Crtc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crtc2
Entrez Gene ID	310615
Full Name	CREB regulated transcription coactivator 2
Synonyms	RGD1308903,Torc2
General protein information	Preferred Names CREB regulated transcription coactivator 2 Names CREB-regulated transcription coactivator 2 TORC-2 transducer of CREB protein 2 transducer of regulated cAMP response element-binding protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033895.1	NP_001029067.1	CREB-regulated transcription coactivator 2
XM_017590877.1	XP_017446366.1	CREB-regulated transcription coactivator 2 isoform X1

Pathways from BioSystems

Homologies

	CRTC2	XP_001112030.1
Rattus norvegicus (Norway rat)	Crtc2	NP_001029067.1
Homo sapiens (human)	CRTC2	NP_859066.1
Pan troglodytes (chimpanzee)	CRTC2	XP_003949646.1
Canis lupus familiaris (dog)	CRTC2	XP_855142.1
Mus musculus (house mouse)	Crtc2	NP_083157.1
Xenopus tropicalis (tropical clawed frog)	crtc2	XP_004921516.1
Bos taurus (cattle)	CRTC2	NP_001069718.1

Gene Ontology
Bibliography

Related articles in PubMed

CRTC2 and Nedd4 ligase involvement in FSH and TGF?1 upregulation of connexin43 gap junction.
Fang WL, Lai SY, Lai WA, Lee MT, Liao CF, Ke FC, Hwang JJ
Journal of molecular endocrinology55(3)263-75(2015 Dec)

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P
World journal of gastroenterology21(25)7777-85(2015 Jul)

CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
Highland JA, Weiser MJ, Hinds LR, Spencer RL
American journal of physiology. Cell physiology307(7)C611-21(2014 Oct)

mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.
Zhou Y, Wang D, Gao X, Lew K, Richards AM, Wang P
PloS one9(6)e99665(2014)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation of connexin43 gap junction
Title: CRTC2 and Nedd4 ligase involvement in FSH and TGF?1 upregulation of connexin43 gap junction.

Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.

Berberine inhibited hepatic gluconeogenesis via the regulation of the LKB1-AMPK-TORC2 signaling pathway.
Title: Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.

Suggest that CRTC2 participates in CREB-dependent photic entrainment of suprachiasmatic nucleus function.
Title: CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.

These data suggest mTORC2 phosphorylation of Akt is a key mediator of H2S-induced cardioprotection in I/R.
Title: mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.

The following Crtc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crtc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08709	NM_001033895.1 Latest version!	Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa59754	XM_017590877.1 Latest version!	Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crtc2 ( NM_001033895.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029067.1 Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), mRNA.

