Eps15 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eps15
Entrez Gene ID	313474
Full Name	epidermal growth factor receptor pathway substrate 15
Synonyms	RGD1307641
General protein information	Preferred Names epidermal growth factor receptor pathway substrate 15 Names epidermal growth factor receptor substrate 15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q34-q35

mRNA and Protein(s)

mRNA	Protein	Name
NM_001365390.1	NP_001352319.1	epidermal growth factor receptor substrate 15
NM_001009424.1	NP_001009424.1	epidermal growth factor receptor substrate 15

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Eps15	NP_031969.1
Rattus norvegicus (Norway rat)	Eps15	NP_001009424.1
	EPS15	XP_002801615.1
Bos taurus (cattle)	EPS15	NP_001091556.1
Homo sapiens (human)	EPS15	NP_001972.1
Gallus gallus (chicken)	EPS15	NP_001026454.1
Xenopus tropicalis (tropical clawed frog)	eps15	NP_001120100.2
Danio rerio (zebrafish)	eps15	XP_002663145.3

Gene Ontology
Bibliography

Related articles in PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Endocytic adaptor epidermal growth factor receptor substrate 15 (Eps15) is involved in the trafficking of ubiquitinated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
Lin A, Man HY
The Journal of biological chemistry289(35)24652-64(2014 Aug)

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20?Ubiquitin E3 Ligase Regulates Protein Trafficking.
Yuan WC, Lee YR, Lin SY, Chang LY, Tan YP, Hung CC, Kuo JC, Liu CH, Lin MY, Xu M, Chen ZJ, Chen RH
Molecular cell54(4)586-600(2014 May)

Synaptic vesicle endocytosis.
Saheki Y, De Camilli P
Cold Spring Harbor perspectives in biology4(9)a005645(2012 Sep)

Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15.
Chi S, Cao H, Wang Y, McNiven MA
The Journal of biological chemistry286(40)35196-208(2011 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Knockdown of Eps15 suppresses the internalization of GluA1 but not the mutant GluA1 that lacks ubiquitination sites, indicating a role of Eps15 for the internalization of ubiquitinated AMPARs
Title: Endocytic adaptor epidermal growth factor receptor substrate 15 (Eps15) is involved in the trafficking of ubiquitinated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.

distinct forms of Eps15 direct EGFR to either the late endosome/lysosome for degradation (Eps15) or to the recycling endosome for transit back to the cell surface (Eps15S)
Title: Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15.

FCHO2 regulates clathrin-mediated endocytosis through its interactions with membranes and Eps15.
Title: Characterization of the EFC/F-BAR domain protein, FCHO2.

Nedd4-mediated ubiquitination of Cx43 is required to recruit Eps15, through its ubiquitin-interacting motif, and targets ubiquitinated Cx43 to the endocytic pathway.
Title: Eps15 interacts with ubiquitinated Cx43 and mediates its internalization.

Eps15 plays an important role in clathrin-coated vesicle formation not only at the plasma membrane but also at the TGN during the secretory process
Title: Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1.

The following Eps15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eps15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00898	NM_001009424.1 Latest version!	Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$468.30 $669.00
ORa63306	NM_001365390.1 Latest version!	Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eps15 ( NM_001009424.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001009424.1 Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), mRNA.

