Map3k7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k7
Entrez Gene ID	313121
Full Name	mitogen activated protein kinase kinase kinase 7
Synonyms	Tak1
General protein information	Preferred Names mitogen activated protein kinase kinase kinase 7 Names mitogen-activated protein kinase kinase kinase 7 TGF-beta activated kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q21

mRNA and Protein(s)

mRNA	Protein	Name
XM_006237966.3	XP_006238028.1	mitogen-activated protein kinase kinase kinase 7 isoform X1
NM_001107920.2	NP_001101390.2	mitogen-activated protein kinase kinase kinase 7

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MAP3K7	XP_001160579.1
Gallus gallus (chicken)	MAP3K7	XP_004940432.1
	MAP3K7	XP_001099849.2
Rattus norvegicus (Norway rat)	Map3k7	NP_001101390.2
Xenopus tropicalis (tropical clawed frog)	map3k7	NP_001093731.1
Bos taurus (cattle)	MAP3K7	NP_001075064.1
Homo sapiens (human)	MAP3K7	NP_663304.1
Canis lupus familiaris (dog)	LOC102156745	XP_005627696.1

Gene Ontology
Bibliography

Related articles in PubMed

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, Chen S, Tang J, Zhang J, Zhang JH
Stroke49(1)175-183(2018 Jan)

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H
Nature medicine(2018 Jan)

Toll-like receptor 9-dependent AMPK? activation occurs via TAK1 and contributes to RhoA/ROCK signaling and actin polymerization in vascular smooth muscle cells.
McCarthy CG, Wenceslau CF, Ogbi S, Szasz T, Webb RC
The Journal of pharmacology and experimental therapeutics(2018 Jan)

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Wade EM, Daniel PB, Jenkins ZA, McInerney-Leo A, Leo P, Morgan T, Addor MC, Ad?s LC, Bertola D, Bohring A, Carter E, Cho TJ, Duba HC, Fletcher E, Kim CA, Krakow D, Morava E, Neuhann T, Superti-Furga A, Veenstra-Knol I, Wieczorek D, Wilson LC, Hennekam RC, Sutherland-Smith AJ, Strom TM, Wilkie AO, Brown MA, Duncan EL, Markie DM, Robertson SP
American journal of human genetics99(2)392-406(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of tumor necrosis factor-alpha receptor-associated factor-6 and transforming growth factor beta-activated kinase 1 (TAK1) are related to the progression of epilepsy. TAK1 might be a potential intervention target for the treatment of epilepsy via neuroprotection.
Title: The inhibition of transforming growth factor beta-activated kinase 1 contributed to neuroprotection via inflammatory reaction in pilocarpine-induced rats with epilepsy.

TAK1 inhibition attenuates early brain injury and improves neurological deficits after subarachnoid hemorrhage.
Title: TGF?-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage.

IL-1alpha-induced expression of C/EBPbeta and SDF-1 was significantly potentiated by knockdown of transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of IKKbeta signaling, in vascular smooth muscle cells.
Title: Transforming growth factor ?-activated kinase 1 negatively regulates interleukin-1?-induced stromal-derived factor-1 expression in vascular smooth muscle cells.

TAK1 itself has no effect on intracellular ROS accumulation, it may affect the inhibitory effects of HSP70 on ROS generation, p38 activity and cardiomyocyte injury.
Title: Transforming growth factor-?-activated kinase 1 enhances H2O2-induced apoptosis independently of reactive oxygen species in cardiomyocytes.

TAK1 activates AMPK-dependent cell death pathway in H2O2-treated cardiomyocytes, and HSP-70 inhibits the signaling pathway by reducing reactive oxygen species content.
Title: TAK1 activates AMPK-dependent cell death pathway in hydrogen peroxide-treated cardiomyocytes, inhibited by heat shock protein-70.

The following Map3k7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06287	NM_001107920.2 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa28085	XM_006237966.3 Latest version!	Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k7 ( NM_001107920.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101390.2 Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), mRNA.

