Il17ra cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il17ra
Entrez Gene ID	312679
Full Name	interleukin 17 receptor A
Synonyms	Il17r
General protein information	Preferred Names interleukin 17 receptor A Names interleukin-17 receptor A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107883.2	NP_001101353.2	interleukin-17 receptor A

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC561494	NP_001093473.1
Danio rerio (zebrafish)	LOC100005924	XP_001921204.3
Pan troglodytes (chimpanzee)	IL17RA	XP_003317126.2
	IL17RA	XP_001102483.1
Gallus gallus (chicken)	IL17RA	XP_416389.3
Homo sapiens (human)	IL17RA	NP_055154.3
Bos taurus (cattle)	IL17RA	XP_002683672.2
Mus musculus (house mouse)	Il17ra	NP_032385.1
Rattus norvegicus (Norway rat)	Il17ra	NP_001101353.2
Canis lupus familiaris (dog)	IL17RA	XP_543886.4

Gene Ontology
Bibliography

Related articles in PubMed

Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis.
Ganesan R, Rasool M
Molecular immunology91134-144(2017 11)

Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6.
Zhang SC, Zheng YH, Yu PP, Min TH, Yu FX, Ye C, Xie YK, Zhang QY
World journal of gastroenterology18(28)3696-704(2012 Jul)

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated ?-cell death.
Arif S, Moore F, Marks K, Bouckenooghe T, Dayan CM, Planas R, Vives-Pi M, Powrie J, Tree T, Marchetti P, Huang GC, Gurzov EN, Pujol-Borrell R, Eizirik DL, Peakman M
Diabetes60(8)2112-9(2011 Aug)

IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.
Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, Zheng M
PloS one6(5)e20333(2011)

IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-?B versus JNK/AP-1 pathways.
Zhu L, Wu Y, Wei H, Xing X, Zhan N, Xiong H, Peng B
Molecular immunology48(4)647-56(2011 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings demonstrate that IL-17 regulates SHP-2 expression and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and RANKL in AA-FLS and may reveal a new insight into the pathogenesis of RA.
Title: Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis.

Down-regulation of the IL-17RA receptor by shRNA decreased IL-6 expression induced by IL-17A via p38 MAPK and ERK1/2 phosphorylation in HSCs
Title: Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6.

Members of the IL-17 family were localized in chondrocytes in the fracture callus. It parallels the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate.
Title: Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing.

The following Il17ra gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il17ra cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06205	NM_001107883.2 Latest version!	Rattus norvegicus interleukin 17 receptor A (Il17ra), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il17ra ( NM_001107883.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101353.2 Rattus norvegicus interleukin 17 receptor A (Il17ra), mRNA.

