Kmt2e cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kmt2e
Entrez Gene ID	311968
Full Name	lysine methyltransferase 2E
Synonyms	Mll5
General protein information	Preferred Names lysine methyltransferase 2E Names histone-lysine N-methyltransferase 2E histone-lysine N-methyltransferase MLL5 lysine (K)-specific methyltransferase 2E myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100851.1	NP_001094321.1	histone-lysine N-methyltransferase 2E

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MLL5	NP_001075920.2
Mus musculus (house mouse)	Kmt2e	NP_081260.1
Rattus norvegicus (Norway rat)	Kmt2e	NP_001094321.1
Pan troglodytes (chimpanzee)	MLL5	XP_003318779.1
Gallus gallus (chicken)	MLL5	XP_003640389.1
Danio rerio (zebrafish)	kmt2e	XP_692965.5
Xenopus tropicalis (tropical clawed frog)	kmt2e	XP_004913074.1
Homo sapiens (human)	KMT2E	NP_891847.1
	LOC697233	XP_002808408.1
Canis lupus familiaris (dog)	KMT2E	XP_533102.3

Gene Ontology
Bibliography

Related articles in PubMed

The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.
Mas-Y-Mas S, Barbon M, Teyssier C, D?m?n? H, Carvalho JE, Bird LE, Lebedev A, Fattori J, Schubert M, Dumas C, Bourguet W, le Maire A
PloS one11(11)e0165139(2016)

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, Wang X, Chen M, Chen J, Yang J, Kong C, Li B, Peng C, Wong CC, Hou F, Zhang Y
PloS one10(12)e0145023(2015)

Targeted silencing of MLL5? inhibits tumor growth and promotes gamma-irradiation sensitization in HPV16/18-associated cervical cancers.
Nin DS, Yew CW, Tay SK, Deng LW
Molecular cancer therapeutics13(11)2572-82(2014 Nov)

De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.
Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF 3rd, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ
Cell reports9(1)16-23(2014 Oct)

Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.
Lucena-Araujo AR, Kim HT, Jacomo RH, Melo RA, Bittencourt R, Pasquini R, Pagnano K, Fagundes EM, de Lourdes Chauffaille M, Chiattone CS, Lima AS, Kwaan HC, Gallagher R, Niemeyer CM, Schrier SL, Tallman MS, Grimwade D, Ganser A, Berliner N, Ribeiro RC, Lo-Coco F, L?wenberg B, Sanz MA, Rego EM
British journal of haematology166(4)540-9(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kmt2e gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kmt2e cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11518	NM_001100851.1 Latest version!	Rattus norvegicus lysine methyltransferase 2E (Kmt2e), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kmt2e ( NM_001100851.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094321.1 Rattus norvegicus lysine methyltransferase 2E (Kmt2e), mRNA.

