG GTCCTGGTAG CAGCACCCTT 
CAGAAGGTGG ATGTGCAACT GATCCCTCAG GACCTGTGCA ATGAGGCCTA CCGTTACCAG 
GTGACCCCAC GCATGCTCTG TGCTGGTTAT CGCAAGGGCA AGAAAGATGC CTGCCAGGGC 
GACTCTGGAG GCCCACTGGT TTGCAAGGAG CCCAGTGGCC GCTGGTTCCT GGCAGGGTTG 
GTTAGCTGGG GCCTGGGTTG TGGCCGACCC AATTTCTTTG GTGTCTACAC TCGTGTCACA 
CGTGTGGTCA ACTGGATCCA GCAGGTGCTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242057.1
CDS	218..2653
Translation	MPRCFQLPCSTRMPTAEVPQAAGGQGDGGDGEEAAEPEGVFKAPRNAKRKDRDYVRFTPLLLVLAALASAGVMLWYFLGYKAEVTISQVYSGSLRVLNRHFSQDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYAFGEGPLICFFWFILDIPEYQRLTLSPEVVRELLVGELLSNSSALASYRTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQDCQVNLTLEGRLDPQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGFRTLQPYAERIPVVASDGITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVLT

Target ORF information:

RefSeq Version	XM_006241995.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241995.3

ORF Insert Sequence:

