Traf6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Traf6
Entrez Gene ID	311245
Full Name	TNF receptor associated factor 6
General protein information	Preferred Names TNF receptor associated factor 6 Names TNF receptor-associated factor 6 E3 ubiquitin-protein ligase TRAF6 RING-type E3 ubiquitin transferase TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q31

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107754.2	NP_001101224.1	TNF receptor-associated factor 6

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TRAF6	XP_001154136.1
Rattus norvegicus (Norway rat)	Traf6	NP_001101224.1
Danio rerio (zebrafish)	traf6	NP_001038217.1
Drosophila melanogaster (fruit fly)	Traf6	NP_511080.2
Xenopus tropicalis (tropical clawed frog)	traf6	NP_001008162.2
	TRAF6	NP_001129268.1
Bos taurus (cattle)	TRAF6	NP_001029833.1
Mus musculus (house mouse)	Traf6	NP_033450.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003004	XP_311879.5
Homo sapiens (human)	TRAF6	NP_665802.1
Canis lupus familiaris (dog)	TRAF6	XP_003432370.1
Gallus gallus (chicken)	TRAF6	XP_004941604.1

Gene Ontology
Bibliography

Related articles in PubMed

MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway.
He X, Zheng Y, Liu S, Shi S, Liu Y, He Y, Zhang C, Zhou X
Journal of cellular physiology233(3)2476-2488(2018 Mar)

Effect of N-Acetylserotonin on TLR-4 and MyD88 Expression during Intestinal Ischemia-Reperfusion in a Rat Model.
Sukhotnik I, Ben Shahar Y, Halabi S, Bitterman N, Dorfman T, Pollak Y, Coran A, Bitterman A
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie(2018 Jan)

Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.
Dou Y, Shen H, Feng D, Li H, Tian X, Zhang J, Wang Z, Chen G
Journal of neurochemistry142(3)478-492(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4, TRAF6, and p-IkappaBalpha, subsequently leading to decreased NF-kappaB p65 nuclear translocation.
Title: MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway.

showed that application of TRAF6 over-expression plasmid and genetic silencing siRNA could increase or decrease expression of TRAF6, respectively, and severely exacerbate or relieve EBI after SAH, including neuronal death, brain edema, and blood-brain barrier injury
Title: Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.

Consistent with cellular studies, icaritin downregulated TRAF6 and NFATc1 protein expression in CD11b(+) /Gr-1(-/low) osteoclast precursors
Title: TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid.

As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions.
Title: MicroRNA-146a Contributes to SCI Recovery via Regulating

MiR-146a regulates inflammatory macrophage infiltration in Polymyositis/Dermatomyositis by targeting TRAF6 and affecting the IL-17/ICAM-1 pathway.
Title: MiR-146a Regulates Inflammatory Infiltration by Macrophages in Polymyositis/Dermatomyositis by Targeting TRAF6 and Affecting IL-17/ICAM-1 Pathway.

The following Traf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Traf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12566	NM_001107754.2 Latest version!	Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Traf6 ( NM_001107754.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101224.1 Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.

