Itgb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgb2
Entrez Gene ID	309684
Full Name	integrin subunit beta 2
Synonyms	Cd18
General protein information	Preferred Names integrin subunit beta 2 Names integrin beta-2 CD18 leukocyte adhesion molecule integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) macrophage antigen 1 (mac-1) beta subunit)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 20 Map Location: 20p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037780.2	NP_001032869.2	integrin beta-2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ITGB2	NP_786975.1
Danio rerio (zebrafish)	itgb2	XP_686012.3
Xenopus tropicalis (tropical clawed frog)	itgb2	XP_002936570.2
Pan troglodytes (chimpanzee)	ITGB2	NP_001029294.1
Canis lupus familiaris (dog)	ITGB2	XP_005639033.1
Homo sapiens (human)	ITGB2	NP_001120963.1
Mus musculus (house mouse)	Itgb2	NP_032430.2
Gallus gallus (chicken)	ITGB2	NP_990582.1
Rattus norvegicus (Norway rat)	Itgb2	NP_001032869.2

Gene Ontology
Bibliography

Related articles in PubMed

CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Bai M, Grieshaber-Bouyer R, Wang J, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA
Blood130(19)2092-2100(2017 11)

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Oksala N, P?rssinen J, Sepp?l? I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, K?h?nen M, Lehtim?ki T, Hyt?nen VP
Atherosclerosis242(1)145-54(2015 Sep)

Cell type-specific differences in ?-glucan recognition and signalling in porcine innate immune cells.
Baert K, Sonck E, Goddeeris BM, Devriendt B, Cox E
Developmental and comparative immunology48(1)192-203(2015 Jan)

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Chiasserini D, van Weering JR, Piersma SR, Pham TV, Malekzadeh A, Teunissen CE, de Wit H, Jim?nez CR
Journal of proteomics106191-204(2014 Jun)

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ?2 integrins (CD11/CD18).
Weckbach LT, Gola A, Winkelmann M, Jakob SM, Groesser L, Borgolte J, Pogoda F, Pick R, Pruenster M, M?ller-H?cker J, Deindl E, Sperandio M, Walzog B
Blood123(12)1887-96(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Beta2 integrin expression showed a 3-4-fold increase in the combined treatment group at all time points and kept increasing till day 56
Title: Modulation of Beta2 and Beta3 integrins in experimental colitis induced by iodoacetamide and enteropathogenic E. coli.

Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil beta(2) integrin function.
Title: Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil ?(2) integrin function.

Our data demonstrated the upregulation of ICAM-1, LFA-1, and Mac-1 in the spinal cords of LPS intraspinal injected rats, and the location of ICAM-1 in microglia cells.
Title: Evaled expression of ICAM-1 and its ligands in the rat spinal cord following lipopolysaccharide intraspinal injection.

TNF-alpha can promote expression of LFA-1 on surface of frozen/thawed polymorphonuclear lymphocytes and adhesion of PMN to vascular endothelial cells.
Title: [Role of TNF-alpha in vascular endothelial cells injury mediated by frozen/thawed PMN].

Freezing/thawing of PMNs can elicit an increase in PMN LFA-1 expression and trigger PMN-vascular endothelial cell adhesion.
Title: [The role of LFA-1 in the vascular endothelial cells injury mediated by frozen/thawed neutrophils].

The following Itgb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08213	NM_001037780.2 Latest version!	Rattus norvegicus integrin subunit beta 2 (Itgb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$454.30 $649.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgb2 ( NM_001037780.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032869.2 Rattus norvegicus integrin subunit beta 2 (Itgb2), mRNA.