Price & Availability↑

CloneID	ORa11518
Clone ID Related Accession (Same CDS sequence)	NM_001100851.1
Accession Version	NM_001100851.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5571bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-03-14
Organism	Rattus norvegicus(Norway rat)
Product	histone-lysine N-methyltransferase 2E
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AAHX01027561.1 and AAHX01027560.1. On or before Sep 8, 2012 this sequence version replaced XM_001059700.3, XM_231287.6. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGCATAG CGATCCCATT GGGGGTTGAT ACAACAGAAA CATCCTACTT GGAAATGGCT 
GCAGGCTCAG AACCAGAATC CGTAGAAGCT AGCCCTGTGG TAGTTGAGAA ATCCAACAGT 
TATCCCCACC AGTTATATAC CAGCAGCTCC CATCATTCAC ACAGCTACAT TGGTTTGCCC 
TATGCGGACC ATAATTATGG TGCTCGTCCT CCTCCAACAC CTCCAGCATC CCCGCCTCCA 
TCAGGTCTCA TTAGCAAAAA CGAAGTAGGC ATATTCACCA CTCCTCACTT TGACGAGACT 
TCCAGTGCTA CTACAATCAG CACGTCTGAA GATGGGAGCT ACGGCACTGA CGTGACCCGG 
TGCATATGTG GCTTTACACA CGATGACGGC TACATGATCT GCTGTGACAA ATGCAGTGTT 
TGGCAACATA TTGACTGCAT GGGGATTGAC AGGCAGCATA TTCCTGATAC ATATCTATGT 
GAACGTTGTC AGCCCAGGAG TTTGGATAAA GAGAGGGCAG TGCTACTGCA ACGCCGGAAA 
AGAGAAAATA TGTCAGATGG TGACACCAGT GCAACTGAAA GTGGCGATGA GGTCCCCGTG 
GAATTATACA CTGCATTCCA GCACACTCCA ACTTCAATCA CCTTAGCTGC TTCCAGAGCC 
CCCAAGGTCA CTGATAAGAG GAGGAAAAAA AGTGGGGAGA AAGAACAAAA CTTTCCAAAA 
TGTAAAAAAG CATTTCGTGA AGGATCTAGG AAATCATCAA GGGTTAAGGG TTCAGCACCA 
GAAATTGATC CTTCGTCTGA TGGTTCAAAT TTTGTATGGG AGACAAAAAT CAAAGCATGG 
ATGGATCGCT ACGAAGAAGC AAATAATAAC CAGTATAGCG AGGGCGTGCA GAGAGAGGCG 
CAAAGACTAG CGCAAAGACT CGGCAGTGGG AGTGACAGCA AAGACATGAG TAAACCAGAA 
TTGAGTGTCA ACAGCTCCCT CTTCAGACCT CCTGTAGAGA GCCATATACA GAAGAATAAA 
AAAATTCTGA AATCTGCCAA AGACTTGCCT CCTGATGCAC TTATCATTGA ATACAGAGGA 
AAGTTTATGC TGAGAGAACA GTTTGAAGCA AATGGATATT TCTTTAAAAG GCCATACCCT 
TTTGTTTTAT TCTACTCCAA GTTCCATGGG CTAGAAATGT GTGTTGATGC AAGGACTTTT 
GGGAATGAGG CTCGATTCAT CAGGCGTTCT TGTACACCGA ATGCAGAGGT GAGGCATGAA 
ATTGAAGAGG GGACCATACA TCTCTACATT TACTCTACAC AGAGTATTCC AAAAGGGACT 
GAAATTACTA TTGCCTTTGA TTTTGACTAT GGGAATTGTA AATACAAGGT GGACTGTGCG 
TGCCTCAAGG AAAATCCAGA GTGCCCTGTT CTAAAGCGCA GCTCAGAATC TACAGAAAAC 
ATTAATAGTG GTTATGAGAC CAGAAGAAAA AAAGGAAAAA AAGAGAAAGA CATTTCAAAA 
GAAAAAGATA TACAAAATCA AAATATTACT TTGGACTGTG AAGGAACAAA CAACAAAATA 
AGGAGTCCAG AAACAAAACA GAGAAAGCTT TCTCCATTAA GGCTGTCAGT GTCCAACAAC 
CAGGAACCAG ATTTTATTGA TGATATGGAA GAAAAAACTC CTATTAGCAC TGAAGTTGAA 
ATGGAATCAG AGGAGCAGAT TGCGGAGAGG AGGAGGAAGA TGACAAGAGA AGAAAGAAAA 
ATGGAAGCAA TTCTGCAAGC TTTTGCCAGA CTTGAAAAGA GAGAGAAGAG ACGAGAACAA 
GCTTTGGAAA GGATCAGCAC AGCCAAGACG GAAGTCAGGC CCGAGTGTAA GGAGTCGCAG 
GTCATCTCTG ACGCTGACGT GGTCCAGGAA CAAGTAAAGG AAGAAACTGC TATCAAGCCA 
ACTGCTGCCA AAGTGAACAG AACTAAGCAG AGAAAAAGCT TTTCTCGTAG TAGGACTCAT 
ATTGGACAGC AGCGTCGGAG ACACAGAACC GTCAGCATGT GTTCAGACAT ACAGCCATCC 
TCTCCCGACG TTGAAGTTAT GTCACAACAG AATGATATTG AAAACACTGT GCTTGCTATA 
GAACCAGAAA CTGAAGCTGC AGTAGCAGAG ATAATCACTG AAGTGGAAGC TCCAGCACTT 
