Axl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Axl
Entrez Gene ID	308444
Full Name	Axl receptor tyrosine kinase
General protein information	Preferred Names Axl receptor tyrosine kinase Names tyrosine-protein kinase receptor UFO
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013147.1	NP_001013165.1	tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_031794.1	NP_113982.1	tyrosine-protein kinase receptor UFO isoform 1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	AXL	NP_068713.2
Bos taurus (cattle)	AXL	XP_002695114.2
Rattus norvegicus (Norway rat)	Axl	NP_113982.1
Pan troglodytes (chimpanzee)	AXL	XP_003316423.2
Xenopus tropicalis (tropical clawed frog)	axl	NP_001090657.1
Canis lupus familiaris (dog)	AXL	XP_005616939.1
Mus musculus (house mouse)	Axl	NP_033491.2

Gene Ontology
Bibliography

Related articles in PubMed

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats.
Wu G, McBride DW, Zhang JH
Neurobiology of disease11059-67(2018 Feb)

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Qiu C, Zheng H, Tao H, Yu W, Jiang X, Li A, Jin H, Lv A, Li H
Molecular and cellular biochemistry433(1-2)149-159(2017 Sep)

Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: role of Axl signaling.
Lee CH, Hung YJ, Shieh YS, Chien CY, Hsu YJ, Lin CY, Chiang CF, Huang CL, Hsieh CH
American journal of physiology. Renal physiology312(3)F398-F406(2017 Mar)

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.
Bosurgi L, Bernink JH, Delgado Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV
Proceedings of the National Academy of Sciences of the United States of America110(32)13091-6(2013 Aug)

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
Brown JE, Krodel M, Pazos M, Lai C, Prieto AL
PloS one7(5)e36800(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cilostazol-mediated protection against uremic toxin-related vascular smooth muscle cell dysfunction via Axl signaling pathway.
Title: Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: role of Axl signaling.

Overexpression of Tyro3 in the Rat2 cell line that expresses Axl, but not Mer or Tyro3, resulted in a 5 fold increase in cell proliferation.
Title: Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.

nerve growth factor affected intracellular localization of full-length Axl-eGFP and Tyro-3-eCFP in PC12 cells
Title: Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells.

Tyro3 and Axl receptors are upregulated by nerve growth factor on the differentiating PC12, where they collaborate with TrkA to support neuronal differentiation and survival.
Title: NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cells.

Glucose alters Axl signaling through coupling to binding partners and suggests a mechanism by which Axl contributes to vascular smooth muscle cells dysfunction in diabetes.
Title: Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.