Price & Availability↑

CloneID	ORa12566
Clone ID Related Accession (Same CDS sequence)	NM_001107754.2
Accession Version	NM_001107754.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1593bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	TNF receptor-associated factor 6
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC168921.1. On Sep 4, 2008 this sequence version replaced NM_001107754.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168921.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTCTCT TAAACTGTGA AAACAGCTGT GCGTCCAGCC AGTCTTCAAG CGACTGCTGT 
GCTGCCATGG CCAACTCCTG CAGTGCTGCC ATGAAAGATG ACAGTGTGAG TGGCTGTGTC 
AGCACGGGGA ACCTGTCCAG CTCCTTCATG GAGGAGATCC AGGGATATGA TGTGGAGTTT 
GACCCACCTT TGGAAAGCAA GTATGAGTGC CCCATCTGCT TGATGGCTTT ACGGGAAGCA 
GTGCAAACAC CATGTGGCCA CAGGTTCTGC AAAGCCTGCA TCACCAAGTC CATAAGGGAT 
GCAGGTCACA AGTGCCCAGT TGACAATGAA ATACTGCTGG AAAATCAACT GTTTCCTGAC 
AATTTTGCAA AGCGAGAGAT TCTTTCCCTG ACGGTAAAGT GTCCAAATAA AGGCTGTGTG 
CAAAAGATGG AGCTGAGACA TCTCGAGGAT CATCAAGTAC ATTGTGAATT CGCTCTAGTG 
ATTTGTCCCC AATGCCAACG TTTTTTCCAA AAGTGCCAGA TTAATAAACA CATTATCGAG 
GATTGTCCCA GGAGACAGGT TTCTTGTGTA AACTGTGCTG TGCCCATGCC GTATGAAGAG 
AAAGAGATCC ACGATCAAAG CTGTCCTCTG GCAAATATCA TCTGTGAATA CTGTGGTACA 
ATCCTCATAA GAGAACAGAT GCCTAATCAT TATGATCTAG ACTGCCCAAC AGCTCCAGTC 
CCCTGCACAT TCAGTGTGTT TGGCTGTCAC GAAAAGATGC AGAGGAATCA CTTGGCACGG 
CACTTGCAAG AGAACACCCA GTTGCACATG AGACTGTTGG CCCAGGCTGT TCATAATGTT 
AACCTCTCTT TGCGGCCATG CGATGCCTCC TCTCCATCCC GGGGATGTCG TCCTGAGGAC 
CCAAATTATG AGGAAACGGT CAAACAGTTG GAGGGGCGCC TAGTAAGACA GGACCATCAA 
ATCCGGGAGC TGACCGCCAA AATGGAAACG CAGAGCATGC ATGTGAGCGA GCTCAAGCGG 
ACCATTCGAA GCCTCGAGGA CAAAGTTGCC GAGATGGAAG CACAGCAGTG TAATGGCATT 
TACATTTGGA AGATTGGCAA CTTTGGGATG CACTTGAAAT CCCAAGAAGA GGAAAGACCT 
GTGGTCATTC ATAGCCCTGG ATTCTACACA GGCAGACCTG GGTACAAGCT GTGCATGCGC 
CTGCACCTCC AGCTACCGAC GGCTCAGCGC TGTGCAAACT ACATTTCCCT CTTTGTCCAC 
ACAATGCAAG GAGAGTATGA CAGCCACCTC CCCTGGCCCT TCCAGGGTAC AATACGCCTC 
ACGATCCTTG ATCAGTCTGA AGCAGTAATA AGGCAAAACC ACGAAGAGGT CATGGATGCT 
AAGCCAGAAC TGCTTGCCTT TCAGCGGCCC ACCATCCCAC GGAACCCCAA AGGTTTTGGC 
TATGTGACAT TCATGCACCT GGAAGCCTTA AGACAGGGAA CCTTCATCAA GGATGATACG 
TTATTAGTGC GCTGTGAAGT CTCTACCCGC TTTGACATGG GGGGCCTTCG GAAGGAGGGG 
TTCCAGCCAC GGAGTACTGA TGCAGGCGTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101224.1
CDS	191..1783
Translation	MSLLNCENSCASSQSSSDCCAAMANSCSAAMKDDSVSGCVSTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQGTFIKDDTLLVRCEVSTRFDMGGLRKEGFQPRSTDAGV

Target ORF information:

RefSeq Version	NM_001107754.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TNF receptor associated factor 6 (Traf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107754.2

ORF Insert Sequence:

ATGAGTCTCT TAAACTGTGA AAACAGCTGT GCGTCCAGCC AGTCTTCAAG CGACTGCTGT 
GCTGCCATGG CCAACTCCTG CAGTGCTGCC ATGAAAGATG ACAGTGTGAG TGGCTGTGTC 
AGCACGGGGA ACCTGTCCAG CTCCTTCATG GAGGAGATCC AGGGATATGA TGTGGAGTTT 
GACCCACCTT TGGAAAGCAA GTATGAGTGC CCCATCTGCT TGATGGCTTT ACGGGAAGCA 
GTGCAAACAC CATGTGGCCA CAGGTTCTGC AAAGCCTGCA TCACCAAGTC CATAAGGGAT 
GCAGGTCACA AGTGCCCAGT TGACAATGAA ATACTGCTGG AAAATCAACT GTTTCCTGAC 
AATTTTGCAA AGCGAGAGAT TCTTTCCCTG ACGGTAAAGT GTCCAAATAA AGGCTGTGTG 
CAAAAGATGG AGCTGAGACA TCTCGAGGAT CATCAAGTAC ATTGTGAATT CGCTCTAGTG 
ATTTGTCCCC AATGCCAACG TTTTTTCCAA AAGTGCCAGA TTAATAAACA CATTATCGAG 
GATTGTCCCA GGAGACAGGT TTCTTGTGTA AACTGTGCTG TGCCCATGCC GTATGAAGAG 
AAAGAGATCC ACGATCAAAG CTGTCCTCTG GCAAATATCA TCTGTGAATA CTGTGGTACA 
ATCCTCATAA GAGAACAGAT GCCTAATCAT TATGATCTAG ACTGCCCAAC AGCTCCAGTC 
CCCTGCACAT TCAGTGTGTT TGGCTGTCAC GAAAAGATGC AGAGGAATCA CTTGGCACGG 
CACTTGCAAG AGAACACCCA GTTGCACATG AGACTGTTGG CCCAGGCTGT TCATAATGTT 
AACCTCTCTT TGCGGCCATG CGATGCCTCC TCTCCATCCC GGGGATGTCG TCCTGAGGAC 
CCAAATTATG AGGAAACGGT CAAACAGTTG GAGGGGCGCC TAGTAAGACA GGACCATCAA 
ATCCGGGAGC TGACCGCCAA AATGGAAACG CAGAGCATGC ATGTGAGCGA GCTCAAGCGG 
ACCATTCGAA GCCTCGAGGA CAAAGTTGCC GAGATGGAAG CACAGCAGTG TAATGGCATT 
TACATTTGGA AGATTGGCAA CTTTGGGATG CACTTGAAAT CCCAAGAAGA GGAAAGACCT 
GTGGTCATTC ATAGCCCTGG ATTCTACACA GGCAGACCTG GGTACAAGCT GTGCATGCGC 
CTGCACCTCC AGCTACCGAC GGCTCAGCGC TGTGCAAACT ACATTTCCCT CTTTGTCCAC 
ACAATGCAAG GAGAGTATGA CAGCCACCTC CCCTGGCCCT TCCAGGGTAC AATACGCCTC 
ACGATCCTTG ATCAGTCTGA AGCAGTAATA AGGCAAAACC ACGAAGAGGT CATGGATGCT 
AAGCCAGAAC TGCTTGCCTT TCAGCGGCCC ACCATCCCAC GGAACCCCAA AGGTTTTGGC 
TATGTGACAT TCATGCACCT GGAAGCCTTA AGACAGGGAA CCTTCATCAA GGATGATACG 
TTATTAGTGC GCTGTGAAGT CTCTACCCGC TTTGACATGG GGGGCCTTCG GAAGGAGGGG 
TTCCAGCCAC GGAGTACTGA TGCAGGCGTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-146a protects small intestine against ischemia/reperfusion injury by down-regulating TLR4/TRAF6/NF-?B pathway.
Journal of cellular physiology233(3)2476-2488(2018 Mar)
He X,Zheng Y,Liu S,Shi S,Liu Y,He Y,Zhang C,Zhou X

Effect of N-Acetylserotonin on TLR-4 and MyD88 Expression during Intestinal Ischemia-Reperfusion in a Rat Model.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie(2018 Jan)
Sukhotnik I,Ben Shahar Y,Halabi S,Bitterman N,Dorfman T,Pollak Y,Coran A,Bitterman A

Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress.
Journal of neurochemistry142(3)478-492(2017 Aug)
Dou Y,Shen H,Feng D,Li H,Tian X,Zhang J,Wang Z,Chen G

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Traf6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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