AATAAATGTC CCACAAAGTA CCCCAAAACA AAGAAGCACT TGGTCAATGA ATGGTTAAGT 
GAGAAGAATG AGAAGACAGG AAAACCTTCA GACAGCCTTT CAGAAAGGCC TCTGCGCATA 
ACTACAGATC CAGAGGTGTT AGCTACACAG CTCAATTCTT TGCCAGGTCT CACTTACAGC 
CCCCATGTAT ACTCTACTCC TAAGCATTAC ATTAGATTCA CATCACCATT CCTTTCGGAA 
AAAAAGAGAA GAAAAGAAAC TACTGAAAAC ATTTCTGGCT CATGCAAAAA GCGATGGTTG 
AAGCAAGCCC TGGAAGAAGA AAATTCAACA GTTTTACACA GATATCATTC ACCGTGTCAG 
GAAAGGCCCA GGAGCCCTAC AGTTAATGGT GAAAGTAAAA GTCCCCTGCT GCTGAGCGAC 
AGCTGCTCCC TCCCAGATTT AACCACACCA CTAAAAAAGC GAAGACTTTA CCAATTGTTA 
GACTCGGCTT ACTCAGAAAG CTCCACCCCT ACTCCTTCAC CATACGCCAC CCCAACTCAC 
ACGGACATCA CTCCTACCGA CCCAGCATTT GCTACTCCCC CACGGATCAA ATCAGATGAT 
GAAACTTACA GAAATAGTTA TAAACCCATA TATTCACCAG TGACCCCAGT GACCCCTGGC 
ACACCAGGAA ACACCATGCA CTTTGAGAAT ATTTCTTCCC CAGAAAGTTC TCCAGAAATA 
AAGAGATGCA CTTACAATCA AGAGGGATAT GACCGACCTT CAACCATGCT AACGCTGGGG 
CCTTTTAGAA ATTCCAACCT AAATGAGCTA GGCCTGCAAG AAATAAAGAC CATTGGTTAC 
ACCAGCCCCA GGAGCAGGAC TGAGGTTAAT AGGCCTTGCC CAGGAGAAAA GGAGTCTGTG 
TCAGACCTTC AACTGGGACT CGATGCAGTC GAGCCAGCTG CCTTACAGAA AACCATGGAA 
ACCCCAGCCC ATGACAGGAC TGAGCCCAGC AGCCAACTGG ATTCGACCCA CTCTGGACGA 
GGCACAATGT ATTCATCCTG GGTAAAGAGT CCTGACAGAA CAGGAGTTAA CTTCTCAGTA 
AACTCCAACT TGAGGGACTT AACACCCTCT CATCAGTTGG AGATTGGAGG CGGCTTCCGA 
ATCAGTGAGT CCAAGTGCCT GACGCAGGAT GATGCTAGAG GCATGTTTAT GGAGACAGCT 
GTCTTTTGTC CCTCTGAAGA TGGGCTTGTC TCTGGTTTTG GACGGACTGT TAATGACAGT 
TTGATCGACG GGAGCTGCAC GCCCCAGAAT CCACCACAAA AGAAAAAGGT CTCTCTACTA 
GAATACCGTA AGAGACAACG TGAAGCTAGG AAGAGTGGTT CTAAGCCAGA GAACCTTGCT 
TTGATTAGTG TGTCACCTCA CCCAAGTGGG ACTCTAAGCA GCAGTGGCGA TGGCTGTGTC 
CACAGCAGTG AGAACGGGGA GCAGCCAGAA AACCGGGCTA GCTTGCCTTT AGCACCGCCA 
GCTGCCGCCT GCACCGCCTC CTGTGAAGAA GGCAGCAGTG ACTGTCCTGT CAGAGACGCC 
AACCCCACTG AGAAGACAGA CCCAGAAGTT CAGTGGACTG CTTCCACCTC AGTGGAGCAA 
GTGAGAGAGA GAAGCTATCA GAGAGCGTTA TTGCTCAGTG ACCACCGCAA AGACAAAGAC 
GGCGGGGGAG AGTCACCATG TGTCTCATGT TCACCGAGTC ATGTTCAGTC TTCACCTTCA 
TCTCATTCAA ACCACATTCC CCAGGTGCCC GCTCAGAGCC TAGCCCCTCC TTTGACTGAA 
CCTATGGCAG ACCTTGATCC TGAAGGTACA GAAGCCACAA GTACAAGTGA ATGTCCATCC 
CCTGACACTT CTCAGAGCCC TTCTAAAACA AGCAAGCCTG GTTCACCAGG GCCAATCAAT 
CCTGCTCAGT CACATGGGAA AATGCTCACA AAACCAGATT CCCACTGGGA GGCAACTGCC 
ACTGTATCAG AAGCTGAGAG CAGTGTTCAC CTAAAACCAG AGCTTCAGCA AAAACAGCTG 
TCAAGTAACA CCCCAGCACT TTCAAAGAAC CATCCTCCTC AGGCCCACGT TCGAAATGCA 
AACGATCAAC TTCCGCAAAA GCTGCCTTCT GCACCAACAA AATTGCACTG TCCTCCGTCC 
CCTCACACAG AAAACCCTCC CCAGTCCTCC ACGCCTCACA CGCCTGTGCA GCATGGTTAC 
CTCTCACCAA AGCCTCCTTC ACAGCACCTA GGATCTCCCT TCAGGCCTCA CCATTCACAG 
TCACCTCAAG TCGGAACTCC TCAACGCGAG ACTCCGAGAA GTTTGTATCC AGCGGCACAG 
AACCTTCAAG CTAATGCTCA GCAGGCACCT TGTGGAGCGT TATTTACCCA GACACCCTCA 
GGCCAGTCCT CGGCAGCATA CAGTCCGTTC AACCAACAGG CTCTGAGCAG CCCGGCCCCG 
CCCCCCCCAC CCCCTCCGCC TCCTTCAGCA TACTATCAAA ACCAGCAGCC CTCTGCAAAC 
TTTCAGAACT ACAATCAGCT AAAAGGTAGT CTTTCCCAAC AAACTGTGTT TACATCTGGA 
CCAAATCAAG CACTTCCTGG CACCACAAGC CAGCCATCCG TTCCTGGACA CCATGTTACT 