ATGCCAAGAT GTTTCCAGCT CCCCTGTTCT ACCAGGATGC CCACCGCTGA GGTTCCCCAA 
GCAGCTGGTG GTCAGGGTGA TGGAGGTGAT GGAGAGGAAG CTGCAGAGCC AGAGGGGGTG 
TTCAAGGCCC CCAGAAACGC CAAGAGAAAA GACAGGGACT ACGTCCGCTT CACACCACTG 
TTGCTGGTCT TGGCTGCGTT GGCTTCGGCA GGAGTCATGC TCTGGTATTT CCTAGGGTAC 
AAGGCGGAAG TGACCATAAG CCAGGTGTAC TCTGGCAGCC TCCGGGTGCT CAACCGCCAT 
TTTTCACAGG ACTTGGCCCG ACGGGAGTCT ATTGCTTTCC GCACTGAAAC TGCCAAAGCC 
CAGAAGATGT TCCAAGAGCT GGTTGCCAGC ACCCGCTTGG GTACTTACTA CAACTCCAGT 
TCCATCTACG CCTTTGGGGA GGGACCCCTT ATCTGCTTCT TCTGGTTCAT CCTTGACATC 
CCCGAGTACC AGCGACTGAC CCTGAGCCCT GAGGTGGTGC GCGAGCTCCT GGTGGGTGAG 
CTACTGTCCA ACAGCTCAGC CTTGGCTTCC TATAGGACCG AATATGAGGT GGACCCGGAA 
GGCCTGGTGA TACTAGAAGC CAGCGTGAAC GACATAGTCG TACTGAATTC CACGCTGGGC 
TGTTACCGCT ACAGCTACGT GAACCCGGGC CAGGTCCTCC GGTTGAGGGG GCCCGACCAG 
CAGACCACTA GCTGCCTGTG GCACCTGCAG GGGCCCGAGG ACCTCATGCT CAAAGTGCAG 
CTAGAGTGGA CTCGGGTTGA TTGCAGAGAC AGGGTGGCGA TGTACGACGC AGCTGGGCCC 
CTGGAGAAGA GACTTATCAC CTCGGTCTAT GGGTGCAGCC GCCAGGAACC CGTGATGGAG 
GTGCTGGCGT CGGGCTCTGT CATGGCCGTG GTGTGGAAGA AGGGCTTGCA TAGCTTCTAT 
GACCCTTTTC TGCTCTCAGT GAAGTCTGTG GCCTTCCAGG ACTGCCAGGT GAACCTGACC 
CTGGAAGGCC GGCTGGATCC ACAGGGCTTC CTCCGTACAC CCTACTACCC CAGTTACTAC 
TCGCCCAGTA CCCACTGCTC CTGGCATCTC ACGGTTCCCT CTCTGGACTA TGGCTTGGCA 
CTCTGGTTTG ACGCCTATGC ACTGAGGAGG CAGAAGTACA ACCTACTATG TACTCAGGGC 
CAGTGGATGA TCCAGAACAG GAGGCTATGT GGCTTCCGTA CCCTGCAGCC ATATGCTGAG 
AGGATCCCCG TGGTGGCCTC GGATGGTATC ACCATCAACT TCACCTCCCA GATCTCCCTC 
ACAGGCCCGG GTGTGCAAGT GTACTACAGC TTGTACAACC AATCAGACCC CTGCCCTGGA 
GAGTTCCTCT GCTCTGTGAA TGGATTGTGT GTCCCTGCTT GTGACGGAAT CAAGGACTGC 
CCCAACGGCC TGGATGAGAG GAACTGTGTC TGCAGAGCCA TGTTCCAGTG CCAAGAGGAC 
AGCACGTGCA TCTCACTGCC GAGAGTCTGT GACCGGCAGC CCGACTGTCT CAATGGTAGC 
GACGAAGAGC AGTGCCAAGA AGGAGTGCCC TGTGGGACAT TCACTTTCCA GTGTGAGGAC 
CGGAGCTGTG TGAAGAAGCC CAACCCCGAG TGTGACGGGC AGGCAGACTG CAGGGATGGC 
TCGGATGAGG AGCACTGTGA CTGTGGCCTC CAGGGCCCCT CCAGCCGCAT TGTGGGCGGG 
GCCATGTCCT CGGAGGGTGA GTGGCCCTGG CAGGCCAGTC TCCAGATTCG GGGTCGACAC 
ATCTGTGGGG GGGCTCTCAT CGCTGACCGC TGGGTCATAA CAGCCGCTCA CTGCTTCCAG 
GAGGACAGCA TGGCCTCCCC GAGGCTGTGG ACCGTGTTTC TGGGAAAGAT GCGGCAGAAT 
TCACGCTGGC CGGGCGAGGT GTCCTTCAAG GTGAGCCGCC TGTTCCTGCA CCCGTATCAT 
GAGGAGGACA GCCATGACTA CGACGTGGCC CTGCTGCAGC TGGACCACCC TGTGGTGTAC 
TCGGCCACCG TGCGCCCCGT CTGCCTGCCC GCACGCTCTC ACTTCTTTGA GCCAGGCCAG 
CACTGCTGGA TCACAGGCTG GGGAGCCCAG CGAGAGGGTG GTCCTGGTAG CAGCACCCTT 
CAGAAGGTGG ATGTGCAACT GATCCCTCAG GACCTGTGCA ATGAGGCCTA CCGTTACCAG 
GTGACCCCAC GCATGCTCTG TGCTGGTTAT CGCAAGGGCA AGAAAGATGC CTGCCAGGGC 
GACTCTGGAG GCCCACTGGT TTGCAAGGAG CCCAGTGGCC GCTGGTTCCT GGCAGGGTTG 
GTTAGCTGGG GCCTGGGTTG TGGCCGACCC AATTTCTTTG GTGTCTACAC TCGTGTCACA 
CGTGTGGTCA ACTGGATCCA GCAGGTGCTG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmprss6 ( XM_006241996.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242058.1 Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X2, mRNA.