Price & Availability↑

CloneID	ORa08213
Clone ID Related Accession (Same CDS sequence)	NM_001037780.2
Accession Version	NM_001037780.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2307bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	integrin beta-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC085817.1. On Dec 27, 2007 this sequence version replaced NM_001037780.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC166721.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGGGCC CACACACACT GCTACTCATC CTAGCTGGAC TACTCTTCCT GGGATCTGCC 
CTGTCCGAGG AATGCACCAA GTACAAAGTC AGCAACTGCC GGGACTGTAT CCAGTCGGGG 
CCTGGCTGCT CGTGGTGCCA GAAGCTGAAC TTCACCGGAC CAGGGGAGCC TGACTCCTTG 
CGCTGTGACA CGCGGGCACA GCTGCTCCTC AAGGGTTGCC CAGCCGATGA TATAATGGAC 
CCCAAGAGCT TTGCTGATCT CCACCCCCAA TATCAGGTGC AACGGAGTCA ACTGTCTCCA 
CAAAAAGTGA CCCTTAACTT GCGACCAGGG CAGGCTGCTG CATTCAATGT GACTTTCCGA 
CGGGCCAAGG GCTACCCCAT TGATCTGTAC TACCTCATGG ACCTCTCCTA CTCTATGCTC 
GATGACCTGA ACAATGTCAA GAAGTTGGGT GGTGATTTGC TGCAGGCCCT CAACGAGATC 
ACAGAGTCCG GCCGCATCGG CTTCGGGTCC TTCGTGGACA AGACGGTGCT GCCTTTTGTC 
AACACCCATC CCGAGAAGCT GAGGAACCCA TGCCCCAACA AGGAGAAAGC CTGCCAGCCT 
CCGTTTGCCT TTCGCCACGT GCTCAAGCTA ACCGACAACT CCAACCAGTT TCAGACAGAG 
GTCGGCAAGC AACTGATTTC CGGAAACCTG GACGCCCCTG AGGGCGGGCT GGATGCCATA 
ATGCAAGTGG CTGCCTGTCC GGAGGAAATT GGCTGGCGCA ATGTCACGAG GCTGCTGGTG 
TTTGCCACAG ACGACGGCTT CCACTTTGCC GGTGATGGGA AACTGGGTGC CATCCTGACC 
CCCAACGATG GCCGCTGCCA CCTGGAGGAT AACATGTACA AGAGGAGCAA TGAGTTCGAC 
TACCCGTCAG TGGGCCAGCT GGCCCACAAA CTTTCCGAGA GCAACATCCA GCCCATCTTT 
GCAGTGACAA AGAAGATGGT GAAAACCTAT GAGAAACTGA CAGAGATTAT CCCCAAGTCA 
GCGGTGGGCG AGCTGTCTGA CGATTCCAGT AACGTAGTCC AGCTTATCAA GAAAGCCTAC 
TACAAACTCT CCTCTAGAGT CTTCCTGGAC CACACCACCA TCCCGGACAC CCTGAAAGTC 
ACCTATGACT CCTTCTGTAA TAACAGAGTA TCGAGTATAG GCAAATCCCG AGGGGACTGT 
GACGGTGTGC AGATCAACAA CCCGGTCACC TTCCAGGTAA AGGTCACGGC TTCGGAGTGT 
ATCCAGGAGC AGTCCTTTGT CATCCGGGCG CTGGGCTTCA CCGACACAGT GACGGTACAG 
GTCCATCCCC AGTGCGAGTG CCAGTGCCGG GACCAGAGTC GGATGAGGAA TCTCTGTGGA 
GGCAAGGGAG TCATGGAGTG TGGCATCTGC AGGTGTGAGT CTGGCTACAT TGGGAAAAAC 
TGTGAGTGTC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGGAACTG CCGGAAGGAC 
AATAGTTCCA TTGTGTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGTGACA TCCCCAACAA AGTGATCTTT GGGCAATACT GCGAGTGTGA CAACTTCAAC 
TGTGAGAGAT ATGATGGCCA AGTCTGCGGT GGCCTAAAGA GAGGCTCCTG CTCCTGTGGC 
CAGTGTAATT GCAAGGAGGG TTTCGAGGGT TCTGCTTGCC AGTGTCAGAG GTCTACCACG 
GGCTGTCTGA ACGCACGGCT GGTGGAGTGC AGTGGCCGTG GCCGGTGCCA ATGCAACAGA 
TGCATCTGTG AGAAAGGTTA CCAGCCACCT CTGTGTGAAG AGTGTCCCGG CTGCCCCTTG 
CCCTGCAGCA CCTACGTCTT CTGTGCCGAG TGCCTGAAAT TTGATAAGGG CCCCTTTCAG 
AAGAATTGTA GTGTTCAGTG TGCCAATGTG ACGCTGCAGA CTGTCCCTTT CAAGAAAAAG 
CCCTGCAAGG AGAGGGACTC GGAGGGCTGC TGGATAACCT ACACTTTGCA GCAGAAGGAC 
GGAAACGCTT ACAACATCCA TGTGGACGAC GATCGAGAGT GTGTGAAAGG CCCCAACGTG 
GCTGCCATCA TAGGGGGCAC TGTGGCCGGC GTTGTACTGA TTGGTGTCCT CCTCCTGGTC 
ATCTGGAAGG CTCTTACCCA CCTGACTGAC CTCAATGAAT ACAGACGCTT TGAGAAGGAG 
AAACTCAAGT CCCAGTGGAA CAACGACAAC CCCCTCTTCA AGAGCGCCAC GACAACGGTC 
ATGAACCCTA AGTTTGCTGA GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032869.2
CDS	254..2560
Translation	MLGPHTLLLILAGLLFLGSALSEECTKYKVSNCRDCIQSGPGCSWCQKLNFTGPGEPDSLRCDTRAQLLLKGCPADDIMDPKSFADLHPQYQVQRSQLSPQKVTLNLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIKKAYYKLSSRVFLDHTTIPDTLKVTYDSFCNNRVSSIGKSRGDCDGVQINNPVTFQVKVTASECIQEQSFVIRALGFTDTVTVQVHPQCECQCRDQSRMRNLCGGKGVMECGICRCESGYIGKNCECQTQGRSSQELEGNCRKDNSSIVCSGLGDCICGQCVCHTSDIPNKVIFGQYCECDNFNCERYDGQVCGGLKRGSCSCGQCNCKEGFEGSACQCQRSTTGCLNARLVECSGRGRCQCNRCICEKGYQPPLCEECPGCPLPCSTYVFCAECLKFDKGPFQKNCSVQCANVTLQTVPFKKKPCKERDSEGCWITYTLQQKDGNAYNIHVDDDRECVKGPNVAAIIGGTVAGVVLIGVLLLVIWKALTHLTDLNEYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES

Target ORF information:

RefSeq Version	NM_001037780.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus integrin subunit beta 2 (Itgb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037780.2

ORF Insert Sequence:

ATGCTGGGCC CACACACACT GCTACTCATC CTAGCTGGAC TACTCTTCCT GGGATCTGCC 
CTGTCCGAGG AATGCACCAA GTACAAAGTC AGCAACTGCC GGGACTGTAT CCAGTCGGGG 
CCTGGCTGCT CGTGGTGCCA GAAGCTGAAC TTCACCGGAC CAGGGGAGCC TGACTCCTTG 
CGCTGTGACA CGCGGGCACA GCTGCTCCTC AAGGGTTGCC CAGCCGATGA TATAATGGAC 
CCCAAGAGCT TTGCTGATCT CCACCCCCAA TATCAGGTGC AACGGAGTCA ACTGTCTCCA 
CAAAAAGTGA CCCTTAACTT GCGACCAGGG CAGGCTGCTG CATTCAATGT GACTTTCCGA 
CGGGCCAAGG GCTACCCCAT TGATCTGTAC TACCTCATGG ACCTCTCCTA CTCTATGCTC 
GATGACCTGA ACAATGTCAA GAAGTTGGGT GGTGATTTGC TGCAGGCCCT CAACGAGATC 
ACAGAGTCCG GCCGCATCGG CTTCGGGTCC TTCGTGGACA AGACGGTGCT GCCTTTTGTC 
AACACCCATC CCGAGAAGCT GAGGAACCCA TGCCCCAACA AGGAGAAAGC CTGCCAGCCT 
CCGTTTGCCT TTCGCCACGT GCTCAAGCTA ACCGACAACT CCAACCAGTT TCAGACAGAG 
GTCGGCAAGC AACTGATTTC CGGAAACCTG GACGCCCCTG AGGGCGGGCT GGATGCCATA 
ATGCAAGTGG CTGCCTGTCC GGAGGAAATT GGCTGGCGCA ATGTCACGAG GCTGCTGGTG 
TTTGCCACAG ACGACGGCTT CCACTTTGCC GGTGATGGGA AACTGGGTGC CATCCTGACC 
CCCAACGATG GCCGCTGCCA CCTGGAGGAT AACATGTACA AGAGGAGCAA TGAGTTCGAC 
TACCCGTCAG TGGGCCAGCT GGCCCACAAA CTTTCCGAGA GCAACATCCA GCCCATCTTT 
GCAGTGACAA AGAAGATGGT GAAAACCTAT GAGAAACTGA CAGAGATTAT CCCCAAGTCA 
GCGGTGGGCG AGCTGTCTGA CGATTCCAGT AACGTAGTCC AGCTTATCAA GAAAGCCTAC 
TACAAACTCT CCTCTAGAGT CTTCCTGGAC CACACCACCA TCCCGGACAC CCTGAAAGTC 
ACCTATGACT CCTTCTGTAA TAACAGAGTA TCGAGTATAG GCAAATCCCG AGGGGACTGT 
GACGGTGTGC AGATCAACAA CCCGGTCACC TTCCAGGTAA AGGTCACGGC TTCGGAGTGT 
ATCCAGGAGC AGTCCTTTGT CATCCGGGCG CTGGGCTTCA CCGACACAGT GACGGTACAG 
GTCCATCCCC AGTGCGAGTG CCAGTGCCGG GACCAGAGTC GGATGAGGAA TCTCTGTGGA 
GGCAAGGGAG TCATGGAGTG TGGCATCTGC AGGTGTGAGT CTGGCTACAT TGGGAAAAAC 
TGTGAGTGTC AGACGCAGGG CCGGAGCAGC CAGGAGCTGG AGGGGAACTG CCGGAAGGAC 
AATAGTTCCA TTGTGTGCTC GGGGCTGGGG GACTGCATCT GCGGGCAGTG CGTGTGCCAC 
ACGAGTGACA TCCCCAACAA AGTGATCTTT GGGCAATACT GCGAGTGTGA CAACTTCAAC 