Price & Availability↑

CloneID	ORa00898
Clone ID Related Accession (Same CDS sequence)	NM_001009424.1
Accession Version	NM_001009424.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2379bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	epidermal growth factor receptor substrate 15
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY190609.1. On Jan 7, 2005 this sequence version replaced XM_233335.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY190609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGG CAGCCCAGCT CTCCCTGACA CAGTTGTCAA GTGGGAATCC TGTATATGAA 
AAATACTATA GACAGGTTGA AGCAGGCAAT ACTGGAAGGG TGTTGGCTTT AGATGCTGCT 
GCATTCCTGA AAAAGTCAGG GCTTCCAGAC CTGATTCTTG GAAAGATTTG GGATTTAGCT 
GACACAGATG GCAAAGGTGT CCTGAACAAA CAAGAATTCT TTATTGCTTT ACGGCTTGTG 
GCATGCGCCC AGAATGGACT GGAAGTGTCA CTGAGTAGCC TAAATCTGGC TGTTCCTCCA 
CCAAGATTTC ATGACTCCAG TAGTCCTTTG CTAACCAGTG GGACCTCAGT TGCTGAGCTC 
CCATGGGCTG TAAAGTCTGA AGATAAAGCC AAATATGATG CAATTTTTGA CAGTTTAAGC 
CCAGTGGATG GATTTTTGTC TGGTGATAAA GTGAAACCAG TGTTGCTCAA CTCTAAGTTA 
CCTGTGGAAA TCCTTGGAAG AGTTTGGGAG TTGAGTGATA TTGACCACGA TGGAAAGCTG 
GACAGAGATG AGTTTGCAGT TGCCATGTTT TTGGTATACT GTGCACTGGA GAAAGAACCT 
GTGCCAATGT CCTTGCCTCC AGCCTTGGTG CCACCTTCTA AGAGAAAAAC GTGGGTTGTG 
TCCCCTGCAG AAAAAGCTAA ATATGATGAA ATCTTTCTGA AAACTGATAA GGATATGGAT 
GGATATGTGT CTGGACTGGA GGTCCGTGAA ACCTTCCTAA AAACAGGTTT ACCTTCTACC 
TTGCTAGCCC ACATTTGGGC ACTATGTGAC ACAAAGAATT GTGGGAAGCT TTCAAAAGAC 
CAGTTTGCCT TGGCTTTTCA CTTAATCAAT CAGAAGTTAA TAAAAGGCAT TGACCCTCCT 
CATAGTCTCA CTCCTGAGAT GATTCCACCA TCAGACAGGT CCAGTTTACA AAAGAACACC 
ATAGGATCAA GTCCTGTTGC AGATTTCTCT GCTATTAAGG AACTAGATAC CCTTAACAAT 
GAAATAATTG ACCTGCAGAG GGAAAAGAAC AATGTGGAAC AGGACCTGAA AGAGAAGGAG 
GACACAGTGA GGCAGAGGAC CACCGAGGCT CAGGATCTTC AAGATGAAGT TCAAAGGGAG 
AGTCTTAATC TACAAAAACT GCAGGCCCAG AAGCAGCAGG TGCAGGAACT CCTGGATGAA 
CTGGATGAGC AGAAAGCCCA GCTGGAAGAG CAGCTCAAAG AAGTCAGAAA AAAATGTGCT 
GAGGAGGCCC AGCTGATTTC TTCCCTGAAA GCAGAAATAA CCAGTCAAGA ATCTCAGATC 
TCCACTTATG AGGAAGAATT GTCGAAAGCT AGAGAAGAAC TAAGTCGCCT ACAACAAGAA 
ACGGCACAAT TGGAAGAAAG TGTGGAGTCA GGAAAGGCTC AGCTAGAACC TCTTCAGCAG 
CACCTACAAG ATTCGCAACA GGAAATCAGT TCAATGCAAA TGAGATTGGC AATGAAAGAT 
CTGGAAACGG ACAATAACCA ATCAAATTGG TGCAGTAGCC CACAAAGCAT TCTGGTCAAT 
GGTGCTGCAG ATTATTGTAG CCTCAGCACC AGCAGCAGTG AAACAGCCAA CCTCAATGAA 
CATGCTGAAG GCCAGAATAA CCTAGAGTCT GAGCCCATCC ATCCGGAGTC ATCAGTGAGA 
AGTAGTCCTG AAATAGCGCC TTCTGATGTG ACTGATGAAA GCGAAGTTGT GACTGCAGCT 
GATATTGAAA AAGTTAGTCC CAGATTTGAT GATGACAAGC ACTCAAAAGA GGAAGATCCA 
TTTAATGTAG AATCCAGTTC ACTGACAGAT GCAGTTGCAG ATACAAACTT GGATTTTTTC 
CAGTCTGACC CTTTTGTTGG CAGTGATCCT TTCAAGGATG ATCCTTTTGG AAAAATTGAT 
CCATTTGGTG GTGATCCTTT CAAAGGTTCA GACCCATTTG CATCTGATTG CTTCTTTAAA 
CAGACTTCTA CTGATCCTTT TGCCACTTCA AGTACTGACC CTTTCAGTGT ATCCAGCAAT 
AGCAGTAATA CATCGGTAGA GACTTGGAAG CACAATGACC CATTTGCTCC TGGTGGGACA 
GTTGTTGCAG CTACTGACTC AGCCACAGAC CCTTTTGCTT CTGTTTTTGG AAATGAATCA 
TTTGGAGATG GATTTGCTGA CTTCAGCACA TTATCTAAGG TCAGCAATGA AGATCCTTTT 
AATCCTACCA TATCAAGTTC TGCCAGCAGT GTGGTCATTC CAAACCCTGT GTTAGAGGAA 
ACACCCAGCA AGAGTGAAGA TGTGCCTCCA GCACTGCCAC CCAAGACCGG CACTCCAACA 
AGACCCTGCC CACCACCCCC TGCCTTTCCC AGGCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009424.1
CDS	145..2523
Translation	MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSVSSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPNPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPAFPRQ

Target ORF information:

RefSeq Version	NM_001009424.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009424.1

ORF Insert Sequence:

ATGGCTGCGG CAGCCCAGCT CTCCCTGACA CAGTTGTCAA GTGGGAATCC TGTATATGAA 
AAATACTATA GACAGGTTGA AGCAGGCAAT ACTGGAAGGG TGTTGGCTTT AGATGCTGCT 
GCATTCCTGA AAAAGTCAGG GCTTCCAGAC CTGATTCTTG GAAAGATTTG GGATTTAGCT 
GACACAGATG GCAAAGGTGT CCTGAACAAA CAAGAATTCT TTATTGCTTT ACGGCTTGTG 
GCATGCGCCC AGAATGGACT GGAAGTGTCA CTGAGTAGCC TAAATCTGGC TGTTCCTCCA 
CCAAGATTTC ATGACTCCAG TAGTCCTTTG CTAACCAGTG GGACCTCAGT TGCTGAGCTC 
CCATGGGCTG TAAAGTCTGA AGATAAAGCC AAATATGATG CAATTTTTGA CAGTTTAAGC 
CCAGTGGATG GATTTTTGTC TGGTGATAAA GTGAAACCAG TGTTGCTCAA CTCTAAGTTA 
CCTGTGGAAA TCCTTGGAAG AGTTTGGGAG TTGAGTGATA TTGACCACGA TGGAAAGCTG 
GACAGAGATG AGTTTGCAGT TGCCATGTTT TTGGTATACT GTGCACTGGA GAAAGAACCT 
GTGCCAATGT CCTTGCCTCC AGCCTTGGTG CCACCTTCTA AGAGAAAAAC GTGGGTTGTG 
TCCCCTGCAG AAAAAGCTAA ATATGATGAA ATCTTTCTGA AAACTGATAA GGATATGGAT 
GGATATGTGT CTGGACTGGA GGTCCGTGAA ACCTTCCTAA AAACAGGTTT ACCTTCTACC 
TTGCTAGCCC ACATTTGGGC ACTATGTGAC ACAAAGAATT GTGGGAAGCT TTCAAAAGAC 
CAGTTTGCCT TGGCTTTTCA CTTAATCAAT CAGAAGTTAA TAAAAGGCAT TGACCCTCCT 
CATAGTCTCA CTCCTGAGAT GATTCCACCA TCAGACAGGT CCAGTTTACA AAAGAACACC 
ATAGGATCAA GTCCTGTTGC AGATTTCTCT GCTATTAAGG AACTAGATAC CCTTAACAAT 
GAAATAATTG ACCTGCAGAG GGAAAAGAAC AATGTGGAAC AGGACCTGAA AGAGAAGGAG 
GACACAGTGA GGCAGAGGAC CACCGAGGCT CAGGATCTTC AAGATGAAGT TCAAAGGGAG 
AGTCTTAATC TACAAAAACT GCAGGCCCAG AAGCAGCAGG TGCAGGAACT CCTGGATGAA 
CTGGATGAGC AGAAAGCCCA GCTGGAAGAG CAGCTCAAAG AAGTCAGAAA AAAATGTGCT 
GAGGAGGCCC AGCTGATTTC TTCCCTGAAA GCAGAAATAA CCAGTCAAGA ATCTCAGATC 
TCCACTTATG AGGAAGAATT GTCGAAAGCT AGAGAAGAAC TAAGTCGCCT ACAACAAGAA 
ACGGCACAAT TGGAAGAAAG TGTGGAGTCA GGAAAGGCTC AGCTAGAACC TCTTCAGCAG 
CACCTACAAG ATTCGCAACA GGAAATCAGT TCAATGCAAA TGAGATTGGC AATGAAAGAT 
CTGGAAACGG ACAATAACCA ATCAAATTGG TGCAGTAGCC CACAAAGCAT TCTGGTCAAT 
GGTGCTGCAG ATTATTGTAG CCTCAGCACC AGCAGCAGTG AAACAGCCAA CCTCAATGAA 
CATGCTGAAG GCCAGAATAA CCTAGAGTCT GAGCCCATCC ATCCGGAGTC ATCAGTGAGA 
AGTAGTCCTG AAATAGCGCC TTCTGATGTG ACTGATGAAA GCGAAGTTGT GACTGCAGCT 
GATATTGAAA AAGTTAGTCC CAGATTTGAT GATGACAAGC ACTCAAAAGA GGAAGATCCA 
TTTAATGTAG AATCCAGTTC ACTGACAGAT GCAGTTGCAG ATACAAACTT GGATTTTTTC 
CAGTCTGACC CTTTTGTTGG CAGTGATCCT TTCAAGGATG ATCCTTTTGG AAAAATTGAT 
CCATTTGGTG GTGATCCTTT CAAAGGTTCA GACCCATTTG CATCTGATTG CTTCTTTAAA 
CAGACTTCTA CTGATCCTTT TGCCACTTCA AGTACTGACC CTTTCAGTGT ATCCAGCAAT 