CCGGGCCATT TTCTGCCGTC TCAAAACCCT ACCATTCACC ATCAAACTGC TGCTGCTGTG 
GTCCCACCCC CGCCTCCACC ACCGCCTGCT CCAGGACCTC ACCTCGTACA ACAGCCAAAC 
TCACATCAGC AGCACTCTGT AGCACATGTA GTTGGGACAG TTCATGCTGT CACCCCTGGG 
TCACACATTC ATTCTCAAAC TGTTGGACAC CATTTACCAC CACCTCCTCC ACCTCCTGGT 
CCTGCCCCAC ATCACCATCC TCCACCCCAT CCTTCCACAG GACTGCAAAG TCTGCAAGCA 
CAACACCAGC ATGTAGTAAA CTCAGCACCC CCACCGCCCC CTCCTCCTCC TCCTCCAGCC 
AGTGTTCTGG TTTCTGGGCA TCATTCAGCA TCAGGTCAAG CCTTACATCA CCCACCTCAT 
CAAGGACCTC CACTTTTTCC TGCGAGTGTT CATCCGGCTG TACCGCCGTA CCCCTCACAA 
GCCACACATC ACACCACTTT GGGACCGGGA CCCCAACACC AGCCTTCCGG AACAGGGCCA 
CATTGTCCAT TACCAGTTCC AGGTCCTCAT CTCCAGCCCC AAGGACCAAA CAGTATTCCA 
ACACCTACTG CTTCAGGGTT CTGTCCTCAT CCTCACCCTG GCTCTGTGGC CCTGCCACAT 
GGGGTGCAAG GACCTCAGCA GGCATCGCCA GTGCCTGGAC AGATTCCAAT TCACAGAGCA 
CAGGTGCCAC CAACATTTCA AAACAATTAC CACGGTTCAG GGTGGCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094321.1
CDS	471..6041
Translation	MSIAIPLGVDTTETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSGLISKNEVGIFTTPHFDETSSATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRSLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLAASRAPKVTDKRRKKSGEKEQNFPKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFVWETKIKAWMDRYEEANNNQYSEGVQREAQRLAQRLGSGSDSKDMSKPELSVNSSLFRPPVESHIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHEIEEGTIHLYIYSTQSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESTENINSGYETRRKKGKKEKDISKEKDIQNQNITLDCEGTNNKIRSPETKQRKLSPLRLSVSNNQEPDFIDDMEEKTPISTEVEMESEEQIAERRRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVRPECKESQVISDADVVQEQVKEETAIKPTAAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDVEVMSQQNDIENTVLAIEPETEAAVAEIITEVEAPALNKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDSLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKKRRKETTENISGSCKKRWLKQALEEENSTVLHRYHSPCQERPRSPTVNGESKSPLLLSDSCSLPDLTTPLKKRRLYQLLDSAYSESSTPTPSPYATPTHTDITPTDPAFATPPRIKSDDETYRNSYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRCTYNQEGYDRPSTMLTLGPFRNSNLNELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAVEPAALQKTMETPAHDRTEPSSQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLTPSHQLEIGGGFRISESKCLTQDDARGMFMETAVFCPSEDGLVSGFGRTVNDSLIDGSCTPQNPPQKKKVSLLEYRKRQREARKSGSKPENLALISVSPHPSGTLSSSGDGCVHSSENGEQPENRASLPLAPPAAACTASCEEGSSDCPVRDANPTEKTDPEVQWTASTSVEQVRERSYQRALLLSDHRKDKDGGGESPCVSCSPSHVQSSPSSHSNHIPQVPAQSLAPPLTEPMADLDPEGTEATSTSECPSPDTSQSPSKTSKPGSPGPINPAQSHGKMLTKPDSHWEATATVSEAESSVHLKPELQQKQLSSNTPALSKNHPPQAHVRNANDQLPQKLPSAPTKLHCPPSPHTENPPQSSTPHTPVQHGYLSPKPPSQHLGSPFRPHHSQSPQVGTPQRETPRSLYPAAQNLQANAQQAPCGALFTQTPSGQSSAAYSPFNQQALSSPAPPPPPPPPPSAYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQPSVPGHHVTPGHFLPSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGTVHAVTPGSHIHSQTVGHHLPPPPPPPGPAPHHHPPPHPSTGLQSLQAQHQHVVNSAPPPPPPPPPPASVLVSGHHSASGQALHHPPHQGPPLFPASVHPAVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVPGPHLQPQGPNSIPTPTASGFCPHPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH

Target ORF information:

RefSeq Version	NM_001100851.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine methyltransferase 2E (Kmt2e), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100851.1

ORF Insert Sequence:

ATGAGCATAG CGATCCCATT GGGGGTTGAT ACAACAGAAA CATCCTACTT GGAAATGGCT 
GCAGGCTCAG AACCAGAATC CGTAGAAGCT AGCCCTGTGG TAGTTGAGAA ATCCAACAGT 
TATCCCCACC AGTTATATAC CAGCAGCTCC CATCATTCAC ACAGCTACAT TGGTTTGCCC 
TATGCGGACC ATAATTATGG TGCTCGTCCT CCTCCAACAC CTCCAGCATC CCCGCCTCCA 
TCAGGTCTCA TTAGCAAAAA CGAAGTAGGC ATATTCACCA CTCCTCACTT TGACGAGACT 
TCCAGTGCTA CTACAATCAG CACGTCTGAA GATGGGAGCT ACGGCACTGA CGTGACCCGG 
TGCATATGTG GCTTTACACA CGATGACGGC TACATGATCT GCTGTGACAA ATGCAGTGTT 
TGGCAACATA TTGACTGCAT GGGGATTGAC AGGCAGCATA TTCCTGATAC ATATCTATGT 
GAACGTTGTC AGCCCAGGAG TTTGGATAAA GAGAGGGCAG TGCTACTGCA ACGCCGGAAA 
AGAGAAAATA TGTCAGATGG TGACACCAGT GCAACTGAAA GTGGCGATGA GGTCCCCGTG 
GAATTATACA CTGCATTCCA GCACACTCCA ACTTCAATCA CCTTAGCTGC TTCCAGAGCC 
CCCAAGGTCA CTGATAAGAG GAGGAAAAAA AGTGGGGAGA AAGAACAAAA CTTTCCAAAA 
TGTAAAAAAG CATTTCGTGA AGGATCTAGG AAATCATCAA GGGTTAAGGG TTCAGCACCA 
GAAATTGATC CTTCGTCTGA TGGTTCAAAT TTTGTATGGG AGACAAAAAT CAAAGCATGG 
ATGGATCGCT ACGAAGAAGC AAATAATAAC CAGTATAGCG AGGGCGTGCA GAGAGAGGCG 
CAAAGACTAG CGCAAAGACT CGGCAGTGGG AGTGACAGCA AAGACATGAG TAAACCAGAA 
TTGAGTGTCA ACAGCTCCCT CTTCAGACCT CCTGTAGAGA GCCATATACA GAAGAATAAA 
AAAATTCTGA AATCTGCCAA AGACTTGCCT CCTGATGCAC TTATCATTGA ATACAGAGGA 
AAGTTTATGC TGAGAGAACA GTTTGAAGCA AATGGATATT TCTTTAAAAG GCCATACCCT 
TTTGTTTTAT TCTACTCCAA GTTCCATGGG CTAGAAATGT GTGTTGATGC AAGGACTTTT 
GGGAATGAGG CTCGATTCAT CAGGCGTTCT TGTACACCGA ATGCAGAGGT GAGGCATGAA 
ATTGAAGAGG GGACCATACA TCTCTACATT TACTCTACAC AGAGTATTCC AAAAGGGACT 
GAAATTACTA TTGCCTTTGA TTTTGACTAT GGGAATTGTA AATACAAGGT GGACTGTGCG 
TGCCTCAAGG AAAATCCAGA GTGCCCTGTT CTAAAGCGCA GCTCAGAATC TACAGAAAAC 
ATTAATAGTG GTTATGAGAC CAGAAGAAAA AAAGGAAAAA AAGAGAAAGA CATTTCAAAA 
GAAAAAGATA TACAAAATCA AAATATTACT TTGGACTGTG AAGGAACAAA CAACAAAATA 
AGGAGTCCAG AAACAAAACA GAGAAAGCTT TCTCCATTAA GGCTGTCAGT GTCCAACAAC 
CAGGAACCAG ATTTTATTGA TGATATGGAA GAAAAAACTC CTATTAGCAC TGAAGTTGAA 
ATGGAATCAG AGGAGCAGAT TGCGGAGAGG AGGAGGAAGA TGACAAGAGA AGAAAGAAAA 
ATGGAAGCAA TTCTGCAAGC TTTTGCCAGA CTTGAAAAGA GAGAGAAGAG ACGAGAACAA 