The following Axl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Axl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08754	NM_031794.1 Latest version!	Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$524.30 $749.00
ORa03548	NM_001013147.1 Latest version!	Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Axl ( NM_031794.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113982.1 Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa08754
Clone ID Related Accession (Same CDS sequence)	NM_031794.1
Accession Version	NM_031794.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2667bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase receptor UFO isoform 1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB067526.1. On Aug 25, 2006 this sequence version replaced XM_001081882.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGCAGGG TCCCGCTGGC CTGGTGCGTG GCGCTGTGCT GCTGGGGGTG TGCAGCCCCT 
AAGGACACAC AGACCGAGGC TGACAGCCCA TTCGTGGGGA ACCCAGGGAA TATCACGGGT 
GCCAGAGGAC TCACGGGGAC CCTTCGGTGT GAGCTCCAGG TTCAGGGGGA GCCCCCTGAG 
GTGATGTGGC TTCGAGATGG ACAGATCCTA GAACTGGCTG ATAACACCCA GACCCAGGTG 
CCTCTGGGCG AAGACTGGCA AGATGAATGG AAAGTCGTCA GTCAGCTCAG AATCTCAGCC 
CTGCAACTTT CAGATGCAGG AGAGTACCAG TGTATGGTGC ACCTGGAAGG ACGGACCTTT 
GTGTCTCAGC CGGGCTTTGT AGGACTGGAA GGTCTCCCGT ACTTCCTGGA GGAACCTGAA 
GACAAAGCTG TGCCTGCCAA CACCCCCTTC AACCTAAGCT GCCAGGCCCA GGGACCCCCG 
GAACCCGTGA CCCTGCTCTG GCTTCAAGAT GCTGTCCCTC TGGCCCCAGT CGCAGGATAC 
AGCTTTCAGC ACAGTTTGCA AGCTCCAGGC CTGAACAAGA CATCTTCTTT CTCATGTGAA 
GCCCACAATG CCAAGGGAGT CACCACCTCC CGCACAGCTA CCATCACAGT GCTCCCACAG 
AGACCTCACA ATCTCCACGT GGTTTCCAGA CATCCCACGG AGCTAGAGGT AGCTTGGATC 
CCTACCCTGA GTGGCATCTA CCCGCTCACC CACTGCACCC TGCAGGCTGT GCTGTCAAAC 
GATGGGGTGG GCGTCTGGCT GGGAAAGTCA GATCCTCCTG AAGAACCCCT CACCGTGCAA 
GTATCAGTGC CCCCCCACCA GCTTCGGCTG GAAAAGCTCC TTCCTCACAC CCCATATCAC 
ATCCGGGTAT CCTGCACTAG CAGCCAGGGC CCCTCACCTT GGACCCACTG GCTTCCTGTG 
GAGACCACGG AGGGAGTGCC CTTGGGTCCC CCTGAGAACG TTAGCGCCAT GCGGAATGGG 
AGCCAGGCCC TCGTGCGTTG GCAGGAGCCA AGGGAGCCCT TGCAGGGCAC CCTGTTAGGG 
TACCGGCTGG CATATCGAGG CCAGGACACC CCCGAGGTAC TTATGGATAT AGGGCTAACT 
CGAGAGGTGA CCTTGGAACT TCGGGGGGAC AGGCCTGTGG CTAACCTGAC TGTGTCTGTG 
GCAGCCTATA CCTCAGCTGG GGATGGGCCC TGGAGCCTTC CTGTGCCCCT AGAGCCCTGG 
