Twnk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Twnk
Entrez Gene ID	309441
Full Name	twinkle mtDNA helicase
Synonyms	Peo1
General protein information	Preferred Names twinkle mtDNA helicase Names twinkle protein, mitochondrial progressive external ophthalmoplegia 1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54

mRNA and Protein(s)

mRNA	Protein	Name
XM_008760430.2	XP_008758652.1	twinkle protein, mitochondrial isoform X2
XM_008760429.2	XP_008758651.1	twinkle protein, mitochondrial isoform X1
XM_008760431.2	XP_008758653.1	twinkle protein, mitochondrial isoform X2
XM_017589287.1	XP_017444776.1	twinkle protein, mitochondrial isoform X2
NM_001107599.1	NP_001101069.1	twinkle protein, mitochondrial

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Peo1	NP_722491.2
Rattus norvegicus (Norway rat)	Peo1	NP_001101069.1
Drosophila melanogaster (fruit fly)	CG5924	NP_609318.1
Homo sapiens (human)	C10orf2	NP_068602.2
Pan troglodytes (chimpanzee)	C10H10orf2	XP_003951780.1
Canis lupus familiaris (dog)	C28H10orf2	XP_543974.1
Danio rerio (zebrafish)	peo1	NP_001264527.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010720	XP_311434.3
Caenorhabditis elegans (roundworm)	F46G11.1	NP_508973.3
Gallus gallus (chicken)	PEO1	NP_001026515.1
Xenopus tropicalis (tropical clawed frog)	LOC100491229	XP_002938766.1
	C9H10orf2	XP_001109287.1
Bos taurus (cattle)	C26H10orf2	NP_001091933.1

Gene Ontology
Bibliography

Related articles in PubMed

Damaged mitochondrial DNA replication system and the development of diabetic retinopathy.
Tewari S, Santos JM, Kowluru RA
Antioxidants & redox signaling17(3)492-504(2012 Aug)

Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy.
Tewari S, Zhong Q, Santos JM, Kowluru RA
Investigative ophthalmology & visual science53(8)4881-8(2012 Jul)

Clinical phenotype of autosomal dominant progressive external ophthalmoplegia in a family with a novel mutation in the C10orf2 gene.
Hong D, Bi H, Yao S, Wang Z, Yuan Y
Muscle & nerve41(1)92-9(2010 Jan)

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Goffart S, Cooper HM, Tyynismaa H, Wanrooij S, Suomalainen A, Spelbrink JN
Human molecular genetics18(2)328-40(2009 Jan)

The layered structure of human mitochondrial DNA nucleoids.
Bogenhagen DF, Rousseau D, Burke S
The Journal of biological chemistry283(6)3665-75(2008 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A heterozygous missense mutation of c.1342A>G in the C10orf2 gene resulting in the p.448N>D mutation in the protein was found in the proband and four other affected family members.
Title: Clinical phenotype of autosomal dominant progressive external ophthalmoplegia in a family with a novel mutation in the C10orf2 gene.

The following Twnk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Twnk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa46747	XM_017589287.1 Latest version!	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa46747	XM_008760430.2 Latest version!	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa46747	XM_008760431.2 Latest version!	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa04146	NM_001107599.1 Latest version!	Rattus norvegicus twinkle mtDNA helicase (Twnk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa46746	XM_008760429.2 Latest version!	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Twnk ( XM_008760430.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758652.1 Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa46747
Clone ID Related Accession (Same CDS sequence)	XM_008760430.2 , XM_008760431.2 , XM_017589287.1
Accession Version	XM_008760430.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	twinkle protein, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760430.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758652.1
CDS	203..898
Translation	MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

Target ORF information:

RefSeq Version	XM_008760430.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760430.2

ORF Insert Sequence:

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Twnk ( XM_008760431.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758653.1 Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa46747
Clone ID Related Accession (Same CDS sequence)	XM_008760430.2 , XM_008760431.2 , XM_017589287.1
Accession Version	XM_008760431.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	twinkle protein, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760431.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758653.1
CDS	251..946
Translation	MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

Target ORF information:

RefSeq Version	XM_008760431.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760431.2

ORF Insert Sequence:

