Xpc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Xpc
Entrez Gene ID	312560
Full Name	XPC complex subunit, DNA damage recognition and repair factor
General protein information	Preferred Names XPC complex subunit, DNA damage recognition and repair factor Names DNA repair protein complementing XP-C cells xeroderma pigmentosum, complementation group C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107874.1	NP_001101344.1	DNA repair protein complementing XP-C cells

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	XPC	XP_003309685.1
	XPC	XP_001091593.2
Gallus gallus (chicken)	XPC	XP_414379.3
Bos taurus (cattle)	XPC	NP_001192837.1
Rattus norvegicus (Norway rat)	Xpc	NP_001101344.1
Homo sapiens (human)	XPC	NP_004619.3
Canis lupus familiaris (dog)	XPC	XP_005632165.1
Danio rerio (zebrafish)	xpc	NP_001038675.1
Xenopus tropicalis (tropical clawed frog)	xpc	XP_002938269.2
Mus musculus (house mouse)	Xpc	NP_033557.2

Gene Ontology
Bibliography

Related articles in PubMed

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.
Cattoglio C, Zhang ET, Grubisic I, Chiba K, Fong YW, Tjian R
Proceedings of the National Academy of Sciences of the United States of America112(18)E2317-26(2015 May)

Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons.
Guthrie OW, Xu H
Hearing research294(1-2)21-30(2012 Dec)

Nucleotide excision repair: new tricks with old bricks.
Kamileri I, Karakasilioti I, Garinis GA
Trends in genetics : TIG28(11)566-73(2012 Nov)

TFIIH: when transcription met DNA repair.
Compe E, Egly JM
Nature reviews. Molecular cell biology13(6)343-54(2012 May)

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
Bergink S, Toussaint W, Luijsterburg MS, Dinant C, Alekseev S, Hoeijmakers JH, Dantuma NP, Houtsmuller AB, Vermeulen W
The Journal of cell biology196(6)681-8(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XP mRNA levels were up to 95% (XPA) and 69% (XPC) of the respective maximum expression capacity of each gene; in addition, these cochlear levels were up to sixfold (XPC) and threefold (XPA)
Title: Real-time quantification of Xeroderma pigmentosum mRNA from the mammalian cochlea.

study examined XPA and XPC immunoreactivity among outer hair cells and spiral limbus cells; data show that outer hair cells failed to acclimate to cisplatin treatment cycles by regulating XPA and XPC immunoreactivity
Title: Preincision complex-I from the excision nuclease reaction among cochlear spiral limbus and outer hair cells.

The following Xpc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xpc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06183	NM_001107874.1 Latest version!	Rattus norvegicus XPC complex subunit, DNA damage recognition and repair factor (Xpc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$552.30 $789.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Xpc ( NM_001107874.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101344.1 Rattus norvegicus XPC complex subunit, DNA damage recognition and repair factor (Xpc), mRNA.