AGCAGTAATA CATCGGTAGA GACTTGGAAG CACAATGACC CATTTGCTCC TGGTGGGACA 
GTTGTTGCAG CTACTGACTC AGCCACAGAC CCTTTTGCTT CTGTTTTTGG AAATGAATCA 
TTTGGAGATG GATTTGCTGA CTTCAGCACA TTATCTAAGG TCAGCAATGA AGATCCTTTT 
AATCCTACCA TATCAAGTTC TGCCAGCAGT GTGGTCATTC CAAACCCTGT GTTAGAGGAA 
ACACCCAGCA AGAGTGAAGA TGTGCCTCCA GCACTGCCAC CCAAGACCGG CACTCCAACA 
AGACCCTGCC CACCACCCCC TGCCTTTCCC AGGCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eps15 ( NM_001365390.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001352319.1 Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa63306
Clone ID Related Accession (Same CDS sequence)	NM_001365390.1
Accession Version	NM_001365390.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2694bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-21
Organism	Rattus norvegicus(Norway rat)
Product	epidermal growth factor receptor substrate 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07049564.1 and AB262963.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB262963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGG CAGCCCAGCT CTCCCTGACA CAGTTGTCAA GTGGGAATCC TGTATATGAA 
AAATACTATA GACAGGTTGA AGCAGGCAAT ACTGGAAGGG TGTTGGCTTT AGATGCTGCT 
GCATTCCTGA AAAAGTCAGG GCTTCCAGAC CTGATTCTTG GAAAGATTTG GGATTTAGCT 
GACACAGATG GCAAAGGTGT CCTGAACAAA CAAGAATTCT TTATTGCTTT ACGGCTTGTG 
GCATGCGCCC AGAATGGACT GGAAGTGTCA CTGAGTAGCC TAAATCTGGC TGTTCCTCCA 
CCAAGATTTC ATGACTCCAG TAGTCCTTTG CTAACCAGTG GGACCTCAGT TGCTGAGCTC 
CCATGGGCTG TAAAGTCTGA AGATAAAGCC AAATATGATG CAATTTTTGA CAGTTTAAGC 
CCAGTGGATG GATTTTTGTC TGGTGATAAA GTGAAACCAG TGTTGCTCAA CTCTAAGTTA 
CCTGTGGAAA TCCTTGGAAG AGTTTGGGAG TTGAGTGATA TTGACCACGA TGGAAAGCTG 
GACAGAGATG AGTTTGCAGT TGCCATGTTT TTGGTATACT GTGCACTGGA GAAAGAACCT 
GTGCCAATGT CCTTGCCTCC AGCCTTGGTG CCACCTTCTA AGAGAAAAAC GTGGGTTGTG 
TCCCCTGCAG AAAAAGCTAA ATATGATGAA ATCTTTCTGA AAACTGATAA GGATATGGAT 
GGATATGTGT CTGGACTGGA GGTCCGTGAA ACCTTCCTAA AAACAGGTTT ACCTTCTACC 
TTGCTAGCCC ACATTTGGGC ACTATGTGAC ACAAAGAATT GTGGGAAGCT TTCAAAAGAC 
CAGTTTGCCT TGGCTTTTCA CTTAATCAAT CAGAAGTTAA TAAAAGGCAT TGACCCTCCT 
CATAGTCTCA CTCCTGAGAT GATTCCACCA TCAGACAGGT CCAGTTTACA AAAGAACACC 
ATAGGATCAA GTCCTGTTGC AGATTTCTCT GCTATTAAGG AACTAGATAC CCTTAACAAT 
GAAATAATTG ACCTGCAGAG GGAAAAGAAC AATGTGGAAC AGGACCTGAA AGAGAAGGAG 
GACACAGTGA GGCAGAGGAC CACCGAGGCT CAGGATCTTC AAGATGAAGT TCAAAGGGAG 
AGTCTTAATC TACAAAAACT GCAGGCCCAG AAGCAGCAGG TGCAGGAACT CCTGGATGAA 
CTGGATGAGC AGAAAGCCCA GCTGGAAGAG CAGCTCAAAG AAGTCAGAAA AAAATGTGCT 