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CloneID	ORa30568
Clone ID Related Accession (Same CDS sequence)	XM_006241996.3
Accession Version	XM_006241996.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2400bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	transmembrane protease serine 6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006241996.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCACCG CTGAGGTTCC CCAAGCAGCT GGTGGTCAGG GTGATGGAGG TGATGGAGAG 
GAAGCTGCAG AGCCAGAGGG GGTGTTCAAG GCCCCCAGAA ACGCCAAGAG AAAAGACAGG 
GACTACGTCC GCTTCACACC ACTGTTGCTG GTCTTGGCTG CGTTGGCTTC GGCAGGAGTC 
ATGCTCTGGT ATTTCCTAGG GTACAAGGCG GAAGTGACCA TAAGCCAGGT GTACTCTGGC 
AGCCTCCGGG TGCTCAACCG CCATTTTTCA CAGGACTTGG CCCGACGGGA GTCTATTGCT 
TTCCGCACTG AAACTGCCAA AGCCCAGAAG ATGTTCCAAG AGCTGGTTGC CAGCACCCGC 
TTGGGTACTT ACTACAACTC CAGTTCCATC TACGCCTTTG GGGAGGGACC CCTTATCTGC 
TTCTTCTGGT TCATCCTTGA CATCCCCGAG TACCAGCGAC TGACCCTGAG CCCTGAGGTG 
GTGCGCGAGC TCCTGGTGGG TGAGCTACTG TCCAACAGCT CAGCCTTGGC TTCCTATAGG 
ACCGAATATG AGGTGGACCC GGAAGGCCTG GTGATACTAG AAGCCAGCGT GAACGACATA 
GTCGTACTGA ATTCCACGCT GGGCTGTTAC CGCTACAGCT ACGTGAACCC GGGCCAGGTC 
CTCCGGTTGA GGGGGCCCGA CCAGCAGACC ACTAGCTGCC TGTGGCACCT GCAGGGGCCC 
GAGGACCTCA TGCTCAAAGT GCAGCTAGAG TGGACTCGGG TTGATTGCAG AGACAGGGTG 
GCGATGTACG ACGCAGCTGG GCCCCTGGAG AAGAGACTTA TCACCTCGGT CTATGGGTGC 
AGCCGCCAGG AACCCGTGAT GGAGGTGCTG GCGTCGGGCT CTGTCATGGC CGTGGTGTGG 
AAGAAGGGCT TGCATAGCTT CTATGACCCT TTTCTGCTCT CAGTGAAGTC TGTGGCCTTC 
CAGGACTGCC AGGTGAACCT GACCCTGGAA GGCCGGCTGG ATCCACAGGG CTTCCTCCGT 
ACACCCTACT ACCCCAGTTA CTACTCGCCC AGTACCCACT GCTCCTGGCA TCTCACGGTT 
CCCTCTCTGG ACTATGGCTT GGCACTCTGG TTTGACGCCT ATGCACTGAG GAGGCAGAAG 
TACAACCTAC TATGTACTCA GGGCCAGTGG ATGATCCAGA ACAGGAGGCT ATGTGGCTTC 
CGTACCCTGC AGCCATATGC TGAGAGGATC CCCGTGGTGG CCTCGGATGG TATCACCATC 
AACTTCACCT CCCAGATCTC CCTCACAGGC CCGGGTGTGC AAGTGTACTA CAGCTTGTAC 
AACCAATCAG ACCCCTGCCC TGGAGAGTTC CTCTGCTCTG TGAATGGATT GTGTGTCCCT 
GCTTGTGACG GAATCAAGGA CTGCCCCAAC GGCCTGGATG AGAGGAACTG TGTCTGCAGA 
GCCATGTTCC AGTGCCAAGA GGACAGCACG TGCATCTCAC TGCCGAGAGT CTGTGACCGG 
CAGCCCGACT GTCTCAATGG TAGCGACGAA GAGCAGTGCC AAGAAGGAGT GCCCTGTGGG 
ACATTCACTT TCCAGTGTGA GGACCGGAGC TGTGTGAAGA AGCCCAACCC CGAGTGTGAC 
GGGCAGGCAG ACTGCAGGGA TGGCTCGGAT GAGGAGCACT GTGACTGTGG CCTCCAGGGC 
CCCTCCAGCC GCATTGTGGG CGGGGCCATG TCCTCGGAGG GTGAGTGGCC CTGGCAGGCC 
AGTCTCCAGA TTCGGGGTCG ACACATCTGT GGGGGGGCTC TCATCGCTGA CCGCTGGGTC 
ATAACAGCCG CTCACTGCTT CCAGGAGGAC AGCATGGCCT CCCCGAGGCT GTGGACCGTG 
TTTCTGGGAA AGATGCGGCA GAATTCACGC TGGCCGGGCG AGGTGTCCTT CAAGGTGAGC 
CGCCTGTTCC TGCACCCGTA TCATGAGGAG GACAGCCATG ACTACGACGT GGCCCTGCTG 
CAGCTGGACC ACCCTGTGGT GTACTCGGCC ACCGTGCGCC CCGTCTGCCT GCCCGCACGC 
TCTCACTTCT TTGAGCCAGG CCAGCACTGC TGGATCACAG GCTGGGGAGC CCAGCGAGAG 
GGTGGTCCTG GTAGCAGCAC CCTTCAGAAG GTGGATGTGC AACTGATCCC TCAGGACCTG 
TGCAATGAGG CCTACCGTTA CCAGGTGACC CCACGCATGC TCTGTGCTGG TTATCGCAAG 
GGCAAGAAAG ATGCCTGCCA GGGCGACTCT GGAGGCCCAC TGGTTTGCAA GGAGCCCAGT 
GGCCGCTGGT TCCTGGCAGG GTTGGTTAGC TGGGGCCTGG GTTGTGGCCG ACCCAATTTC 
TTTGGTGTCT ACACTCGTGT CACACGTGTG GTCAACTGGA TCCAGCAGGT GCTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242058.1
CDS	219..2618
Translation	MPTAEVPQAAGGQGDGGDGEEAAEPEGVFKAPRNAKRKDRDYVRFTPLLLVLAALASAGVMLWYFLGYKAEVTISQVYSGSLRVLNRHFSQDLARRESIAFRTETAKAQKMFQELVASTRLGTYYNSSSIYAFGEGPLICFFWFILDIPEYQRLTLSPEVVRELLVGELLSNSSALASYRTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLRLRGPDQQTTSCLWHLQGPEDLMLKVQLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGLHSFYDPFLLSVKSVAFQDCQVNLTLEGRLDPQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNLLCTQGQWMIQNRRLCGFRTLQPYAERIPVVASDGITINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHCDCGLQGPSSRIVGGAMSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPGSSTLQKVDVQLIPQDLCNEAYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQVLT

Target ORF information:

RefSeq Version	XM_006241996.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transmembrane protease, serine 6 (Tmprss6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006241996.3

ORF Insert Sequence:

ATGCCCACCG CTGAGGTTCC CCAAGCAGCT GGTGGTCAGG GTGATGGAGG TGATGGAGAG 
GAAGCTGCAG AGCCAGAGGG GGTGTTCAAG GCCCCCAGAA ACGCCAAGAG AAAAGACAGG 
GACTACGTCC GCTTCACACC ACTGTTGCTG GTCTTGGCTG CGTTGGCTTC GGCAGGAGTC 
ATGCTCTGGT ATTTCCTAGG GTACAAGGCG GAAGTGACCA TAAGCCAGGT GTACTCTGGC 
AGCCTCCGGG TGCTCAACCG CCATTTTTCA CAGGACTTGG CCCGACGGGA GTCTATTGCT 
TTCCGCACTG AAACTGCCAA AGCCCAGAAG ATGTTCCAAG AGCTGGTTGC CAGCACCCGC 
TTGGGTACTT ACTACAACTC CAGTTCCATC TACGCCTTTG GGGAGGGACC CCTTATCTGC 
TTCTTCTGGT TCATCCTTGA CATCCCCGAG TACCAGCGAC TGACCCTGAG CCCTGAGGTG 
GTGCGCGAGC TCCTGGTGGG TGAGCTACTG TCCAACAGCT CAGCCTTGGC TTCCTATAGG 
ACCGAATATG AGGTGGACCC GGAAGGCCTG GTGATACTAG AAGCCAGCGT GAACGACATA 
GTCGTACTGA ATTCCACGCT GGGCTGTTAC CGCTACAGCT ACGTGAACCC GGGCCAGGTC 
CTCCGGTTGA GGGGGCCCGA CCAGCAGACC ACTAGCTGCC TGTGGCACCT GCAGGGGCCC 
GAGGACCTCA TGCTCAAAGT GCAGCTAGAG TGGACTCGGG TTGATTGCAG AGACAGGGTG 
GCGATGTACG ACGCAGCTGG GCCCCTGGAG AAGAGACTTA TCACCTCGGT CTATGGGTGC 
AGCCGCCAGG AACCCGTGAT GGAGGTGCTG GCGTCGGGCT CTGTCATGGC CGTGGTGTGG 
AAGAAGGGCT TGCATAGCTT CTATGACCCT TTTCTGCTCT CAGTGAAGTC TGTGGCCTTC 
CAGGACTGCC AGGTGAACCT GACCCTGGAA GGCCGGCTGG ATCCACAGGG CTTCCTCCGT 
ACACCCTACT ACCCCAGTTA CTACTCGCCC AGTACCCACT GCTCCTGGCA TCTCACGGTT 
CCCTCTCTGG ACTATGGCTT GGCACTCTGG TTTGACGCCT ATGCACTGAG GAGGCAGAAG 
TACAACCTAC TATGTACTCA GGGCCAGTGG ATGATCCAGA ACAGGAGGCT ATGTGGCTTC 
CGTACCCTGC AGCCATATGC TGAGAGGATC CCCGTGGTGG CCTCGGATGG TATCACCATC 
AACTTCACCT CCCAGATCTC CCTCACAGGC CCGGGTGTGC AAGTGTACTA CAGCTTGTAC 
AACCAATCAG ACCCCTGCCC TGGAGAGTTC CTCTGCTCTG TGAATGGATT GTGTGTCCCT 
GCTTGTGACG GAATCAAGGA CTGCCCCAAC GGCCTGGATG AGAGGAACTG TGTCTGCAGA 
GCCATGTTCC AGTGCCAAGA GGACAGCACG TGCATCTCAC TGCCGAGAGT CTGTGACCGG 
CAGCCCGACT GTCTCAATGG TAGCGACGAA GAGCAGTGCC AAGAAGGAGT GCCCTGTGGG 
ACATTCACTT TCCAGTGTGA GGACCGGAGC TGTGTGAAGA AGCCCAACCC CGAGTGTGAC 
