Ddx41 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ddx41
Entrez Gene ID	314336
Full Name	DEAD-box helicase 41
General protein information	Preferred Names DEAD-box helicase 41 Names probable ATP-dependent RNA helicase DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108046.2	NP_001101516.1	probable ATP-dependent RNA helicase DDX41

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	abs	NP_524220.1
Caenorhabditis elegans (roundworm)	sacy-1	NP_491962.1
Arabidopsis thaliana (thale cress)	AT4G33370	NP_195063.1
Canis lupus familiaris (dog)	DDX41	XP_536417.2
Rattus norvegicus (Norway rat)	Ddx41	NP_001101516.1
Homo sapiens (human)	DDX41	NP_057306.2
Pan troglodytes (chimpanzee)	DDX41	XP_518135.1
Gallus gallus (chicken)	LOC100859810	XP_003643723.2
Arabidopsis thaliana (thale cress)	AT5G51280	NP_199941.1
Oryza sativa (rice)	Os02g0150100	NP_001045900.1
	DDX41	XP_001092587.1
Bos taurus (cattle)	DDX41	NP_001076071.1
Mus musculus (house mouse)	Ddx41	NP_598820.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004711	XP_318117.4
Xenopus tropicalis (tropical clawed frog)	ddx41	XP_002936986.1
Danio rerio (zebrafish)	ddx41	NP_957339.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood127(8)1017-23(2016 Feb)

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, M?ller-Tidow C, Maciejewski JP
Cancer cell27(5)658-70(2015 May)

Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41).
Zhu X, Wang D, Zhang H, Zhou Y, Luo R, Chen H, Xiao S, Fang L
Developmental and comparative immunology47(2)191-6(2014 Dec)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DDX41 is involved in the dsDNA- and dsDNA-virus-mediated type IFN-beta signaling pathway in porcine kidney cells. [DDX41]
Title: Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41).

The following Ddx41 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddx41 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06575	NM_001108046.2 Latest version!	Rattus norvegicus DEAD-box helicase 41 (Ddx41), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$363.30 $519.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ddx41 ( NM_001108046.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101516.1 Rattus norvegicus DEAD-box helicase 41 (Ddx41), mRNA.