GAGGAGGCCC AGCTGATTTC TTCCCTGAAA GCAGAAATAA CCAGTCAAGA ATCTCAGATC 
TCCACTTATG AGGAAGAATT GTCGAAAGCT AGAGAAGAAC TAAGTCGCCT ACAACAAGAA 
ACGGCACAAT TGGAAGAAAG TGTGGAGTCA GGAAAGGCTC AGCTAGAACC TCTTCAGCAG 
CACCTACAAG ATTCGCAACA GGAAATCAGT TCAATGCAAA TGAGATTGGC AATGAAAGAT 
CTGGAAACGG ACAATAACCA ATCAAATTGG TGCAGTAGCC CACAAAGCAT TCTGGTCAAT 
GGTGCTGCAG ATTATTGTAG CCTCAGCACC AGCAGCAGTG AAACAGCCAA CCTCAATGAA 
CATGCTGAAG GCCAGAATAA CCTAGAGTCT GAGCCCATCC ATCCGGAGTC ATCAGTGAGA 
AGTAGTCCTG AAATAGCGCC TTCTGATGTG ACTGATGAAA GCGAAGTTGT GACTGCAGCT 
GATATTGAAA AAGTTAGTCC CAGATTTGAT GATGACAAGC ACTCAAAAGA GGAAGATCCA 
TTTAATGTAG AATCCAGTTC ACTGACAGAT GCAGTTGCAG ATACAAACTT GGATTTTTTC 
CAGTCTGACC CTTTTGTTGG CAGTGATCCT TTCAAGGATG ATCCTTTTGG AAAAATTGAT 
CCATTTGGTG GTGATCCTTT CAAAGGTTCA GACCCATTTG CATCTGATTG CTTCTTTAAA 
CAGACTTCTA CTGATCCTTT TGCCACTTCA AGTACTGACC CTTTCAGTGC ATCCAGCAAT 
AGCAGTAATA CATCGGTAGA GACTTGGAAG CACAATGACC CATTTGCTCC TGGTGGGACA 
GTTGTTGCAG CTACTGACTC AGCCACAGAC CCTTTTGCTT CTGTTTTTGG AAATGAATCA 
TTTGGAGATG GATTTGCTGA CTTCAGCACA TTATCTAAGG TCAGCAATGA AGATCCTTTT 
AATCCTACCA TATCAAGTTC TGCCAGCAGT GTGGTCATTC CAAAACCTGT GTTAGAGGAA 
ACACCCAGCA AGAGTGAAGA TGTGCCTCCA GCACTGCCAC CCAAGACCGG CACTCCAACA 
AGACCCTGCC CACCACCCCC TGGGAAAAGA CCCATCAACA AATTGGATTC TTCTGATCCC 
TTTAAACTGA ATGATCCATT TCAGCCTTTC CCAGGCAATG ATAGTCCCAA AGAAAAGGAT 
CCTGATATGT TTTGTGATCC ATTCACTTCT TCTTCTACCA CTGCCAATAA AGAGGCTGAG 
CCAAGCAATT TTGCTAACTT CAGTGCTTAT CCCTCTGAAG AAGACATGAT TGAGTGGGCC 
AAGAGGGAGA GTGAGCGAGA AGAAGAGCAG AGGCTCGCCA GACTAAATCA GCAGGAACAA 
GAAGACTTGG AACTGGCCAT TGCACTTAGC AAATCAGAGA TCTCAGAAGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001352319.1
CDS	126..2819
Translation	MAAAAQLSLTQLSSGNPVYEKYYRQVEAGNTGRVLALDAAAFLKKSGLPDLILGKIWDLADTDGKGVLNKQEFFIALRLVACAQNGLEVSLSSLNLAVPPPRFHDSSSPLLTSGTSVAELPWAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLINQKLIKGIDPPHSLTPEMIPPSDRSSLQKNTIGSSPVADFSAIKELDTLNNEIIDLQREKNNVEQDLKEKEDTVRQRTTEAQDLQDEVQRESLNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAEITSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLAMKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLNEHAEGQNNLESEPIHPESSVRSSPEIAPSDVTDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASSNSSNTSVETWKHNDPFAPGGTVVAATDSATDPFASVFGNESFGDGFADFSTLSKVSNEDPFNPTISSSASSVVIPKPVLEETPSKSEDVPPALPPKTGTPTRPCPPPPGKRPINKLDSSDPFKLNDPFQPFPGNDSPKEKDPDMFCDPFTSSSTTANKEAEPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA

Target ORF information:

RefSeq Version	NM_001365390.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus epidermal growth factor receptor pathway substrate 15 (Eps15), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001365390.1

ORF Insert Sequence:

ATGGCTGCGG CAGCCCAGCT CTCCCTGACA CAGTTGTCAA GTGGGAATCC TGTATATGAA 
AAATACTATA GACAGGTTGA AGCAGGCAAT ACTGGAAGGG TGTTGGCTTT AGATGCTGCT 
GCATTCCTGA AAAAGTCAGG GCTTCCAGAC CTGATTCTTG GAAAGATTTG GGATTTAGCT 
GACACAGATG GCAAAGGTGT CCTGAACAAA CAAGAATTCT TTATTGCTTT ACGGCTTGTG 
GCATGCGCCC AGAATGGACT GGAAGTGTCA CTGAGTAGCC TAAATCTGGC TGTTCCTCCA 
CCAAGATTTC ATGACTCCAG TAGTCCTTTG CTAACCAGTG GGACCTCAGT TGCTGAGCTC 
CCATGGGCTG TAAAGTCTGA AGATAAAGCC AAATATGATG CAATTTTTGA CAGTTTAAGC 
CCAGTGGATG GATTTTTGTC TGGTGATAAA GTGAAACCAG TGTTGCTCAA CTCTAAGTTA 
CCTGTGGAAA TCCTTGGAAG AGTTTGGGAG TTGAGTGATA TTGACCACGA TGGAAAGCTG 
GACAGAGATG AGTTTGCAGT TGCCATGTTT TTGGTATACT GTGCACTGGA GAAAGAACCT 
GTGCCAATGT CCTTGCCTCC AGCCTTGGTG CCACCTTCTA AGAGAAAAAC GTGGGTTGTG 
TCCCCTGCAG AAAAAGCTAA ATATGATGAA ATCTTTCTGA AAACTGATAA GGATATGGAT 
GGATATGTGT CTGGACTGGA GGTCCGTGAA ACCTTCCTAA AAACAGGTTT ACCTTCTACC 
TTGCTAGCCC ACATTTGGGC ACTATGTGAC ACAAAGAATT GTGGGAAGCT TTCAAAAGAC 
CAGTTTGCCT TGGCTTTTCA CTTAATCAAT CAGAAGTTAA TAAAAGGCAT TGACCCTCCT 
CATAGTCTCA CTCCTGAGAT GATTCCACCA TCAGACAGGT CCAGTTTACA AAAGAACACC 
ATAGGATCAA GTCCTGTTGC AGATTTCTCT GCTATTAAGG AACTAGATAC CCTTAACAAT 
GAAATAATTG ACCTGCAGAG GGAAAAGAAC AATGTGGAAC AGGACCTGAA AGAGAAGGAG 
GACACAGTGA GGCAGAGGAC CACCGAGGCT CAGGATCTTC AAGATGAAGT TCAAAGGGAG 
AGTCTTAATC TACAAAAACT GCAGGCCCAG AAGCAGCAGG TGCAGGAACT CCTGGATGAA 
CTGGATGAGC AGAAAGCCCA GCTGGAAGAG CAGCTCAAAG AAGTCAGAAA AAAATGTGCT 
GAGGAGGCCC AGCTGATTTC TTCCCTGAAA GCAGAAATAA CCAGTCAAGA ATCTCAGATC 
TCCACTTATG AGGAAGAATT GTCGAAAGCT AGAGAAGAAC TAAGTCGCCT ACAACAAGAA 
ACGGCACAAT TGGAAGAAAG TGTGGAGTCA GGAAAGGCTC AGCTAGAACC TCTTCAGCAG 
CACCTACAAG ATTCGCAACA GGAAATCAGT TCAATGCAAA TGAGATTGGC AATGAAAGAT 
CTGGAAACGG ACAATAACCA ATCAAATTGG TGCAGTAGCC CACAAAGCAT TCTGGTCAAT 
GGTGCTGCAG ATTATTGTAG CCTCAGCACC AGCAGCAGTG AAACAGCCAA CCTCAATGAA 
CATGCTGAAG GCCAGAATAA CCTAGAGTCT GAGCCCATCC ATCCGGAGTC ATCAGTGAGA 