GGGCAGGCAG ACTGCAGGGA TGGCTCGGAT GAGGAGCACT GTGACTGTGG CCTCCAGGGC 
CCCTCCAGCC GCATTGTGGG CGGGGCCATG TCCTCGGAGG GTGAGTGGCC CTGGCAGGCC 
AGTCTCCAGA TTCGGGGTCG ACACATCTGT GGGGGGGCTC TCATCGCTGA CCGCTGGGTC 
ATAACAGCCG CTCACTGCTT CCAGGAGGAC AGCATGGCCT CCCCGAGGCT GTGGACCGTG 
TTTCTGGGAA AGATGCGGCA GAATTCACGC TGGCCGGGCG AGGTGTCCTT CAAGGTGAGC 
CGCCTGTTCC TGCACCCGTA TCATGAGGAG GACAGCCATG ACTACGACGT GGCCCTGCTG 
CAGCTGGACC ACCCTGTGGT GTACTCGGCC ACCGTGCGCC CCGTCTGCCT GCCCGCACGC 
TCTCACTTCT TTGAGCCAGG CCAGCACTGC TGGATCACAG GCTGGGGAGC CCAGCGAGAG 
GGTGGTCCTG GTAGCAGCAC CCTTCAGAAG GTGGATGTGC AACTGATCCC TCAGGACCTG 
TGCAATGAGG CCTACCGTTA CCAGGTGACC CCACGCATGC TCTGTGCTGG TTATCGCAAG 
GGCAAGAAAG ATGCCTGCCA GGGCGACTCT GGAGGCCCAC TGGTTTGCAA GGAGCCCAGT 
GGCCGCTGGT TCCTGGCAGG GTTGGTTAGC TGGGGCCTGG GTTGTGGCCG ACCCAATTTC 
TTTGGTGTCT ACACTCGTGT CACACGTGTG GTCAACTGGA TCCAGCAGGT GCTGACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats.
Blood cells, molecules & diseases641-7(2017 May)
Gurieva I,Fr?dlov? J,Rychtar??kov? Z,Vokurka M,Truksa J,Krijt J

Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?
PloS one10(4)e0122696(2015)
Rausa M,Pagani A,Nai A,Campanella A,Gilberti ME,Apostoli P,Camaschella C,Silvestri L

Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies.
Human mutation35(11)1321-9(2014 Nov)
De Falco L,Silvestri L,Kannengiesser C,Mor?n E,Oudin C,Rausa M,Bruno M,Aranda J,Argiles B,Yenicesu I,Falcon-Rodriguez M,Yilmaz-Keskin E,Kocak U,Beaumont C,Camaschella C,Iolascon A,Grandchamp B,Sanchez M

Matriptase-2- and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression.
The Journal of biological chemistry285(50)39021-8(2010 Dec)
Maxson JE,Chen J,Enns CA,Zhang AS

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6.
British journal of haematology147(4)571-81(2009 Nov)
Truksa J,Gelbart T,Peng H,Beutler E,Beutler B,Lee P

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Tmprss6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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