Price & Availability↑

CloneID	ORa06287
Clone ID Related Accession (Same CDS sequence)	NM_001107920.2
Accession Version	NM_001107920.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1821bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-01
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07047779.1. On Dec 23, 2009 this sequence version replaced NM_001107920.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACAG CATCCGCCGC CTCGTCCTCC TCCTCGTCTT CTGCCAGTGA GATGATCGAA 
GCGCCATCGC AGGTCCTTAA CTTCGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 
GTTGTTGGGA GAGGAGCTTT TGGAGTGGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 
GCAATTAAAC AGATTGAAAG TGAATCTGAG AGGAAGGCTT TCATCGTGGA GCTCCGGCAG 
TTGTCCCGTG TGAACCATCC TAATATTGTA AAGTTGTATG GAGCCTGCTT GAATCCAGTC 
TGTCTTGTGA TGGAGTATGC TGAAGGAGGC TCGTTGTATA ATGTGCTGCA CGGTGCTGAA 
CCATTGCCTT ATTACACTGC TGCTCATGCC ATGAGCTGGT GTCTACAGTG TTCCCAAGGA 
GTGGCCTACC TGCACAGCAT GCAGCCCAAA GCTCTCATTC ATAGGGACCT CAAGCCTCCA 
AACTTGCTGC TGGTTGCAGG AGGGACAGTT CTAAAAATCT GCGATTTTGG TACAGCTTGT 
GACATCCAGA CACACATGAC CAATAATAAA GGGAGTGCTG CTTGGATGGC ACCCGAAGTG 
TTCGAAGGTA GCAATTACAG TGAAAAGTGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 
GAGGTGATAA CACGCCGGAA ACCCTTTGAT GAGATCGGTG GCCCAGCTTT CAGAATCATG 
TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ACTTGCCTAA GCCCATTGAG 
AGCTTGATGA CCCGCTGTTG GTCTAAGGAC CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 
GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CTGATGAGCC GTTACAGTAC 
CCCTGTCAGT ACTCTGATGA AGGGCAGAGC AACTCAGCCA CCAGCACAGG CTCATTTATG 
GACATCGCTT CTACAAATAC CAGTAATAAA AGTGACACAA ATATGGAACA AGTCCCTGCC 
ACAAACGACA CTATTAAACG CTTGGAGTCA AAACTGTTGA AAAACCAGGC AAAGCAACAG 
AGTGACTCTG GACGCCTGAG TTTGGGAGCC TCTCGAGGGA GCAGTGTGGA GAGCTTGCCC 
CCGACTTCTG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC GAGGATCGTG 
GCGACTACAG CCTATACCAA GCCTAAACGG GGCCACCGTA AAACCGCTTC ATTTGGCAAC 
ATTCTGGATG TCCCTGAGAT CGTCATATCA GGCAACGGGC AACCAAGGCG TAGATCCATC 
CAAGACTTGA CTGTTACTGG GACAGAACCT GGTCAGGTGA GCAGCAGGTC ATCCAGCCCT 
AGTGTCAGAA TGATCACTAC CTCAGGACCA ACCTCAGAGA AGCCAGCTCG CAGTCTTCCT 
TGGACCCCTG ATGATTCCAC AGATACCAAT GGCTCGGATA ACTCCATCCC AATGGCGTAT 
CTTACACTGG ATCACCAGCT GCAGCCTCTA GCACCATGCC CAAACTCCAA AGAATCCATG 
GCAGTGTTCG AACAGCATTG TAAAATGGCA CAGGAATATA TGAAAGTTCA AACCGAAATC 
GCATTGTTAC TACAGAGGAA GCAAGAACTA GTTGCAGAAT TGGACCAGGA TGAAAAGGAC 
CAGCAAAATA CATCTCGCCT GGTACAGGAA CATAAAAAGC TTTTAGACGA AAACAAAAGC 
CTTTCTACTT ATTACCAGCA ATGCAAAAAA CAACTAGAGG TCATCAGAAG CCAGCAGCAG 
AAACGACAAG GCACTTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101390.2
CDS	157..1977
Translation	MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATTAYTKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSLPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS

Target ORF information:

RefSeq Version	NM_001107920.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107920.2

ORF Insert Sequence:

ATGTCGACAG CATCCGCCGC CTCGTCCTCC TCCTCGTCTT CTGCCAGTGA GATGATCGAA 
GCGCCATCGC AGGTCCTTAA CTTCGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 
GTTGTTGGGA GAGGAGCTTT TGGAGTGGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 
GCAATTAAAC AGATTGAAAG TGAATCTGAG AGGAAGGCTT TCATCGTGGA GCTCCGGCAG 
TTGTCCCGTG TGAACCATCC TAATATTGTA AAGTTGTATG GAGCCTGCTT GAATCCAGTC 
TGTCTTGTGA TGGAGTATGC TGAAGGAGGC TCGTTGTATA ATGTGCTGCA CGGTGCTGAA 
CCATTGCCTT ATTACACTGC TGCTCATGCC ATGAGCTGGT GTCTACAGTG TTCCCAAGGA 
GTGGCCTACC TGCACAGCAT GCAGCCCAAA GCTCTCATTC ATAGGGACCT CAAGCCTCCA 
AACTTGCTGC TGGTTGCAGG AGGGACAGTT CTAAAAATCT GCGATTTTGG TACAGCTTGT 
GACATCCAGA CACACATGAC CAATAATAAA GGGAGTGCTG CTTGGATGGC ACCCGAAGTG 
TTCGAAGGTA GCAATTACAG TGAAAAGTGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 
GAGGTGATAA CACGCCGGAA ACCCTTTGAT GAGATCGGTG GCCCAGCTTT CAGAATCATG 
TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ACTTGCCTAA GCCCATTGAG 
AGCTTGATGA CCCGCTGTTG GTCTAAGGAC CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 
GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CTGATGAGCC GTTACAGTAC 
CCCTGTCAGT ACTCTGATGA AGGGCAGAGC AACTCAGCCA CCAGCACAGG CTCATTTATG 
GACATCGCTT CTACAAATAC CAGTAATAAA AGTGACACAA ATATGGAACA AGTCCCTGCC 
ACAAACGACA CTATTAAACG CTTGGAGTCA AAACTGTTGA AAAACCAGGC AAAGCAACAG 
AGTGACTCTG GACGCCTGAG TTTGGGAGCC TCTCGAGGGA GCAGTGTGGA GAGCTTGCCC 
CCGACTTCTG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC GAGGATCGTG 
GCGACTACAG CCTATACCAA GCCTAAACGG GGCCACCGTA AAACCGCTTC ATTTGGCAAC 
ATTCTGGATG TCCCTGAGAT CGTCATATCA GGCAACGGGC AACCAAGGCG TAGATCCATC 
CAAGACTTGA CTGTTACTGG GACAGAACCT GGTCAGGTGA GCAGCAGGTC ATCCAGCCCT 
AGTGTCAGAA TGATCACTAC CTCAGGACCA ACCTCAGAGA AGCCAGCTCG CAGTCTTCCT 
TGGACCCCTG ATGATTCCAC AGATACCAAT GGCTCGGATA ACTCCATCCC AATGGCGTAT 
CTTACACTGG ATCACCAGCT GCAGCCTCTA GCACCATGCC CAAACTCCAA AGAATCCATG 
GCAGTGTTCG AACAGCATTG TAAAATGGCA CAGGAATATA TGAAAGTTCA AACCGAAATC 
GCATTGTTAC TACAGAGGAA GCAAGAACTA GTTGCAGAAT TGGACCAGGA TGAAAAGGAC 
CAGCAAAATA CATCTCGCCT GGTACAGGAA CATAAAAAGC TTTTAGACGA AAACAAAAGC 
CTTTCTACTT ATTACCAGCA ATGCAAAAAA CAACTAGAGG TCATCAGAAG CCAGCAGCAG 
AAACGACAAG GCACTTCATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Map3k7 ( XM_006237966.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006238028.1 Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28085
Clone ID Related Accession (Same CDS sequence)	XM_006237966.3
