Ppa2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppa2
Entrez Gene ID	310856
Full Name	pyrophosphatase (inorganic) 2
Synonyms	RGD1307965
General protein information	Preferred Names pyrophosphatase (inorganic) 2 Names inorganic pyrophosphatase 2, mitochondrial
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q43

mRNA and Protein(s)

mRNA	Protein	Name
XM_006233327.3	XP_006233389.1	inorganic pyrophosphatase 2, mitochondrial isoform X1
NM_001135871.1	NP_001129343.1	inorganic pyrophosphatase 2, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPA2	NP_789845.1
Rattus norvegicus (Norway rat)	Ppa2	NP_001129343.1
Pan troglodytes (chimpanzee)	PPA2	XP_517378.2
Canis lupus familiaris (dog)	PPA2	XP_535679.3
Xenopus tropicalis (tropical clawed frog)	ppa1	NP_001017130.1
	PPA2	XP_001082969.2
Mus musculus (house mouse)	Ppa2	NP_666253.1
Danio rerio (zebrafish)	ppa1a	NP_957027.1
Bos taurus (cattle)	PPA2	NP_001069864.1
Gallus gallus (chicken)	PPA2	XP_420502.3

Gene Ontology
Bibliography

Related articles in PubMed

Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2.
Kennedy H, Haack TB, Hartill V, Matakovi? L, Baumgartner ER, Potter H, Mackay R, Alston CL, O'Sullivan S, McFarland R, Connolly G, Gannon C, King R, Mead S, Crozier I, Chan W, Florkowski CM, Sage M, H?fken T, Alhaddad B, Kremer LS, Kopajtich R, Feichtinger RG, Sperl W, Rodenburg RJ, Minet JC, Dobbie A, Strom TM, Meitinger T, George PM, Johnson CA, Taylor RW, Prokisch H, Doudney K, Mayr JA
American journal of human genetics99(3)674-682(2016 Sep)

Biallelic PPA2 Mutations Cause Sudden Unexpected Cardiac Arrest in Infancy.
Guimier A, Gordon CT, Godard F, Ravenscroft G, Oufadem M, Vasnier C, Rambaud C, Nitschke P, Bole-Feysot C, Masson C, Dauger S, Longman C, Laing NG, Kugener B, Bonnet D, Bouvagnet P, Di Filippo S, Probst V, Redon R, Charron P, R?tig A, Lyonnet S, Dautant A, de Pontual L, di Rago JP, Delahodde A, Amiel J
American journal of human genetics99(3)666-673(2016 Sep)

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.
Xing Y, Igarashi H, Wang X, Sakaguchi N
The Journal of experimental medicine202(5)707-19(2005 Sep)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ppa2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppa2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04144	NM_001135871.1 Latest version!	Rattus norvegicus inorganic pyrophosphatase 2 (Ppa2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa25274	XM_006233327.3 Latest version!	Rattus norvegicus pyrophosphatase (inorganic) 2 (Ppa2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppa2 ( NM_001135871.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001129343.1 Rattus norvegicus inorganic pyrophosphatase 2 (Ppa2), mRNA.

