Dll4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dll4
Entrez Gene ID	311332
Full Name	delta like canonical Notch ligand 4
General protein information	Preferred Names delta like canonical Notch ligand 4 Names delta-like protein 4 delta-like 4 delta4 drosophila Delta homolog 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q35

mRNA and Protein(s)

mRNA	Protein	Name
XM_006234765.2	XP_006234827.1	delta-like protein 4 isoform X1
NM_001107760.1	NP_001101230.1	delta-like protein 4 precursor

Pathways from BioSystems

Homologies

	DLL4	XP_002804774.1
Canis lupus familiaris (dog)	DLL4	XP_858084.1
Gallus gallus (chicken)	DLL4	XP_421132.2
Danio rerio (zebrafish)	dll4	NP_001073304.1
Homo sapiens (human)	DLL4	NP_061947.1
Pan troglodytes (chimpanzee)	DLL4	XP_510318.2
Bos taurus (cattle)	DLL4	NP_001069247.1
Mus musculus (house mouse)	Dll4	NP_062327.2
Rattus norvegicus (Norway rat)	Dll4	NP_001101230.1
Xenopus tropicalis (tropical clawed frog)	dll4	XP_002939596.2

Gene Ontology
Bibliography

Related articles in PubMed

Notch-Tnf signalling is required for development and homeostasis of arterial valves.
Wang Y, Wu B, Farrar E, Lui W, Lu P, Zhang D, Alfieri CM, Mao K, Chu M, Yang D, Xu D, Rauchman M, Taylor V, Conway SJ, Yutzey KE, Butcher JT, Zhou B
European heart journal38(9)675-686(2017 Mar)

MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.
Tian Y, Guo R, Shi B, Chen L, Yang L, Fu Q
Life sciences148220-8(2016 Mar)

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC
Science (New York, N.Y.)347(6224)847-53(2015 Feb)

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
Del Barrio MG, Taveira-Marques R, Muroyama Y, Yuk DI, Li S, Wines-Samuelson M, Shen J, Smith HK, Xiang M, Rowitch D, Richardson WD
Development (Cambridge, England)134(19)3427-36(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Down-regulation of DLL4 expression is involved in chondrogenic differentiation of mesenchymal stem cells.
Title: MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.

DLL4 expression increased in ischemic tissues and DLL4 expression was upregulated in capillary endothelial cells after ischemia.
Title: Inhibition of the Notch Pathway Promotes Flap Survival by Inducing Functional Neoangiogenesis.

The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Title: Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

Data suggest that DLL4, NOTCH1, and NOTCH4 are expressed in nuclei of small/large luteal cells of corpora lutea (CL) from pregnant rats and that luteolytic hormone PGF2alpha decreases the CL mRNA and protein expression of these NOTCH family members.
Title: Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat.

The following Dll4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dll4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05893	NM_001107760.1 Latest version!	Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$405.30 $579.00
ORa26226	XM_006234765.2 Latest version!	Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dll4 ( NM_001107760.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101230.1 Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), mRNA.

Price & Availability↑

CloneID	ORa05893
Clone ID Related Accession (Same CDS sequence)	NM_001107760.1
Accession Version	NM_001107760.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	delta-like protein 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473949.1. On or before Oct 4, 2007 this sequence version replaced XM_001080829.1, XM_230472.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906355, SAMN02642772 [ECO:0000348] ##Evidence-Data-END##