Price & Availability↑

CloneID	ORa06183
Clone ID Related Accession (Same CDS sequence)	NM_001107874.1
Accession Version	NM_001107874.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2802bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	DNA repair protein complementing XP-C cells
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473957.1. On or before Oct 4, 2007 this sequence version replaced XM_001073450.1, XM_232194.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCCCGAA AGCGTACCGC AGGCGGAAAG CGGAGGAAGC GCGGCCAGGA AGCCGAGGAC 
AACAAAGCAA CCCGGCCTGA GGAGAGCGAT GCGGACGACT TTGAAGATGA GAAACAGAAA 
CCCCCAAGGA AGTGCTTTCT CCCGAAAGTT TCCCAAGGAA AGAGGAAGAG AGACTGCAGT 
GATCCAGGGG ACCCCACAAA TGGTGCAGCA AAAAAGAAAG TGGCCAAAGC CACCACTAAG 
TCCAAGAATC TCAAGGCTGT GAAGGAGGAA GCACTCAGCG ACGACGGGGA TGATTTCCGG 
GACTCATTGA GTAACTGCAG AAAGGCAAAG AAACATCCCA AAAGAGAGGT GGTGGACCAA 
GGCACCGATG AAGATGACAG CGAGGATGAC TGGGAGGAGG TGGAAGAACT TACTGAGCCT 
GTGCTGGACA TGGGAGAAAA TTCTGCTACC TCGCGGTCTG ACCTGCCTGT GAAGGCAGTG 
GAGATAGAAA TTGAAACACC AGAGCAGGCG AAGGCACGGG AAAGAAGTGA GAAGATAAAG 
ATGGAGTTTG AGACATACCT GCGGAGGATG ATGAAGCGTT TCAATAAGGA AGTGCAGGAG 
AACATGCACA AGGTTCACTT GCTGTGCCTG CTGGCCAGTG GCTTCTATCG AAATAGCATC 
TGCCAGCAGC CAGATCTGCT GGCCATCGGC CTCTCCATCA TCCCTATTCG CTTTACCAAA 
GTGCCACTTC AAGACCGGGA TGTCTACTAC CTTTCAAACC TGGTAAAGTG GTTCATTGGA 
ACCTTCACTG TCAATGCTGA CCTTTCAGCC AGTGAGCAGG ACAGCCTGCA GACGACCTTG 
GAAAGGAGGA TCGCCATTTA CTCTGCGAGG GATAATGAAG AGTTGGTCCA TATATTTCTT 
CTGATTCTTC GGGCTCTGCA GCTGCTCACC CGGCTGGTCT TGTCTCTGCA GCCCATTCCA 
CTGAAGTCAG CTGTGGCAAA GGGGAAGAAA TCTTCCAAGG AGACATCTTT AGAGGGTCCT 
GGAGACTCTT CAGAACCTTC TAGTAACATT CCAGAAAGCC ACAACAAACC CAAGACCAGC 
AAAAGAATCA AACAAGAAGA AACCTTGTCT GAAGGCAGTG GCAAGGCAAA TGCCAGAGGA 
AAGAGAGGCA CTGCCACCGC TGGCAGCAGG CAGCAGAGGA AGCCCTCCTG CAGCGAGGGA 
GAGGAGGCCA AGCAGGAAAT CCAGAGCCAT CCACAGGCCC AGAAGCGGCG TGTGGCTGCC 
AAGGTGTCTT ACAAAGAGGA GAGTGAGAGT GATGGGGCAG GCAGTGGCTC TGACTTTGAA 
CTGTCCAGTG GGGAGGGCCA GCATTCCTCT GATGAGGATT GTAAGCCTGG CCCTCGAAAG 
CAGAAGAGGG CCTCAGCTCC TCAGAGGTCA AAGGCTGGTT CTAAGAGTGC TTCCAAGACC 
CAAAGTGGGA GCCAATGGGA GCCACCAAGC TTTTCAGTGG CATCTTCAAG CTCTTCAGCC 
TGCAAGCGAG GCAAGAAGAT TTCCTGTGGT GGTGAAGAGA CAGATGATAG GAAAGCTGCT 
GGTGTAGACC AGTGGCTCGA GGTGTTCTGT GAGCCACAGG CAAAGTGGGT GTGTGTGGAC 