GCTTTGGAAA GGATCAGCAC AGCCAAGACG GAAGTCAGGC CCGAGTGTAA GGAGTCGCAG 
GTCATCTCTG ACGCTGACGT GGTCCAGGAA CAAGTAAAGG AAGAAACTGC TATCAAGCCA 
ACTGCTGCCA AAGTGAACAG AACTAAGCAG AGAAAAAGCT TTTCTCGTAG TAGGACTCAT 
ATTGGACAGC AGCGTCGGAG ACACAGAACC GTCAGCATGT GTTCAGACAT ACAGCCATCC 
TCTCCCGACG TTGAAGTTAT GTCACAACAG AATGATATTG AAAACACTGT GCTTGCTATA 
GAACCAGAAA CTGAAGCTGC AGTAGCAGAG ATAATCACTG AAGTGGAAGC TCCAGCACTT 
AATAAATGTC CCACAAAGTA CCCCAAAACA AAGAAGCACT TGGTCAATGA ATGGTTAAGT 
GAGAAGAATG AGAAGACAGG AAAACCTTCA GACAGCCTTT CAGAAAGGCC TCTGCGCATA 
ACTACAGATC CAGAGGTGTT AGCTACACAG CTCAATTCTT TGCCAGGTCT CACTTACAGC 
CCCCATGTAT ACTCTACTCC TAAGCATTAC ATTAGATTCA CATCACCATT CCTTTCGGAA 
AAAAAGAGAA GAAAAGAAAC TACTGAAAAC ATTTCTGGCT CATGCAAAAA GCGATGGTTG 
AAGCAAGCCC TGGAAGAAGA AAATTCAACA GTTTTACACA GATATCATTC ACCGTGTCAG 
GAAAGGCCCA GGAGCCCTAC AGTTAATGGT GAAAGTAAAA GTCCCCTGCT GCTGAGCGAC 
AGCTGCTCCC TCCCAGATTT AACCACACCA CTAAAAAAGC GAAGACTTTA CCAATTGTTA 
GACTCGGCTT ACTCAGAAAG CTCCACCCCT ACTCCTTCAC CATACGCCAC CCCAACTCAC 
ACGGACATCA CTCCTACCGA CCCAGCATTT GCTACTCCCC CACGGATCAA ATCAGATGAT 
GAAACTTACA GAAATAGTTA TAAACCCATA TATTCACCAG TGACCCCAGT GACCCCTGGC 
ACACCAGGAA ACACCATGCA CTTTGAGAAT ATTTCTTCCC CAGAAAGTTC TCCAGAAATA 
AAGAGATGCA CTTACAATCA AGAGGGATAT GACCGACCTT CAACCATGCT AACGCTGGGG 
CCTTTTAGAA ATTCCAACCT AAATGAGCTA GGCCTGCAAG AAATAAAGAC CATTGGTTAC 
ACCAGCCCCA GGAGCAGGAC TGAGGTTAAT AGGCCTTGCC CAGGAGAAAA GGAGTCTGTG 
TCAGACCTTC AACTGGGACT CGATGCAGTC GAGCCAGCTG CCTTACAGAA AACCATGGAA 
ACCCCAGCCC ATGACAGGAC TGAGCCCAGC AGCCAACTGG ATTCGACCCA CTCTGGACGA 
GGCACAATGT ATTCATCCTG GGTAAAGAGT CCTGACAGAA CAGGAGTTAA CTTCTCAGTA 
AACTCCAACT TGAGGGACTT AACACCCTCT CATCAGTTGG AGATTGGAGG CGGCTTCCGA 
ATCAGTGAGT CCAAGTGCCT GACGCAGGAT GATGCTAGAG GCATGTTTAT GGAGACAGCT 
GTCTTTTGTC CCTCTGAAGA TGGGCTTGTC TCTGGTTTTG GACGGACTGT TAATGACAGT 
TTGATCGACG GGAGCTGCAC GCCCCAGAAT CCACCACAAA AGAAAAAGGT CTCTCTACTA 
GAATACCGTA AGAGACAACG TGAAGCTAGG AAGAGTGGTT CTAAGCCAGA GAACCTTGCT 
TTGATTAGTG TGTCACCTCA CCCAAGTGGG ACTCTAAGCA GCAGTGGCGA TGGCTGTGTC 
CACAGCAGTG AGAACGGGGA GCAGCCAGAA AACCGGGCTA GCTTGCCTTT AGCACCGCCA 
GCTGCCGCCT GCACCGCCTC CTGTGAAGAA GGCAGCAGTG ACTGTCCTGT CAGAGACGCC 
AACCCCACTG AGAAGACAGA CCCAGAAGTT CAGTGGACTG CTTCCACCTC AGTGGAGCAA 