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Twnk ( XM_017589287.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444776.1 Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa46747
Clone ID Related Accession (Same CDS sequence)	XM_008760430.2 , XM_008760431.2 , XM_017589287.1
Accession Version	XM_017589287.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 696bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	twinkle protein, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444776.1
CDS	238..933
Translation	MLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

Target ORF information:

RefSeq Version	XM_017589287.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589287.1

ORF Insert Sequence:

ATGCTGACTC AGTTTGCTGT GACACGGCTA GAAGAACAAC TGGACAAGTA TGAAGAGTGG 
GCAGACCGTT TTGAGGACCT GCCTCTCTAT TTCATGACTT TCCACGGACA ACAGAGCATC 
AGGTCTGTCA TAGACACAAT GCAACATGCT GTCTACGTCT ATGACGTTTG TCATGTAGTC 
ATCGACAACT TGCAGTTCAT GATGGGTCAT GAGCAGCTCT CTACTGACAG GATCGCAGCT 
CAAGACTACA TTGTTGGAGC CTTTCGGAAG TTTGCCACAG ACAATAGCTG CCACGTGACT 
CTGGTTATTC ACCCACGGAA AGAAGATGAC GACAAGGAAC TACAGACAGC ATCCATTTTT 
GGCTCAGCCA AAGCCAGCCA AGAAGCAGAC AATGTTCTGA TCTTGCAGGA CAGGAAGCTG 
GTGACTGGGC CTGGGAAACG GTATCTGCAG GTGTCCAAAA ATCGCTTTGA TGGAGACGTA 
GGCGTCTTCC CACTTGAGTT CAACAAGAGT TCCCTTACCT TCTCCATCCC ACCTAAGAGC 
AAAGCCCGAC TCAAGAAGAT TAAGGATGAC AATGGACTAG TGGCCAAGAA GTCCTCCTCT 
GGAAAAAAAG GGTCTGCGCA CCAGAACTCT GAGACTTGCA TAGGCCAGGA CCCCTGCCAG 
CCAGATACCT CCCCGTCCTC AAGGCATAAG AATTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Twnk ( NM_001107599.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101069.1 Rattus norvegicus twinkle mtDNA helicase (Twnk), mRNA.