TGTGTGCATG GTGTGGTGGG CCAGCCTGTG GCCTGTTACA AATATGCCAC CAAACCCATG 
ACCTATGTTG TAGGCATTGA CAGTGATGGC TGGGTCCGAG ATGTCACTCA GAGGTATGAC 
CCAGCCTGGA TGACAGCAAC CCGCAAGTGC CGGGTTGACG CTGAGTGGTG GGCTGAGACT 
TTGAGGCCCT ATCGGAGCCC ACTTACCGAG AGGGAGAAGA AGGAAGACCA GGAGTTTCAG 
GCAAAGCACC TGGACCAGCC TTTGCCCACC TCCATCAGCA CATACAAGAA CCACCCTCTG 
TATGCCCTGA AGCGCCACCT CTTGAAATTC CAGGCTATTT ACCCTGAGTC AGCTGCGGTC 
CTTGGGTATT GTCGTGGAGA AGCTGTCTAT TCCAGGGATT GTGTGCATAC CTTGCACTCC 
AGGGACACGT GGCTGAAGCA AGCAAGAGTG GTGCGGCTTG GAGAAGTGCC CTATAAGATG 
GTGAAAGGTT TCTCTAACCG TGCCCGGAAA GCCCGGCTTT CGGAGCCCCA GCTGCATGAC 
CACAATGACT TGGGCCTCTT TGGTCACTGG CAGACAGAAG AGTATCAACC TCCTGTGGCT 
GTAGACGGGA AGGTGCCCCG GAATGAGTTT GGGAACGTGT ACCTCTTCCT GCCCAGCATG 
ATGCCTATCG GCTGTGTCCA GATGAACCTA CCCAACCTGC ACCGCGTGGC CCGCAAGCTG 
GGCATCGACT GCGTGCAGGC CATCACTGGC TTCGATTTCC ATGGAGGCTA TTGCCACCCA 
GTAACTGATG GCTACGTTGT CTGTGAGGAA TTCAGAGATG TGCTGCTGGC TGCTTGGGAG 
AATGAACAGG CCCTCATTGA AAAGAAGGAA AAGGAGAAAA AGGAAAAGCG GGCACTGGGG 
AACTGGAAGC TGCTGGTCAG AGGACTGCTC ATCAGAGAAA GGCTGAAACT CCGCTACGGG 
GCCAAGAGTG AGGCAGCAGC TCCCCATGCA AATGCAGGAG GCGGACTCTC TTCTGATGAA 
GAGGAAGGGA CCAGTTCACA AGCAGAAGCT GCCAGAGTTC TGGCTGCTTC CTGGCCACAG 
AACCGAGAGA CTAAAGAAGA ACAGAAGCCC GACTACACGA AGATGACTCG GAGAAGGCGG 
GCAGCAGAGG CTTCCCATCT CTTCCCATTT GAGAAGCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101344.1
CDS	60..2861
Translation	MARKRTAGGKRRKRGQEAEDNKATRPEESDADDFEDEKQKPPRKCFLPKVSQGKRKRDCSDPGDPTNGAAKKKVAKATTKSKNLKAVKEEALSDDGDDFRDSLSNCRKAKKHPKREVVDQGTDEDDSEDDWEEVEELTEPVLDMGENSATSRSDLPVKAVEIEIETPEQAKARERSEKIKMEFETYLRRMMKRFNKEVQENMHKVHLLCLLASGFYRNSICQQPDLLAIGLSIIPIRFTKVPLQDRDVYYLSNLVKWFIGTFTVNADLSASEQDSLQTTLERRIAIYSARDNEELVHIFLLILRALQLLTRLVLSLQPIPLKSAVAKGKKSSKETSLEGPGDSSEPSSNIPESHNKPKTSKRIKQEETLSEGSGKANARGKRGTATAGSRQQRKPSCSEGEEAKQEIQSHPQAQKRRVAAKVSYKEESESDGAGSGSDFELSSGEGQHSSDEDCKPGPRKQKRASAPQRSKAGSKSASKTQSGSQWEPPSFSVASSSSSACKRGKKISCGGEETDDRKAAGVDQWLEVFCEPQAKWVCVDCVHGVVGQPVACYKYATKPMTYVVGIDSDGWVRDVTQRYDPAWMTATRKCRVDAEWWAETLRPYRSPLTEREKKEDQEFQAKHLDQPLPTSISTYKNHPLYALKRHLLKFQAIYPESAAVLGYCRGEAVYSRDCVHTLHSRDTWLKQARVVRLGEVPYKMVKGFSNRARKARLSEPQLHDHNDLGLFGHWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQMNLPNLHRVARKLGIDCVQAITGFDFHGGYCHPVTDGYVVCEEFRDVLLAAWENEQALIEKKEKEKKEKRALGNWKLLVRGLLIRERLKLRYGAKSEAAAPHANAGGGLSSDEEEGTSSQAEAARVLAASWPQNRETKEEQKPDYTKMTRRRRAAEASHLFPFEKL

