Rnf139 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rnf139
Entrez Gene ID	315000
Full Name	ring finger protein 139
Synonyms	TRC8
General protein information	Preferred Names ring finger protein 139 Names E3 ubiquitin-protein ligase RNF139
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q33

mRNA and Protein(s)

mRNA	Protein	Name
NM_001127545.1	NP_001121017.1	E3 ubiquitin-protein ligase RNF139

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	RNF139	NP_001026126.1
Xenopus tropicalis (tropical clawed frog)	rnf139	NP_001001242.1
Pan troglodytes (chimpanzee)	RNF139	XP_519946.2
Mus musculus (house mouse)	Rnf139	NP_780435.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003666	XP_313450.5
Homo sapiens (human)	RNF139	NP_009149.2
Bos taurus (cattle)	RNF139	XP_002692671.1
Rattus norvegicus (Norway rat)	Rnf139	NP_001121017.1
Drosophila melanogaster (fruit fly)	Trc8	NP_996303.1
	RNF139	XP_001102164.1
Canis lupus familiaris (dog)	RNF139	XP_851772.1
Danio rerio (zebrafish)	rnf139	NP_001116520.1

Gene Ontology
Bibliography

Related articles in PubMed

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.
Chen CY, Malchus NS, Hehn B, Stelzer W, Avci D, Langosch D, Lemberg MK
The EMBO journal33(21)2492-506(2014 Nov)

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
Lee JP, Brauweiler A, Rudolph M, Hooper JE, Drabkin HA, Gemmill RM
Molecular cancer research : MCR8(1)93-106(2010 Jan)

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
Irisawa M, Inoue J, Ozawa N, Mori K, Sato R
The Journal of biological chemistry284(42)28995-9004(2009 Oct)

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.
Stagg HR, Thomas M, van den Boomen D, Wiertz EJ, Drabkin HA, Gemmill RM, Lehner PJ
The Journal of cell biology186(5)685-92(2009 Sep)

A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
Poland KS, Azim M, Folsom M, Goldfarb R, Naeem R, Korch C, Drabkin HA, Gemmill RM, Plon SE
Genes, chromosomes & cancer46(9)805-12(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rnf139 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnf139 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01836	NM_001127545.1 Latest version!	Rattus norvegicus ring finger protein 139 (Rnf139), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rnf139 ( NM_001127545.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001121017.1 Rattus norvegicus ring finger protein 139 (Rnf139), mRNA.