GTGAGAGAGA GAAGCTATCA GAGAGCGTTA TTGCTCAGTG ACCACCGCAA AGACAAAGAC 
GGCGGGGGAG AGTCACCATG TGTCTCATGT TCACCGAGTC ATGTTCAGTC TTCACCTTCA 
TCTCATTCAA ACCACATTCC CCAGGTGCCC GCTCAGAGCC TAGCCCCTCC TTTGACTGAA 
CCTATGGCAG ACCTTGATCC TGAAGGTACA GAAGCCACAA GTACAAGTGA ATGTCCATCC 
CCTGACACTT CTCAGAGCCC TTCTAAAACA AGCAAGCCTG GTTCACCAGG GCCAATCAAT 
CCTGCTCAGT CACATGGGAA AATGCTCACA AAACCAGATT CCCACTGGGA GGCAACTGCC 
ACTGTATCAG AAGCTGAGAG CAGTGTTCAC CTAAAACCAG AGCTTCAGCA AAAACAGCTG 
TCAAGTAACA CCCCAGCACT TTCAAAGAAC CATCCTCCTC AGGCCCACGT TCGAAATGCA 
AACGATCAAC TTCCGCAAAA GCTGCCTTCT GCACCAACAA AATTGCACTG TCCTCCGTCC 
CCTCACACAG AAAACCCTCC CCAGTCCTCC ACGCCTCACA CGCCTGTGCA GCATGGTTAC 
CTCTCACCAA AGCCTCCTTC ACAGCACCTA GGATCTCCCT TCAGGCCTCA CCATTCACAG 
TCACCTCAAG TCGGAACTCC TCAACGCGAG ACTCCGAGAA GTTTGTATCC AGCGGCACAG 
AACCTTCAAG CTAATGCTCA GCAGGCACCT TGTGGAGCGT TATTTACCCA GACACCCTCA 
GGCCAGTCCT CGGCAGCATA CAGTCCGTTC AACCAACAGG CTCTGAGCAG CCCGGCCCCG 
CCCCCCCCAC CCCCTCCGCC TCCTTCAGCA TACTATCAAA ACCAGCAGCC CTCTGCAAAC 
TTTCAGAACT ACAATCAGCT AAAAGGTAGT CTTTCCCAAC AAACTGTGTT TACATCTGGA 
CCAAATCAAG CACTTCCTGG CACCACAAGC CAGCCATCCG TTCCTGGACA CCATGTTACT 
CCGGGCCATT TTCTGCCGTC TCAAAACCCT ACCATTCACC ATCAAACTGC TGCTGCTGTG 
GTCCCACCCC CGCCTCCACC ACCGCCTGCT CCAGGACCTC ACCTCGTACA ACAGCCAAAC 
TCACATCAGC AGCACTCTGT AGCACATGTA GTTGGGACAG TTCATGCTGT CACCCCTGGG 
TCACACATTC ATTCTCAAAC TGTTGGACAC CATTTACCAC CACCTCCTCC ACCTCCTGGT 
CCTGCCCCAC ATCACCATCC TCCACCCCAT CCTTCCACAG GACTGCAAAG TCTGCAAGCA 
CAACACCAGC ATGTAGTAAA CTCAGCACCC CCACCGCCCC CTCCTCCTCC TCCTCCAGCC 
AGTGTTCTGG TTTCTGGGCA TCATTCAGCA TCAGGTCAAG CCTTACATCA CCCACCTCAT 
CAAGGACCTC CACTTTTTCC TGCGAGTGTT CATCCGGCTG TACCGCCGTA CCCCTCACAA 
GCCACACATC ACACCACTTT GGGACCGGGA CCCCAACACC AGCCTTCCGG AACAGGGCCA 
CATTGTCCAT TACCAGTTCC AGGTCCTCAT CTCCAGCCCC AAGGACCAAA CAGTATTCCA 
ACACCTACTG CTTCAGGGTT CTGTCCTCAT CCTCACCCTG GCTCTGTGGC CCTGCCACAT 
GGGGTGCAAG GACCTCAGCA GGCATCGCCA GTGCCTGGAC AGATTCCAAT TCACAGAGCA 
CAGGTGCCAC CAACATTTCA AAACAATTAC CACGGTTCAG GGTGGCATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.
PloS one11(11)e0165139(2016)
Mas-Y-Mas S,Barbon M,Teyssier C,D?m?n? H,Carvalho JE,Bird LE,Lebedev A,Fattori J,Schubert M,Dumas C,Bourguet W,le Maire A

