Shoc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Shoc2
Entrez Gene ID	309548
Full Name	SHOC2 leucine-rich repeat scaffold protein
General protein information	Preferred Names SHOC2 leucine-rich repeat scaffold protein Names leucine-rich repeat protein SHOC-2 protein soc-2 homolog protein sur-8 homolog soc-2 (suppressor of clear) homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q55

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013155.1	NP_001013173.1	leucine-rich repeat protein SHOC-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SHOC2	NP_031399.2
Pan troglodytes (chimpanzee)	SHOC2	XP_521602.2
Mus musculus (house mouse)	Shoc2	NP_062632.2
Gallus gallus (chicken)	SHOC2	NP_001026407.1
Danio rerio (zebrafish)	shoc2	NP_001038251.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004485	XP_313783.5
Oryza sativa (rice)	Os10g0119200	NP_001064062.2
Canis lupus familiaris (dog)	SHOC2	XP_535013.2
Bos taurus (cattle)	SHOC2	NP_001095413.1
Drosophila melanogaster (fruit fly)	Sur-8	NP_001262665.1
	SHOC2	XP_001087610.1
Rattus norvegicus (Norway rat)	Shoc2	NP_001013173.1
Caenorhabditis elegans (roundworm)	soc-2	NP_741391.2
Xenopus tropicalis (tropical clawed frog)	shoc2	XP_004915781.1

Gene Ontology
Bibliography

Related articles in PubMed

A Novel SHOC2 Variant in Rasopathy.
Hannig V, Jeoung M, Jang ER, Phillips JA 3rd, Galperin E
Human mutation35(11)1290-4(2014 Nov)

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
Cordeddu V, Di Schiavi E, Pennacchio LA, Ma'ayan A, Sarkozy A, Fodale V, Cecchetti S, Cardinale A, Martin J, Schackwitz W, Lipzen A, Zampino G, Mazzanti L, Digilio MC, Martinelli S, Flex E, Lepri F, Bartholdi D, Kutsche K, Ferrero GB, Anichini C, Selicorni A, Rossi C, Tenconi R, Zenker M, Merlo D, Dallapiccola B, Iyengar R, Bazzicalupo P, Gelb BD, Tartaglia M
Nature genetics41(9)1022-6(2009 Sep)

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F
Molecular cell22(2)217-30(2006 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Shoc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Shoc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03616	NM_001013155.1 Latest version!	Rattus norvegicus SHOC2 leucine-rich repeat scaffold protein (Shoc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Shoc2 ( NM_001013155.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013173.1 Rattus norvegicus SHOC2 leucine-rich repeat scaffold protein (Shoc2), mRNA.