Price & Availability↑

CloneID	ORa06575
Clone ID Related Accession (Same CDS sequence)	NM_001108046.2
Accession Version	NM_001108046.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	probable ATP-dependent RNA helicase DDX41
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC166825.1. On May 11, 2008 this sequence version replaced NM_001108046.1. ##Evidence-Data-START## Transcript exon combination :: BC166825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGAGT CGGAACCCGA GCGGAAGCGG GCTCGCACGA ACGAGGCGAC TGCGGGTGGG 
AGCCGCTCCG AGGACGAAGA TGAGGACGAC GAGGACTACG TGCCCTACGT GCCGTTGCGG 
CAGCGCCGGC AGCTTCTGCT CCAGAAGCTG CTGCAGCGAA GACGCAAGGG AGCTGCAGAG 
GAAGAGCAGC AGGACAGTGG CAGTGAGCCC CGAGGAGATG AGGACGACAT CCCGCTGGGT 
CCTCAGTCCA ATGTCAGCCT CCTGGATCAG CACCAGCACC TCAAAGAGAA GGCTGAAGCA 
CGCAAGGAGT CCGCCAAGGA AAAGCAACTG AAGGAAGAAG AAAAGATTCT GGAGAGTGTG 
GCTGAAGGCC GAGCCTTGAT GTCAGTGAAG GAAATGGCCA AAGGCATTAC CTACGACGAT 
CCAATCAAAA CTAGTTGGAC ACCCCCGCGC TATGTCCTGA GCATGTCAGA AGAGCGGCAC 
GAGCGTGTTC GGAAGAAGTA CCACATCCTG GTGGAGGGAG ACGGTATCCC GCCACCCATC 
AAGAGCTTCA AGGAAATGAA GCTCCCTGCA GCTATCCTTC GAGGCCTGAA GAAAAAGGGC 
ATCCTCCACC CAACACCCAT TCAGATCCAG GGCATCCCTA CCATTCTGTC TGGTCGGGAC 
ATGATTGGCA TCGCCTTCAC GGGGTCAGGC AAGACTCTGG TATTCACACT GCCCGTCATC 
ATGTTCTGCC TGGAACAAGA GAAGCGGTTG CCTTTCTCCA AGCGGGAAGG GCCTTATGGA 
CTTATCATCT GCCCCTCACG AGAGCTGGCT CGGCAGACCC ATGGCATCCT GGAGTATTAC 
TGCCGTCTGC TGCAGGAAGA CAGCTCCCCT CTCCTGCGCT GCGCACTCTG CATCGGGGGC 
ATGTCGGTGA AGGAGCAGAT GGAGACCATC CGACATGGTG TGCACATGAT GGTAGCCACA 
CCGGGACGCC TCATGGATTT GCTGCAGAAG AAAATGGTCA GCCTAGACAT CTGCCGCTAC 
CTGGCCCTGG ATGAGGCTGA CCGCATGATC GACATGGGCT TTGAGGGTGA CATCCGTACC 
ATCTTCTCCT ACTTCAAGGG CCAGCGGCAG ACTCTGCTCT TCAGTGCCAC CATGCCGAAG 
AAGATTCAGA ACTTCGCCAA GAGCGCCCTG GTCAAGCCTG TCACCATCAA TGTTGGTCGT 
GCTGGAGCAG CCAGCCTTGA CGTCATCCAG GAGGTGGAAT ATGTGAAGGA GGAAGCCAAG 
ATGGTGTACC TGCTTGAGTG CTTGCAGAAG ACGCCCCCAC CTGTACTCAT CTTTGCAGAG 
AAGAAAGCAG ATGTGGATGC CATTCACGAA TACCTCCTGC TCAAAGGAGT TGAGGCTGTG 
GCCATTCATG GGGGCAAAGA CCAGGAAGAG CGGACCAAGG CCATTGAGGC ATTCCGGGAA 
GGCAAGAAGG ACGTCTTAGT GGCCACGGAC GTGGCCTCTA AAGGCCTAGA CTTTCCTGCC 
ATCCAGCACG TCATCAACTA TGACATGCCT GAAGAAATCG AGAACTATGT GCACCGAATC 
GGCCGCACTG GGCGCTCAGG AAACACAGGC ATTGCCACCA CCTTTATCAA CAAGGCCTGC 
GATGAGTCAG TGCTCATGGA CCTCAAAGCC TTGCTGCTGG AGGCCAAGCA GAAGGTACCA 
CCTGTTCTGC AAGTGCTGCA CTGTGGGGAT GAGTCCATGC TGGACATCGG AGGAGAACGG 
GGCTGCGCCT TCTGTGGAGG CCTTGGTCAT CGAATCACTG ACTGCCCCAA ACTCGAAGCT 
ATGCAGACCA AGCAGGTCAG CAACATTGGC CGCAAGGACT ACCTGGCGCA CAGCTCCATG 
GACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101516.1
CDS	6..1874
Translation	MEESEPERKRARTNEATAGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQQDSGSEPRGDEDDIPLGPQSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVAEGRALMSVKEMAKGITYDDPIKTSWTPPRYVLSMSEERHERVRKKYHILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLLQKKMVSLDICRYLALDEADRMIDMGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINKACDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGERGCAFCGGLGHRITDCPKLEAMQTKQVSNIGRKDYLAHSSMDF

Target ORF information:

RefSeq Version	NM_001108046.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DEAD-box helicase 41 (Ddx41), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108046.2

ORF Insert Sequence:

ATGGAGGAGT CGGAACCCGA GCGGAAGCGG GCTCGCACGA ACGAGGCGAC TGCGGGTGGG 
AGCCGCTCCG AGGACGAAGA TGAGGACGAC GAGGACTACG TGCCCTACGT GCCGTTGCGG 
CAGCGCCGGC AGCTTCTGCT CCAGAAGCTG CTGCAGCGAA GACGCAAGGG AGCTGCAGAG 
GAAGAGCAGC AGGACAGTGG CAGTGAGCCC CGAGGAGATG AGGACGACAT CCCGCTGGGT 
CCTCAGTCCA ATGTCAGCCT CCTGGATCAG CACCAGCACC TCAAAGAGAA GGCTGAAGCA 
CGCAAGGAGT CCGCCAAGGA AAAGCAACTG AAGGAAGAAG AAAAGATTCT GGAGAGTGTG 
GCTGAAGGCC GAGCCTTGAT GTCAGTGAAG GAAATGGCCA AAGGCATTAC CTACGACGAT 
CCAATCAAAA CTAGTTGGAC ACCCCCGCGC TATGTCCTGA GCATGTCAGA AGAGCGGCAC 
GAGCGTGTTC GGAAGAAGTA CCACATCCTG GTGGAGGGAG ACGGTATCCC GCCACCCATC 
AAGAGCTTCA AGGAAATGAA GCTCCCTGCA GCTATCCTTC GAGGCCTGAA GAAAAAGGGC 
ATCCTCCACC CAACACCCAT TCAGATCCAG GGCATCCCTA CCATTCTGTC TGGTCGGGAC 
ATGATTGGCA TCGCCTTCAC GGGGTCAGGC AAGACTCTGG TATTCACACT GCCCGTCATC 
ATGTTCTGCC TGGAACAAGA GAAGCGGTTG CCTTTCTCCA AGCGGGAAGG GCCTTATGGA 
CTTATCATCT GCCCCTCACG AGAGCTGGCT CGGCAGACCC ATGGCATCCT GGAGTATTAC 
TGCCGTCTGC TGCAGGAAGA CAGCTCCCCT CTCCTGCGCT GCGCACTCTG CATCGGGGGC 
ATGTCGGTGA AGGAGCAGAT GGAGACCATC CGACATGGTG TGCACATGAT GGTAGCCACA 
CCGGGACGCC TCATGGATTT GCTGCAGAAG AAAATGGTCA GCCTAGACAT CTGCCGCTAC 
CTGGCCCTGG ATGAGGCTGA CCGCATGATC GACATGGGCT TTGAGGGTGA CATCCGTACC 
ATCTTCTCCT ACTTCAAGGG CCAGCGGCAG ACTCTGCTCT TCAGTGCCAC CATGCCGAAG 
AAGATTCAGA ACTTCGCCAA GAGCGCCCTG GTCAAGCCTG TCACCATCAA TGTTGGTCGT 
GCTGGAGCAG CCAGCCTTGA CGTCATCCAG GAGGTGGAAT ATGTGAAGGA GGAAGCCAAG 
ATGGTGTACC TGCTTGAGTG CTTGCAGAAG ACGCCCCCAC CTGTACTCAT CTTTGCAGAG 
AAGAAAGCAG ATGTGGATGC CATTCACGAA TACCTCCTGC TCAAAGGAGT TGAGGCTGTG 
GCCATTCATG GGGGCAAAGA CCAGGAAGAG CGGACCAAGG CCATTGAGGC ATTCCGGGAA 
GGCAAGAAGG ACGTCTTAGT GGCCACGGAC GTGGCCTCTA AAGGCCTAGA CTTTCCTGCC 
ATCCAGCACG TCATCAACTA TGACATGCCT GAAGAAATCG AGAACTATGT GCACCGAATC 
GGCCGCACTG GGCGCTCAGG AAACACAGGC ATTGCCACCA CCTTTATCAA CAAGGCCTGC 
GATGAGTCAG TGCTCATGGA CCTCAAAGCC TTGCTGCTGG AGGCCAAGCA GAAGGTACCA 
CCTGTTCTGC AAGTGCTGCA CTGTGGGGAT GAGTCCATGC TGGACATCGG AGGAGAACGG 
GGCTGCGCCT TCTGTGGAGG CCTTGGTCAT CGAATCACTG ACTGCCCCAA ACTCGAAGCT 
ATGCAGACCA AGCAGGTCAG CAACATTGGC CGCAAGGACT ACCTGGCGCA CAGCTCCATG 
GACTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Blood127(8)1017-23(2016 Feb)
Lewinsohn M,Brown AL,Weinel LM,Phung C,Rafidi G,Lee MK,Schreiber AW,Feng J,Babic M,Chong CE,Lee Y,Yong A,Suthers GK,Poplawski N,Altree M,Phillips K,Jaensch L,Fine M,D'Andrea RJ,Lewis ID,Medeiros BC,Pollyea DA,King MC,Walsh T,Keel S,Shimamura A,Godley LA,Hahn CN,Churpek JE,Scott HS

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Cancer cell27(5)658-70(2015 May)
Polprasert C,Schulze I,Sekeres MA,Makishima H,Przychodzen B,Hosono N,Singh J,Padgett RA,Gu X,Phillips JG,Clemente M,Parker Y,Lindner D,Dienes B,Jankowsky E,Saunthararajah Y,Du Y,Oakley K,Nguyen N,Mukherjee S,Pabst C,Godley LA,Churpek JE,Pollyea DA,Krug U,Berdel WE,Klein HU,Dugas M,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Yoshida K,Ogawa S,M?ller-Tidow C,Maciejewski JP

Molecular cloning and functional characterization of porcine DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41).
Developmental and comparative immunology47(2)191-6(2014 Dec)
Zhu X,Wang D,Zhang H,Zhou Y,Luo R,Chen H,Xiao S,Fang L

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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Ddx41 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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