Price & Availability↑

CloneID	ORa08709
Clone ID Related Accession (Same CDS sequence)	NM_001033895.1
Accession Version	NM_001033895.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2076bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	CREB-regulated transcription coactivator 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ185515.1. On Sep 30, 2005 this sequence version replaced XM_227389.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ185515.1, BC128708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACGT CAGGGGCGAA CGGGCCGGGT TCCGCCACAG CCTCGGCGTC CAATCCACGC 
AAGTTTAGTG AAAAGATCGC GCTGCAGAAG CAGCGTCAGG CCGAGGAGAC GGCGGCCTTT 
GAGGAGGTGA TGATGGACAT CGGCTCCACT CGGTTACAGG CCCAAAAGCT GCGACTGGCT 
TATACAAGGA GCTCCCATTA TGGTGGTTCT CTGCCCAATG TTAACCAGAT TGGCTGTGGC 
CTGGCTGAGT TCCAGAGCCC CCTTCATTCA CCTTTGGATT CATCTCGGAG CACTCGGCAC 
CATGGATTGG TGGAACGGGT ACAACGAGAC CCTCGCAGAA TGGTGTCCCC ACTCCGCCGA 
TACCCCCGCC ACATTGACAG TTCTCCCTAT AGCCCTGCCT ACTTATCTCC TCCCCCTGAG 
TCTGGCTGGC GAAGGATGAT GCCCTGGGGC AACCTCCCAG CTGAGAAGGG GCAGTTGTTT 
AGACTGCCAT CTGCACTTAA CAGGACAAGC TCTGACTCTG CTCTTCACAC AAGTGTGATG 
AACCCTAACC CCCAAGACAC TTATCCAGGC CCTACACCTC CCAGTGTCCT GCCCAGCCGG 
CGAGGAGGTT TTCTGGATGG CGAGATGGAT GCTAAAGTCC CTGCTATTGA GGAGAACTTG 
GTAGATGACA AGCATTTGCT GAAACCTTGG GATGCTAAGA AGCTGTCCTC ATCTTCCTCT 
CGACCTCGAT CCTGTGAAGT CCCTGGAATC AACATCTTTC CATCTCCTGA CCAGCCTGCT 
AATGTGCCTG TCCTCCCACC TGCCATGAGC ACAGGGGGCT CCCTACCTGA CCTCACCAAC 
CTACACTTCC CCCCTCCACT GCCCACGCCC CTGGACCCTG AGGAGACAGT CTATCCCAGC 
CTGAGTGGGG GCAACAGTAC CACCAATTTG ACTCACACTA TGACCCATTT GGGCATCAGT 
GGAGGTCTGG GCTTGGGCCC CAGCTATGAT GTACCAGGAC TTCACTCACC TCTTAGCCAC 
CCGTCCCTGC AGTCCTCCCT AAGCAATCCC AACCTCCAGG CTTCCCTAAG CAGTCCTCAG 
CCCCAGCTCC AGGGCTCCCA TAGTCACCCA TCACTGCCTG CCTCCTCCTT GGCCCACCAT 
GCACTGCCCA CCACCTCCCT GGGCCACCCG TCACTTAGTG CCCCAGCCCT TTCCTCCTCC 
TCTTCCTCTT CGTCCACTTC ATCTCCTGTC CTGAGTGCCC CCCCTTACCC AGCTTCTACT 
CCTGGGGCCT CTCCCCGCCA CCGTCGTGTG CCCCTCAGCC CCCTGAGCTT GCCTGCAGGC 
CCAGCCGACG CCAGAAGGTC CCAACAGCAG CTGCCCAAAC AGTTTTCGCC AACAATGTCA 
CCCACCTTGT CTTCCATCAC TCAGGGCGTC CCCTTGGATA CCAGTAAACT GCCTACTGAC 
CAGCGATTGC CCCCATACCC ATATAGCCCC CCAAGTCTAG TTATACCCAG CCATCCACCC 
ACCCCAAAGT CTCTACAGCA GTTGCCCTCT CAGGCCTGCT TAGTACAGCC CTCAGGTGGA 
CAGCCTCCAG GCAGGCAGCC ACATTATGGG ACACTGTACC CACCTGGGTC CAGTGGACAT 
GGGCAACAGC CTTACCACCG CCCAATAAAT GACTTCAGCC TGGGGAATCT GGAGCAATTC 
AACATGGAGA GCCCATCTAC CAGCCTGGTG CTGGATCCCC CTGCCTTTTC TGAAGGTCCT 
GGATTTTTAG GGAGTGAGGG ATCAGTGAGT GGCCCCCAGG ACTCTCATGT CCTCAATCAC 
CAGAACTTGA CCCACTGTTC CCGCCATGGC TCAGGACCTA ATATCATACT CACAGGAGAC 
TCTTCCCCAG GTTTCTCTAA GGAGATTGCA GCAGCCCTGG CTGGAGTACC TGGCTTTGAG 
GTGTCAGCAT CTGGGTTGGA GCTGGGACTG GGGCTGGAAG ATGAGTTGCG CATGGAGCCA 
CTGGGCCTGG AAGGACTAAC CATGCTGAGT GACCCTTGTG CTCTGCTGCC TGACCCTGCT 
GTGGAAGACT CATTCCGTAG TGATCGGCTA CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029067.1
CDS	1..2076
Translation	MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGFLDGEMDAKVPAIEENLVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMSTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPSHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGTLYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPSTSLVLDPPAFSEGPGFLGSEGSVSGPQDSHVLNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRLQ

Target ORF information:

RefSeq Version	NM_001033895.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033895.1

ORF Insert Sequence:

ATGGCGACGT CAGGGGCGAA CGGGCCGGGT TCCGCCACAG CCTCGGCGTC CAATCCACGC 
AAGTTTAGTG AAAAGATCGC GCTGCAGAAG CAGCGTCAGG CCGAGGAGAC GGCGGCCTTT 
GAGGAGGTGA TGATGGACAT CGGCTCCACT CGGTTACAGG CCCAAAAGCT GCGACTGGCT 
TATACAAGGA GCTCCCATTA TGGTGGTTCT CTGCCCAATG TTAACCAGAT TGGCTGTGGC 
CTGGCTGAGT TCCAGAGCCC CCTTCATTCA CCTTTGGATT CATCTCGGAG CACTCGGCAC 
CATGGATTGG TGGAACGGGT ACAACGAGAC CCTCGCAGAA TGGTGTCCCC ACTCCGCCGA 
TACCCCCGCC ACATTGACAG TTCTCCCTAT AGCCCTGCCT ACTTATCTCC TCCCCCTGAG 
TCTGGCTGGC GAAGGATGAT GCCCTGGGGC AACCTCCCAG CTGAGAAGGG GCAGTTGTTT 
AGACTGCCAT CTGCACTTAA CAGGACAAGC TCTGACTCTG CTCTTCACAC AAGTGTGATG 
AACCCTAACC CCCAAGACAC TTATCCAGGC CCTACACCTC CCAGTGTCCT GCCCAGCCGG 
CGAGGAGGTT TTCTGGATGG CGAGATGGAT GCTAAAGTCC CTGCTATTGA GGAGAACTTG 
GTAGATGACA AGCATTTGCT GAAACCTTGG GATGCTAAGA AGCTGTCCTC ATCTTCCTCT 
CGACCTCGAT CCTGTGAAGT CCCTGGAATC AACATCTTTC CATCTCCTGA CCAGCCTGCT 
AATGTGCCTG TCCTCCCACC TGCCATGAGC ACAGGGGGCT CCCTACCTGA CCTCACCAAC 
CTACACTTCC CCCCTCCACT GCCCACGCCC CTGGACCCTG AGGAGACAGT CTATCCCAGC 
CTGAGTGGGG GCAACAGTAC CACCAATTTG ACTCACACTA TGACCCATTT GGGCATCAGT 
GGAGGTCTGG GCTTGGGCCC CAGCTATGAT GTACCAGGAC TTCACTCACC TCTTAGCCAC 
CCGTCCCTGC AGTCCTCCCT AAGCAATCCC AACCTCCAGG CTTCCCTAAG CAGTCCTCAG 
CCCCAGCTCC AGGGCTCCCA TAGTCACCCA TCACTGCCTG CCTCCTCCTT GGCCCACCAT 
GCACTGCCCA CCACCTCCCT GGGCCACCCG TCACTTAGTG CCCCAGCCCT TTCCTCCTCC 
TCTTCCTCTT CGTCCACTTC ATCTCCTGTC CTGAGTGCCC CCCCTTACCC AGCTTCTACT 
CCTGGGGCCT CTCCCCGCCA CCGTCGTGTG CCCCTCAGCC CCCTGAGCTT GCCTGCAGGC 
CCAGCCGACG CCAGAAGGTC CCAACAGCAG CTGCCCAAAC AGTTTTCGCC AACAATGTCA 
CCCACCTTGT CTTCCATCAC TCAGGGCGTC CCCTTGGATA CCAGTAAACT GCCTACTGAC 
CAGCGATTGC CCCCATACCC ATATAGCCCC CCAAGTCTAG TTATACCCAG CCATCCACCC 
ACCCCAAAGT CTCTACAGCA GTTGCCCTCT CAGGCCTGCT TAGTACAGCC CTCAGGTGGA 
CAGCCTCCAG GCAGGCAGCC ACATTATGGG ACACTGTACC CACCTGGGTC CAGTGGACAT 
GGGCAACAGC CTTACCACCG CCCAATAAAT GACTTCAGCC TGGGGAATCT GGAGCAATTC 
AACATGGAGA GCCCATCTAC CAGCCTGGTG CTGGATCCCC CTGCCTTTTC TGAAGGTCCT 
GGATTTTTAG GGAGTGAGGG ATCAGTGAGT GGCCCCCAGG ACTCTCATGT CCTCAATCAC 
CAGAACTTGA CCCACTGTTC CCGCCATGGC TCAGGACCTA ATATCATACT CACAGGAGAC 
TCTTCCCCAG GTTTCTCTAA GGAGATTGCA GCAGCCCTGG CTGGAGTACC TGGCTTTGAG 
GTGTCAGCAT CTGGGTTGGA GCTGGGACTG GGGCTGGAAG ATGAGTTGCG CATGGAGCCA 
CTGGGCCTGG AAGGACTAAC CATGCTGAGT GACCCTTGTG CTCTGCTGCC TGACCCTGCT 
GTGGAAGACT CATTCCGTAG TGATCGGCTA CAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Crtc2 ( XM_017590877.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446366.1 Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59754