TGTGAGAGAT ATGATGGCCA AGTCTGCGGT GGCCTAAAGA GAGGCTCCTG CTCCTGTGGC 
CAGTGTAATT GCAAGGAGGG TTTCGAGGGT TCTGCTTGCC AGTGTCAGAG GTCTACCACG 
GGCTGTCTGA ACGCACGGCT GGTGGAGTGC AGTGGCCGTG GCCGGTGCCA ATGCAACAGA 
TGCATCTGTG AGAAAGGTTA CCAGCCACCT CTGTGTGAAG AGTGTCCCGG CTGCCCCTTG 
CCCTGCAGCA CCTACGTCTT CTGTGCCGAG TGCCTGAAAT TTGATAAGGG CCCCTTTCAG 
AAGAATTGTA GTGTTCAGTG TGCCAATGTG ACGCTGCAGA CTGTCCCTTT CAAGAAAAAG 
CCCTGCAAGG AGAGGGACTC GGAGGGCTGC TGGATAACCT ACACTTTGCA GCAGAAGGAC 
GGAAACGCTT ACAACATCCA TGTGGACGAC GATCGAGAGT GTGTGAAAGG CCCCAACGTG 
GCTGCCATCA TAGGGGGCAC TGTGGCCGGC GTTGTACTGA TTGGTGTCCT CCTCCTGGTC 
ATCTGGAAGG CTCTTACCCA CCTGACTGAC CTCAATGAAT ACAGACGCTT TGAGAAGGAG 
AAACTCAAGT CCCAGTGGAA CAACGACAAC CCCCTCTTCA AGAGCGCCAC GACAACGGTC 
ATGAACCCTA AGTTTGCTGA GAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.
Blood130(19)2092-2100(2017 11)
Bai M,Grieshaber-Bouyer R,Wang J,Schmider AB,Wilson ZS,Zeng L,Halyabar O,Godin MD,Nguyen HN,Levescot A,Cunin P,Lefort CT,Soberman RJ,Nigrovic PA

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Atherosclerosis242(1)145-54(2015 Sep)
Oksala N,P?rssinen J,Sepp?l? I,Klopp N,Illig T,Laaksonen R,Levula M,Raitoharju E,Kholova I,Sioris T,K?h?nen M,Lehtim?ki T,Hyt?nen VP

Cell type-specific differences in ?-glucan recognition and signalling in porcine innate immune cells.
Developmental and comparative immunology48(1)192-203(2015 Jan)
Baert K,Sonck E,Goddeeris BM,Devriendt B,Cox E

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Journal of proteomics106191-204(2014 Jun)
Chiasserini D,van Weering JR,Piersma SR,Pham TV,Malekzadeh A,Teunissen CE,de Wit H,Jim?nez CR

The cytokine midkine supports neutrophil trafficking during acute inflammation by promoting adhesion via ?2 integrins (CD11/CD18).
Blood123(12)1887-96(2014 Mar)
Weckbach LT,Gola A,Winkelmann M,Jakob SM,Groesser L,Borgolte J,Pogoda F,Pick R,Pruenster M,M?ller-H?cker J,Deindl E,Sperandio M,Walzog B

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Itgb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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