Price & Availability↑

CloneID	ORa04146
Clone ID Related Accession (Same CDS sequence)	NM_001107599.1
Accession Version	NM_001107599.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2052bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	twinkle protein, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473986.1. On or before Oct 4, 2007 this sequence version replaced XM_219939.4, XM_001063420.1. ##Evidence-Data-START## Transcript exon combination :: EV770275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGTGGCTCC TTCTCCGGCG TGCTTATCCC CTCCGGATCT TGCTGCCACT GCGTGGGGAG 
TGGATGGGTA GGAGAGGCCT GCCCCGAAGC TTGGCTCCAG GCCCTCCCCG AAGAAGGTAC 
AGAAAAGAAG CGCTTCCAGC CTTAGAGGTA CCAGTATCAC CTGTGACTAC AACTGAAATC 
CGCCAATATT TACGAGCACA TGGGATCCCC TTCCAGGATG GCCACAGCTG CCTTCGAGCA 
CCAAGTCCCT TTGTGGCACC CTCAGACATC AAAAATCAGA AGAAGGATGC TACCACTTCC 
TTCTGCCTCT TCATCGACAA GACCACAGGA CACTTTCTCT GCATGACCAG CCTAGCAGAA 
GGGAGCTGGG AAGACCTCCA GGCCAGTGTG GAGGGACGAG GCGATGGGGC CAAAGAGGGA 
ATCCTACTTG GGGAGGGCCC AGAAGCTGAG GACAGGGAGG AGGTCTTGAG AATCTGGAAC 
CGAGCCATAC CTCTTTGGGA GCTGCCTGAT CCCCAGGAAA CCCAGCTAGC TCGTGTGATG 
TTTGGCCTTA CCAAGGTGAC AGATGACACA CTCAGGAGAT TCAATGTCCG CTATCTTCGA 
TCTACTCGAA GTCTGGTCTT CCCTTGGTTC ACCCCTGGGA GCTCAGGATT ACGTGGCCTG 
AAGCTACTAG GGGTTGAGGG TCAGGAAAAT GGAGTACAGT ATGTAGAGAC CACCATTCCC 
CGGCCTGGTG TCTATCACAA CCTATTTGGA TTACCCCTGA TCGGCCGTAG AGACACTGAG 
GTGGTCCTGA CAAGTCGAGA GCTGGACAGC CTGGCCTTGA GCCAGTCCAC GGGGCTGCCA 
ACCCTTTCCC TACCCCGAGG AACGGTCTGC TTACCCCCAG CCCTACTCCC TTACCTCGAA 
CAGTTCCGGA GGATTGTGTT CTGGCTAGGG GATGACCTTC GATCGTGGGA AGCTGCCAAA 
CTGTTTGCCC GAAAACTGAA CCCCAAGCGA TGCTCTTTGG TGAGGCCTGG GAACCAACAA 
CCTCGTCCCC TGGAGGCCTT AAACCAAGGC TTAAGTCTTC CCCGTATTCT CCGTACTGCC 
CTCCCTGCCT GGCACAAGTC TATTGTGTCT TTTCGCCAGC TCCGAGAAGA GGTTTTAGGA 
GAGCTATCAA ATGTGGACCA AGCAGCCGGT GTCCGTTGGA GCCGATTCCC AGACCTTAAT 
CGGCTGCTGA AGGGTCATCG GAAGGGCGAG CTGACGGTCT TTACAGGGCC AACAGGCAGT 
GGCAAGACAA CATTCATCAG TGAGTATGCC CTGGACTTGT GTACCCAGGG AGTGAACACA 
CTGTGGGGTA GCTTTGAGAT CAGCAATGTG AGACTAGCCC GGGTCATGCT GACTCAGTTT 
GCTGTGACAC GGCTAGAAGA ACAACTGGAC AAGTATGAAG AGTGGGCAGA CCGTTTTGAG 
GACCTGCCTC TCTATTTCAT GACTTTCCAC GGACAACAGA GCATCAGGTC TGTCATAGAC 
ACAATGCAAC ATGCTGTCTA CGTCTATGAC GTTTGTCATG TAGTCATCGA CAACTTGCAG 
TTCATGATGG GTCATGAGCA GCTCTCTACT GACAGGATCG CAGCTCAAGA CTACATTGTT 
GGAGCCTTTC GGAAGTTTGC CACAGACAAT AGCTGCCACG TGACTCTGGT TATTCACCCA 
CGGAAAGAAG ATGACGACAA GGAACTACAG ACAGCATCCA TTTTTGGCTC AGCCAAAGCC 
AGCCAAGAAG CAGACAATGT TCTGATCTTG CAGGACAGGA AGCTGGTGAC TGGGCCTGGG 
AAACGGTATC TGCAGGTGTC CAAAAATCGC TTTGATGGAG ACGTAGGCGT CTTCCCACTT 
GAGTTCAACA AGAGTTCCCT TACCTTCTCC ATCCCACCTA AGAGCAAAGC CCGACTCAAG 
AAGATTAAGG ATGACAATGG ACTAGTGGCC AAGAAGTCCT CCTCTGGAAA AAAAGGGTCT 
GCGCACCAGA ACTCTGAGAC TTGCATAGGC CAGGACCCCT GCCAGCCAGA TACCTCCCCG 
TCCTCAAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101069.1
CDS	713..2764
Translation	MWLLLRRAYPLRILLPLRGEWMGRRGLPRSLAPGPPRRRYRKEALPALEVPVSPVTTTEIRQYLRAHGIPFQDGHSCLRAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLCMTSLAEGSWEDLQASVEGRGDGAKEGILLGEGPEAEDREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLRRFNVRYLRSTRSLVFPWFTPGSSGLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGRRDTEVVLTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVDQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSR

Target ORF information:

RefSeq Version	NM_001107599.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus twinkle mtDNA helicase (Twnk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107599.1

ORF Insert Sequence:

ATGTGGCTCC TTCTCCGGCG TGCTTATCCC CTCCGGATCT TGCTGCCACT GCGTGGGGAG 
TGGATGGGTA GGAGAGGCCT GCCCCGAAGC TTGGCTCCAG GCCCTCCCCG AAGAAGGTAC 
AGAAAAGAAG CGCTTCCAGC CTTAGAGGTA CCAGTATCAC CTGTGACTAC AACTGAAATC 
CGCCAATATT TACGAGCACA TGGGATCCCC TTCCAGGATG GCCACAGCTG CCTTCGAGCA 
CCAAGTCCCT TTGTGGCACC CTCAGACATC AAAAATCAGA AGAAGGATGC TACCACTTCC 
TTCTGCCTCT TCATCGACAA GACCACAGGA CACTTTCTCT GCATGACCAG CCTAGCAGAA 
GGGAGCTGGG AAGACCTCCA GGCCAGTGTG GAGGGACGAG GCGATGGGGC CAAAGAGGGA 
ATCCTACTTG GGGAGGGCCC AGAAGCTGAG GACAGGGAGG AGGTCTTGAG AATCTGGAAC 
CGAGCCATAC CTCTTTGGGA GCTGCCTGAT CCCCAGGAAA CCCAGCTAGC TCGTGTGATG 
TTTGGCCTTA CCAAGGTGAC AGATGACACA CTCAGGAGAT TCAATGTCCG CTATCTTCGA 
TCTACTCGAA GTCTGGTCTT CCCTTGGTTC ACCCCTGGGA GCTCAGGATT ACGTGGCCTG 
AAGCTACTAG GGGTTGAGGG TCAGGAAAAT GGAGTACAGT ATGTAGAGAC CACCATTCCC 
CGGCCTGGTG TCTATCACAA CCTATTTGGA TTACCCCTGA TCGGCCGTAG AGACACTGAG 
GTGGTCCTGA CAAGTCGAGA GCTGGACAGC CTGGCCTTGA GCCAGTCCAC GGGGCTGCCA 
ACCCTTTCCC TACCCCGAGG AACGGTCTGC TTACCCCCAG CCCTACTCCC TTACCTCGAA 
CAGTTCCGGA GGATTGTGTT CTGGCTAGGG GATGACCTTC GATCGTGGGA AGCTGCCAAA 
CTGTTTGCCC GAAAACTGAA CCCCAAGCGA TGCTCTTTGG TGAGGCCTGG GAACCAACAA 
CCTCGTCCCC TGGAGGCCTT AAACCAAGGC TTAAGTCTTC CCCGTATTCT CCGTACTGCC 
CTCCCTGCCT GGCACAAGTC TATTGTGTCT TTTCGCCAGC TCCGAGAAGA GGTTTTAGGA 
GAGCTATCAA ATGTGGACCA AGCAGCCGGT GTCCGTTGGA GCCGATTCCC AGACCTTAAT 
CGGCTGCTGA AGGGTCATCG GAAGGGCGAG CTGACGGTCT TTACAGGGCC AACAGGCAGT 
GGCAAGACAA CATTCATCAG TGAGTATGCC CTGGACTTGT GTACCCAGGG AGTGAACACA 
CTGTGGGGTA GCTTTGAGAT CAGCAATGTG AGACTAGCCC GGGTCATGCT GACTCAGTTT 
GCTGTGACAC GGCTAGAAGA ACAACTGGAC AAGTATGAAG AGTGGGCAGA CCGTTTTGAG 
GACCTGCCTC TCTATTTCAT GACTTTCCAC GGACAACAGA GCATCAGGTC TGTCATAGAC 
ACAATGCAAC ATGCTGTCTA CGTCTATGAC GTTTGTCATG TAGTCATCGA CAACTTGCAG 
TTCATGATGG GTCATGAGCA GCTCTCTACT GACAGGATCG CAGCTCAAGA CTACATTGTT 
GGAGCCTTTC GGAAGTTTGC CACAGACAAT AGCTGCCACG TGACTCTGGT TATTCACCCA 
CGGAAAGAAG ATGACGACAA GGAACTACAG ACAGCATCCA TTTTTGGCTC AGCCAAAGCC 
AGCCAAGAAG CAGACAATGT TCTGATCTTG CAGGACAGGA AGCTGGTGAC TGGGCCTGGG 
AAACGGTATC TGCAGGTGTC CAAAAATCGC TTTGATGGAG ACGTAGGCGT CTTCCCACTT 
GAGTTCAACA AGAGTTCCCT TACCTTCTCC ATCCCACCTA AGAGCAAAGC CCGACTCAAG 
AAGATTAAGG ATGACAATGG ACTAGTGGCC AAGAAGTCCT CCTCTGGAAA AAAAGGGTCT 
GCGCACCAGA ACTCTGAGAC TTGCATAGGC CAGGACCCCT GCCAGCCAGA TACCTCCCCG 
TCCTCAAGGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Twnk ( XM_008760429.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758651.1 Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X1, mRNA.