CGCCCAGGGC AAGGACAGCC ACTCCACCAT CTGGTGAGTG AACCCCCACC TCCCGCCTTC 
TCGTGGCCTT GGTGGTATGT ACTGCTGGGA GCACTTGTGG CCGCCGCCTG TGTCCTTATC 
TTGACCCTGT TCCTTGTCCA TCGGAGGAAG AAGGAGACGA GATATGGGGA GGTGTTCGAG 
CCAACTGTGG AAAGGGGTGA ACTGGTAGTC AGGTACCGTG CCCGAAAGTC CTACAGTCGC 
CGGACCACGG AAGCCACCTT GAACAGTCTG GGCATCAGCG AAGAGCTGAA GGAGAAACTA 
CGAGACGTCA TGGTAGATCG GCATAAGGTG GCCTTGGGGA AGACCCTGGG AGAGGGAGAA 
TTTGGTGCTG TGATGGAGGG CCAGCTCAAC CAGGATGACT CCATCCTCAA GGTCGCTGTG 
AAGACCATGA AAATTGCCAT CTGCACAAGA TCAGAGCTGG AGGATTTCCT GAGTGAAGCT 
GTCTGCATGA AGGAATTTGA CCACCCCAAC GTCATGAGGC TCATTGGCGT CTGTTTCCAG 
GGTTCTGACC GAGAGGGTTT CCCAGAACCG GTGGTCATCT TGCCTTTCAT GAAACATGGA 
GACCTCCACA GTTTCCTCCT GTACTCGCGG CTCGGGGACC AGCCAGTGTT CCTGCCCACT 
CAGATGCTAG TGAAGTTTAT GGCCGACATT GCCAGTGGCA TGGAGTACCT CAGTACCAAG 
AGATTCATAC ACCGGGACCT AGCTGCCAGG AACTGCATGC TGAATGAGAA CATGTCCGTG 
TGCGTGGCAG ACTTCGGGCT CTCCAAGAAG ATCTACAATG GGGATTACTA CCGCCAAGGG 
CGCATTGCCA AGATGCCAGT CAAGTGGATT GCTATCGAGA GTCTGGCAGA TCGAGTCTAC 
ACCAGCAAGA GTGACGTGTG GTCCTTCGGT GTGACAATGT GGGAGATCGC CACCCGAGGC 
CAAACTCCCT ATCCAGGGGT GGAGAACAGT GAGATTTACG ACTACCTACG TCAAGGAAAT 
CGCCTGAAAC AGCCTCTGGA CTGTCTGGAT GGCCTCTATG CCCTGATGTC CCGGTGCTGG 
GAGCTGAACC CTCGAGACCG GCCAAGTTTT GCAGAGCTCC GGGAAGACTT GGAGAACACA 
TTGAAGGCTC TACCCCCTGC TCAGGAGCCT GATGAAATCC TCTATGTCAA CATGGATGAG 
GGCGGAAGTC ACCTTGAACC CCGTGGGGCT GCTGGAGGAG CTGACCCCCC AACCCAACCT 
GATCCTAAGG ATTACTGTAG CTGTCTCACT GCAGCTGACG TCCACTCAGC TGGACGCTAT 
GTCCTTTGTC CTTCTACAGC CCCAGGACCC ACTCTGTCTG CTGACAGAGG CTGCCCAGCA 
CCTCCAGGGC AGGAGGACGG AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113982.1
CDS	1..2667
Translation	MGRVPLAWCVALCCWGCAAPKDTQTEADSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVMWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVAGYSFQHSLQAPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHNLHVVSRHPTELEVAWIPTLSGIYPLTHCTLQAVLSNDGVGVWLGKSDPPEEPLTVQVSVPPHQLRLEKLLPHTPYHIRVSCTSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQALVRWQEPREPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVAAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPPAFSWPWWYVLLGALVAAACVLILTLFLVHRRKKETRYGEVFEPTVERGELVVRYRARKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDYCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA

Target ORF information:

RefSeq Version	NM_031794.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031794.1

ORF Insert Sequence:

ATGGGCAGGG TCCCGCTGGC CTGGTGCGTG GCGCTGTGCT GCTGGGGGTG TGCAGCCCCT 
AAGGACACAC AGACCGAGGC TGACAGCCCA TTCGTGGGGA ACCCAGGGAA TATCACGGGT 
GCCAGAGGAC TCACGGGGAC CCTTCGGTGT GAGCTCCAGG TTCAGGGGGA GCCCCCTGAG 
GTGATGTGGC TTCGAGATGG ACAGATCCTA GAACTGGCTG ATAACACCCA GACCCAGGTG 
CCTCTGGGCG AAGACTGGCA AGATGAATGG AAAGTCGTCA GTCAGCTCAG AATCTCAGCC 
CTGCAACTTT CAGATGCAGG AGAGTACCAG TGTATGGTGC ACCTGGAAGG ACGGACCTTT 
GTGTCTCAGC CGGGCTTTGT AGGACTGGAA GGTCTCCCGT ACTTCCTGGA GGAACCTGAA 
GACAAAGCTG TGCCTGCCAA CACCCCCTTC AACCTAAGCT GCCAGGCCCA GGGACCCCCG 
GAACCCGTGA CCCTGCTCTG GCTTCAAGAT GCTGTCCCTC TGGCCCCAGT CGCAGGATAC 
AGCTTTCAGC ACAGTTTGCA AGCTCCAGGC CTGAACAAGA CATCTTCTTT CTCATGTGAA 
GCCCACAATG CCAAGGGAGT CACCACCTCC CGCACAGCTA CCATCACAGT GCTCCCACAG 
AGACCTCACA ATCTCCACGT GGTTTCCAGA CATCCCACGG AGCTAGAGGT AGCTTGGATC 
CCTACCCTGA GTGGCATCTA CCCGCTCACC CACTGCACCC TGCAGGCTGT GCTGTCAAAC 
GATGGGGTGG GCGTCTGGCT GGGAAAGTCA GATCCTCCTG AAGAACCCCT CACCGTGCAA 
GTATCAGTGC CCCCCCACCA GCTTCGGCTG GAAAAGCTCC TTCCTCACAC CCCATATCAC 
ATCCGGGTAT CCTGCACTAG CAGCCAGGGC CCCTCACCTT GGACCCACTG GCTTCCTGTG 
GAGACCACGG AGGGAGTGCC CTTGGGTCCC CCTGAGAACG TTAGCGCCAT GCGGAATGGG 
AGCCAGGCCC TCGTGCGTTG GCAGGAGCCA AGGGAGCCCT TGCAGGGCAC CCTGTTAGGG 
TACCGGCTGG CATATCGAGG CCAGGACACC CCCGAGGTAC TTATGGATAT AGGGCTAACT 
CGAGAGGTGA CCTTGGAACT TCGGGGGGAC AGGCCTGTGG CTAACCTGAC TGTGTCTGTG 
GCAGCCTATA CCTCAGCTGG GGATGGGCCC TGGAGCCTTC CTGTGCCCCT AGAGCCCTGG 
CGCCCAGGGC AAGGACAGCC ACTCCACCAT CTGGTGAGTG AACCCCCACC TCCCGCCTTC 
TCGTGGCCTT GGTGGTATGT ACTGCTGGGA GCACTTGTGG CCGCCGCCTG TGTCCTTATC 
TTGACCCTGT TCCTTGTCCA TCGGAGGAAG AAGGAGACGA GATATGGGGA GGTGTTCGAG 
CCAACTGTGG AAAGGGGTGA ACTGGTAGTC AGGTACCGTG CCCGAAAGTC CTACAGTCGC 
CGGACCACGG AAGCCACCTT GAACAGTCTG GGCATCAGCG AAGAGCTGAA GGAGAAACTA 
CGAGACGTCA TGGTAGATCG GCATAAGGTG GCCTTGGGGA AGACCCTGGG AGAGGGAGAA 
TTTGGTGCTG TGATGGAGGG CCAGCTCAAC CAGGATGACT CCATCCTCAA GGTCGCTGTG 
AAGACCATGA AAATTGCCAT CTGCACAAGA TCAGAGCTGG AGGATTTCCT GAGTGAAGCT 
GTCTGCATGA AGGAATTTGA CCACCCCAAC GTCATGAGGC TCATTGGCGT CTGTTTCCAG 
GGTTCTGACC GAGAGGGTTT CCCAGAACCG GTGGTCATCT TGCCTTTCAT GAAACATGGA 
GACCTCCACA GTTTCCTCCT GTACTCGCGG CTCGGGGACC AGCCAGTGTT CCTGCCCACT 
CAGATGCTAG TGAAGTTTAT GGCCGACATT GCCAGTGGCA TGGAGTACCT CAGTACCAAG 
AGATTCATAC ACCGGGACCT AGCTGCCAGG AACTGCATGC TGAATGAGAA CATGTCCGTG 
TGCGTGGCAG ACTTCGGGCT CTCCAAGAAG ATCTACAATG GGGATTACTA CCGCCAAGGG 
