Map3k11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Map3k11
Entrez Gene ID	309168
Full Name	mitogen-activated protein kinase kinase kinase 11
Synonyms	Mlk-3,Mlk3,RHOE
General protein information	Preferred Names mitogen-activated protein kinase kinase kinase 11 Names mitogen-activated protein kinase kinase kinase 11 mixed lineage kinase 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013150.1	NP_001013168.1	mitogen-activated protein kinase kinase kinase 11

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MAP3K11	NP_001095461.1
Mus musculus (house mouse)	Map3k11	NP_071295.2
Arabidopsis thaliana (thale cress)	HT1	NP_176430.1
Homo sapiens (human)	MAP3K11	NP_002410.1
Canis lupus familiaris (dog)	MAP3K11	XP_540853.3
Pan troglodytes (chimpanzee)	MAP3K11	XP_508556.2
	MAP3K11	XP_001113486.1
Rattus norvegicus (Norway rat)	Map3k11	NP_001013168.1
Oryza sativa (rice)	Os06g0636600	NP_001058144.1

Gene Ontology
Bibliography

Related articles in PubMed

Enhanced Expression of miR-199b-5p Promotes Proliferation of Pancreatic ?-Cells by Down-Regulation of MLK3.
Sato-Kunisada R, Yoshida N, Nakamura S, Uchiyama H, Matsumoto H
MicroRNA (Shariqah, United Arab Emirates)5(1)57-65(2016)

SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation.
Zhu QJ, Xu Y, Du CP, Hou XY
FEBS letters586(9)1259-64(2012 May)

S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.
Hu SQ, Ye JS, Zong YY, Sun CC, Liu DH, Wu YP, Song T, Zhang GY
The Journal of biological chemistry287(4)2364-77(2012 Jan)

K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Wang Q, Yin XH, Liu Y, Zhang GY
Journal of receptor and signal transduction research31(4)307-13(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that the up-regulation of miR-199b-5p enhances proliferation of beta-cells at least in part through down-regulation of Mixed lineage kinase-3.
Title: Enhanced Expression of miR-199b-5p Promotes Proliferation of Pancreatic ?-Cells by Down-Regulation of MLK3.

the activation of MLK3 during the early stages of ischemia/reperfusion is modulated by S-nitrosylation and provides a potential new approach for stroke therapy whereby the post-translational modification machinery is targeted.
Title: S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.

Data suggest that K252a induced neuroprotection against ischemia/reperfusion in rat hippocampal CA1 subregion via inhibiting the mitochondrial Bax apoptosis pathway induced by JNK/MLK3 activation.
Title: K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.

these studies demonstrate an important role for Rac1 in activation of the prodeath MLK3-JNK kinase signaling pathway and delayed neuronal cell death following cerebral ischemia
Title: Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia.

stimulation of the inhibitory GABA receptors can attenuate the excitatory JNK3 apoptotic signaling pathway via inhibiting the increased assembly of the GluR6-PSD-95-MLK3 signaling module in cerebral ischemia
Title: Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.

The following Map3k11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Map3k11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03572	NM_001013150.1 Latest version!	Rattus norvegicus mitogen-activated protein kinase kinase kinase 11 (Map3k11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$503.30 $719.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Map3k11 ( NM_001013150.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013168.1 Rattus norvegicus mitogen-activated protein kinase kinase kinase 11 (Map3k11), mRNA.