Price & Availability↑

CloneID	ORa06205
Clone ID Related Accession (Same CDS sequence)	NM_001107883.2
Accession Version	NM_001107883.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2607bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-28
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-17 receptor A
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07061911.1. On Aug 11, 2009 this sequence version replaced NM_001107883.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGACTC CGCGCCGCTG GCCACGGGTC GTCCCCGGGC CCGCGCTGGG ATGGCTGCTT 
CTGCTGTTGA GCGCGCTGTT CCGGGGCCGC GCCTCCCTGC GCCTCCTCGA CTTCCCGGCT 
CTAGTCTGCT CGCAGGAGGG GCTGAACTGC AGAGTCGAGA ATAGTACTTG CCTGGATGAC 
AGCTGGATTT ACCCTCGAAA CCTGACGCCG TCTTCCCCGA AAAACATCTA TCTCCATCTG 
AACGTTTCGT CTACCCAGCA CGGAGACCTA GTCCCTGTGT TGCACGTTGA GTGGACCTTG 
CAGACAGATG CCAGCATCCT GTATCTCGAG GGTGCAGAGC TGTCCATCCT GAAGCTGAAC 
ACCAATGAGC AGCTGTGTGT CAAGTTCAAG TTTCTGTCCA AGCTGTCGAA TCATCATAAG 
CGGTGGCGGT TCTCCTTCAG TCACTTCGTG GTAGATCCTG GCCAGGAGTA TGAGGTGACT 
GTTCACCACC TGCCCAAGCC CATCCCTGAC GGGGACCCAA ACCACAAGTC CAAGACCATC 
TTAGTGCCTG GCTGCGAGGA CACGGAGATG AAGATGACTA CACCGTGTGT GAGCTCAGGC 
AGCCTTTGGA ACCCCAACAT CACAGTGGAG ACCTTGGACA CCCAGCATCT TCGAGTGGAC 
TTCACCCTGT GGAATGAATC CACCCCCTAC CAGATCCTGC TGGAAAGTTT TTCGGGCTCA 
GAGAACCAGA GCTGCTTTGA AGACATTAAA CAGATATCTG CGCCCGGACA GGAGGAATTC 
CACCAGCGAT CCAATGTCAC ATTCACTCTG AGCAAGTCTG GCTGGTGCTG CCACCACCTC 
GTGCAGGTCC AGCCCTTCTT CAACAGCTGC CAAAATGACT GCTTGAGACA CGCTGTGACT 
GTGCCCTGCC CAGTCATCTC AGAGACCCCA GTTTCCATAA CAGCCGCAGA CTATATTCCC 
CTCTGGGTGT ATGGCCTCAT CACCCTCATC GCCATCCTGC TGGTGGGCTC TGTCATCCTG 
CTGATTATCT GCATGACCTG GAGGCTTTCT GGTGCTGATC AAGAGAAACA TGGAGATGAC 
TCCAAAGTCA ATGGCATCTT GCCAACAACA GACCTGACTC CCCCACCCCT GCAGCCCAGG 
AAGGTCTGGA TCGTCTACTC GGCTGACCAC CCCCTCTATG TGGACGTGGT CCTAAAGTTC 
GCCCAGTTCC TGATCACTGC CTGTGGTACT GAAGTAGCCC TTGACCTGCT GGAAGAGCAG 
ACCATCTCTG AGATGGGGGT CATGACTTGG GTGAGCCGGC AGAAGCAGGA AATGGAGGAG 
AGCGGTTCCA AGATCATCGT CCTGTGCTCC CGAGGGACCC GAGCTAAGTG GAAAGCCATC 
TTGGGTTGGG CGGAGCCTGC TGTCCAGCTA CGGTGTGACC ACTGGAAGCC TGCTGGGGAC 
CTTTTCACAG CAGCCATGAA CATGATTCTA CCAGACTTCA AGAGGCCAGC CTGCTTCGGC 