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CloneID	ORa46746
Clone ID Related Accession (Same CDS sequence)	XM_008760429.2
Accession Version	XM_008760429.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2061bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	twinkle protein, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760429.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCTCC TTCTCCGGCG TGCTTATCCC CTCCGGATCT TGCTGCCACT GCGTGGGGAG 
TGGATGGGTA GGAGAGGCCT GCCCCGAAGC TTGGCTCCAG GCCCTCCCCG AAGAAGGTAC 
AGAAAAGAAG CGCTTCCAGC CTTAGAGGTA CCAGTATCAC CTGTGACTAC AACTGAAATC 
CGCCAATATT TACGAGCACA TGGGATCCCC TTCCAGGATG GCCACAGCTG CCTTCGAGCA 
CCAAGTCCCT TTGTGGCACC CTCAGACATC AAAAATCAGA AGAAGGATGC TACCACTTCC 
TTCTGCCTCT TCATCGACAA GACCACAGGA CACTTTCTCT GCATGACCAG CCTAGCAGAA 
GGGAGCTGGG AAGACCTCCA GGCCAGTGTG GAGGGACGAG GCGATGGGGC CAAAGAGGGA 
ATCCTACTTG GGGAGGGCCC AGAAGCTGAG GACAGGGAGG AGGTCTTGAG AATCTGGAAC 
CGAGCCATAC CTCTTTGGGA GCTGCCTGAT CCCCAGGAAA CCCAGCTAGC TCGTGTGATG 
TTTGGCCTTA CCAAGGTGAC AGATGACACA CTCAGGAGAT TCAATGTCCG CTATCTTCGA 
TCTACTCGAA GTCTGGTCTT CCCTTGGTTC ACCCCTGGGA GCTCAGGATT ACGTGGCCTG 
AAGCTACTAG GGGTTGAGGG TCAGGAAAAT GGAGTACAGT ATGTAGAGAC CACCATTCCC 
CGGCCTGGTG TCTATCACAA CCTATTTGGA TTACCCCTGA TCGGCCGTAG AGACACTGAG 
GTGGTCCTGA CAAGTCGAGA GCTGGACAGC CTGGCCTTGA GCCAGTCCAC GGGGCTGCCA 
ACCCTTTCCC TACCCCGAGG AACGGTCTGC TTACCCCCAG CCCTACTCCC TTACCTCGAA 
CAGTTCCGGA GGATTGTGTT CTGGCTAGGG GATGACCTTC GATCGTGGGA AGCTGCCAAA 
CTGTTTGCCC GAAAACTGAA CCCCAAGCGA TGCTCTTTGG TGAGGCCTGG GAACCAACAA 
CCTCGTCCCC TGGAGGCCTT AAACCAAGGC TTAAGTCTTC CCCGTATTCT CCGTACTGCC 
CTCCCTGCCT GGCACAAGTC TATTGTGTCT TTTCGCCAGC TCCGAGAAGA GGTTTTAGGA 
GAGCTATCAA ATGTGGACCA AGCAGCCGGT GTCCGTTGGA GCCGATTCCC AGACCTTAAT 
CGGCTGCTGA AGGGTCATCG GAAGGGCGAG CTGACGGTCT TTACAGGGCC AACAGGCAGT 
GGCAAGACAA CATTCATCAG TGAGTATGCC CTGGACTTGT GTACCCAGGG AGTGAACACA 
CTGTGGGGTA GCTTTGAGAT CAGCAATGTG AGACTAGCCC GGGTCATGCT GACTCAGTTT 
GCTGTGACAC GGCTAGAAGA ACAACTGGAC AAGTATGAAG AGTGGGCAGA CCGTTTTGAG 
GACCTGCCTC TCTATTTCAT GACTTTCCAC GGACAACAGA GCATCAGGTC TGTCATAGAC 
ACAATGCAAC ATGCTGTCTA CGTCTATGAC GTTTGTCATG TAGTCATCGA CAACTTGCAG 
TTCATGATGG GTCATGAGCA GCTCTCTACT GACAGGATCG CAGCTCAAGA CTACATTGTT 
GGAGCCTTTC GGAAGTTTGC CACAGACAAT AGCTGCCACG TGACTCTGGT TATTCACCCA 
CGGAAAGAAG ATGACGACAA GGAACTACAG ACAGCATCCA TTTTTGGCTC AGCCAAAGCC 
AGCCAAGAAG CAGACAATGT TCTGATCTTG CAGGACAGGA AGCTGGTGAC TGGGCCTGGG 
AAACGGTATC TGCAGGTGTC CAAAAATCGC TTTGATGGAG ACGTAGGCGT CTTCCCACTT 
GAGTTCAACA AGAGTTCCCT TACCTTCTCC ATCCCACCTA AGAGCAAAGC CCGACTCAAG 
AAGATTAAGG ATGACAATGG ACTAGTGGCC AAGAAGTCCT CCTCTGGAAA AAAAGGGTCT 
GCGCACCAGA ACTCTGAGAC TTGCATAGGC CAGGACCCCT GCCAGCCAGA TACCTCCCCG 
TCCTCAAGGC ATAAGAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758651.1
CDS	769..2829
Translation	MWLLLRRAYPLRILLPLRGEWMGRRGLPRSLAPGPPRRRYRKEALPALEVPVSPVTTTEIRQYLRAHGIPFQDGHSCLRAPSPFVAPSDIKNQKKDATTSFCLFIDKTTGHFLCMTSLAEGSWEDLQASVEGRGDGAKEGILLGEGPEAEDREEVLRIWNRAIPLWELPDPQETQLARVMFGLTKVTDDTLRRFNVRYLRSTRSLVFPWFTPGSSGLRGLKLLGVEGQENGVQYVETTIPRPGVYHNLFGLPLIGRRDTEVVLTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVDQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSTDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKSSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGSAHQNSETCIGQDPCQPDTSPSSRHKN