ATGACGCCTG GGTCCCGGAG CGCCTGTCGC TGGGCGCTAC TGCTGCTGGC GGTCCTGTGG 
CCGCAGCGCG CGGCGGGCTC CGGCATCTTC CAGTTGCGGC TGCAGGAGTT CGCCAACGAG 
CGCGGTATGC TGGCCAATGG GCGGCCCTGC GAGCCCGGCT GCCGGACTTT CTTCCGAATC 
TGCCTTAAGC ATTACCAGGC AACCTTCTCC GAGGGACCCT GCACCTTTGG CAATGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGTC ATCAGGGACA AGAATAGCGG CAGTGGTCGT 
AACCCTCTTC AATTGCCCTT CAATTTTACC TGGCCGGGAA CCTTCTCACT CAACATCCAA 
GCTTGGCACA CGCCGGGAGA CGACCTGCGG CCAGAGACTT CACCAGGAAA TTCACTTATC 
AGCCAAATCA TCATCCAAGG CTCCCTTGCT GTGGGTAAGA ATTGGAAATC AGATGAGCAA 
AATAACACCC TCACAAGACT GCGCTACTCT TACCGGGTCG TCTGCAGCGA CAACTACTAT 
GGAGATAGCT GTTCTCGCCT GTGCAAGAAG CGCGATGACC ACTTCGGACA TTATGAGTGC 
CAACCAGATG GCAGCCTGTC CTGCCTGCCG GGCTGGACTG GGAAATACTG TGATCAGCCT 
ATATGTCTTT CTGGCTGTCA TGAGCAGAAT GGCTACTGCA GCAAGCCAGA TGAGTGCAAC 
TGCCGTCCAG GTTGGCAGGG CCCCTTATGC AATGAATGTA TCCCCCACAA TGGCTGTCGT 
CATGGCACCT GCACCATCCC CTGGCAATGT GCCTGCGATG AGGGCTGGGG AGGTCTGTTT 
TGTGACCAAG ATCTTAATTA CTGCACTCAC CACTCTCCGT GCAAGAATGG ATCAACTTGC 
TCCAACAGTG GGCCGAGGGG CTATACCTGC ACCTGTCTCC CAGGCTACAC TGGTGAGCAC 
TGTGAGCTGG AACTCAGCAA GTGTGCCAGC AACCCCTGTC GAAATGGTGG CAGCTGTAAG 
GACCATGAGA ATAGCTACCA CTGCCTGTGT CCCCCGGGCT ACTATGGCCA GCACTGTGAA 
CACAGTACCT TGACCTGTGC GGATTCACCC TGCTTCAATG GAGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAGTTATGC CTGCGAGTGT CCCCCTAACT TCACTGGGTC CAACTGTGAG 
AAGAAAGTTG ACAGGTGTAC CAGCAACCCC TGTGCCAATG GAGGTCAGTG CCTGAACAGA 
GGTCCAAGCC GGACCTGCCG CTGTCGACCT GGATTCACAG GCACCCACTG TGAACTGCAC 
ATCAGCGATT GTGCCCGAAG CCCTTGTGCC CATGGGGGCA CTTGCCACGA TCTGGAGAAC 
GGGCCTGTGT GCACCTGCCC TGCTGGCTTT TCTGGCAGGC GCTGCGAGGT GCGGATAACC 
AACGACGCCT GTGCCTCAGG ACCCTGCTTC AATGGGGCCA CTTGCTACAC TGGCCTCTCC 
CCAAACAACT TTGTCTGCAA CTGTCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTTCCC 
GTGGGCTTGC CACCCAGCTT CCCCTGGGTA GCTGTCTCCC TGGGTGTGGG GCTGGTGGTA 
CTGCTGGTGT TGCTGGTCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGGAGGCCC 
GATGACGACA GCAGGGAAGC CATGAACAAT TTGTCAGACT TCCAGAAGGA CAACCTAATC 
CCTGCTGCCC AGCTCAAGAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA TTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACTGCAGAAC CACACACTGG ACTATAATCT GGCCCCAGGA 
TTCCTGGGGC GGGGGAGCAC GCCTGGGAAG TATCCTCACA GCGACAAGAG TTTAGGAGAG 
AAGGTGCCAC TTCGGTTACA CAGTGAAAAG CCGGCATGTC GAATATCAGC GATATGCTCC 
CCCAGGGACT CTATGTACCA GTCAGTATGT TTGATATCAG AAGAGAGGAA CGAATGTGTC 
ATTGCCACAG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101230.1
CDS	316..2373
Translation	MTPGSRSACRWALLLLAVLWPQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV

Target ORF information:

RefSeq Version	NM_001107760.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107760.1

ORF Insert Sequence:

ATGACGCCTG GGTCCCGGAG CGCCTGTCGC TGGGCGCTAC TGCTGCTGGC GGTCCTGTGG 
CCGCAGCGCG CGGCGGGCTC CGGCATCTTC CAGTTGCGGC TGCAGGAGTT CGCCAACGAG 
CGCGGTATGC TGGCCAATGG GCGGCCCTGC GAGCCCGGCT GCCGGACTTT CTTCCGAATC 
TGCCTTAAGC ATTACCAGGC AACCTTCTCC GAGGGACCCT GCACCTTTGG CAATGTCTCC 
ACGCCGGTAT TGGGCACCAA CTCCTTCGTC ATCAGGGACA AGAATAGCGG CAGTGGTCGT 
AACCCTCTTC AATTGCCCTT CAATTTTACC TGGCCGGGAA CCTTCTCACT CAACATCCAA 
GCTTGGCACA CGCCGGGAGA CGACCTGCGG CCAGAGACTT CACCAGGAAA TTCACTTATC 
AGCCAAATCA TCATCCAAGG CTCCCTTGCT GTGGGTAAGA ATTGGAAATC AGATGAGCAA 
AATAACACCC TCACAAGACT GCGCTACTCT TACCGGGTCG TCTGCAGCGA CAACTACTAT 
GGAGATAGCT GTTCTCGCCT GTGCAAGAAG CGCGATGACC ACTTCGGACA TTATGAGTGC 
CAACCAGATG GCAGCCTGTC CTGCCTGCCG GGCTGGACTG GGAAATACTG TGATCAGCCT 
ATATGTCTTT CTGGCTGTCA TGAGCAGAAT GGCTACTGCA GCAAGCCAGA TGAGTGCAAC 
TGCCGTCCAG GTTGGCAGGG CCCCTTATGC AATGAATGTA TCCCCCACAA TGGCTGTCGT 
CATGGCACCT GCACCATCCC CTGGCAATGT GCCTGCGATG AGGGCTGGGG AGGTCTGTTT 
TGTGACCAAG ATCTTAATTA CTGCACTCAC CACTCTCCGT GCAAGAATGG ATCAACTTGC 
TCCAACAGTG GGCCGAGGGG CTATACCTGC ACCTGTCTCC CAGGCTACAC TGGTGAGCAC 
TGTGAGCTGG AACTCAGCAA GTGTGCCAGC AACCCCTGTC GAAATGGTGG CAGCTGTAAG 
GACCATGAGA ATAGCTACCA CTGCCTGTGT CCCCCGGGCT ACTATGGCCA GCACTGTGAA 
CACAGTACCT TGACCTGTGC GGATTCACCC TGCTTCAATG GAGGCTCCTG CCGGGAGCGC 
AACCAGGGGG CCAGTTATGC CTGCGAGTGT CCCCCTAACT TCACTGGGTC CAACTGTGAG 
AAGAAAGTTG ACAGGTGTAC CAGCAACCCC TGTGCCAATG GAGGTCAGTG CCTGAACAGA 
GGTCCAAGCC GGACCTGCCG CTGTCGACCT GGATTCACAG GCACCCACTG TGAACTGCAC 
ATCAGCGATT GTGCCCGAAG CCCTTGTGCC CATGGGGGCA CTTGCCACGA TCTGGAGAAC 
GGGCCTGTGT GCACCTGCCC TGCTGGCTTT TCTGGCAGGC GCTGCGAGGT GCGGATAACC 
AACGACGCCT GTGCCTCAGG ACCCTGCTTC AATGGGGCCA CTTGCTACAC TGGCCTCTCC 
CCAAACAACT TTGTCTGCAA CTGTCCTTAT GGCTTTGTGG GCAGCCGCTG CGAGTTTCCC 
GTGGGCTTGC CACCCAGCTT CCCCTGGGTA GCTGTCTCCC TGGGTGTGGG GCTGGTGGTA 
CTGCTGGTGT TGCTGGTCAT GGTGGCAGTG GCTGTGCGGC AGCTGCGGCT TCGGAGGCCC 
GATGACGACA GCAGGGAAGC CATGAACAAT TTGTCAGACT TCCAGAAGGA CAACCTAATC 
CCTGCTGCCC AGCTCAAGAA CACAAACCAG AAGAAGGAGC TGGAAGTGGA TTGTGGCCTG 
GACAAGTCCA ACTGTGGCAA ACTGCAGAAC CACACACTGG ACTATAATCT GGCCCCAGGA 
TTCCTGGGGC GGGGGAGCAC GCCTGGGAAG TATCCTCACA GCGACAAGAG TTTAGGAGAG 
AAGGTGCCAC TTCGGTTACA CAGTGAAAAG CCGGCATGTC GAATATCAGC GATATGCTCC 
CCCAGGGACT CTATGTACCA GTCAGTATGT TTGATATCAG AAGAGAGGAA CGAATGTGTC 
ATTGCCACAG AGGTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dll4 ( XM_006234765.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234827.1 Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26226
Clone ID Related Accession (Same CDS sequence)	XM_006234765.2