ACCTACATTG TTTGCTACTT CAGTGGCATC TGTAACGAGA GGGATGTCCC CGACCTCTTC 
AACATCACCT CCAGGTACCC ACTTATGGAC AAATTTGAGG AGGTTTACTT CCGGATCCAG 
GACCTGGAGA TGTTTGAACC TGGCCGGATG CACCATGTCA AAGAGCTCAC AGGGGAAAAT 
TACCTGCAGA GCCCTAGTGG CCGGCAGCTC AAGGAGGCTG TGGTTAGGTT CCAGGAGTGG 
CAAACCCGGT ACCCCGACTG GTTTGAGCGA GAGAACCTCT GCTTAGCAGG TGACCAAGAC 
CTTCCATCCC TGGATGAGGA AGTGTTTGAA GACCCACTGC TGCCACCAGG GGGAAGAATC 
GTCAAACAGC AGCCCCTGGT GCGGGAGCTG CCTTCAGAAG GCTGCCTTGT GGTAGATGTC 
TGTGCCAGGG AGGAAGAAAG TGGAGTGGTA AAGCTGGAGC CTCAGCTGTG GCCACAAAGA 
CAGCTAATGG CTCAGACCCT CCAAACCTTG GTGCTGCCAA CAGAACAGGT CCCTGCAGCT 
CATGTGGTGG AGCCTGTCCG TCTTCTAGAT GGCACTGGAG CAGCTACCCA GCTGGCCATT 
GCCGAGGACG GCGAGGCTTG CCCGCTGCTT GGGGTCCGGA GGAACAGCAT CCTTTGCCTC 
CCCATGGACT CAGATGACTC GCCTCTCTGT AGCACTCCAA TGATGTCACC TGACCACCTC 
CAAGGCGATG CAAGAGAGCA GCTAGAAAGC CTGATGCTCT CGGTGCTGCA GCATAGCCTG 
AGCGCACAGG CTCAGGAGGG CTGGCCGAGG CCTGAGGTGG TCCTCAAGGA CTGCATGCCC 
TCTGAGGAGG AGCAGCGGCA GTCAGTGCAG TCAGACCAGG GCTACATCTC CAGAAGCTCC 
CCGCAACCCC CCGACTGGCT CACAGAGGAG GAAGAGCTAG AACTGGGTGA GTCCGGTGAG 
TCTCTCTCTC CGGAGGAGCT GCGGAGCCTG AGGAGTGTCC AGCGGCGGCT TTTCTTCTGG 
GAGCTTGAGA AGAACCCTGG CTGGGACAGC AGAGGCCAGG AGCAGAAGAT CAGCCTCCCC 
CCTGGGCCTC CTAATCCTGC TACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101353.2
CDS	101..2707
Translation	MATPRRWPRVVPGPALGWLLLLLSALFRGRASLRLLDFPALVCSQEGLNCRVENSTCLDDSWIYPRNLTPSSPKNIYLHLNVSSTQHGDLVPVLHVEWTLQTDASILYLEGAELSILKLNTNEQLCVKFKFLSKLSNHHKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKTILVPGCEDTEMKMTTPCVSSGSLWNPNITVETLDTQHLRVDFTLWNESTPYQILLESFSGSENQSCFEDIKQISAPGQEEFHQRSNVTFTLSKSGWCCHHLVQVQPFFNSCQNDCLRHAVTVPCPVISETPVSITAADYIPLWVYGLITLIAILLVGSVILLIICMTWRLSGADQEKHGDDSKVNGILPTTDLTPPPLQPRKVWIVYSADHPLYVDVVLKFAQFLITACGTEVALDLLEEQTISEMGVMTWVSRQKQEMEESGSKIIVLCSRGTRAKWKAILGWAEPAVQLRCDHWKPAGDLFTAAMNMILPDFKRPACFGTYIVCYFSGICNERDVPDLFNITSRYPLMDKFEEVYFRIQDLEMFEPGRMHHVKELTGENYLQSPSGRQLKEAVVRFQEWQTRYPDWFERENLCLAGDQDLPSLDEEVFEDPLLPPGGRIVKQQPLVRELPSEGCLVVDVCAREEESGVVKLEPQLWPQRQLMAQTLQTLVLPTEQVPAAHVVEPVRLLDGTGAATQLAIAEDGEACPLLGVRRNSILCLPMDSDDSPLCSTPMMSPDHLQGDAREQLESLMLSVLQHSLSAQAQEGWPRPEVVLKDCMPSEEEQRQSVQSDQGYISRSSPQPPDWLTEEEELELGESGESLSPEELRSLRSVQRRLFFWELEKNPGWDSRGQEQKISLPPGPPNPAT