Price & Availability↑

CloneID	ORa03616
Clone ID Related Accession (Same CDS sequence)	NM_001013155.1
Accession Version	NM_001013155.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1749bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-07
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat protein SHOC-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079032.1. On Apr 20, 2005 this sequence version replaced XM_220082.2. ##Evidence-Data-START## CDS exon combination :: BC079032.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGTAGTA GTTTAGGAAA AGAAAAAGAC TCGAAAGAGA AAGATCCCAA AGTACCATCT 
GCCAAGGAAA GAGAAAAGGA GGCAAAAGCC TCTGGAGGTT TTGGGAAAGA AAGCAAAGAA 
AAAGAACCTA AAACCAAAGG GAAAGATGCC AAAGATGGAA AGAAGGAGTC CAGTGCTGCC 
CAACCTGGTG TGGCTTTTTC AGTCGACAAT ACCATCAAAC GGCCTAATCC AGCACTTGGG 
ACTAGAAAGA AATCCAGCAA TGCCGAGGTA ACTAAGGAGC TTAACAAATG CCGGGAGGAG 
AACTCAATGC GCTTGGACTT ATCCAAGCGG TCTATACATA TACTGCCGCC GTCAGTCAAA 
GAGTTGACAC AACTCACGGA ACTTTATTTA TACAGTAACA AATTGCAGTC CCTCCCAGCA 
GAGGTGGGCT GTCTAGTCAA TCTTATGACG CTGGCTCTCA GTGAGAATTC ACTCACCAGT 
TTGCCTGACT CTCTCGATAA CTTGAAGAAG CTGCGGATGC TTGATTTACG GCATAATAAA 
CTGAGAGAAA TCCCTTCGGT GGTGTACAGG CTAGACTCCC TGACTACTCT CTACCTTCGC 
TTTAACCGCA TAACCGCTGT GGAGAAGGAC GTCAGAAACC TGCCGAGGCT CAGCACGCTT 
AGCATCCGAG AGAACAAAAT CAAGCAGCTC CCTGCCGAGA TCGGTGAACT GTGTAACCTC 
ATTACCCTGG ATGTAGCTCA CAATCAACTT GAACACCTTC CGAAGGAGAT TGGGAACTGC 
ACCCAGATAA CCAACCTGGA CCTGCAGCAC AATGAGCTGC TAGACCTCCC AGACACAATA 
GGAAACCTGT CCAGTTTAAA TCGCCTTGGC CTGAGGTACA ATAGATTGTC AGCAATACCC 
AGATCATTAG CAAAATGCAG CGCACTTGAG GAGCTAAATC TAGAGAACAA TAACATTTCT 
ACTCTGCCAG AGAGTCTTTT ATCCAGTCTT GTAAAATTGA ATAGCTTGAC CTTAGCTAGA 
AATTGCTTCC AGTTGTACCC AGTGGGAGGC CCATCTCAGT TTTCCACCAT TTATTCCCTC 
AACATGGAAC ACAATCGAAT CAACAAAATC CCATTTGGAA TTTTTTCCAG AGCTAAAGTG 
CTGAGTAAGC TGAATATGAA GGACAATCAG TTAACATCAC TTCCTTTGGA TTTTGGAACT 
TGGACCAGTA TGGTAGAATT GAATTTAGCG ACCAATCAGC TCACAAAGAT CCCGGAGGAC 
GTGTCTGGTC TTGTTTCTCT TGAGGTTCTA ATATTATCGA ACAATCTTCT AAAGAAGCTT 
CCCCATGGTC TTGGAAACCT TAGAAAGTTA CGAGAATTAG ACCTGGAGGA GAACAAGCTG 
GAGTCCTTGC CCAATGAGAT TGCTTATCTT AAGGATTTAC AGAAATTAGT CTTGACAAAC 
AACCAGTTGA CCACTCTCCC CAGAGGCATC GGTCACCTTA CCAACCTCAC ACACCTTGGT 
CTCGGAGAGA ACCTTCTCAC TCACCTTCCT GAGGAAATTG GTACACTGGA AAACCTAGAG 
GAGCTGTACT TGAATGACAA CCCCAACCTT CACAGCCTCC CCTTCGAGCT TGCCCTCTGC 
AGCAAGCTGT CAATCATGAG TATTGAGAAC TGTCCACTCA GTCACCTCCC ACCTCAAATT 
GTTGCTGGAG GGCCTTCATT CATTATTCAG TTCTTAAAGA TGCAGGGTCC GTATCGTGCC 
ATGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013173.1
CDS	234..1982
Translation	MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPALGTRKKSSNAEVTKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV

Target ORF information:

RefSeq Version	NM_001013155.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SHOC2 leucine-rich repeat scaffold protein (Shoc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013155.1

ORF Insert Sequence:

ATGAGTAGTA GTTTAGGAAA AGAAAAAGAC TCGAAAGAGA AAGATCCCAA AGTACCATCT 
GCCAAGGAAA GAGAAAAGGA GGCAAAAGCC TCTGGAGGTT TTGGGAAAGA AAGCAAAGAA 
AAAGAACCTA AAACCAAAGG GAAAGATGCC AAAGATGGAA AGAAGGAGTC CAGTGCTGCC 
CAACCTGGTG TGGCTTTTTC AGTCGACAAT ACCATCAAAC GGCCTAATCC AGCACTTGGG 
ACTAGAAAGA AATCCAGCAA TGCCGAGGTA ACTAAGGAGC TTAACAAATG CCGGGAGGAG 
AACTCAATGC GCTTGGACTT ATCCAAGCGG TCTATACATA TACTGCCGCC GTCAGTCAAA 
GAGTTGACAC AACTCACGGA ACTTTATTTA TACAGTAACA AATTGCAGTC CCTCCCAGCA 
GAGGTGGGCT GTCTAGTCAA TCTTATGACG CTGGCTCTCA GTGAGAATTC ACTCACCAGT 
TTGCCTGACT CTCTCGATAA CTTGAAGAAG CTGCGGATGC TTGATTTACG GCATAATAAA 
CTGAGAGAAA TCCCTTCGGT GGTGTACAGG CTAGACTCCC TGACTACTCT CTACCTTCGC 
TTTAACCGCA TAACCGCTGT GGAGAAGGAC GTCAGAAACC TGCCGAGGCT CAGCACGCTT 
AGCATCCGAG AGAACAAAAT CAAGCAGCTC CCTGCCGAGA TCGGTGAACT GTGTAACCTC 
ATTACCCTGG ATGTAGCTCA CAATCAACTT GAACACCTTC CGAAGGAGAT TGGGAACTGC 
ACCCAGATAA CCAACCTGGA CCTGCAGCAC AATGAGCTGC TAGACCTCCC AGACACAATA 
GGAAACCTGT CCAGTTTAAA TCGCCTTGGC CTGAGGTACA ATAGATTGTC AGCAATACCC 
AGATCATTAG CAAAATGCAG CGCACTTGAG GAGCTAAATC TAGAGAACAA TAACATTTCT 
ACTCTGCCAG AGAGTCTTTT ATCCAGTCTT GTAAAATTGA ATAGCTTGAC CTTAGCTAGA 
AATTGCTTCC AGTTGTACCC AGTGGGAGGC CCATCTCAGT TTTCCACCAT TTATTCCCTC 
AACATGGAAC ACAATCGAAT CAACAAAATC CCATTTGGAA TTTTTTCCAG AGCTAAAGTG 
CTGAGTAAGC TGAATATGAA GGACAATCAG TTAACATCAC TTCCTTTGGA TTTTGGAACT 
TGGACCAGTA TGGTAGAATT GAATTTAGCG ACCAATCAGC TCACAAAGAT CCCGGAGGAC 
GTGTCTGGTC TTGTTTCTCT TGAGGTTCTA ATATTATCGA ACAATCTTCT AAAGAAGCTT 
CCCCATGGTC TTGGAAACCT TAGAAAGTTA CGAGAATTAG ACCTGGAGGA GAACAAGCTG 
GAGTCCTTGC CCAATGAGAT TGCTTATCTT AAGGATTTAC AGAAATTAGT CTTGACAAAC 
AACCAGTTGA CCACTCTCCC CAGAGGCATC GGTCACCTTA CCAACCTCAC ACACCTTGGT 
CTCGGAGAGA ACCTTCTCAC TCACCTTCCT GAGGAAATTG GTACACTGGA AAACCTAGAG 
GAGCTGTACT TGAATGACAA CCCCAACCTT CACAGCCTCC CCTTCGAGCT TGCCCTCTGC 
AGCAAGCTGT CAATCATGAG TATTGAGAAC TGTCCACTCA GTCACCTCCC ACCTCAAATT 
GTTGCTGGAG GGCCTTCATT CATTATTCAG TTCTTAAAGA TGCAGGGTCC GTATCGTGCC 
ATGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Novel SHOC2 Variant in Rasopathy.
Human mutation35(11)1290-4(2014 Nov)
Hannig V,Jeoung M,Jang ER,Phillips JA 3rd,Galperin E

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair.
Nature genetics41(9)1022-6(2009 Sep)
Cordeddu V,Di Schiavi E,Pennacchio LA,Ma'ayan A,Sarkozy A,Fodale V,Cecchetti S,Cardinale A,Martin J,Schackwitz W,Lipzen A,Zampino G,Mazzanti L,Digilio MC,Martinelli S,Flex E,Lepri F,Bartholdi D,Kutsche K,Ferrero GB,Anichini C,Selicorni A,Rossi C,Tenconi R,Zenker M,Merlo D,Dallapiccola B,Iyengar R,Bazzicalupo P,Gelb BD,Tartaglia M

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity.
Molecular cell22(2)217-30(2006 Apr)
Rodriguez-Viciana P,Oses-Prieto J,Burlingame A,Fried M,McCormick F

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Shoc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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