Target ORF information:

RefSeq Version	NM_001107874.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus XPC complex subunit, DNA damage recognition and repair factor (Xpc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107874.1

ORF Insert Sequence:

ATGGCCCGAA AGCGTACCGC AGGCGGAAAG CGGAGGAAGC GCGGCCAGGA AGCCGAGGAC 
AACAAAGCAA CCCGGCCTGA GGAGAGCGAT GCGGACGACT TTGAAGATGA GAAACAGAAA 
CCCCCAAGGA AGTGCTTTCT CCCGAAAGTT TCCCAAGGAA AGAGGAAGAG AGACTGCAGT 
GATCCAGGGG ACCCCACAAA TGGTGCAGCA AAAAAGAAAG TGGCCAAAGC CACCACTAAG 
TCCAAGAATC TCAAGGCTGT GAAGGAGGAA GCACTCAGCG ACGACGGGGA TGATTTCCGG 
GACTCATTGA GTAACTGCAG AAAGGCAAAG AAACATCCCA AAAGAGAGGT GGTGGACCAA 
GGCACCGATG AAGATGACAG CGAGGATGAC TGGGAGGAGG TGGAAGAACT TACTGAGCCT 
GTGCTGGACA TGGGAGAAAA TTCTGCTACC TCGCGGTCTG ACCTGCCTGT GAAGGCAGTG 
GAGATAGAAA TTGAAACACC AGAGCAGGCG AAGGCACGGG AAAGAAGTGA GAAGATAAAG 
ATGGAGTTTG AGACATACCT GCGGAGGATG ATGAAGCGTT TCAATAAGGA AGTGCAGGAG 
AACATGCACA AGGTTCACTT GCTGTGCCTG CTGGCCAGTG GCTTCTATCG AAATAGCATC 
TGCCAGCAGC CAGATCTGCT GGCCATCGGC CTCTCCATCA TCCCTATTCG CTTTACCAAA 
GTGCCACTTC AAGACCGGGA TGTCTACTAC CTTTCAAACC TGGTAAAGTG GTTCATTGGA 
ACCTTCACTG TCAATGCTGA CCTTTCAGCC AGTGAGCAGG ACAGCCTGCA GACGACCTTG 
GAAAGGAGGA TCGCCATTTA CTCTGCGAGG GATAATGAAG AGTTGGTCCA TATATTTCTT 
CTGATTCTTC GGGCTCTGCA GCTGCTCACC CGGCTGGTCT TGTCTCTGCA GCCCATTCCA 
CTGAAGTCAG CTGTGGCAAA GGGGAAGAAA TCTTCCAAGG AGACATCTTT AGAGGGTCCT 
GGAGACTCTT CAGAACCTTC TAGTAACATT CCAGAAAGCC ACAACAAACC CAAGACCAGC 
AAAAGAATCA AACAAGAAGA AACCTTGTCT GAAGGCAGTG GCAAGGCAAA TGCCAGAGGA 
AAGAGAGGCA CTGCCACCGC TGGCAGCAGG CAGCAGAGGA AGCCCTCCTG CAGCGAGGGA 
GAGGAGGCCA AGCAGGAAAT CCAGAGCCAT CCACAGGCCC AGAAGCGGCG TGTGGCTGCC 
AAGGTGTCTT ACAAAGAGGA GAGTGAGAGT GATGGGGCAG GCAGTGGCTC TGACTTTGAA 
CTGTCCAGTG GGGAGGGCCA GCATTCCTCT GATGAGGATT GTAAGCCTGG CCCTCGAAAG 
CAGAAGAGGG CCTCAGCTCC TCAGAGGTCA AAGGCTGGTT CTAAGAGTGC TTCCAAGACC 
CAAAGTGGGA GCCAATGGGA GCCACCAAGC TTTTCAGTGG CATCTTCAAG CTCTTCAGCC 
TGCAAGCGAG GCAAGAAGAT TTCCTGTGGT GGTGAAGAGA CAGATGATAG GAAAGCTGCT 
GGTGTAGACC AGTGGCTCGA GGTGTTCTGT GAGCCACAGG CAAAGTGGGT GTGTGTGGAC 
TGTGTGCATG GTGTGGTGGG CCAGCCTGTG GCCTGTTACA AATATGCCAC CAAACCCATG 
ACCTATGTTG TAGGCATTGA CAGTGATGGC TGGGTCCGAG ATGTCACTCA GAGGTATGAC 