Target ORF information:

RefSeq Version	NM_001107883.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 17 receptor A (Il17ra), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107883.2

ORF Insert Sequence:

ATGGCGACTC CGCGCCGCTG GCCACGGGTC GTCCCCGGGC CCGCGCTGGG ATGGCTGCTT 
CTGCTGTTGA GCGCGCTGTT CCGGGGCCGC GCCTCCCTGC GCCTCCTCGA CTTCCCGGCT 
CTAGTCTGCT CGCAGGAGGG GCTGAACTGC AGAGTCGAGA ATAGTACTTG CCTGGATGAC 
AGCTGGATTT ACCCTCGAAA CCTGACGCCG TCTTCCCCGA AAAACATCTA TCTCCATCTG 
AACGTTTCGT CTACCCAGCA CGGAGACCTA GTCCCTGTGT TGCACGTTGA GTGGACCTTG 
CAGACAGATG CCAGCATCCT GTATCTCGAG GGTGCAGAGC TGTCCATCCT GAAGCTGAAC 
ACCAATGAGC AGCTGTGTGT CAAGTTCAAG TTTCTGTCCA AGCTGTCGAA TCATCATAAG 
CGGTGGCGGT TCTCCTTCAG TCACTTCGTG GTAGATCCTG GCCAGGAGTA TGAGGTGACT 
GTTCACCACC TGCCCAAGCC CATCCCTGAC GGGGACCCAA ACCACAAGTC CAAGACCATC 
TTAGTGCCTG GCTGCGAGGA CACGGAGATG AAGATGACTA CACCGTGTGT GAGCTCAGGC 
AGCCTTTGGA ACCCCAACAT CACAGTGGAG ACCTTGGACA CCCAGCATCT TCGAGTGGAC 
TTCACCCTGT GGAATGAATC CACCCCCTAC CAGATCCTGC TGGAAAGTTT TTCGGGCTCA 
GAGAACCAGA GCTGCTTTGA AGACATTAAA CAGATATCTG CGCCCGGACA GGAGGAATTC 
CACCAGCGAT CCAATGTCAC ATTCACTCTG AGCAAGTCTG GCTGGTGCTG CCACCACCTC 
GTGCAGGTCC AGCCCTTCTT CAACAGCTGC CAAAATGACT GCTTGAGACA CGCTGTGACT 
GTGCCCTGCC CAGTCATCTC AGAGACCCCA GTTTCCATAA CAGCCGCAGA CTATATTCCC 
CTCTGGGTGT ATGGCCTCAT CACCCTCATC GCCATCCTGC TGGTGGGCTC TGTCATCCTG 
CTGATTATCT GCATGACCTG GAGGCTTTCT GGTGCTGATC AAGAGAAACA TGGAGATGAC 
TCCAAAGTCA ATGGCATCTT GCCAACAACA GACCTGACTC CCCCACCCCT GCAGCCCAGG 
AAGGTCTGGA TCGTCTACTC GGCTGACCAC CCCCTCTATG TGGACGTGGT CCTAAAGTTC 
GCCCAGTTCC TGATCACTGC CTGTGGTACT GAAGTAGCCC TTGACCTGCT GGAAGAGCAG 
ACCATCTCTG AGATGGGGGT CATGACTTGG GTGAGCCGGC AGAAGCAGGA AATGGAGGAG 
AGCGGTTCCA AGATCATCGT CCTGTGCTCC CGAGGGACCC GAGCTAAGTG GAAAGCCATC 
TTGGGTTGGG CGGAGCCTGC TGTCCAGCTA CGGTGTGACC ACTGGAAGCC TGCTGGGGAC 
CTTTTCACAG CAGCCATGAA CATGATTCTA CCAGACTTCA AGAGGCCAGC CTGCTTCGGC 
ACCTACATTG TTTGCTACTT CAGTGGCATC TGTAACGAGA GGGATGTCCC CGACCTCTTC 
AACATCACCT CCAGGTACCC ACTTATGGAC AAATTTGAGG AGGTTTACTT CCGGATCCAG 
GACCTGGAGA TGTTTGAACC TGGCCGGATG CACCATGTCA AAGAGCTCAC AGGGGAAAAT 
TACCTGCAGA GCCCTAGTGG CCGGCAGCTC AAGGAGGCTG TGGTTAGGTT CCAGGAGTGG 
CAAACCCGGT ACCCCGACTG GTTTGAGCGA GAGAACCTCT GCTTAGCAGG TGACCAAGAC 
CTTCCATCCC TGGATGAGGA AGTGTTTGAA GACCCACTGC TGCCACCAGG GGGAAGAATC 
GTCAAACAGC AGCCCCTGGT GCGGGAGCTG CCTTCAGAAG GCTGCCTTGT GGTAGATGTC 
TGTGCCAGGG AGGAAGAAAG TGGAGTGGTA AAGCTGGAGC CTCAGCTGTG GCCACAAAGA 
CAGCTAATGG CTCAGACCCT CCAAACCTTG GTGCTGCCAA CAGAACAGGT CCCTGCAGCT 
CATGTGGTGG AGCCTGTCCG TCTTCTAGAT GGCACTGGAG CAGCTACCCA GCTGGCCATT 
GCCGAGGACG GCGAGGCTTG CCCGCTGCTT GGGGTCCGGA GGAACAGCAT CCTTTGCCTC 
CCCATGGACT CAGATGACTC GCCTCTCTGT AGCACTCCAA TGATGTCACC TGACCACCTC 
CAAGGCGATG CAAGAGAGCA GCTAGAAAGC CTGATGCTCT CGGTGCTGCA GCATAGCCTG 
AGCGCACAGG CTCAGGAGGG CTGGCCGAGG CCTGAGGTGG TCCTCAAGGA CTGCATGCCC 
TCTGAGGAGG AGCAGCGGCA GTCAGTGCAG TCAGACCAGG GCTACATCTC CAGAAGCTCC 
CCGCAACCCC CCGACTGGCT CACAGAGGAG GAAGAGCTAG AACTGGGTGA GTCCGGTGAG 
TCTCTCTCTC CGGAGGAGCT GCGGAGCCTG AGGAGTGTCC AGCGGCGGCT TTTCTTCTGG 
GAGCTTGAGA AGAACCCTGG CTGGGACAGC AGAGGCCAGG AGCAGAAGAT CAGCCTCCCC 
CCTGGGCCTC CTAATCCTGC TACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis.
Molecular immunology91134-144(2017 11)
Ganesan R,Rasool M

Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6.
World journal of gastroenterology18(28)3696-704(2012 Jul)
Zhang SC,Zheng YH,Yu PP,Min TH,Yu FX,Ye C,Xie YK,Zhang QY

Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated ?-cell death.
Diabetes60(8)2112-9(2011 Aug)
Arif S,Moore F,Marks K,Bouckenooghe T,Dayan CM,Planas R,Vives-Pi M,Powrie J,Tree T,Marchetti P,Huang GC,Gurzov EN,Pujol-Borrell R,Eizirik DL,Peakman M

IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke.
PloS one6(5)e20333(2011)
Chen K,Pociask DA,McAleer JP,Chan YR,Alcorn JF,Kreindler JL,Keyser MR,Shapiro SD,Houghton AM,Kolls JK,Zheng M

IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-?B versus JNK/AP-1 pathways.
Molecular immunology48(4)647-56(2011 Jan)
Zhu L,Wu Y,Wei H,Xing X,Zhan N,Xiong H,Peng B

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Il17ra cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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