Nsmce3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nsmce3
Entrez Gene ID	309259
Full Name	NSE3 homolog, SMC5-SMC6 complex component
Synonyms	Ndnl2
General protein information	Preferred Names NSE3 homolog, SMC5-SMC6 complex component Names non-structural maintenance of chromosomes element 3 homolog melanoma-associated antigen G1 necdin-like 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001173527.1	NP_001166998.1	non-structural maintenance of chromosomes element 3 homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	NDNL2	NP_619649.1
Pan troglodytes (chimpanzee)	NDNL2	XP_001163393.1
Bos taurus (cattle)	NDNL2	NP_001071548.1
Rattus norvegicus (Norway rat)	Ndnl2	NP_001166998.1
Xenopus tropicalis (tropical clawed frog)	ndnl2	NP_001016930.1
	NDNL2	XP_001109764.1
Canis lupus familiaris (dog)	NDNL2	XP_005618335.1
Gallus gallus (chicken)	NDNL2	NP_001098534.1
Mus musculus (house mouse)	Ndnl2	NP_075728.1

Gene Ontology
Bibliography

Related articles in PubMed

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.
van der Crabben SN, Hennus MP, McGregor GA, Ritter DI, Nagamani SC, Wells OS, Harakalova M, Chinn IK, Alt A, Vondrova L, Hochstenbach R, van Montfrans JM, Terheggen-Lagro SW, van Lieshout S, van Roosmalen MJ, Renkens I, Duran K, Nijman IJ, Kloosterman WP, Hennekam E, Orange JS, van Hasselt PM, Wheeler DA, Palecek JJ, Lehmann AR, Oliver AW, Pearl LH, Plon SE, Murray JM, van Haaften G
The Journal of clinical investigation126(8)2881-92(2016 Aug)

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Doyle JM, Gao J, Wang J, Yang M, Potts PR
Molecular cell39(6)963-74(2010 Sep)

Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Taylor EM, Copsey AC, Hudson JJ, Vidot S, Lehmann AR
Molecular and cellular biology28(4)1197-206(2008 Feb)

Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
Kuwako K, Taniura H, Yoshikawa K
The Journal of biological chemistry279(3)1703-12(2004 Jan)

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA,
Proceedings of the National Academy of Sciences of the United States of America99(26)16899-903(2002 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nsmce3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nsmce3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41845	NM_001173527.1 Latest version!	Rattus norvegicus NSE3 homolog, SMC5-SMC6 complex component (Nsmce3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nsmce3 ( NM_001173527.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001166998.1 Rattus norvegicus NSE3 homolog, SMC5-SMC6 complex component (Nsmce3), mRNA.

Price & Availability↑

CloneID	ORa41845
Clone ID Related Accession (Same CDS sequence)	NM_001173527.1
Accession Version	NM_001173527.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 837bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	non-structural maintenance of chromosomes element 3 homolog
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC098730.1. On May 13, 2010 this sequence version replaced XM_219708.4. ##Evidence-Data-START## Transcript is intronless :: BC098730.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCAGA AACCGAGGGG CCGCGGCCGG CCCAGCACTC AGGGTGATCG GGAGCGGGAC 
TGGGGAGGCT CTGGCGAGGA AGCGCCGAGC ACGTCCCGCG GCGCGGGCGG CACCTCTCAG 
GGCTCCCGCG CTTCCCTGTC GGCCCCCACC GTGGGGCCGC GCACACAGAA GCAGCTAGAG 
CTGAAGGTGG CCGAACTGGT GCAGTTCCTG CTGATTAAGG ACCAGAAGAA GATCCCGATC 
AAGCGCACCG ACATCCTGAA GCACGTGGTG GGAGACTACC GGGACGTGTA CCCCAATCTT 
CTGAAGCTGG CCGCCGAGCG CCTGCAGTAC GTGTTCGGGT ACAAGCTGGT GGAACTGGAG 
CCCAAGAGCC ACACCTACAT CCTCATCAAC GCGCTGGAGC CGGTGGAGGA GGATGCTGAG 
GTGAGAGGCG ATCAGGGTAC ACCCACCTCG GGCCTGCTTA TGATAGTCCT CGGGCTTATC 
TTCATGAAAG GCAACACCAT CACCGAGACT GAAGTCTGGG ACTTTCTCCG ACGGCTCGGA 
GTGTATCCCA CTAAGAAGCA TTTAATTTTT GGCGACCCAA AGAAACTCAT TACCGAAGAC 
TTTGTGCGGC AGCGCTATTT GGAGTACCGG AGGATACCCC ACACCGATCC TGTGGACTAT 
GAACTACAGT GGGGCCCGCG AACCAACCTG GAAACCAGCA AGATGAAAGT TCTTAAGTTC 
GTGGCCAAAG TCCATAATCA GGACCCCAAA GACTGGCCGG CACAATACTG CGAGGCTTTG 
GCAGATGAGG AGAGTAGGGC CAGACCTGCA GCTAGTGGTC TAGCCACATC CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166998.1
CDS	83..919
Translation	MLQKPRGRGRPSTQGDRERDWGGSGEEAPSTSRGAGGTSQGSRASLSAPTVGPRTQKQLELKVAELVQFLLIKDQKKIPIKRTDILKHVVGDYRDVYPNLLKLAAERLQYVFGYKLVELEPKSHTYILINALEPVEEDAEVRGDQGTPTSGLLMIVLGLIFMKGNTITETEVWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYELQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEESRARPAASGLATSS

Target ORF information:

RefSeq Version	NM_001173527.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NSE3 homolog, SMC5-SMC6 complex component (Nsmce3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001173527.1

ORF Insert Sequence:

ATGCTGCAGA AACCGAGGGG CCGCGGCCGG CCCAGCACTC AGGGTGATCG GGAGCGGGAC 
TGGGGAGGCT CTGGCGAGGA AGCGCCGAGC ACGTCCCGCG GCGCGGGCGG CACCTCTCAG 
GGCTCCCGCG CTTCCCTGTC GGCCCCCACC GTGGGGCCGC GCACACAGAA GCAGCTAGAG 
CTGAAGGTGG CCGAACTGGT GCAGTTCCTG CTGATTAAGG ACCAGAAGAA GATCCCGATC 
AAGCGCACCG ACATCCTGAA GCACGTGGTG GGAGACTACC GGGACGTGTA CCCCAATCTT 
CTGAAGCTGG CCGCCGAGCG CCTGCAGTAC GTGTTCGGGT ACAAGCTGGT GGAACTGGAG 
CCCAAGAGCC ACACCTACAT CCTCATCAAC GCGCTGGAGC CGGTGGAGGA GGATGCTGAG 
GTGAGAGGCG ATCAGGGTAC ACCCACCTCG GGCCTGCTTA TGATAGTCCT CGGGCTTATC 
TTCATGAAAG GCAACACCAT CACCGAGACT GAAGTCTGGG ACTTTCTCCG ACGGCTCGGA 
GTGTATCCCA CTAAGAAGCA TTTAATTTTT GGCGACCCAA AGAAACTCAT TACCGAAGAC 
TTTGTGCGGC AGCGCTATTT GGAGTACCGG AGGATACCCC ACACCGATCC TGTGGACTAT 
GAACTACAGT GGGGCCCGCG AACCAACCTG GAAACCAGCA AGATGAAAGT TCTTAAGTTC 
GTGGCCAAAG TCCATAATCA GGACCCCAAA GACTGGCCGG CACAATACTG CGAGGCTTTG 
GCAGATGAGG AGAGTAGGGC CAGACCTGCA GCTAGTGGTC TAGCCACATC CTCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.
The Journal of clinical investigation126(8)2881-92(2016 Aug)
van der Crabben SN,Hennus MP,McGregor GA,Ritter DI,Nagamani SC,Wells OS,Harakalova M,Chinn IK,Alt A,Vondrova L,Hochstenbach R,van Montfrans JM,Terheggen-Lagro SW,van Lieshout S,van Roosmalen MJ,Renkens I,Duran K,Nijman IJ,Kloosterman WP,Hennekam E,Orange JS,van Hasselt PM,Wheeler DA,Palecek JJ,Lehmann AR,Oliver AW,Pearl LH,Plon SE,Murray JM,van Haaften G

MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
Molecular cell39(6)963-74(2010 Sep)
Doyle JM,Gao J,Wang J,Yang M,Potts PR

Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Molecular and cellular biology28(4)1197-206(2008 Feb)
Taylor EM,Copsey AC,Hudson JJ,Vidot S,Lehmann AR

Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
The Journal of biological chemistry279(3)1703-12(2004 Jan)
Kuwako K,Taniura H,Yoshikawa K

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Proceedings of the National Academy of Sciences of the United States of America99(26)16899-903(2002 Dec)
Strausberg RL,Feingold EA,Grouse LH,Derge JG,Klausner RD,Collins FS,Wagner L,Shenmen CM,Schuler GD,Altschul SF,Zeeberg B,Buetow KH,Schaefer CF,Bhat NK,Hopkins RF,Jordan H,Moore T,Max SI,Wang J,Hsieh F,Diatchenko L,Marusina K,Farmer AA,Rubin GM,Hong L,Stapleton M,Soares MB,Bonaldo MF,Casavant TL,Scheetz TE,Brownstein MJ,Usdin TB,Toshiyuki S,Carninci P,Prange C,Raha SS,Loquellano NA,Peters GJ,Abramson RD,Mullahy SJ,Bosak SA,McEwan PJ,McKernan KJ,Malek JA,Gunaratne PH,Richards S,Worley KC,Hale S,Garcia AM,Gay LJ,Hulyk SW,Villalon DK,Muzny DM,Sodergren EJ,Lu X,Gibbs RA,Fahey J,Helton E,Ketteman M,Madan A,Rodrigues S,Sanchez A,Whiting M,Madan A,Young AC,Shevchenko Y,Bouffard GG,Blakesley RW,Touchman JW,Green ED,Dickson MC,Rodriguez AC,Grimwood J,Schmutz J,Myers RM,Butterfield YS,Krzywinski MI,Skalska U,Smailus DE,Schnerch A,Schein JE,Jones SJ,Marra MA,

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Nsmce3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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