Price & Availability↑

CloneID	ORa04144
Clone ID Related Accession (Same CDS sequence)	NM_001135871.1
Accession Version	NM_001135871.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Rattus norvegicus(Norway rat)
Product	inorganic pyrophosphatase 2, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07013467.1 and AABR07013468.1. On Oct 16, 2008 this sequence version replaced XM_227690.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCGCGCGC TGCTGCCACT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC 
CTCCCTCCGC GCCGCGTAAT GTCCCTGTAC CGCACGGAGG AGCTGGGCCA TCCCCGCTCG 
AAGGATTACC GCCTGTTCTT CAAGCACGTA GCTGGCCACT ACATCTCCCC TTTCCATGAC 
ATTCCTCTGA AGGCAGACTG TGAAGAGGAA CATGGCATTC CCAGGAAAAA GGCACGGAAT 
GATGAATATA AGGCTTCGTT TAATATGGTT GTGGAAATAC CTCGGTGGAC AAATGCCAAG 
ATGGAGATTG CCACCGAGGA GCCACTGAAC CCCATTAAGC AAGACACCAA GAACGGGAGG 
CTGCGCTACA CCCCGAACAT CTTCCCCCAC AAGGGCTACA TATGGAATTA CGGGGCCCTC 
CCTCAGACCT GGGAAGATCC TCATCTAAAA GACAAGAGTA CAAACTGCTG TGGAGACAAC 
GACCCCATTG ACGTTTGTGA AATAGGCTCC AAGGTTCTTT CCCGTGGAGA CGTGGTCCAT 
GTGAAGATCC TGGGGACTTT GGCACTTATC GATCAGAGTG AAACAGATTG GAAAATAATT 
GCTATCAATG TGAATGATCC TGAGGCTGAA AAATTTCATG ATATTGATGA TGTTAAGAAG 
TTCAAACCAG GTTACCTAGA AGCCACTGTC AATTGGTTTA GACTCTATAA GGTACCAGAT 
GGAAAACCAG AAAACAAGTT TGCTTTTAAT GGAGAATTCA AAAACAAGGC TTTTGCCCTC 
GAAGTTATTA ACTCTGCACA TGAACATTGG AAAGAGATGG TGATGAAGAA GTGTGACAAG 
GGAGCTATCA GTTGTGTGAA CGTGCACATC TGTGATAGCC CTTTCCACTG CACTACAGAG 
GAAGCAAGGT CACTAGTTGA ATCGATCCCA ACACCTTCAA TGAGTAAAGA AAGCAGTGTA 
GAAGAAGAAG TGTGGCACTT CCTCCGCAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129343.1
CDS	1..993
Translation	MRALLPLLSVGRGWRVGAAALPPRRVMSLYRTEELGHPRSKDYRLFFKHVAGHYISPFHDIPLKADCEEEHGIPRKKARNDEYKASFNMVVEIPRWTNAKMEIATEEPLNPIKQDTKNGRLRYTPNIFPHKGYIWNYGALPQTWEDPHLKDKSTNCCGDNDPIDVCEIGSKVLSRGDVVHVKILGTLALIDQSETDWKIIAINVNDPEAEKFHDIDDVKKFKPGYLEATVNWFRLYKVPDGKPENKFAFNGEFKNKAFALEVINSAHEHWKEMVMKKCDKGAISCVNVHICDSPFHCTTEEARSLVESIPTPSMSKESSVEEEVWHFLRN

Target ORF information:

RefSeq Version	NM_001135871.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus inorganic pyrophosphatase 2 (Ppa2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135871.1

ORF Insert Sequence:

ATGCGCGCGC TGCTGCCACT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC 
CTCCCTCCGC GCCGCGTAAT GTCCCTGTAC CGCACGGAGG AGCTGGGCCA TCCCCGCTCG 
AAGGATTACC GCCTGTTCTT CAAGCACGTA GCTGGCCACT ACATCTCCCC TTTCCATGAC 
ATTCCTCTGA AGGCAGACTG TGAAGAGGAA CATGGCATTC CCAGGAAAAA GGCACGGAAT 
GATGAATATA AGGCTTCGTT TAATATGGTT GTGGAAATAC CTCGGTGGAC AAATGCCAAG 
ATGGAGATTG CCACCGAGGA GCCACTGAAC CCCATTAAGC AAGACACCAA GAACGGGAGG 
CTGCGCTACA CCCCGAACAT CTTCCCCCAC AAGGGCTACA TATGGAATTA CGGGGCCCTC 
CCTCAGACCT GGGAAGATCC TCATCTAAAA GACAAGAGTA CAAACTGCTG TGGAGACAAC 
GACCCCATTG ACGTTTGTGA AATAGGCTCC AAGGTTCTTT CCCGTGGAGA CGTGGTCCAT 
GTGAAGATCC TGGGGACTTT GGCACTTATC GATCAGAGTG AAACAGATTG GAAAATAATT 
GCTATCAATG TGAATGATCC TGAGGCTGAA AAATTTCATG ATATTGATGA TGTTAAGAAG 
TTCAAACCAG GTTACCTAGA AGCCACTGTC AATTGGTTTA GACTCTATAA GGTACCAGAT 
GGAAAACCAG AAAACAAGTT TGCTTTTAAT GGAGAATTCA AAAACAAGGC TTTTGCCCTC 
GAAGTTATTA ACTCTGCACA TGAACATTGG AAAGAGATGG TGATGAAGAA GTGTGACAAG 
GGAGCTATCA GTTGTGTGAA CGTGCACATC TGTGATAGCC CTTTCCACTG CACTACAGAG 
GAAGCAAGGT CACTAGTTGA ATCGATCCCA ACACCTTCAA TGAGTAAAGA AAGCAGTGTA 
GAAGAAGAAG TGTGGCACTT CCTCCGCAAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ppa2 ( XM_006233327.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233389.1 Rattus norvegicus pyrophosphatase (inorganic) 2 (Ppa2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25274
Clone ID Related Accession (Same CDS sequence)	XM_006233327.3
Accession Version	XM_006233327.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 990bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	inorganic pyrophosphatase 2, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233327.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCGCGC TGCTGCCACT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC 
CTCCCTCCGC GCCGCGTAAT GTCCCTGTAC CGCACGGAGG AGCTGGGCCA TCCCCGCTCG 
AAGGATTACC GCCTGTTCTT CAAGCACGTA GCTGGCCACT ACATCTCCCC TTTCCATGAC 
ATTCCTCTGA AGGCAGACTG TGAAGAGGAA CATGGCATTC CCAGGAAAAA GGCACGGAAT 
GATGAATATA AGGCTTCGTT TAATATGGTT GTGGAAATAC CTCGGTGGAC AAATGCCAAG 
ATGGAGATTG CCACCGAGGA GCCACTGAAC CCCATTAAGC AAGACACCAA GAACGGGAGG 
CTGCGCTACA CCCCGAACAT CTTCCCCCAC AAGGGCTACA TATGGAATTA CGGGGCCCTC 
CCTCAGACCT GGGAAGATCC TCATCTAAAA GACAAGAGTA CAAACTGCTG TGGAGACAAC 
GACCCCATTG ACGTTTGTGA AATAGGCTCC AAGGTTCTTT CCCGTGGAGA CGTGGTCCAT 
GTGAAGATCC TGGGGACTTT GGCACTTATC GATCAGAGTG AAACAGATTG GAAAATAATT 
GCTATCAATG TGAATGATCC TGAGGCTGAA AAATTTCATG ATATTGATGA TGTTAAGAAG 
TTCAAACCAG GTTACCTAGA AGCCACTGTC AATTGGTTTA GACTCTATAA GGTACCAGAT 
GGAAAACCAG AAAACAAGTT TGCTTTTAAT GGAGAATTCA AAAACAAGGC TTTTGCCCTC 
GAAGTTATTA ACTCTGCACA TGAACATTGG AAAGAGATGG TGATGAAGAA GTGTGACAAG 
GGAGCTATCA GTTGTGTGAA CGTGCACATC TGTGATAGCC CTTTCCACTG CACTACAGAG 
GAAGCAAGGT CACTAGTTGA ATCGATCCCA ACACCTTCAA TGAGTAAAGA AAGCAGTGTA 
GAAGAAGTGT GGCACTTCCT CCGCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233389.1
CDS	95..1084
Translation	MRALLPLLSVGRGWRVGAAALPPRRVMSLYRTEELGHPRSKDYRLFFKHVAGHYISPFHDIPLKADCEEEHGIPRKKARNDEYKASFNMVVEIPRWTNAKMEIATEEPLNPIKQDTKNGRLRYTPNIFPHKGYIWNYGALPQTWEDPHLKDKSTNCCGDNDPIDVCEIGSKVLSRGDVVHVKILGTLALIDQSETDWKIIAINVNDPEAEKFHDIDDVKKFKPGYLEATVNWFRLYKVPDGKPENKFAFNGEFKNKAFALEVINSAHEHWKEMVMKKCDKGAISCVNVHICDSPFHCTTEEARSLVESIPTPSMSKESSVEEVWHFLRN

