Chp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chp2
Entrez Gene ID	308965
Full Name	calcineurin-like EF hand protein 2
Synonyms	chp-2
General protein information	Preferred Names calcineurin-like EF hand protein 2 Names calcineurin B homologous protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q36
Summary	cofactor for catalysis of the electroneutral exchange of Na+ and H+ mediated by the Na+/H+ exchanger (NHE) family of membrane proteins [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589206.1	XP_017444695.1	calcineurin B homologous protein 2 isoform X1
NM_182738.1	NP_877402.1	calcineurin B homologous protein 2
XM_008759746.2	XP_008757968.1	calcineurin B homologous protein 2 isoform X1

Pathways from BioSystems

Homologies

	CHP2	XP_001095666.1
Bos taurus (cattle)	CHP2	NP_001179334.1
Pan troglodytes (chimpanzee)	CHP2	XP_523319.3
Mus musculus (house mouse)	Chp2	NP_081639.1
Caenorhabditis elegans (roundworm)	pbo-1	NP_497601.1
Homo sapiens (human)	CHP2	NP_071380.1
Danio rerio (zebrafish)	chp2	NP_956130.1
Rattus norvegicus (Norway rat)	Chp2	NP_877402.1

Gene Ontology
Bibliography

Related articles in PubMed

Prevalence of left and balanced coronary arterial dominance decreases with increasing age of patients at autopsy. A postmortem coronary angiograms study.
Knaapen M, Koch AH, Koch C, Koch KT, Li X, van Rooij PC, Tijssen JG, Peters RJ, van der Wal AC, Damman P, de Winter RJ
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology22(1)49-53(2013 Jan-Feb)

Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH, Wang LH, Lin YN, Chang GQ, Li HW, Jin WN, Hu RH, Pang TX
Genes to cells : devoted to molecular & cellular mechanisms16(4)416-26(2011 Apr)

Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury.
Bales JW, Ma X, Yan HQ, Jenkins LW, Dixon CE
Brain research1358211-20(2010 Oct)

CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.
Li GD, Zhang X, Li R, Wang YD, Wang YL, Han KJ, Qian XP, Yang CG, Liu P, Wei Q, Chen WF, Zhang J, Zhang Y
The Journal of biological chemistry283(47)32660-8(2008 Nov)

Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.
Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H
Biological & pharmaceutical bulletin26(2)148-55(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Calcineurin B isoforms showed increased expression throughout the CA1 and CA2 while there was a decrease in expression within the ipsilateral dentate gyrus.
Title: Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury.

CHP2 is predominantly expressed in epithelial cells of the small and large intestine where it may regulate epithelial Na+/H+ exchanger(NHE)isoforms NHE2-4.
Title: Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.

The following Chp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04561	NM_182738.1 Latest version!	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa04561	XM_017589206.1 Latest version!	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa04561	XM_008759746.2 Latest version!	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chp2 ( NM_182738.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_877402.1 Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), mRNA.

Price & Availability↑

CloneID	ORa04561
Clone ID Related Accession (Same CDS sequence)	XM_017589206.1 , NM_182738.1 , XM_008759746.2
Accession Version	NM_182738.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	calcineurin B homologous protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB086189.1. ##Evidence-Data-START## Transcript exon combination :: AB086189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_877402.1
CDS	39..629
Translation	MGSRSSHVALIPDVDQIRRETGFSQASLLRLYHRFQALDREEKGFLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVYFAGFARVLAYFRPIDEDDATLRDPKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRTVQEADEDGDGAVSFLEFAKSLEKMNIEQKMSIRILK

Target ORF information:

RefSeq Version	NM_182738.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_182738.1

ORF Insert Sequence:

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Chp2 ( XM_017589206.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444695.1 Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa04561
Clone ID Related Accession (Same CDS sequence)	XM_017589206.1 , NM_182738.1 , XM_008759746.2
Accession Version	XM_017589206.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcineurin B homologous protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444695.1
CDS	268..858
Translation	MGSRSSHVALIPDVDQIRRETGFSQASLLRLYHRFQALDREEKGFLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVYFAGFARVLAYFRPIDEDDATLRDPKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRTVQEADEDGDGAVSFLEFAKSLEKMNIEQKMSIRILK

Target ORF information:

RefSeq Version	XM_017589206.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589206.1

ORF Insert Sequence:

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Chp2 ( XM_008759746.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757968.1 Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa04561
Clone ID Related Accession (Same CDS sequence)	XM_017589206.1 , NM_182738.1 , XM_008759746.2
Accession Version	XM_008759746.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 591bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcineurin B homologous protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759746.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757968.1
CDS	247..837
Translation	MGSRSSHVALIPDVDQIRRETGFSQASLLRLYHRFQALDREEKGFLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVYFAGFARVLAYFRPIDEDDATLRDPKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRTVQEADEDGDGAVSFLEFAKSLEKMNIEQKMSIRILK

Target ORF information:

RefSeq Version	XM_008759746.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcineurin-like EF hand protein 2 (Chp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759746.2

ORF Insert Sequence:

ATGGGCTCAC GGAGCTCTCA TGTCGCGCTC ATTCCTGATG TGGACCAAAT TCGCAGAGAG 
ACGGGCTTCT CCCAAGCTAG CCTGCTCCGT CTCTACCACA GGTTCCAAGC CCTAGACAGG 
GAGGAAAAGG GCTTCCTGAG CCGCCTAGAC CTCCAGCAGA TTGGAGCCCT GGCTGTGAAC 
CCCCTGGGTG ACCGCATTAT AGACAGCTTC TTCCCCAATG GGAGTCAGAG AGTGTATTTC 
GCAGGCTTTG CCAGAGTCCT GGCTTATTTT CGACCTATAG ATGAAGACGA TGCCACACTC 
CGAGACCCCA AGCAACCTGA ACCCCTAAAC AGCAGAATGA ATAAACTGCG CTTTGCATTT 
CAGCTCTATG ATCTGGATCG GGATGGGAAG ATCTCCAGGA ATGAAATGCT ACAGGTTCTC 
CGCCTCATGG TTGGGGTCCA GGTGACAGAC GAGCAGTTGG AGAGCATCAC AGACCGCACA 
GTGCAGGAAG CCGATGAAGA TGGGGATGGG GCCGTGTCCT TCCTGGAGTT CGCCAAGTCC 
TTAGAGAAGA TGAACATCGA GCAGAAGATG AGCATCCGGA TCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prevalence of left and balanced coronary arterial dominance decreases with increasing age of patients at autopsy. A postmortem coronary angiograms study.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology22(1)49-53(2013 Jan-Feb)
Knaapen M,Koch AH,Koch C,Koch KT,Li X,van Rooij PC,Tijssen JG,Peters RJ,van der Wal AC,Damman P,de Winter RJ

Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Genes to cells : devoted to molecular & cellular mechanisms16(4)416-26(2011 Apr)
Li QH,Wang LH,Lin YN,Chang GQ,Li HW,Jin WN,Hu RH,Pang TX

Regional calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury.
Brain research1358211-20(2010 Oct)
Bales JW,Ma X,Yan HQ,Jenkins LW,Dixon CE

CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.
The Journal of biological chemistry283(47)32660-8(2008 Nov)
Li GD,Zhang X,Li R,Wang YD,Wang YL,Han KJ,Qian XP,Yang CG,Liu P,Wei Q,Chen WF,Zhang J,Zhang Y

Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.
Biological & pharmaceutical bulletin26(2)148-55(2003 Feb)
Inoue H,Nakamura Y,Nagita M,Takai T,Masuda M,Nakamura N,Kanazawa H

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Chp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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