Price & Availability↑

CloneID	ORa03572
Clone ID Related Accession (Same CDS sequence)	NM_001013150.1
Accession Version	NM_001013150.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2553bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	mitogen-activated protein kinase kinase kinase 11
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081952.1. On Apr 20, 2005 this sequence version replaced XM_219517.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCT TGAAGAACCT CTTCCTCAAG AGCCCGCTGG GGTCATGGAA CGGCAGTGGC 
AGTGGGGGCG GTGGGGGTTC TGGTGGAGTC CGGCCAGAGG GGTCCCCGAA GGCAACAGCA 
GCTTATGCCA ACCCTGTCTG GACAGCCCTG TTCGACTATG AGCCCAATGG GCAGGACGAA 
CTAGCCCTGA GGAAGGGCGA CCGTGTGGAG GTGCTGTCCA GGGATGCAGC CATCTCAGGA 
GATGAAGGCT GGTGGGCGGG CCAGGTGGGT GGCCAGGTGG GCATTTTTCC ATCCAACTAT 
GTATCTCGGG GTGGAGGCCC ACCCCCCTGT GAGGTGGCCA GCTTCCAGGA GCTGCGACTG 
GAGGAGGTGA TCGGCATCGG TGGCTTCGGC AAGGTCTACC GTGGCAGCTG GCGAGGGGAG 
CTGGTGGCTG TGAAAGCAGC TCGACAGGAT CCTGATGAGG ACATCAGTGT AACAGCTGAG 
AGTGTTCGAC AGGAGGCCCG GCTTTTTGCC ATGCTGGCAC ATCCCAACAT CATTGCCCTC 
AAAGCTGTGT GCCTGGAGGA GCCAAACCTA TGCCTGGTGA TGGAGTATGC AGCTGGTGGA 
CCTCTTAGCC GTGCCCTGGC TGGTCGGCGG GTGCCCCCCC ATGTGCTGGT CAACTGGGCT 
GTGCAGATTG CCCGAGGGAT GCACTACCTG CACTGTGAGG CTCTAGTGCC TGTGATACAC 
CGAGACCTGA AGTCCAACAA CATTCTGCTG CTGCAGCCCA TTGAAGGTGA CGACATGGAG 
CACAAGACCC TAAAGATTAC TGACTTTGGC CTCGCCCGAG AGTGGCACAA AACCACACAG 
ATGAGTGCTG CGGGGACCTA TGCGTGGATG GCTCCTGAGG TTATCAAGGC ATCTACCTTC 
TCCAAGGGCA GCGATGTCTG GAGCTTTGGG GTGCTGCTGT GGGAACTGCT GACTGGGGAG 
GTACCCTACC GTGGTATCGA CTGTCTTGCG GTAGCCTATG GTGTGGCTGT AAACAAGTTA 
ACATTACCCA TCCCATCCAC TTGCCCTGAG CCCTTCGCAC AACTCATGGC TGACTGCTGG 
GCACAGGACC CCCACCGCAG GCCCGACTTC GCCTCCATCC TGCAGCAGTT GGAAGCTCTA 
GAGGCTCAGG TGCTGAGGGA GATGCCACGG GACTCCTTCC ATTCCATGCA GGAGGGCTGG 
AAACGCGAGA TCCAGGGCCT TTTTGATGAG CTGCGGGCCA AGGAAAAGGA ACTACTGAGC 
CGCGAGGAGG AACTGACGCG CGCAGCACGC GAGCAGCGGT CCCAGGCAGA GCAGCTGCGA 
CGGCGCGAGC ACCTGCTGGC GCAGTGGGAG CTGGAGGTGT TCGAGCGCGA GCTGACACTG 
CTGCTACAGC AGGTGGACCG AGAACGGCCA CACGTGCGCC GCCGACGCGG CACCTTCAAG 
CGGAGCAAGC TCCGAGCGAG GGATGGCGGA GAACGCATCA GCATGCCCCT GGACTTCAAA 
CATCGCATCA CTGTGCAGGC CTCTCCAGGA CTTGACCGGA GGAGAAATGT GTTCGAGGTT 
GGGGCTGGGG ACTCGCCCAC CTTCCCTCGG TTCCGAGCTA TCCAGTTGGA ACCTGCAGAA 
TCAGGCCAGA CTTGGGGTCG CCAGTCCCCT AGACGTCTTG ACGATTCAAG CAATGGAGAG 
AGGCGTGCTT GCTGGGCCTG GGGTCCCAGT TCCCCCAAGC CTGGGGAGGC CCAGAATGGG 
AGGAGAAGGT CCCGCATGGA TGAAGCCACG TGGTACCTAG ATTCAGATGA CTCATCCCCA 
TTAGGGTCTC CTTCTACTCC CCCAGCACTC AACGGTAATC CTCCAAGGCC TAGCCCTGAG 
CCAGAGGAGC CACGGCGGTC TGGGCCCACA GAACGGGGCA ATAGCTCTGG GACGCCTAAA 
CTGATCCAAC GTGCATTGCT CCGGGGGACC GCTCTGCTGG CTTCCCTAGG CCTTGGCCGA 
GACCTGCAGC CTCCAGGAGG CCTGAGCCGT GAACGTGGAG AGTCCCCGAC AGCACCACCC 
CCTGCACAGA TGGCTTCACC CTGTCCACCT GACCTGCCCT CCACCCCGCT CATCCACCTC 
TCACAAGCAA CACCTGATGC CCGTGGACCA CTCACCCCTG CACCCTTATT GCTGGACCTA 
GGTGTTTCCT CTGGCCAGCC ATCAGCCAAG AGCCCTCGGC GGGAAGAGAC ACGTGGAAGA 
ACTGTTTCAC CTCCACCAGG AATATCACGC TCTGCTCCTG GCACCCCTGG AACCCCTCGC 
TCACCACCTT TGGGCCTCAT CAGCCGACCT CGGCCATCAC CACTCCGTAA CCGTATTGAC 
CCATGGAGCT TCGTGTCAGC TGGGCCACGG CCTTCACCCC TGCCCTCTCC ACAGCCTGCA 
CCCCGACGGG CACCATGGAC CTTATTCCCA GACTCAGATC CCTTCTGGGA CTCCCCACCT 
GCCAACCCCT TCCGGGGAGG CTCCCAGGAC TGCAGGACGC AGACCAAAGA TGTGGGTGCT 
CAGGCGCCAT GGGCACCAGA AGCAGGGCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013168.1
CDS	436..2988
Translation	MEPLKNLFLKSPLGSWNGSGSGGGGGSGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPAESGQTWGRQSPRRLDDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRSGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMASPCPPDLPSTPLIHLSQATPDARGPLTPAPLLLDLGVSSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLISRPRPSPLRNRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCRTQTKDVGAQAPWAPEAGP

Target ORF information:

RefSeq Version	NM_001013150.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mitogen-activated protein kinase kinase kinase 11 (Map3k11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013150.1

ORF Insert Sequence:

ATGGAGCCCT TGAAGAACCT CTTCCTCAAG AGCCCGCTGG GGTCATGGAA CGGCAGTGGC 
AGTGGGGGCG GTGGGGGTTC TGGTGGAGTC CGGCCAGAGG GGTCCCCGAA GGCAACAGCA 
GCTTATGCCA ACCCTGTCTG GACAGCCCTG TTCGACTATG AGCCCAATGG GCAGGACGAA 
CTAGCCCTGA GGAAGGGCGA CCGTGTGGAG GTGCTGTCCA GGGATGCAGC CATCTCAGGA 
GATGAAGGCT GGTGGGCGGG CCAGGTGGGT GGCCAGGTGG GCATTTTTCC ATCCAACTAT 
GTATCTCGGG GTGGAGGCCC ACCCCCCTGT GAGGTGGCCA GCTTCCAGGA GCTGCGACTG 
GAGGAGGTGA TCGGCATCGG TGGCTTCGGC AAGGTCTACC GTGGCAGCTG GCGAGGGGAG 
CTGGTGGCTG TGAAAGCAGC TCGACAGGAT CCTGATGAGG ACATCAGTGT AACAGCTGAG 
AGTGTTCGAC AGGAGGCCCG GCTTTTTGCC ATGCTGGCAC ATCCCAACAT CATTGCCCTC 
AAAGCTGTGT GCCTGGAGGA GCCAAACCTA TGCCTGGTGA TGGAGTATGC AGCTGGTGGA 
CCTCTTAGCC GTGCCCTGGC TGGTCGGCGG GTGCCCCCCC ATGTGCTGGT CAACTGGGCT 
GTGCAGATTG CCCGAGGGAT GCACTACCTG CACTGTGAGG CTCTAGTGCC TGTGATACAC 
CGAGACCTGA AGTCCAACAA CATTCTGCTG CTGCAGCCCA TTGAAGGTGA CGACATGGAG 
CACAAGACCC TAAAGATTAC TGACTTTGGC CTCGCCCGAG AGTGGCACAA AACCACACAG 
ATGAGTGCTG CGGGGACCTA TGCGTGGATG GCTCCTGAGG TTATCAAGGC ATCTACCTTC 
TCCAAGGGCA GCGATGTCTG GAGCTTTGGG GTGCTGCTGT GGGAACTGCT GACTGGGGAG 
GTACCCTACC GTGGTATCGA CTGTCTTGCG GTAGCCTATG GTGTGGCTGT AAACAAGTTA 
ACATTACCCA TCCCATCCAC TTGCCCTGAG CCCTTCGCAC AACTCATGGC TGACTGCTGG 
GCACAGGACC CCCACCGCAG GCCCGACTTC GCCTCCATCC TGCAGCAGTT GGAAGCTCTA 
GAGGCTCAGG TGCTGAGGGA GATGCCACGG GACTCCTTCC ATTCCATGCA GGAGGGCTGG 
AAACGCGAGA TCCAGGGCCT TTTTGATGAG CTGCGGGCCA AGGAAAAGGA ACTACTGAGC 
CGCGAGGAGG AACTGACGCG CGCAGCACGC GAGCAGCGGT CCCAGGCAGA GCAGCTGCGA 
CGGCGCGAGC ACCTGCTGGC GCAGTGGGAG CTGGAGGTGT TCGAGCGCGA GCTGACACTG 
CTGCTACAGC AGGTGGACCG AGAACGGCCA CACGTGCGCC GCCGACGCGG CACCTTCAAG 
CGGAGCAAGC TCCGAGCGAG GGATGGCGGA GAACGCATCA GCATGCCCCT GGACTTCAAA 
CATCGCATCA CTGTGCAGGC CTCTCCAGGA CTTGACCGGA GGAGAAATGT GTTCGAGGTT 