Target ORF information:

RefSeq Version	XM_008760429.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus progressive external ophthalmoplegia 1 (Peo1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760429.2

ORF Insert Sequence:

ATGTGGCTCC TTCTCCGGCG TGCTTATCCC CTCCGGATCT TGCTGCCACT GCGTGGGGAG 
TGGATGGGTA GGAGAGGCCT GCCCCGAAGC TTGGCTCCAG GCCCTCCCCG AAGAAGGTAC 
AGAAAAGAAG CGCTTCCAGC CTTAGAGGTA CCAGTATCAC CTGTGACTAC AACTGAAATC 
CGCCAATATT TACGAGCACA TGGGATCCCC TTCCAGGATG GCCACAGCTG CCTTCGAGCA 
CCAAGTCCCT TTGTGGCACC CTCAGACATC AAAAATCAGA AGAAGGATGC TACCACTTCC 
TTCTGCCTCT TCATCGACAA GACCACAGGA CACTTTCTCT GCATGACCAG CCTAGCAGAA 
GGGAGCTGGG AAGACCTCCA GGCCAGTGTG GAGGGACGAG GCGATGGGGC CAAAGAGGGA 
ATCCTACTTG GGGAGGGCCC AGAAGCTGAG GACAGGGAGG AGGTCTTGAG AATCTGGAAC 
CGAGCCATAC CTCTTTGGGA GCTGCCTGAT CCCCAGGAAA CCCAGCTAGC TCGTGTGATG 
TTTGGCCTTA CCAAGGTGAC AGATGACACA CTCAGGAGAT TCAATGTCCG CTATCTTCGA 
TCTACTCGAA GTCTGGTCTT CCCTTGGTTC ACCCCTGGGA GCTCAGGATT ACGTGGCCTG 
AAGCTACTAG GGGTTGAGGG TCAGGAAAAT GGAGTACAGT ATGTAGAGAC CACCATTCCC 
CGGCCTGGTG TCTATCACAA CCTATTTGGA TTACCCCTGA TCGGCCGTAG AGACACTGAG 
GTGGTCCTGA CAAGTCGAGA GCTGGACAGC CTGGCCTTGA GCCAGTCCAC GGGGCTGCCA 
ACCCTTTCCC TACCCCGAGG AACGGTCTGC TTACCCCCAG CCCTACTCCC TTACCTCGAA 
CAGTTCCGGA GGATTGTGTT CTGGCTAGGG GATGACCTTC GATCGTGGGA AGCTGCCAAA 
CTGTTTGCCC GAAAACTGAA CCCCAAGCGA TGCTCTTTGG TGAGGCCTGG GAACCAACAA 
CCTCGTCCCC TGGAGGCCTT AAACCAAGGC TTAAGTCTTC CCCGTATTCT CCGTACTGCC 
CTCCCTGCCT GGCACAAGTC TATTGTGTCT TTTCGCCAGC TCCGAGAAGA GGTTTTAGGA 
GAGCTATCAA ATGTGGACCA AGCAGCCGGT GTCCGTTGGA GCCGATTCCC AGACCTTAAT 
CGGCTGCTGA AGGGTCATCG GAAGGGCGAG CTGACGGTCT TTACAGGGCC AACAGGCAGT 
GGCAAGACAA CATTCATCAG TGAGTATGCC CTGGACTTGT GTACCCAGGG AGTGAACACA 
CTGTGGGGTA GCTTTGAGAT CAGCAATGTG AGACTAGCCC GGGTCATGCT GACTCAGTTT 