Target ORF information:

RefSeq Version	XM_006233327.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus pyrophosphatase (inorganic) 2 (Ppa2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233327.3

ORF Insert Sequence:

ATGCGCGCGC TGCTGCCACT GCTGAGCGTC GGCCGAGGGT GGCGCGTGGG GGCCGCCGCC 
CTCCCTCCGC GCCGCGTAAT GTCCCTGTAC CGCACGGAGG AGCTGGGCCA TCCCCGCTCG 
AAGGATTACC GCCTGTTCTT CAAGCACGTA GCTGGCCACT ACATCTCCCC TTTCCATGAC 
ATTCCTCTGA AGGCAGACTG TGAAGAGGAA CATGGCATTC CCAGGAAAAA GGCACGGAAT 
GATGAATATA AGGCTTCGTT TAATATGGTT GTGGAAATAC CTCGGTGGAC AAATGCCAAG 
ATGGAGATTG CCACCGAGGA GCCACTGAAC CCCATTAAGC AAGACACCAA GAACGGGAGG 
CTGCGCTACA CCCCGAACAT CTTCCCCCAC AAGGGCTACA TATGGAATTA CGGGGCCCTC 
CCTCAGACCT GGGAAGATCC TCATCTAAAA GACAAGAGTA CAAACTGCTG TGGAGACAAC 
GACCCCATTG ACGTTTGTGA AATAGGCTCC AAGGTTCTTT CCCGTGGAGA CGTGGTCCAT 
GTGAAGATCC TGGGGACTTT GGCACTTATC GATCAGAGTG AAACAGATTG GAAAATAATT 
GCTATCAATG TGAATGATCC TGAGGCTGAA AAATTTCATG ATATTGATGA TGTTAAGAAG 
TTCAAACCAG GTTACCTAGA AGCCACTGTC AATTGGTTTA GACTCTATAA GGTACCAGAT 
GGAAAACCAG AAAACAAGTT TGCTTTTAAT GGAGAATTCA AAAACAAGGC TTTTGCCCTC 
GAAGTTATTA ACTCTGCACA TGAACATTGG AAAGAGATGG TGATGAAGAA GTGTGACAAG 
GGAGCTATCA GTTGTGTGAA CGTGCACATC TGTGATAGCC CTTTCCACTG CACTACAGAG 
GAAGCAAGGT CACTAGTTGA ATCGATCCCA ACACCTTCAA TGAGTAAAGA AAGCAGTGTA 
GAAGAAGTGT GGCACTTCCT CCGCAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2.
American journal of human genetics99(3)674-682(2016 Sep)
Kennedy H,Haack TB,Hartill V,Matakovi? L,Baumgartner ER,Potter H,Mackay R,Alston CL,O'Sullivan S,McFarland R,Connolly G,Gannon C,King R,Mead S,Crozier I,Chan W,Florkowski CM,Sage M,H?fken T,Alhaddad B,Kremer LS,Kopajtich R,Feichtinger RG,Sperl W,Rodenburg RJ,Minet JC,Dobbie A,Strom TM,Meitinger T,George PM,Johnson CA,Taylor RW,Prokisch H,Doudney K,Mayr JA

Biallelic PPA2 Mutations Cause Sudden Unexpected Cardiac Arrest in Infancy.
American journal of human genetics99(3)666-673(2016 Sep)
Guimier A,Gordon CT,Godard F,Ravenscroft G,Oufadem M,Vasnier C,Rambaud C,Nitschke P,Bole-Feysot C,Masson C,Dauger S,Longman C,Laing NG,Kugener B,Bonnet D,Bouvagnet P,Di Filippo S,Probst V,Redon R,Charron P,R?tig A,Lyonnet S,Dautant A,de Pontual L,di Rago JP,Delahodde A,Amiel J

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.
The Journal of experimental medicine202(5)707-19(2005 Sep)
Xing Y,Igarashi H,Wang X,Sakaguchi N

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

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Ppa2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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