Accession Version	XM_006234765.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	delta-like protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006234765.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGCCTG GGTCCCGGAG CGCCTGTCGC TGGGCGCTAC TGCTGCTGGC GGTCCTGTGG 
CCGCAGCAGC GCGCGGCGGG CTCCGGCATC TTCCAGTTGC GGCTGCAGGA GTTCGCCAAC 
GAGCGCGGTA TGCTGGCCAA TGGGCGGCCC TGCGAGCCCG GCTGCCGGAC TTTCTTCCGA 
ATCTGCCTTA AGCATTACCA GGCAACCTTC TCCGAGGGAC CCTGCACCTT TGGCAATGTC 
TCCACGCCGG TATTGGGCAC CAACTCCTTC GTCATCAGGG ACAAGAATAG CGGCAGTGGT 
CGTAACCCTC TTCAATTGCC CTTCAATTTT ACCTGGCCGG GAACCTTCTC ACTCAACATC 
CAAGCTTGGC ACACGCCGGG AGACGACCTG CGGCCAGAGA CTTCACCAGG AAATTCACTT 
ATCAGCCAAA TCATCATCCA AGGCTCCCTT GCTGTGGGTA AGAATTGGAA ATCAGATGAG 
CAAAATAACA CCCTCACAAG ACTGCGCTAC TCTTACCGGG TCGTCTGCAG CGACAACTAC 
TATGGAGATA GCTGTTCTCG CCTGTGCAAG AAGCGCGATG ACCACTTCGG ACATTATGAG 
TGCCAACCAG ATGGCAGCCT GTCCTGCCTG CCGGGCTGGA CTGGGAAATA CTGTGATCAG 
CCTATATGTC TTTCTGGCTG TCATGAGCAG AATGGCTACT GCAGCAAGCC AGATGAGTGC 
AACTGCCGTC CAGGTTGGCA GGGCCCCTTA TGCAATGAAT GTATCCCCCA CAATGGCTGT 
CGTCATGGCA CCTGCACCAT CCCCTGGCAA TGTGCCTGCG ATGAGGGCTG GGGAGGTCTG 
TTTTGTGACC AAGATCTTAA TTACTGCACT CACCACTCTC CGTGCAAGAA TGGATCAACT 
TGCTCCAACA GTGGGCCGAG GGGCTATACC TGCACCTGTC TCCCAGGCTA CACTGGTGAG 
CACTGTGAGC TGGAACTCAG CAAGTGTGCC AGCAACCCCT GTCGAAATGG TGGCAGCTGT 
AAGGACCATG AGAATAGCTA CCACTGCCTG TGTCCCCCGG GCTACTATGG CCAGCACTGT 
GAACACAGTA CCTTGACCTG TGCGGATTCA CCCTGCTTCA ATGGAGGCTC CTGCCGGGAG 
CGCAACCAGG GGGCCAGTTA TGCCTGCGAG TGTCCCCCTA ACTTCACTGG GTCCAACTGT 
GAGAAGAAAG TTGACAGGTG TACCAGCAAC CCCTGTGCCA ATGGAGGTCA GTGCCTGAAC 
AGAGGTCCAA GCCGGACCTG CCGCTGTCGA CCTGGATTCA CAGGCACCCA CTGTGAACTG 
CACATCAGCG ATTGTGCCCG AAGCCCTTGT GCCCATGGGG GCACTTGCCA CGATCTGGAG 
AACGGGCCTG TGTGCACCTG CCCTGCTGGC TTTTCTGGCA GGCGCTGCGA GGTGCGGATA 
ACCAACGACG CCTGTGCCTC AGGACCCTGC TTCAATGGGG CCACTTGCTA CACTGGCCTC 
TCCCCAAACA ACTTTGTCTG CAACTGTCCT TATGGCTTTG TGGGCAGCCG CTGCGAGTTT 
CCCGTGGGCT TGCCACCCAG CTTCCCCTGG GTAGCTGTCT CCCTGGGTGT GGGGCTGGTG 
GTACTGCTGG TGTTGCTGGT CATGGTGGCA GTGGCTGTGC GGCAGCTGCG GCTTCGGAGG 
CCCGATGACG ACAGCAGGGA AGCCATGAAC AATTTGTCAG ACTTCCAGAA GGACAACCTA 
ATCCCTGCTG CCCAGCTCAA GAACACAAAC CAGAAGAAGG AGCTGGAAGT GGATTGTGGC 
CTGGACAAGT CCAACTGTGG CAAACTGCAG AACCACACAC TGGACTATAA TCTGGCCCCA 
GGATTCCTGG GGCGGGGGAG CACGCCTGGG AAGTATCCTC ACAGCGACAA GAGTTTAGGA 
GAGAAGGTGC CACTTCGGTT ACACAGTGAA AAGCCGGCAT GTCGAATATC AGCGATATGC 
TCCCCCAGGG ACTCTATGTA CCAGTCAGTA TGTTTGATAT CAGAAGAGAG GAACGAATGT 
GTCATTGCCA CAGAGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234827.1
CDS	324..2384
Translation	MTPGSRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV

Target ORF information:

RefSeq Version	XM_006234765.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus delta like canonical Notch ligand 4 (Dll4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234765.2

ORF Insert Sequence:

ATGACGCCTG GGTCCCGGAG CGCCTGTCGC TGGGCGCTAC TGCTGCTGGC GGTCCTGTGG 
CCGCAGCAGC GCGCGGCGGG CTCCGGCATC TTCCAGTTGC GGCTGCAGGA GTTCGCCAAC 
GAGCGCGGTA TGCTGGCCAA TGGGCGGCCC TGCGAGCCCG GCTGCCGGAC TTTCTTCCGA 
ATCTGCCTTA AGCATTACCA GGCAACCTTC TCCGAGGGAC CCTGCACCTT TGGCAATGTC 
TCCACGCCGG TATTGGGCAC CAACTCCTTC GTCATCAGGG ACAAGAATAG CGGCAGTGGT 
CGTAACCCTC TTCAATTGCC CTTCAATTTT ACCTGGCCGG GAACCTTCTC ACTCAACATC 
CAAGCTTGGC ACACGCCGGG AGACGACCTG CGGCCAGAGA CTTCACCAGG AAATTCACTT 
ATCAGCCAAA TCATCATCCA AGGCTCCCTT GCTGTGGGTA AGAATTGGAA ATCAGATGAG 
CAAAATAACA CCCTCACAAG ACTGCGCTAC TCTTACCGGG TCGTCTGCAG CGACAACTAC 
TATGGAGATA GCTGTTCTCG CCTGTGCAAG AAGCGCGATG ACCACTTCGG ACATTATGAG 
TGCCAACCAG ATGGCAGCCT GTCCTGCCTG CCGGGCTGGA CTGGGAAATA CTGTGATCAG 
CCTATATGTC TTTCTGGCTG TCATGAGCAG AATGGCTACT GCAGCAAGCC AGATGAGTGC 
AACTGCCGTC CAGGTTGGCA GGGCCCCTTA TGCAATGAAT GTATCCCCCA CAATGGCTGT 
CGTCATGGCA CCTGCACCAT CCCCTGGCAA TGTGCCTGCG ATGAGGGCTG GGGAGGTCTG 
TTTTGTGACC AAGATCTTAA TTACTGCACT CACCACTCTC CGTGCAAGAA TGGATCAACT 
TGCTCCAACA GTGGGCCGAG GGGCTATACC TGCACCTGTC TCCCAGGCTA CACTGGTGAG 
CACTGTGAGC TGGAACTCAG CAAGTGTGCC AGCAACCCCT GTCGAAATGG TGGCAGCTGT 
AAGGACCATG AGAATAGCTA CCACTGCCTG TGTCCCCCGG GCTACTATGG CCAGCACTGT 
GAACACAGTA CCTTGACCTG TGCGGATTCA CCCTGCTTCA ATGGAGGCTC CTGCCGGGAG 
CGCAACCAGG GGGCCAGTTA TGCCTGCGAG TGTCCCCCTA ACTTCACTGG GTCCAACTGT 
GAGAAGAAAG TTGACAGGTG TACCAGCAAC CCCTGTGCCA ATGGAGGTCA GTGCCTGAAC 
AGAGGTCCAA GCCGGACCTG CCGCTGTCGA CCTGGATTCA CAGGCACCCA CTGTGAACTG 
CACATCAGCG ATTGTGCCCG AAGCCCTTGT GCCCATGGGG GCACTTGCCA CGATCTGGAG 