GCTGTGACAC GGCTAGAAGA ACAACTGGAC AAGTATGAAG AGTGGGCAGA CCGTTTTGAG 
GACCTGCCTC TCTATTTCAT GACTTTCCAC GGACAACAGA GCATCAGGTC TGTCATAGAC 
ACAATGCAAC ATGCTGTCTA CGTCTATGAC GTTTGTCATG TAGTCATCGA CAACTTGCAG 
TTCATGATGG GTCATGAGCA GCTCTCTACT GACAGGATCG CAGCTCAAGA CTACATTGTT 
GGAGCCTTTC GGAAGTTTGC CACAGACAAT AGCTGCCACG TGACTCTGGT TATTCACCCA 
CGGAAAGAAG ATGACGACAA GGAACTACAG ACAGCATCCA TTTTTGGCTC AGCCAAAGCC 
AGCCAAGAAG CAGACAATGT TCTGATCTTG CAGGACAGGA AGCTGGTGAC TGGGCCTGGG 
AAACGGTATC TGCAGGTGTC CAAAAATCGC TTTGATGGAG ACGTAGGCGT CTTCCCACTT 
GAGTTCAACA AGAGTTCCCT TACCTTCTCC ATCCCACCTA AGAGCAAAGC CCGACTCAAG 
AAGATTAAGG ATGACAATGG ACTAGTGGCC AAGAAGTCCT CCTCTGGAAA AAAAGGGTCT 
GCGCACCAGA ACTCTGAGAC TTGCATAGGC CAGGACCCCT GCCAGCCAGA TACCTCCCCG 
TCCTCAAGGC ATAAGAATTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Damaged mitochondrial DNA replication system and the development of diabetic retinopathy.
Antioxidants & redox signaling17(3)492-504(2012 Aug)
Tewari S,Santos JM,Kowluru RA

Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy.
Investigative ophthalmology & visual science53(8)4881-8(2012 Jul)
Tewari S,Zhong Q,Santos JM,Kowluru RA

Clinical phenotype of autosomal dominant progressive external ophthalmoplegia in a family with a novel mutation in the C10orf2 gene.
Muscle & nerve41(1)92-9(2010 Jan)
Hong D,Bi H,Yao S,Wang Z,Yuan Y

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Human molecular genetics18(2)328-40(2009 Jan)
Goffart S,Cooper HM,Tyynismaa H,Wanrooij S,Suomalainen A,Spelbrink JN

The layered structure of human mitochondrial DNA nucleoids.
The Journal of biological chemistry283(6)3665-75(2008 Feb)
Bogenhagen DF,Rousseau D,Burke S

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Twnk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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