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
PloS one10(12)e0145023(2015)
Ding X,Jiang W,Zhou P,Liu L,Wan X,Yuan X,Wang X,Chen M,Chen J,Yang J,Kong C,Li B,Peng C,Wong CC,Hou F,Zhang Y

Targeted silencing of MLL5? inhibits tumor growth and promotes gamma-irradiation sensitization in HPV16/18-associated cervical cancers.
Molecular cancer therapeutics13(11)2572-82(2014 Nov)
Nin DS,Yew CW,Tay SK,Deng LW

De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder.
Cell reports9(1)16-23(2014 Oct)
Dong S,Walker MF,Carriero NJ,DiCola M,Willsey AJ,Ye AY,Waqar Z,Gonzalez LE,Overton JD,Frahm S,Keaney JF 3rd,Teran NA,Dea J,Mandell JD,Hus Bal V,Sullivan CA,DiLullo NM,Khalil RO,Gockley J,Yuksel Z,Sertel SM,Ercan-Sencicek AG,Gupta AR,Mane SM,Sheldon M,Brooks AI,Roeder K,Devlin B,State MW,Wei L,Sanders SJ

Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study.
British journal of haematology166(4)540-9(2014 Aug)
Lucena-Araujo AR,Kim HT,Jacomo RH,Melo RA,Bittencourt R,Pasquini R,Pagnano K,Fagundes EM,de Lourdes Chauffaille M,Chiattone CS,Lima AS,Kwaan HC,Gallagher R,Niemeyer CM,Schrier SL,Tallman MS,Grimwade D,Ganser A,Berliner N,Ribeiro RC,Lo-Coco F,L?wenberg B,Sanz MA,Rego EM

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Kmt2e cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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