GGGGCTGGGG ACTCGCCCAC CTTCCCTCGG TTCCGAGCTA TCCAGTTGGA ACCTGCAGAA 
TCAGGCCAGA CTTGGGGTCG CCAGTCCCCT AGACGTCTTG ACGATTCAAG CAATGGAGAG 
AGGCGTGCTT GCTGGGCCTG GGGTCCCAGT TCCCCCAAGC CTGGGGAGGC CCAGAATGGG 
AGGAGAAGGT CCCGCATGGA TGAAGCCACG TGGTACCTAG ATTCAGATGA CTCATCCCCA 
TTAGGGTCTC CTTCTACTCC CCCAGCACTC AACGGTAATC CTCCAAGGCC TAGCCCTGAG 
CCAGAGGAGC CACGGCGGTC TGGGCCCACA GAACGGGGCA ATAGCTCTGG GACGCCTAAA 
CTGATCCAAC GTGCATTGCT CCGGGGGACC GCTCTGCTGG CTTCCCTAGG CCTTGGCCGA 
GACCTGCAGC CTCCAGGAGG CCTGAGCCGT GAACGTGGAG AGTCCCCGAC AGCACCACCC 
CCTGCACAGA TGGCTTCACC CTGTCCACCT GACCTGCCCT CCACCCCGCT CATCCACCTC 
TCACAAGCAA CACCTGATGC CCGTGGACCA CTCACCCCTG CACCCTTATT GCTGGACCTA 
GGTGTTTCCT CTGGCCAGCC ATCAGCCAAG AGCCCTCGGC GGGAAGAGAC ACGTGGAAGA 
ACTGTTTCAC CTCCACCAGG AATATCACGC TCTGCTCCTG GCACCCCTGG AACCCCTCGC 
TCACCACCTT TGGGCCTCAT CAGCCGACCT CGGCCATCAC CACTCCGTAA CCGTATTGAC 
CCATGGAGCT TCGTGTCAGC TGGGCCACGG CCTTCACCCC TGCCCTCTCC ACAGCCTGCA 
CCCCGACGGG CACCATGGAC CTTATTCCCA GACTCAGATC CCTTCTGGGA CTCCCCACCT 
GCCAACCCCT TCCGGGGAGG CTCCCAGGAC TGCAGGACGC AGACCAAAGA TGTGGGTGCT 
CAGGCGCCAT GGGCACCAGA AGCAGGGCCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Enhanced Expression of miR-199b-5p Promotes Proliferation of Pancreatic ?-Cells by Down-Regulation of MLK3.
MicroRNA (Shariqah, United Arab Emirates)5(1)57-65(2016)
Sato-Kunisada R,Yoshida N,Nakamura S,Uchiyama H,Matsumoto H

SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation.
FEBS letters586(9)1259-64(2012 May)
Zhu QJ,Xu Y,Du CP,Hou XY

S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.
The Journal of biological chemistry287(4)2364-77(2012 Jan)
Hu SQ,Ye JS,Zong YY,Sun CC,Liu DH,Wu YP,Song T,Zhang GY

K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion.
Journal of receptor and signal transduction research31(4)307-13(2011 Aug)
Wang Q,Yin XH,Liu Y,Zhang GY

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Map3k11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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