CGCATTGCCA AGATGCCAGT CAAGTGGATT GCTATCGAGA GTCTGGCAGA TCGAGTCTAC 
ACCAGCAAGA GTGACGTGTG GTCCTTCGGT GTGACAATGT GGGAGATCGC CACCCGAGGC 
CAAACTCCCT ATCCAGGGGT GGAGAACAGT GAGATTTACG ACTACCTACG TCAAGGAAAT 
CGCCTGAAAC AGCCTCTGGA CTGTCTGGAT GGCCTCTATG CCCTGATGTC CCGGTGCTGG 
GAGCTGAACC CTCGAGACCG GCCAAGTTTT GCAGAGCTCC GGGAAGACTT GGAGAACACA 
TTGAAGGCTC TACCCCCTGC TCAGGAGCCT GATGAAATCC TCTATGTCAA CATGGATGAG 
GGCGGAAGTC ACCTTGAACC CCGTGGGGCT GCTGGAGGAG CTGACCCCCC AACCCAACCT 
GATCCTAAGG ATTACTGTAG CTGTCTCACT GCAGCTGACG TCCACTCAGC TGGACGCTAT 
GTCCTTTGTC CTTCTACAGC CCCAGGACCC ACTCTGTCTG CTGACAGAGG CTGCCCAGCA 
CCTCCAGGGC AGGAGGACGG AGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Axl ( NM_001013147.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013165.1 Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa03548
Clone ID Related Accession (Same CDS sequence)	NM_001013147.1
Accession Version	NM_001013147.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2640bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-09
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase receptor UFO isoform 2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB067527.1. On Apr 20, 2005 this sequence version replaced XM_218346.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGCAGGG TCCCGCTGGC CTGGTGCGTG GCGCTGTGCT GCTGGGGGTG TGCAGCCCCT 
AAGGACACAC AGACCGAGGC TGACAGCCCA TTCGTGGGGA ACCCAGGGAA TATCACGGGT 
GCCAGAGGAC TCACGGGGAC CCTTCGGTGT GAGCTCCAGG TTCAGGGGGA GCCCCCTGAG 
GTGATGTGGC TTCGAGATGG ACAGATCCTA GAACTGGCTG ATAACACCCA GACCCAGGTG 
CCTCTGGGCG AAGACTGGCA AGATGAATGG AAAGTCGTCA GTCAGCTCAG AATCTCAGCC 
CTGCAACTTT CAGATGCAGG AGAGTACCAG TGTATGGTGC ACCTGGAAGG ACGGACCTTT 
GTGTCTCAGC CGGGCTTTGT AGGACTGGAA GGTCTCCCGT ACTTCCTGGA GGAACCTGAA 
GACAAAGCTG TGCCTGCCAA CACCCCCTTC AACCTAAGCT GCCAGGCCCA GGGACCCCCG 
GAACCCGTGA CCCTGCTCTG GCTTCAAGAT GCTGTCCCTC TGGCCCCAGT CGCAGGATAC 
AGCTTTCAGC ACAGTTTGCA AGCTCCAGGC CTGAACAAGA CATCTTCTTT CTCATGTGAA 
GCCCACAATG CCAAGGGAGT CACCACCTCC CGCACAGCTA CCATCACAGT GCTCCCACAG 
AGACCTCACA ATCTCCACGT GGTTTCCAGA CATCCCACGG AGCTAGAGGT AGCTTGGATC 
CCTACCCTGA GTGGCATCTA CCCGCTCACC CACTGCACCC TGCAGGCTGT GCTGTCAAAC 
GATGGGGTGG GCGTCTGGCT GGGAAAGTCA GATCCTCCTG AAGAACCCCT CACCGTGCAA 
GTATCAGTGC CCCCCCACCA GCTTCGGCTG GAAAAGCTCC TTCCTCACAC CCCATATCAC 
ATCCGGGTAT CCTGCACTAG CAGCCAGGGC CCCTCACCTT GGACCCACTG GCTTCCTGTG 
GAGACCACGG AGGGAGTGCC CTTGGGTCCC CCTGAGAACG TTAGCGCCAT GCGGAATGGG 
AGCCAGGCCC TCGTGCGTTG GCAGGAGCCA AGGGAGCCCT TGCAGGGCAC CCTGTTAGGG 
TACCGGCTGG CATATCGAGG CCAGGACACC CCCGAGGTAC TTATGGATAT AGGGCTAACT 