AGTAGTCCTG AAATAGCGCC TTCTGATGTG ACTGATGAAA GCGAAGTTGT GACTGCAGCT 
GATATTGAAA AAGTTAGTCC CAGATTTGAT GATGACAAGC ACTCAAAAGA GGAAGATCCA 
TTTAATGTAG AATCCAGTTC ACTGACAGAT GCAGTTGCAG ATACAAACTT GGATTTTTTC 
CAGTCTGACC CTTTTGTTGG CAGTGATCCT TTCAAGGATG ATCCTTTTGG AAAAATTGAT 
CCATTTGGTG GTGATCCTTT CAAAGGTTCA GACCCATTTG CATCTGATTG CTTCTTTAAA 
CAGACTTCTA CTGATCCTTT TGCCACTTCA AGTACTGACC CTTTCAGTGC ATCCAGCAAT 
AGCAGTAATA CATCGGTAGA GACTTGGAAG CACAATGACC CATTTGCTCC TGGTGGGACA 
GTTGTTGCAG CTACTGACTC AGCCACAGAC CCTTTTGCTT CTGTTTTTGG AAATGAATCA 
TTTGGAGATG GATTTGCTGA CTTCAGCACA TTATCTAAGG TCAGCAATGA AGATCCTTTT 
AATCCTACCA TATCAAGTTC TGCCAGCAGT GTGGTCATTC CAAAACCTGT GTTAGAGGAA 
ACACCCAGCA AGAGTGAAGA TGTGCCTCCA GCACTGCCAC CCAAGACCGG CACTCCAACA 
AGACCCTGCC CACCACCCCC TGGGAAAAGA CCCATCAACA AATTGGATTC TTCTGATCCC 
TTTAAACTGA ATGATCCATT TCAGCCTTTC CCAGGCAATG ATAGTCCCAA AGAAAAGGAT 
CCTGATATGT TTTGTGATCC ATTCACTTCT TCTTCTACCA CTGCCAATAA AGAGGCTGAG 
CCAAGCAATT TTGCTAACTT CAGTGCTTAT CCCTCTGAAG AAGACATGAT TGAGTGGGCC 
AAGAGGGAGA GTGAGCGAGA AGAAGAGCAG AGGCTCGCCA GACTAAATCA GCAGGAACAA 
GAAGACTTGG AACTGGCCAT TGCACTTAGC AAATCAGAGA TCTCAGAAGC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Endocytic adaptor epidermal growth factor receptor substrate 15 (Eps15) is involved in the trafficking of ubiquitinated ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.
The Journal of biological chemistry289(35)24652-64(2014 Aug)
Lin A,Man HY

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20?Ubiquitin E3 Ligase Regulates Protein Trafficking.
Molecular cell54(4)586-600(2014 May)
Yuan WC,Lee YR,Lin SY,Chang LY,Tan YP,Hung CC,Kuo JC,Liu CH,Lin MY,Xu M,Chen ZJ,Chen RH

Synaptic vesicle endocytosis.
Cold Spring Harbor perspectives in biology4(9)a005645(2012 Sep)
Saheki Y,De Camilli P

Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15.
The Journal of biological chemistry286(40)35196-208(2011 Oct)
Chi S,Cao H,Wang Y,McNiven MA

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Eps15 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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