CCAGCCTGGA TGACAGCAAC CCGCAAGTGC CGGGTTGACG CTGAGTGGTG GGCTGAGACT 
TTGAGGCCCT ATCGGAGCCC ACTTACCGAG AGGGAGAAGA AGGAAGACCA GGAGTTTCAG 
GCAAAGCACC TGGACCAGCC TTTGCCCACC TCCATCAGCA CATACAAGAA CCACCCTCTG 
TATGCCCTGA AGCGCCACCT CTTGAAATTC CAGGCTATTT ACCCTGAGTC AGCTGCGGTC 
CTTGGGTATT GTCGTGGAGA AGCTGTCTAT TCCAGGGATT GTGTGCATAC CTTGCACTCC 
AGGGACACGT GGCTGAAGCA AGCAAGAGTG GTGCGGCTTG GAGAAGTGCC CTATAAGATG 
GTGAAAGGTT TCTCTAACCG TGCCCGGAAA GCCCGGCTTT CGGAGCCCCA GCTGCATGAC 
CACAATGACT TGGGCCTCTT TGGTCACTGG CAGACAGAAG AGTATCAACC TCCTGTGGCT 
GTAGACGGGA AGGTGCCCCG GAATGAGTTT GGGAACGTGT ACCTCTTCCT GCCCAGCATG 
ATGCCTATCG GCTGTGTCCA GATGAACCTA CCCAACCTGC ACCGCGTGGC CCGCAAGCTG 
GGCATCGACT GCGTGCAGGC CATCACTGGC TTCGATTTCC ATGGAGGCTA TTGCCACCCA 
GTAACTGATG GCTACGTTGT CTGTGAGGAA TTCAGAGATG TGCTGCTGGC TGCTTGGGAG 
AATGAACAGG CCCTCATTGA AAAGAAGGAA AAGGAGAAAA AGGAAAAGCG GGCACTGGGG 
AACTGGAAGC TGCTGGTCAG AGGACTGCTC ATCAGAGAAA GGCTGAAACT CCGCTACGGG 
GCCAAGAGTG AGGCAGCAGC TCCCCATGCA AATGCAGGAG GCGGACTCTC TTCTGATGAA 
GAGGAAGGGA CCAGTTCACA AGCAGAAGCT GCCAGAGTTC TGGCTGCTTC CTGGCCACAG 
AACCGAGAGA CTAAAGAAGA ACAGAAGCCC GACTACACGA AGATGACTCG GAGAAGGCGG 
GCAGCAGAGG CTTCCCATCT CTTCCCATTT GAGAAGCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America112(18)E2317-26(2015 May)
Cattoglio C,Zhang ET,Grubisic I,Chiba K,Fong YW,Tjian R

Noise exposure potentiates the subcellular distribution of nucleotide excision repair proteins within spiral ganglion neurons.
Hearing research294(1-2)21-30(2012 Dec)
Guthrie OW,Xu H

Nucleotide excision repair: new tricks with old bricks.
Trends in genetics : TIG28(11)566-73(2012 Nov)
Kamileri I,Karakasilioti I,Garinis GA

TFIIH: when transcription met DNA repair.
Nature reviews. Molecular cell biology13(6)343-54(2012 May)
Compe E,Egly JM

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
The Journal of cell biology196(6)681-8(2012 Mar)
Bergink S,Toussaint W,Luijsterburg MS,Dinant C,Alekseev S,Hoeijmakers JH,Dantuma NP,Houtsmuller AB,Vermeulen W

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Xpc cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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