CGAGAGGTGA CCTTGGAACT TCGGGGGGAC AGGCCTGTGG CTAACCTGAC TGTGTCTGTG 
GCAGCCTATA CCTCAGCTGG GGATGGGCCC TGGAGCCTTC CTGTGCCCCT AGAGCCCTGG 
CGCCCAGTGA GTGAACCCCC ACCTCCCGCC TTCTCGTGGC CTTGGTGGTA TGTACTGCTG 
GGAGCACTTG TGGCCGCCGC CTGTGTCCTT ATCTTGACCC TGTTCCTTGT CCATCGGAGG 
AAGAAGGAGA CGAGATATGG GGAGGTGTTC GAGCCAACTG TGGAAAGGGG TGAACTGGTA 
GTCAGGTACC GTGCCCGAAA GTCCTACAGT CGCCGGACCA CGGAAGCCAC CTTGAACAGT 
CTGGGCATCA GCGAAGAGCT GAAGGAGAAA CTACGAGACG TCATGGTAGA TCGGCATAAG 
GTGGCCTTGG GGAAGACCCT GGGAGAGGGA GAATTTGGTG CTGTGATGGA GGGCCAGCTC 
AACCAGGATG ACTCCATCCT CAAGGTCGCT GTGAAGACCA TGAAAATTGC CATCTGCACA 
AGATCAGAGC TGGAGGATTT CCTGAGTGAA GCTGTCTGCA TGAAGGAATT TGACCACCCC 
AACGTCATGA GGCTCATTGG CGTCTGTTTC CAGGGTTCTG ACCGAGAGGG TTTCCCAGAA 
CCGGTGGTCA TCTTGCCTTT CATGAAACAT GGAGACCTCC ACAGTTTCCT CCTGTACTCG 
CGGCTCGGGG ACCAGCCAGT GTTCCTGCCC ACTCAGATGC TAGTGAAGTT TATGGCCGAC 
ATTGCCAGTG GCATGGAGTA CCTCAGTACC AAGAGATTCA TACACCGGGA CCTAGCTGCC 
AGGAACTGCA TGCTGAATGA GAACATGTCC GTGTGCGTGG CAGACTTCGG GCTCTCCAAG 
AAGATCTACA ATGGGGATTA CTACCGCCAA GGGCGCATTG CCAAGATGCC AGTCAAGTGG 
ATTGCTATCG AGAGTCTGGC AGATCGAGTC TACACCAGCA AGAGTGACGT GTGGTCCTTC 
GGTGTGACAA TGTGGGAGAT CGCCACCCGA GGCCAAACTC CCTATCCAGG GGTGGAGAAC 
AGTGAGATTT ACGACTACCT ACGTCAAGGA AATCGCCTGA AACAGCCTCT GGACTGTCTG 
GATGGCCTCT ATGCCCTGAT GTCCCGGTGC TGGGAGCTGA ACCCTCGAGA CCGGCCAAGT 
TTTGCAGAGC TCCGGGAAGA CTTGGAGAAC ACATTGAAGG CTCTACCCCC TGCTCAGGAG 
CCTGATGAAA TCCTCTATGT CAACATGGAT GAGGGCGGAA GTCACCTTGA ACCCCGTGGG 
GCTGCTGGAG GAGCTGACCC CCCAACCCAA CCTGATCCTA AGGATTACTG TAGCTGTCTC 
ACTGCAGCTG ACGTCCACTC AGCTGGACGC TATGTCCTTT GTCCTTCTAC AGCCCCAGGA 
CCCACTCTGT CTGCTGACAG AGGCTGCCCA GCACCTCCAG GGCAGGAGGA CGGAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013165.1
CDS	1..2640
Translation	MGRVPLAWCVALCCWGCAAPKDTQTEADSPFVGNPGNITGARGLTGTLRCELQVQGEPPEVMWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQLSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPPEPVTLLWLQDAVPLAPVAGYSFQHSLQAPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQRPHNLHVVSRHPTELEVAWIPTLSGIYPLTHCTLQAVLSNDGVGVWLGKSDPPEEPLTVQVSVPPHQLRLEKLLPHTPYHIRVSCTSSQGPSPWTHWLPVETTEGVPLGPPENVSAMRNGSQALVRWQEPREPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRPVANLTVSVAAYTSAGDGPWSLPVPLEPWRPVSEPPPPAFSWPWWYVLLGALVAAACVLILTLFLVHRRKKETRYGEVFEPTVERGELVVRYRARKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYALMSRCWELNPRDRPSFAELREDLENTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDYCSCLTAADVHSAGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA

Target ORF information:

RefSeq Version	NM_001013147.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013147.1

ORF Insert Sequence:

ATGGGCAGGG TCCCGCTGGC CTGGTGCGTG GCGCTGTGCT GCTGGGGGTG TGCAGCCCCT 
AAGGACACAC AGACCGAGGC TGACAGCCCA TTCGTGGGGA ACCCAGGGAA TATCACGGGT 
GCCAGAGGAC TCACGGGGAC CCTTCGGTGT GAGCTCCAGG TTCAGGGGGA GCCCCCTGAG 
GTGATGTGGC TTCGAGATGG ACAGATCCTA GAACTGGCTG ATAACACCCA GACCCAGGTG 
CCTCTGGGCG AAGACTGGCA AGATGAATGG AAAGTCGTCA GTCAGCTCAG AATCTCAGCC 
CTGCAACTTT CAGATGCAGG AGAGTACCAG TGTATGGTGC ACCTGGAAGG ACGGACCTTT 
GTGTCTCAGC CGGGCTTTGT AGGACTGGAA GGTCTCCCGT ACTTCCTGGA GGAACCTGAA 
GACAAAGCTG TGCCTGCCAA CACCCCCTTC AACCTAAGCT GCCAGGCCCA GGGACCCCCG 
GAACCCGTGA CCCTGCTCTG GCTTCAAGAT GCTGTCCCTC TGGCCCCAGT CGCAGGATAC 
AGCTTTCAGC ACAGTTTGCA AGCTCCAGGC CTGAACAAGA CATCTTCTTT CTCATGTGAA 
GCCCACAATG CCAAGGGAGT CACCACCTCC CGCACAGCTA CCATCACAGT GCTCCCACAG 
AGACCTCACA ATCTCCACGT GGTTTCCAGA CATCCCACGG AGCTAGAGGT AGCTTGGATC 
CCTACCCTGA GTGGCATCTA CCCGCTCACC CACTGCACCC TGCAGGCTGT GCTGTCAAAC 
GATGGGGTGG GCGTCTGGCT GGGAAAGTCA GATCCTCCTG AAGAACCCCT CACCGTGCAA 
GTATCAGTGC CCCCCCACCA GCTTCGGCTG GAAAAGCTCC TTCCTCACAC CCCATATCAC 
ATCCGGGTAT CCTGCACTAG CAGCCAGGGC CCCTCACCTT GGACCCACTG GCTTCCTGTG 
GAGACCACGG AGGGAGTGCC CTTGGGTCCC CCTGAGAACG TTAGCGCCAT GCGGAATGGG 
AGCCAGGCCC TCGTGCGTTG GCAGGAGCCA AGGGAGCCCT TGCAGGGCAC CCTGTTAGGG 
TACCGGCTGG CATATCGAGG CCAGGACACC CCCGAGGTAC TTATGGATAT AGGGCTAACT 
CGAGAGGTGA CCTTGGAACT TCGGGGGGAC AGGCCTGTGG CTAACCTGAC TGTGTCTGTG 
GCAGCCTATA CCTCAGCTGG GGATGGGCCC TGGAGCCTTC CTGTGCCCCT AGAGCCCTGG 
CGCCCAGTGA GTGAACCCCC ACCTCCCGCC TTCTCGTGGC CTTGGTGGTA TGTACTGCTG 
GGAGCACTTG TGGCCGCCGC CTGTGTCCTT ATCTTGACCC TGTTCCTTGT CCATCGGAGG 
AAGAAGGAGA CGAGATATGG GGAGGTGTTC GAGCCAACTG TGGAAAGGGG TGAACTGGTA 
GTCAGGTACC GTGCCCGAAA GTCCTACAGT CGCCGGACCA CGGAAGCCAC CTTGAACAGT 
CTGGGCATCA GCGAAGAGCT GAAGGAGAAA CTACGAGACG TCATGGTAGA TCGGCATAAG 
GTGGCCTTGG GGAAGACCCT GGGAGAGGGA GAATTTGGTG CTGTGATGGA GGGCCAGCTC 
AACCAGGATG ACTCCATCCT CAAGGTCGCT GTGAAGACCA TGAAAATTGC CATCTGCACA 
AGATCAGAGC TGGAGGATTT CCTGAGTGAA GCTGTCTGCA TGAAGGAATT TGACCACCCC 
AACGTCATGA GGCTCATTGG CGTCTGTTTC CAGGGTTCTG ACCGAGAGGG TTTCCCAGAA 