AACGGGCCTG TGTGCACCTG CCCTGCTGGC TTTTCTGGCA GGCGCTGCGA GGTGCGGATA 
ACCAACGACG CCTGTGCCTC AGGACCCTGC TTCAATGGGG CCACTTGCTA CACTGGCCTC 
TCCCCAAACA ACTTTGTCTG CAACTGTCCT TATGGCTTTG TGGGCAGCCG CTGCGAGTTT 
CCCGTGGGCT TGCCACCCAG CTTCCCCTGG GTAGCTGTCT CCCTGGGTGT GGGGCTGGTG 
GTACTGCTGG TGTTGCTGGT CATGGTGGCA GTGGCTGTGC GGCAGCTGCG GCTTCGGAGG 
CCCGATGACG ACAGCAGGGA AGCCATGAAC AATTTGTCAG ACTTCCAGAA GGACAACCTA 
ATCCCTGCTG CCCAGCTCAA GAACACAAAC CAGAAGAAGG AGCTGGAAGT GGATTGTGGC 
CTGGACAAGT CCAACTGTGG CAAACTGCAG AACCACACAC TGGACTATAA TCTGGCCCCA 
GGATTCCTGG GGCGGGGGAG CACGCCTGGG AAGTATCCTC ACAGCGACAA GAGTTTAGGA 
GAGAAGGTGC CACTTCGGTT ACACAGTGAA AAGCCGGCAT GTCGAATATC AGCGATATGC 
TCCCCCAGGG ACTCTATGTA CCAGTCAGTA TGTTTGATAT CAGAAGAGAG GAACGAATGT 
GTCATTGCCA CAGAGGTATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch-Tnf signalling is required for development and homeostasis of arterial valves.
European heart journal38(9)675-686(2017 Mar)
Wang Y,Wu B,Farrar E,Lui W,Lu P,Zhang D,Alfieri CM,Mao K,Chu M,Yang D,Xu D,Rauchman M,Taylor V,Conway SJ,Yutzey KE,Butcher JT,Zhou B

MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.
Life sciences148220-8(2016 Mar)
Tian Y,Guo R,Shi B,Chen L,Yang L,Fu Q

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Science (New York, N.Y.)347(6224)847-53(2015 Feb)
Luca VC,Jude KM,Pierce NW,Nachury MV,Fischer S,Garcia KC

A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
Development (Cambridge, England)134(19)3427-36(2007 Oct)
Del Barrio MG,Taveira-Marques R,Muroyama Y,Yuk DI,Li S,Wines-Samuelson M,Shen J,Smith HK,Xiang M,Rowitch D,Richardson WD

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Dll4 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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