Rhog cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rhog
Entrez Gene ID	308875
Full Name	ras homolog family member G
Synonyms	Arhg
General protein information	Preferred Names ras homolog family member G Names rho-related GTP-binding protein RhoG ras homolog gene family, member G (rho G)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32

mRNA and Protein(s)

mRNA	Protein	Name
XM_006229882.3	XP_006229944.1	rho-related GTP-binding protein RhoG isoform X1
NM_001037195.1	NP_001032272.1	rho-related GTP-binding protein RhoG
XM_006229883.3	XP_006229945.1	rho-related GTP-binding protein RhoG isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rhog	NP_062512.1
Danio rerio (zebrafish)	rhogb	NP_956334.1
Homo sapiens (human)	RHOG	NP_001656.2
	RHOG	XP_001113546.1
Bos taurus (cattle)	RHOG	NP_001073774.1
Gallus gallus (chicken)	LOC100859599	XP_004939037.1
Xenopus tropicalis (tropical clawed frog)	LOC100489878	XP_004920315.1
Canis lupus familiaris (dog)	RHOG	XP_542335.2
Rattus norvegicus (Norway rat)	Rhog	NP_001032272.1

Gene Ontology
Bibliography

Related articles in PubMed

RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
Ubba V, Soni UK, Chadchan S, Maurya VK, Kumar V, Maurya R, Chaturvedi H, Singh R, Dwivedi A, Jha RK
Reproductive sciences (Thousand Oaks, Calif.)24(5)738-752(2017 05)

Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
Schulz J, Franke K, Frick M, Schumacher S
Journal of neurochemistry139(1)26-39(2016 10)

The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
Samson T, van Buul JD, Kroon J, Welch C, Bakker EN, Matlung HL, van den Berg TK, Sharek L, Doerschuk C, Hahn K, Burridge K
PloS one8(1)e55202(2013)

Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
Namekata K, Watanabe H, Guo X, Kittaka D, Kawamura K, Kimura A, Harada C, Harada T
Genes to cells : devoted to molecular & cellular mechanisms17(8)688-97(2012 Aug)

miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
Franke K, Otto W, Johannes S, Baumgart J, Nitsch R, Schumacher S
The EMBO journal31(13)2908-21(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RHOG can mediate signaling through downstream effectors DOCK1 and RAC1 during ovarian follicular development (theca and granulosa cells and oocyte), but dehydroepiandrosterone downregulated them in the polycystic ovarian syndrome ovary.
Title: RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.

Rac1, Cdc42, and RhoG perform very specific and non-redundant functions at different levels of hierarchy in regulating dendritic tree complexity induced by CALEB/NGC
Title: Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.

Dock3 forms a complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling and induces neurite outgrowth via Rac1 activation in PC12 cells.
Title: Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.

RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching.
Title: miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.

The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.

The following Rhog gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rhog cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09239	NM_001037195.1 Latest version!	Rattus norvegicus ras homolog family member G (Rhog), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa09239	XM_006229883.3 Latest version!	Rattus norvegicus ras homolog family member G (Rhog), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa09239	XM_006229882.3 Latest version!	Rattus norvegicus ras homolog family member G (Rhog), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rhog ( NM_001037195.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032272.1 Rattus norvegicus ras homolog family member G (Rhog), mRNA.

Price & Availability↑

CloneID	ORa09239
Clone ID Related Accession (Same CDS sequence)	XM_006229882.3 , NM_001037195.1 , XM_006229883.3
Accession Version	NM_001037195.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	rho-related GTP-binding protein RhoG
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC107943.1. On Nov 23, 2005 this sequence version replaced XM_218977.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107943.1, CV079351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032272.1
CDS	96..671
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	NM_001037195.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ras homolog family member G (Rhog), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037195.1

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rhog ( XM_006229882.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229944.1 Rattus norvegicus ras homolog family member G (Rhog), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09239
Clone ID Related Accession (Same CDS sequence)	XM_006229882.3 , NM_001037195.1 , XM_006229883.3
Accession Version	XM_006229882.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rho-related GTP-binding protein RhoG isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229882.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229944.1
CDS	249..824
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	XM_006229882.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ras homolog family member G (Rhog), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229882.3

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rhog ( XM_006229883.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229945.1 Rattus norvegicus ras homolog family member G (Rhog), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09239
Clone ID Related Accession (Same CDS sequence)	XM_006229882.3 , NM_001037195.1 , XM_006229883.3
Accession Version	XM_006229883.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 576bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	rho-related GTP-binding protein RhoG isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229883.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229945.1
CDS	332..907
Translation	MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

Target ORF information:

RefSeq Version	XM_006229883.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ras homolog family member G (Rhog), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229883.3

ORF Insert Sequence:

ATGCAGAGCA TCAAGTGTGT GGTGGTGGGT GATGGGGCCG TAGGCAAGAC GTGCCTTCTC 
ATCTGCTATA CAACTAATGC CTTCCCCAAG GAATACATCC CCACTGTGTT CGACAATTAC 
AGCGCCCAGA GTGCGGTTGA TGGGCGCACC GTGAACCTAA ACCTGTGGGA CACTGCCGGC 
CAGGAGGAGT ACGACCGCCT CCGCACCCTT TCCTACCCCC AGACCAACGT CTTCGTCATC 
TGTTTCTCCA TTGCCAGTCC ACCCTCCTAT GAGAACGTGA GGCACAAATG GCACCCAGAG 
GTGTGTCACC ACTGCCCTGA TGTGCCCATC CTCCTGGTGG GCACCAAGAA GGACCTCAGA 
GCCCAGCCTG ATACCCTACG GCGCCTCAAG GAGCAGGGTC AAGCGCCCAT CACACCACAG 
CAGGGCCAGG CGCTGGCCAA GCAGATCCAC GCTGTGCGCT ACCTCGAGTG CTCAGCGCTG 
CAGCAAGACG GTGTCAAGGA GGTGTTTGCC GAGGCTGTCC GGGCGGTGCT CAACCCAACA 
CCGATAAAGC GTGGGCGGTC CTGCATCCTC TTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
Reproductive sciences (Thousand Oaks, Calif.)24(5)738-752(2017 05)
Ubba V,Soni UK,Chadchan S,Maurya VK,Kumar V,Maurya R,Chaturvedi H,Singh R,Dwivedi A,Jha RK

Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.
Journal of neurochemistry139(1)26-39(2016 10)
Schulz J,Franke K,Frick M,Schumacher S

The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
PloS one8(1)e55202(2013)
Samson T,van Buul JD,Kroon J,Welch C,Bakker EN,Matlung HL,van den Berg TK,Sharek L,Doerschuk C,Hahn K,Burridge K

Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
Genes to cells : devoted to molecular & cellular mechanisms17(8)688-97(2012 Aug)
Namekata K,Watanabe H,Guo X,Kittaka D,Kawamura K,Kimura A,Harada C,Harada T

miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
The EMBO journal31(13)2908-21(2012 Jun)
Franke K,Otto W,Johannes S,Baumgart J,Nitsch R,Schumacher S