CCGGTGGTCA TCTTGCCTTT CATGAAACAT GGAGACCTCC ACAGTTTCCT CCTGTACTCG 
CGGCTCGGGG ACCAGCCAGT GTTCCTGCCC ACTCAGATGC TAGTGAAGTT TATGGCCGAC 
ATTGCCAGTG GCATGGAGTA CCTCAGTACC AAGAGATTCA TACACCGGGA CCTAGCTGCC 
AGGAACTGCA TGCTGAATGA GAACATGTCC GTGTGCGTGG CAGACTTCGG GCTCTCCAAG 
AAGATCTACA ATGGGGATTA CTACCGCCAA GGGCGCATTG CCAAGATGCC AGTCAAGTGG 
ATTGCTATCG AGAGTCTGGC AGATCGAGTC TACACCAGCA AGAGTGACGT GTGGTCCTTC 
GGTGTGACAA TGTGGGAGAT CGCCACCCGA GGCCAAACTC CCTATCCAGG GGTGGAGAAC 
AGTGAGATTT ACGACTACCT ACGTCAAGGA AATCGCCTGA AACAGCCTCT GGACTGTCTG 
GATGGCCTCT ATGCCCTGAT GTCCCGGTGC TGGGAGCTGA ACCCTCGAGA CCGGCCAAGT 
TTTGCAGAGC TCCGGGAAGA CTTGGAGAAC ACATTGAAGG CTCTACCCCC TGCTCAGGAG 
CCTGATGAAA TCCTCTATGT CAACATGGAT GAGGGCGGAA GTCACCTTGA ACCCCGTGGG 
GCTGCTGGAG GAGCTGACCC CCCAACCCAA CCTGATCCTA AGGATTACTG TAGCTGTCTC 
ACTGCAGCTG ACGTCCACTC AGCTGGACGC TATGTCCTTT GTCCTTCTAC AGCCCCAGGA 
CCCACTCTGT CTGCTGACAG AGGCTGCCCA GCACCTCCAG GGCAGGAGGA CGGAGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats.
Neurobiology of disease11059-67(2018 Feb)
Wu G,McBride DW,Zhang JH

Vitamin K2 inhibits rat vascular smooth muscle cell calcification by restoring the Gas6/Axl/Akt anti-apoptotic pathway.
Molecular and cellular biochemistry433(1-2)149-159(2017 Sep)
Qiu C,Zheng H,Tao H,Yu W,Jiang X,Li A,Jin H,Lv A,Li H

Cilostazol inhibits uremic toxin-induced vascular smooth muscle cell dysfunction: role of Axl signaling.
American journal of physiology. Renal physiology312(3)F398-F406(2017 Mar)
Lee CH,Hung YJ,Shieh YS,Chien CY,Hsu YJ,Lin CY,Chiang CF,Huang CL,Hsieh CH

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.
Proceedings of the National Academy of Sciences of the United States of America110(32)13091-6(2013 Aug)
Bosurgi L,Bernink JH,Delgado Cuevas V,Gagliani N,Joannas L,Schmid ET,Booth CJ,Ghosh S,Rothlin CV

Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells.
PloS one7(5)e36800(2012)
Brown JE,Krodel M,Pazos M,Lai C,Prieto AL

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Axl cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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