Accession Version	XM_006237966.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1740bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006237966.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGACAG CATCCGCCGC CTCGTCCTCC TCCTCGTCTT CTGCCAGTGA GATGATCGAA 
GCGCCATCGC AGGTCCTTAA CTTCGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 
GTTGTTGGGA GAGGAGCTTT TGGAGTGGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 
GCAATTAAAC AGATTGAAAG TGAATCTGAG AGGAAGGCTT TCATCGTGGA GCTCCGGCAG 
TTGTCCCGTG TGAACCATCC TAATATTGTA AAGTTGTATG GAGCCTGCTT GAATCCAGTC 
TGTCTTGTGA TGGAGTATGC TGAAGGAGGC TCGTTGTATA ATGTGCTGCA CGGTGCTGAA 
CCATTGCCTT ATTACACTGC TGCTCATGCC ATGAGCTGGT GTCTACAGTG TTCCCAAGGA 
GTGGCCTACC TGCACAGCAT GCAGCCCAAA GCTCTCATTC ATAGGGACCT CAAGCCTCCA 
AACTTGCTGC TGGTTGCAGG AGGGACAGTT CTAAAAATCT GCGATTTTGG TACAGCTTGT 
GACATCCAGA CACACATGAC CAATAATAAA GGGAGTGCTG CTTGGATGGC ACCCGAAGTG 
TTCGAAGGTA GCAATTACAG TGAAAAGTGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 
GAGGTGATAA CACGCCGGAA ACCCTTTGAT GAGATCGGTG GCCCAGCTTT CAGAATCATG 
TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ACTTGCCTAA GCCCATTGAG 
AGCTTGATGA CCCGCTGTTG GTCTAAGGAC CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 
GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CTGATGAGCC GTTACAGTAC 
CCCTGTCAGT ACTCTGATGA AGGGCAGAGC AACTCAGCCA CCAGCACAGG CTCATTTATG 
GACATCGCTT CTACAAATAC CAGTAATAAA AGTGACACAA ATATGGAACA AGTCCCTGCC 
ACAAACGACA CTATTAAACG CTTGGAGTCA AAACTGTTGA AAAACCAGGC AAAGCAACAG 
AGTGACTCTG GACGCCTGAG TTTGGGAGCC TCTCGAGGGA GCAGTGTGGA GAGCTTGCCC 
CCGACTTCTG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC GAGGATCGTG 
GCGACTACAG GCAACGGGCA ACCAAGGCGT AGATCCATCC AAGACTTGAC TGTTACTGGG 
ACAGAACCTG GTCAGGTGAG CAGCAGGTCA TCCAGCCCTA GTGTCAGAAT GATCACTACC 
TCAGGACCAA CCTCAGAGAA GCCAGCTCGC AGTCTTCCTT GGACCCCTGA TGATTCCACA 
GATACCAATG GCTCGGATAA CTCCATCCCA ATGGCGTATC TTACACTGGA TCACCAGCTG 
CAGCCTCTAG CACCATGCCC AAACTCCAAA GAATCCATGG CAGTGTTCGA ACAGCATTGT 
AAAATGGCAC AGGAATATAT GAAAGTTCAA ACCGAAATCG CATTGTTACT ACAGAGGAAG 
CAAGAACTAG TTGCAGAATT GGACCAGGAT GAAAAGGACC AGCAAAATAC ATCTCGCCTG 
GTACAGGAAC ATAAAAAGCT TTTAGACGAA AACAAAAGCC TTTCTACTTA TTACCAGCAA 
TGCAAAAAAC AACTAGAGGT CATCAGAAGC CAGCAGCAGA AACGACAAGG CACTTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006238028.1
CDS	3573..5312
Translation	MSTASAASSSSSSSASEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSDSGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIVATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPARSLPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS

Target ORF information:

RefSeq Version	XM_006237966.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen activated protein kinase kinase kinase 7 (Map3k7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006237966.3

ORF Insert Sequence:

ATGTCGACAG CATCCGCCGC CTCGTCCTCC TCCTCGTCTT CTGCCAGTGA GATGATCGAA 
GCGCCATCGC AGGTCCTTAA CTTCGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 
GTTGTTGGGA GAGGAGCTTT TGGAGTGGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 
GCAATTAAAC AGATTGAAAG TGAATCTGAG AGGAAGGCTT TCATCGTGGA GCTCCGGCAG 
TTGTCCCGTG TGAACCATCC TAATATTGTA AAGTTGTATG GAGCCTGCTT GAATCCAGTC 
TGTCTTGTGA TGGAGTATGC TGAAGGAGGC TCGTTGTATA ATGTGCTGCA CGGTGCTGAA 
CCATTGCCTT ATTACACTGC TGCTCATGCC ATGAGCTGGT GTCTACAGTG TTCCCAAGGA 
GTGGCCTACC TGCACAGCAT GCAGCCCAAA GCTCTCATTC ATAGGGACCT CAAGCCTCCA 
AACTTGCTGC TGGTTGCAGG AGGGACAGTT CTAAAAATCT GCGATTTTGG TACAGCTTGT 
GACATCCAGA CACACATGAC CAATAATAAA GGGAGTGCTG CTTGGATGGC ACCCGAAGTG 
TTCGAAGGTA GCAATTACAG TGAAAAGTGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 
GAGGTGATAA CACGCCGGAA ACCCTTTGAT GAGATCGGTG GCCCAGCTTT CAGAATCATG 
TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ACTTGCCTAA GCCCATTGAG 
AGCTTGATGA CCCGCTGTTG GTCTAAGGAC CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 
GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CTGATGAGCC GTTACAGTAC 
CCCTGTCAGT ACTCTGATGA AGGGCAGAGC AACTCAGCCA CCAGCACAGG CTCATTTATG 
GACATCGCTT CTACAAATAC CAGTAATAAA AGTGACACAA ATATGGAACA AGTCCCTGCC 
ACAAACGACA CTATTAAACG CTTGGAGTCA AAACTGTTGA AAAACCAGGC AAAGCAACAG 
AGTGACTCTG GACGCCTGAG TTTGGGAGCC TCTCGAGGGA GCAGTGTGGA GAGCTTGCCC 
CCGACTTCTG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC GAGGATCGTG 
GCGACTACAG GCAACGGGCA ACCAAGGCGT AGATCCATCC AAGACTTGAC TGTTACTGGG 
ACAGAACCTG GTCAGGTGAG CAGCAGGTCA TCCAGCCCTA GTGTCAGAAT GATCACTACC 
TCAGGACCAA CCTCAGAGAA GCCAGCTCGC AGTCTTCCTT GGACCCCTGA TGATTCCACA 
GATACCAATG GCTCGGATAA CTCCATCCCA ATGGCGTATC TTACACTGGA TCACCAGCTG 
CAGCCTCTAG CACCATGCCC AAACTCCAAA GAATCCATGG CAGTGTTCGA ACAGCATTGT 
AAAATGGCAC AGGAATATAT GAAAGTTCAA ACCGAAATCG CATTGTTACT ACAGAGGAAG 
CAAGAACTAG TTGCAGAATT GGACCAGGAT GAAAAGGACC AGCAAAATAC ATCTCGCCTG 
GTACAGGAAC ATAAAAAGCT TTTAGACGAA AACAAAAGCC TTTCTACTTA TTACCAGCAA 
TGCAAAAAAC AACTAGAGGT CATCAGAAGC CAGCAGCAGA AACGACAAGG CACTTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Stroke49(1)175-183(2018 Jan)
Zhou K,Enkhjargal B,Xie Z,Sun C,Wu L,Malaguit J,Chen S,Tang J,Zhang J,Zhang JH

The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Nature medicine(2018 Jan)
Ji YX,Huang Z,Yang X,Wang X,Zhao LP,Wang PX,Zhang XJ,Alves-Bezerra M,Cai L,Zhang P,Lu YX,Bai L,Gao MM,Zhao H,Tian S,Wang Y,Huang ZX,Zhu XY,Zhang Y,Gong J,She ZG,Li F,Cohen DE,Li H

Toll-like receptor 9-dependent AMPK? activation occurs via TAK1 and contributes to RhoA/ROCK signaling and actin polymerization in vascular smooth muscle cells.
The Journal of pharmacology and experimental therapeutics(2018 Jan)
McCarthy CG,Wenceslau CF,Ogbi S,Szasz T,Webb RC

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
American journal of human genetics99(2)392-406(2016 Aug)
Wade EM,Daniel PB,Jenkins ZA,McInerney-Leo A,Leo P,Morgan T,Addor MC,Ad?s LC,Bertola D,Bohring A,Carter E,Cho TJ,Duba HC,Fletcher E,Kim CA,Krakow D,Morava E,Neuhann T,Superti-Furga A,Veenstra-Knol I,Wieczorek D,Wilson LC,Hennekam RC,Sutherland-Smith AJ,Strom TM,Wilkie AO,Brown MA,Duncan EL,Markie DM,Robertson SP

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Map3k7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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