Gpr68 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr68
Entrez Gene ID	314386
Full Name	G protein-coupled receptor 68
General protein information	Preferred Names G protein-coupled receptor 68 Names ovarian cancer G-protein coupled receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108049.1	NP_001101519.1	ovarian cancer G-protein coupled receptor 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gpr68	NP_001171145.1
Homo sapiens (human)	GPR68	NP_003476.3
Bos taurus (cattle)	GPR68	NP_776754.1
Rattus norvegicus (Norway rat)	LOC102553138	XP_006240515.1
Xenopus tropicalis (tropical clawed frog)	LOC101733637	XP_004917470.1
Rattus norvegicus (Norway rat)	Gpr68	NP_001101519.1
Danio rerio (zebrafish)	LOC799203	XP_001339588.2
Xenopus tropicalis (tropical clawed frog)	gpr68	XP_002933271.1
Pan troglodytes (chimpanzee)	GPR68	XP_001143865.1
	GPR68	XP_001091059.1
Canis lupus familiaris (dog)	GPR68	XP_005623803.1
Gallus gallus (chicken)	GPR68	XP_004941982.1

Gene Ontology
Bibliography

Related articles in PubMed

Proton receptor GPR68 expression in dendritic-cell-like S100?-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.
Horiguchi K, Higuchi M, Yoshida S, Nakakura T, Tateno K, Hasegawa R, Takigami S, Ohsako S, Kato T, Kato Y
Cell and tissue research358(2)515-25(2014 Nov)

Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Nakakura T, Mogi C, Tobo M, Tomura H, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F
Endocrinology153(9)4171-80(2012 Sep)

Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.
Li H, Wang D, Singh LS, Berk M, Tan H, Zhao Z, Steinmetz R, Kirmani K, Wei G, Xu Y
PloS one4(5)e5705(2009 May)

Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
Yang M, Mailhot G, Birnbaum MJ, MacKay CA, Mason-Savas A, Odgren PR
The Journal of biological chemistry281(33)23598-605(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

S100beta-positive dendritic-like cells can sense an increase in extracellular protons via GPR68 and respond by the production of IL-6 in order to suppress the up-regulation of Pomc expression.
Title: Proton receptor GPR68 expression in dendritic-cell-like S100?-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.

OGR1 is expressed early during osteoclastogenesis both in vivo and in vitro and plays a role in osteoclast differentiation.
Title: Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.

The following Gpr68 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr68 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa29548	NM_001108049.1 Latest version!	Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr68 ( NM_001108049.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101519.1 Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA.

Price & Availability↑

CloneID	ORa29548
Clone ID Related Accession (Same CDS sequence)	NM_001108049.1
Accession Version	NM_001108049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	ovarian cancer G-protein coupled receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473982.1. On or before Oct 4, 2007 this sequence version replaced XM_001065526.1, XM_234483.3.

ATGAGGAGTA AGGCCCCTTC TGGCCCAAAG ATGGGGAACA TCACTACAGA AAACTCCTCA 
CTACCTTGCC CCATTGACCA CACCATCCAC CAGACACTGG CCCCAGTGGT CTATGTGACC 
GTGCTGGTGG TGGGCTTCCC GGCCAACTGC CTATCCCTCT ACTTTGGGTA CTTGCAGATC 
AAGGCCCGAA ATGAGCTGGG AGTGTACCTG TGTAACCTGA CCATTGCAGA CCTATTCTAT 
ATCTGTTCGC TCCCCTTCTG GCTGCAGTAC GTACTCCAGC ATGACAACTG GTCCCACGGT 
GACCTATCCT GCCAGGTGTG TGGCATCCTC CTCTATGAGA ACATTTACAT CAGCGTGGGC 
TTCCTCTGCT GTATCTCCAT CGACCGCTAC CTGGCTGTGG CCCACCCCTT CCGCTTCCAC 
CAGTTCCGCA CCCTGAAGGC AGCCGTGGGT GTCAGTGTGC TCATCTGGGC CAAGGAGCTG 
CTGACCAGCA TCTACTTCCT CAAGCACAAG GAGGTCATCG AAGACGAGGA CCGGCACCGA 
GTCTGCTTTG AGCATTACCC TATCCAGGCG TGGCAGCGTG GCATCAACTA CTACCGTTTC 
CTGGTGGGCT TTCTCTTTCC CATCTGCCTG CTGCTGGCCT CCTACCAGGG CATCCTGCGG 
GCTGTGCGCC GCAGCCATGG CACCCAGAAG AGCCGCAAGG ACCAGATTCA GCGGCTGGTG 
CTCAGCACCG TGGTCATCTT CCTGGCTTGC TTCCTGCCCT ACCACGTGCT GCTGCTGGTG 
CGCAGCCTCT GGGAGAGCAG CTGTGACTTT GCCAAGAGCA TCTTCAACAT CTATCACTTC 
TCCCTCCTCC TCACCAGCTT CAACTGTGTA GCTGACCCGG TGCTGTACTG CTTTGTCAGT 
GAGACCACTC ACAGGGACCT AGCCCGCCTC CGAGGAGCCT GCCTAGCCTT CCTTACCTGC 
TCTAGGACAA GCAGGGCCAG GGAGGCCTAC CCTCTGGGTG CCCCTGAGGC CTCTGGGAAA 
AGTGGGGCCC AGGGCGAGGA GCCTGAATTG TTAACCAAGC TCCACTCAGC CTTCCAGACC 
CCTAACTCAC TGGGATTGGG AGGGCCCCCC ACAGTTGGCT TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101519.1
CDS	656..1783
Translation	MRSKAPSGPKMGNITTENSSLPCPIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKELLTSIYFLKHKEVIEDEDRHRVCFEHYPIQAWQRGINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWESSCDFAKSIFNIYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTSRAREAYPLGAPEASGKSGAQGEEPELLTKLHSAFQTPNSLGLGGPPTVGLA