Price & Availability↑

CloneID	ORa01836
Clone ID Related Accession (Same CDS sequence)	NM_001127545.1
Accession Version	NM_001127545.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1971bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase RNF139
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473950.2. On May 23, 2008 this sequence version replaced XM_235338.4. ##Evidence-Data-START## Transcript exon combination :: CB796312.1, BC161975.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCAGC AGCAGGTCTG GGCGGCGCTC GAAGTGGCGC TCCGGGTGCC CTGCCTCTAC 
ATCATCGACG CCATCTTCAA CTCCTACTAC GATTCCAGCC AAAGCCGGTT CTGCATCGGG 
CTTCAGATCT TTCTCCGGCT CCTCGGTATA GTTGTATCCA GTATTGTTCT GATCTTGTCA 
CAGCGATCAC TTTTCAAGTT TTACATGTAC AGCTCAGCCT TTCTATTAGC TGCAACTTCA 
GTGTTGGTGA ACTACTATGC TGCTTTGCAC ATTGACTTCT ACGGTGCCTA CAACACGTCA 
GCATTTGGAA TTGAGTTGCT TCCTCGGAAA GGGCCCTCAC TGTGGATGGC ACTCATCGTT 
CTGCAGCTAA CCTTTGGAAT CGGATACGTC ACTCTACTCC ACATTCAGTC TATCTATTCA 
CAGCTGATTA TTCTGAATAT CTTGGTTCCT GTAATCGGCT TAATCACAGA GCTACCATTA 
CACATCAGAG AGACGTTAGT TTTCATGTCT TCCTTGATTC TCATATTTAA CACAATGCTT 
GTCTTGGCAG TGAAACTTAA GTGGTTTTAT TACTCTACTC GGTATGTTTA CTTGTTAGTG 
AGGCATATGT ACCGAATTTA TGGATTACAG TTATTGATGG AGGACACATG GAAGCGGATT 
CGTTTCCCAG ACATACTTCG GGTCTTCTGG CTAACAAGGA TTACAGCTCA GGCTACAGTG 
TTGATGTACA TTTTAAGGAT GGCGAATGAG ACTGAGTCCT TCCTTATTTC TTGGGATGAT 
TTCTGGGACA TCATTTGCAA TCTAATAATT AGTGGGTGCG ATTCTACACT AACTGTACTA 
GGCATGAGTG CTGTAATTTC TTCAATAGCC CATTACTTGG GCCTTGGAAT ATTGGCCTTT 
ATTGGATCAA CTGAAGAAGA TGACAGGCGG CTTGGCTTTG TAGCACCTGT TTTATTTTTC 
ATTTTGGCTC TTCAGACTGG TTTAAGTGGG CTGAGACCTG AAGAGAGACT TATTCGCTTA 
AGTAGAAACA TGTGCCTTTT ATTAACTGCA GTCCTACATT TCATCCACGG AATGACAGAC 
CCCGTGTTAA TGTCTCTCAG TGCCTCCCAC GTGTCATCTT TCCACAGACA TTTTCCTGTG 
CTGTTTGTCT CTGCTTGCCT GTTTATTCTT CCTGTTTTAC TCAGTTATGT CCTTTGGCAC 
CACTATGCAC TAAACACGTG GCTGTTTGCA GTTACAGCCT TCTGTGTGGA ACTCTGCTTG 
AAAGTAATTG TTTCCCTCAC TGTCTACACG CTATTCATGA TTGATGGCTA CTATAATGTC 
CTCTGGGAAA AGCTTGATGA TTATGTCTAC TTTGTTCGCT CGACAGGCAA TATTATCGAA 
TTTATATTTG GAGTAGTAAT GTTTGGGAAT GGGGCCTATA CCATGATGTT TGAGTCAGGA 
AGTAAAATCC GGGCTTGTAT GATGTGCCTA CATGCATATT TTAACATCTA CTTACAAGTA 
AAAAATGGCT GGAAGACATT CATGAATCGT AGAACTGCTG TTAAGAAAAT TAATTCACTT 
CCTGAAATAA AAGGGAGCCA CTTGCAAGAA ATAGATGATG TTTGTGCCAT CTGCTATCAT 
GAGTTCACAA CGTCTGCTCG GATTACACCG TGTAACCATT ATTTCCATGC ACTCTGCCTT 
CGGAAATGGC TGTACATTCA AGATACTTGT CCAATGTGTC ATCAGAAAGT GTACATCGAA 
GACGATATCA AGGACAATTC AAATGTATCT AACAACAACG GATTTATTGC ACCCAATGAA 
AATCAAAACC CAGAGGAAGC TTTAAGAGAA GATGCTGCTG GATCTGACCG AGAAATGAAC 
GAGGATGACA GTACAGACTG TGATGATGAT ATTCAAAGAG AAAGAAACGG GGGGATTCAG 
CACACAGGCG CAGCAGCAGC AGCAGCAGAA TTTAATGATG ACACTGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001121017.1
CDS	24..1994
Translation	MAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLHIQSIYSQLIILNILVPVIGLITELPLHIRETLVFMSSLILIFNTMLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITAQATVLMYILRMANETESFLISWDDFWDIICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIAPNENQNPEEALREDAAGSDREMNEDDSTDCDDDIQRERNGGIQHTGAAAAAAEFNDDTD

Target ORF information:

RefSeq Version	NM_001127545.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ring finger protein 139 (Rnf139), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001127545.1

ORF Insert Sequence:

ATGGCCCAGC AGCAGGTCTG GGCGGCGCTC GAAGTGGCGC TCCGGGTGCC CTGCCTCTAC 
ATCATCGACG CCATCTTCAA CTCCTACTAC GATTCCAGCC AAAGCCGGTT CTGCATCGGG 
CTTCAGATCT TTCTCCGGCT CCTCGGTATA GTTGTATCCA GTATTGTTCT GATCTTGTCA 
CAGCGATCAC TTTTCAAGTT TTACATGTAC AGCTCAGCCT TTCTATTAGC TGCAACTTCA 
GTGTTGGTGA ACTACTATGC TGCTTTGCAC ATTGACTTCT ACGGTGCCTA CAACACGTCA 
GCATTTGGAA TTGAGTTGCT TCCTCGGAAA GGGCCCTCAC TGTGGATGGC ACTCATCGTT 
CTGCAGCTAA CCTTTGGAAT CGGATACGTC ACTCTACTCC ACATTCAGTC TATCTATTCA 
CAGCTGATTA TTCTGAATAT CTTGGTTCCT GTAATCGGCT TAATCACAGA GCTACCATTA 
CACATCAGAG AGACGTTAGT TTTCATGTCT TCCTTGATTC TCATATTTAA CACAATGCTT 
GTCTTGGCAG TGAAACTTAA GTGGTTTTAT TACTCTACTC GGTATGTTTA CTTGTTAGTG 
AGGCATATGT ACCGAATTTA TGGATTACAG TTATTGATGG AGGACACATG GAAGCGGATT 
CGTTTCCCAG ACATACTTCG GGTCTTCTGG CTAACAAGGA TTACAGCTCA GGCTACAGTG 
TTGATGTACA TTTTAAGGAT GGCGAATGAG ACTGAGTCCT TCCTTATTTC TTGGGATGAT 
TTCTGGGACA TCATTTGCAA TCTAATAATT AGTGGGTGCG ATTCTACACT AACTGTACTA 
GGCATGAGTG CTGTAATTTC TTCAATAGCC CATTACTTGG GCCTTGGAAT ATTGGCCTTT 
ATTGGATCAA CTGAAGAAGA TGACAGGCGG CTTGGCTTTG TAGCACCTGT TTTATTTTTC 
ATTTTGGCTC TTCAGACTGG TTTAAGTGGG CTGAGACCTG AAGAGAGACT TATTCGCTTA 
AGTAGAAACA TGTGCCTTTT ATTAACTGCA GTCCTACATT TCATCCACGG AATGACAGAC 
CCCGTGTTAA TGTCTCTCAG TGCCTCCCAC GTGTCATCTT TCCACAGACA TTTTCCTGTG 
CTGTTTGTCT CTGCTTGCCT GTTTATTCTT CCTGTTTTAC TCAGTTATGT CCTTTGGCAC 
CACTATGCAC TAAACACGTG GCTGTTTGCA GTTACAGCCT TCTGTGTGGA ACTCTGCTTG 
AAAGTAATTG TTTCCCTCAC TGTCTACACG CTATTCATGA TTGATGGCTA CTATAATGTC 
CTCTGGGAAA AGCTTGATGA TTATGTCTAC TTTGTTCGCT CGACAGGCAA TATTATCGAA 
TTTATATTTG GAGTAGTAAT GTTTGGGAAT GGGGCCTATA CCATGATGTT TGAGTCAGGA 
AGTAAAATCC GGGCTTGTAT GATGTGCCTA CATGCATATT TTAACATCTA CTTACAAGTA 
AAAAATGGCT GGAAGACATT CATGAATCGT AGAACTGCTG TTAAGAAAAT TAATTCACTT 
CCTGAAATAA AAGGGAGCCA CTTGCAAGAA ATAGATGATG TTTGTGCCAT CTGCTATCAT 
GAGTTCACAA CGTCTGCTCG GATTACACCG TGTAACCATT ATTTCCATGC ACTCTGCCTT 
CGGAAATGGC TGTACATTCA AGATACTTGT CCAATGTGTC ATCAGAAAGT GTACATCGAA 
GACGATATCA AGGACAATTC AAATGTATCT AACAACAACG GATTTATTGC ACCCAATGAA 
AATCAAAACC CAGAGGAAGC TTTAAGAGAA GATGCTGCTG GATCTGACCG AGAAATGAAC 
GAGGATGACA GTACAGACTG TGATGATGAT ATTCAAAGAG AAAGAAACGG GGGGATTCAG 
CACACAGGCG CAGCAGCAGC AGCAGCAGAA TTTAATGATG ACACTGATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.
The EMBO journal33(21)2492-506(2014 Nov)
Chen CY,Malchus NS,Hehn B,Stelzer W,Avci D,Langosch D,Lemberg MK

The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
Molecular cancer research : MCR8(1)93-106(2010 Jan)
Lee JP,Brauweiler A,Rudolph M,Hooper JE,Drabkin HA,Gemmill RM

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
The Journal of biological chemistry284(42)28995-9004(2009 Oct)
Irisawa M,Inoue J,Ozawa N,Mori K,Sato R

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER.
The Journal of cell biology186(5)685-92(2009 Sep)
Stagg HR,Thomas M,van den Boomen D,Wiertz EJ,Drabkin HA,Gemmill RM,Lehner PJ

A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.
Genes, chromosomes & cancer46(9)805-12(2007 Sep)
Poland KS,Azim M,Folsom M,Goldfarb R,Naeem R,Korch C,Drabkin HA,Gemmill RM,Plon SE

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Rnf139 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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