Clone ID Related Accession (Same CDS sequence)	XM_017590877.1
Accession Version	XM_017590877.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1677bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	CREB-regulated transcription coactivator 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACGT CAGGGGCGAA CGGGCCGGGT TCCGCCACAG CCTCGGCGTC CAATCCACGC 
AAGTTTAGTG AAAAGATCGC GCTGCAGAAG CAGCGTCAGG CCGAGGAGAC GGCGGCCTTT 
GAGGAGGTGA TGATGGACAT CGGCTCCACT CGGTTACAGG CCCAAAAGCT GCGACTGGCT 
TATACAAGGA GCTCCCATTA TGGTGGTTCT CTGCCCAATG TTAACCAGAT TGGCTGTGGC 
CTGGCTGAGT TCCAGAGCCC CCTTCATTCA CCTTTGGATT CATCTCGGAG CACTCGGCAC 
CATGGATTGG TGGAACGGGT ACAACGAGAC CCTCGCAGAA TGGTGTCCCC ACTCCGCCGA 
TACCCCCGCC ACATTGACAG TTCTCCCTAT AGCCCTGCCT ACTTATCTCC TCCCCCTGAG 
TCTGGCTGGC GAAGGATGAT GCCCTGGGGC AACCTCCCAG CTGAGAAGGG GCAGTTGTTT 
AGACTGCCAT CTGCACTTAA CAGGACAAGC TCTGACTCTG CTCTTCACAC AAGTGTGATG 
AACCCTAACC CCCAAGACAC TTATCCAGGC CCTACACCTC CCAGTGTCCT GCCCAGCCGG 
CGAGGAGGTT TTCTGGATGG CGAGATGGAT GCTAAAGTCC CTGCTATTGA GGAGAACTTG 
GTAGATGACA AGCATTTGCT GAAACCTTGG GATGCTAAGA AGCTGTCCTC ATCTTCCTCT 
CGACCTCGAT CCTGTGAAGT CCCTGGAATC AACATCTTTC CATCTCCTGA CCAGCCTGCT 
AATGTGCCTG TCCTCCCACC TGCCATGAGC ACAGGGGGCT CCCTACCTGA CCTCACCAAC 
CTACACTTCC CCCCTCCACT GCCCACGCCC CTGGACCCTG AGGAGACAGT CTATCCCAGC 
CTGAGTGGGG GCAACAGTAC CACCAATTTG ACTCACACTA TGACCCATTT GGGCATCAGT 
GGAGGTCTGG GCTTGGGCCC CAGCTATGAT GTACCAGGAC TTCACTCACC TCTTAGCCAC 
CCGTCCCTGC AGTCCTCCCT AAGCAATCCC AACCTCCAGG CTTCCCTAAG CAGTCCTCAG 
CCCCAGCTCC AGGGCTCCCA TAGTCACCCA TCACTGCCTG CCTCCTCCTT GGCCCACCAT 
GCACTGCCCA CCACCTCCCT GGGCCACCCG TCACTTAGTG CCCCAGCCCT TTCCTCCTCC 
TCTTCCTCTT CGTCCACTTC ATCTCCTGTC CTGAGTGCCC CCCCTTACCC AGCTTCTACT 
CCTGGGGCCT CTCCCCGCCA CCGTCGTGTG CCCCTCAGCC CCCTGAGCTT GCCTGCAGGC 
CCAGCCGACG CCAGAAGGTC CCAACAGCAG CTGCCCAAAC AGTTTTCGCC AACAATGTCA 
CCCACCTTGT CTTCCATCAC TCAGGGCGTC CCCTTGGATA CCAGTAAACT GCCTACTGAC 
CAGCGATTGC CCCCATACCC ATATAGCCCC CCAAGTCTAG TTATACCCAG CCATCCACCC 
ACCCCAAAGT CTCTACAGCA GTTGCCCTCT CAGGCCTGCT TAGTACAGCC CTCAGGTGGA 
CAGCCTCCAG GCAGGCAGCC ACATTATGGG ACACTGTACC CACCTGGGTC CAGTGGACAT 
GGGCAACAGC CTTACCACCG CCCAATAAAT GACTTCAGCC TGGGGAATGT AACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446366.1
CDS	134..1810
Translation	MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGFLDGEMDAKVPAIEENLVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMSTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPSHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGTLYPPGSSGHGQQPYHRPINDFSLGNVT