Target ORF information:

RefSeq Version	NM_001108049.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus G protein-coupled receptor 68 (Gpr68), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108049.1

ORF Insert Sequence:

ATGAGGAGTA AGGCCCCTTC TGGCCCAAAG ATGGGGAACA TCACTACAGA AAACTCCTCA 
CTACCTTGCC CCATTGACCA CACCATCCAC CAGACACTGG CCCCAGTGGT CTATGTGACC 
GTGCTGGTGG TGGGCTTCCC GGCCAACTGC CTATCCCTCT ACTTTGGGTA CTTGCAGATC 
AAGGCCCGAA ATGAGCTGGG AGTGTACCTG TGTAACCTGA CCATTGCAGA CCTATTCTAT 
ATCTGTTCGC TCCCCTTCTG GCTGCAGTAC GTACTCCAGC ATGACAACTG GTCCCACGGT 
GACCTATCCT GCCAGGTGTG TGGCATCCTC CTCTATGAGA ACATTTACAT CAGCGTGGGC 
TTCCTCTGCT GTATCTCCAT CGACCGCTAC CTGGCTGTGG CCCACCCCTT CCGCTTCCAC 
CAGTTCCGCA CCCTGAAGGC AGCCGTGGGT GTCAGTGTGC TCATCTGGGC CAAGGAGCTG 
CTGACCAGCA TCTACTTCCT CAAGCACAAG GAGGTCATCG AAGACGAGGA CCGGCACCGA 
GTCTGCTTTG AGCATTACCC TATCCAGGCG TGGCAGCGTG GCATCAACTA CTACCGTTTC 
CTGGTGGGCT TTCTCTTTCC CATCTGCCTG CTGCTGGCCT CCTACCAGGG CATCCTGCGG 
GCTGTGCGCC GCAGCCATGG CACCCAGAAG AGCCGCAAGG ACCAGATTCA GCGGCTGGTG 
CTCAGCACCG TGGTCATCTT CCTGGCTTGC TTCCTGCCCT ACCACGTGCT GCTGCTGGTG 
CGCAGCCTCT GGGAGAGCAG CTGTGACTTT GCCAAGAGCA TCTTCAACAT CTATCACTTC 
TCCCTCCTCC TCACCAGCTT CAACTGTGTA GCTGACCCGG TGCTGTACTG CTTTGTCAGT 
GAGACCACTC ACAGGGACCT AGCCCGCCTC CGAGGAGCCT GCCTAGCCTT CCTTACCTGC 
TCTAGGACAA GCAGGGCCAG GGAGGCCTAC CCTCTGGGTG CCCCTGAGGC CTCTGGGAAA 
AGTGGGGCCC AGGGCGAGGA GCCTGAATTG TTAACCAAGC TCCACTCAGC CTTCCAGACC 
CCTAACTCAC TGGGATTGGG AGGGCCCCCC ACAGTTGGCT TGGCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proton receptor GPR68 expression in dendritic-cell-like S100?-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.
Cell and tissue research358(2)515-25(2014 Nov)
Horiguchi K,Higuchi M,Yoshida S,Nakakura T,Tateno K,Hasegawa R,Takigami S,Ohsako S,Kato T,Kato Y

Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion.
Endocrinology153(9)4171-80(2012 Sep)
Nakakura T,Mogi C,Tobo M,Tomura H,Sato K,Kobayashi M,Ohnishi H,Tanaka S,Wayama M,Sugiyama T,Kitamura T,Harada A,Okajima F

Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.
PloS one4(5)e5705(2009 May)
Li H,Wang D,Singh LS,Berk M,Tan H,Zhao Z,Steinmetz R,Kirmani K,Wei G,Xu Y

Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
The Journal of biological chemistry281(33)23598-605(2006 Aug)
Yang M,Mailhot G,Birnbaum MJ,MacKay CA,Mason-Savas A,Odgren PR

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Gpr68 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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