Target ORF information:

RefSeq Version	XM_017590877.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CREB regulated transcription coactivator 2 (Crtc2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590877.1

ORF Insert Sequence:

ATGGCGACGT CAGGGGCGAA CGGGCCGGGT TCCGCCACAG CCTCGGCGTC CAATCCACGC 
AAGTTTAGTG AAAAGATCGC GCTGCAGAAG CAGCGTCAGG CCGAGGAGAC GGCGGCCTTT 
GAGGAGGTGA TGATGGACAT CGGCTCCACT CGGTTACAGG CCCAAAAGCT GCGACTGGCT 
TATACAAGGA GCTCCCATTA TGGTGGTTCT CTGCCCAATG TTAACCAGAT TGGCTGTGGC 
CTGGCTGAGT TCCAGAGCCC CCTTCATTCA CCTTTGGATT CATCTCGGAG CACTCGGCAC 
CATGGATTGG TGGAACGGGT ACAACGAGAC CCTCGCAGAA TGGTGTCCCC ACTCCGCCGA 
TACCCCCGCC ACATTGACAG TTCTCCCTAT AGCCCTGCCT ACTTATCTCC TCCCCCTGAG 
TCTGGCTGGC GAAGGATGAT GCCCTGGGGC AACCTCCCAG CTGAGAAGGG GCAGTTGTTT 
AGACTGCCAT CTGCACTTAA CAGGACAAGC TCTGACTCTG CTCTTCACAC AAGTGTGATG 
AACCCTAACC CCCAAGACAC TTATCCAGGC CCTACACCTC CCAGTGTCCT GCCCAGCCGG 
CGAGGAGGTT TTCTGGATGG CGAGATGGAT GCTAAAGTCC CTGCTATTGA GGAGAACTTG 
GTAGATGACA AGCATTTGCT GAAACCTTGG GATGCTAAGA AGCTGTCCTC ATCTTCCTCT 
CGACCTCGAT CCTGTGAAGT CCCTGGAATC AACATCTTTC CATCTCCTGA CCAGCCTGCT 
AATGTGCCTG TCCTCCCACC TGCCATGAGC ACAGGGGGCT CCCTACCTGA CCTCACCAAC 
CTACACTTCC CCCCTCCACT GCCCACGCCC CTGGACCCTG AGGAGACAGT CTATCCCAGC 
CTGAGTGGGG GCAACAGTAC CACCAATTTG ACTCACACTA TGACCCATTT GGGCATCAGT 
GGAGGTCTGG GCTTGGGCCC CAGCTATGAT GTACCAGGAC TTCACTCACC TCTTAGCCAC 
CCGTCCCTGC AGTCCTCCCT AAGCAATCCC AACCTCCAGG CTTCCCTAAG CAGTCCTCAG 
CCCCAGCTCC AGGGCTCCCA TAGTCACCCA TCACTGCCTG CCTCCTCCTT GGCCCACCAT 
GCACTGCCCA CCACCTCCCT GGGCCACCCG TCACTTAGTG CCCCAGCCCT TTCCTCCTCC 
TCTTCCTCTT CGTCCACTTC ATCTCCTGTC CTGAGTGCCC CCCCTTACCC AGCTTCTACT 
CCTGGGGCCT CTCCCCGCCA CCGTCGTGTG CCCCTCAGCC CCCTGAGCTT GCCTGCAGGC 
CCAGCCGACG CCAGAAGGTC CCAACAGCAG CTGCCCAAAC AGTTTTCGCC AACAATGTCA 
CCCACCTTGT CTTCCATCAC TCAGGGCGTC CCCTTGGATA CCAGTAAACT GCCTACTGAC 
CAGCGATTGC CCCCATACCC ATATAGCCCC CCAAGTCTAG TTATACCCAG CCATCCACCC 
ACCCCAAAGT CTCTACAGCA GTTGCCCTCT CAGGCCTGCT TAGTACAGCC CTCAGGTGGA 
CAGCCTCCAG GCAGGCAGCC ACATTATGGG ACACTGTACC CACCTGGGTC CAGTGGACAT 
GGGCAACAGC CTTACCACCG CCCAATAAAT GACTTCAGCC TGGGGAATGT AACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CRTC2 and Nedd4 ligase involvement in FSH and TGF?1 upregulation of connexin43 gap junction.
Journal of molecular endocrinology55(3)263-75(2015 Dec)
Fang WL,Lai SY,Lai WA,Lee MT,Liao CF,Ke FC,Hwang JJ

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
World journal of gastroenterology21(25)7777-85(2015 Jul)
Jiang SJ,Dong H,Li JB,Xu LJ,Zou X,Wang KF,Lu FE,Yi P

CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure.
American journal of physiology. Cell physiology307(7)C611-21(2014 Oct)
Highland JA,Weiser MJ,Hinds LR,Spencer RL

mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection.
PloS one9(6)e99665(2014)
Zhou Y,Wang D,Gao X,Lew K,Richards AM,Wang P

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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Crtc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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