Rnf146 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rnf146
Entrez Gene ID	308051
Full Name	ring finger protein 146
General protein information	Preferred Names ring finger protein 146 Names E3 ubiquitin-protein ligase RNF146 RING-type E3 ubiquitin transferase RNF146 iduna
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p11

mRNA and Protein(s)

mRNA	Protein	Name
XM_006227744.3	XP_006227806.1	E3 ubiquitin-protein ligase RNF146 isoform X1
NM_001012060.2	NP_001012060.2	E3 ubiquitin-protein ligase RNF146
XM_006227745.3	XP_006227807.1	E3 ubiquitin-protein ligase RNF146 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	RNF146	NP_001229780.1
Pan troglodytes (chimpanzee)	RNF146	XP_001166481.2
	RNF146	XP_001106392.2
Gallus gallus (chicken)	RNF146	XP_423089.3
Danio rerio (zebrafish)	rnf146	NP_956148.1
Xenopus tropicalis (tropical clawed frog)	rnf146	NP_001008060.1
Canis lupus familiaris (dog)	RNF146	XP_005615679.1
Bos taurus (cattle)	RNF146B	NP_001070448.1
Mus musculus (house mouse)	Rnf146	NP_001103666.1
Rattus norvegicus (Norway rat)	Rnf146	NP_001012060.2

Gene Ontology
Bibliography

Related articles in PubMed

Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Yang X, Cheng J, Gao Y, Ding J, Ni X
Neuroscience34674-80(2017 Mar)

Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes.
Gero D, Szabo C
British journal of pharmacology172(20)4817-32(2015 Oct)

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.
Barkauskaite E, Jankevicius G, Ahel I
Molecular cell58(6)935-46(2015 Jun)

Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes.
Ger? D, Szoleczky P, Chatzianastasiou A, Papapetropoulos A, Szabo C
Molecular medicine (Cambridge, Mass.)20313-28(2014 Jul)

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F
Nature cell biology13(5)623-9(2011 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that apoptosis-inducing factor nuclear translocation and neuronal cell death are associated with Iduna loss after severe hypoxic-ischemic in the immature brain.
Title: Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.

Modulation of PARP-1-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes
Title: Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes.

The following Rnf146 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rnf146 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02095	NM_001012060.2 Latest version!	Rattus norvegicus ring finger protein 146 (Rnf146), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa02095	XM_006227745.3 Latest version!	Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa02095	XM_006227744.3 Latest version!	Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rnf146 ( NM_001012060.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012060.2 Rattus norvegicus ring finger protein 146 (Rnf146), mRNA.

Price & Availability↑

CloneID	ORa02095
Clone ID Related Accession (Same CDS sequence)	XM_006227744.3 , NM_001012060.2 , XM_006227745.3
Accession Version	NM_001012060.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-20
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase RNF146
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC083675.1 and CK845087.1. On Oct 30, 2007 this sequence version replaced NM_001012060.1. ##Evidence-Data-START## Transcript exon combination :: BC083675.1, CV105582.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642614 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012060.2
CDS	146..1213
Translation	MEMMAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPVPSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	NM_001012060.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ring finger protein 146 (Rnf146), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012060.2

ORF Insert Sequence:

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( XM_006227744.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006227806.1 Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa02095
Clone ID Related Accession (Same CDS sequence)	XM_006227744.3 , NM_001012060.2 , XM_006227745.3
Accession Version	XM_006227744.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase RNF146 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227744.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006227806.1
CDS	210..1277
Translation	MEMMAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPVPSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	XM_006227744.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006227744.3

ORF Insert Sequence:

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rnf146 ( XM_006227745.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006227807.1 Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa02095
Clone ID Related Accession (Same CDS sequence)	XM_006227744.3 , NM_001012060.2 , XM_006227745.3
Accession Version	XM_006227745.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase RNF146 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227745.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006227807.1
CDS	259..1326
Translation	MEMMAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPVPSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGGGTMSVNVRSRRPDGQCTVTEV

Target ORF information:

RefSeq Version	XM_006227745.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ring finger protein 146 (Rnf146), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006227745.3

ORF Insert Sequence:

ATGGAAATGA TGGCCGGCTG TGGTGAAATT GATCACTCAC TAAATATGCT TCCTACCAAT 
AAGAAGGCGA GTGAGACCTG TTCTAACACT GCACCTTCTC TAACAGTTCC CGAGTGTGCC 
ATTTGTCTAC AAACATGTGT TCATCCAGTC AGTCTGCCCT GTAAGCATGT TTTCTGTTAT 
CTGTGTGTAA AGGGCGCTTC ATGGCTCGGG AAGCGATGTG CTCTTTGTCG GCAAGAGATT 
CCTGAGGATT TTCTTGACAA GCCAACCTTG TTGTCACCAG AAGAACTTAA GGCTGCAAGC 
AGAGGAAATG GTGAATATGT GTGGTATTAT GAAGGAAGAA ATGGATGGTG GCAGTATGAT 
GAGCGCACCA GTCGGGAGCT AGAAGATGCT TTTTCCAAAG GTAAAAAGAA CACGGAAATG 
TTAATTGCTG GATTTCTGTA CGTTGCTGAT CTTGAAAACA TGGTTCAATA TAGGAGAAAT 
GAACATGGAC GTCGCAGAAA GATTAAAAGA GATATAATAG ATATACCAAA GAAGGGAGTG 
GCTGGACTTC GGCTGGACTG TGACAGCAAC ACTGTAAATC TAGCCAGAGA GAGTTCTGCC 
GATGGTGCGG ACAGTGGGTC AGCACACACT GGAGCTTCTG TGCAGCTTCC AGTGCCATCT 
TCTACAAGGC CTCTAACATC AGTCGATGGT CAGTTAACCA GCCCTGTAAC ACCGTCCCCT 
GATGCAGGCG CTTCTTTGGA AGACTCTTTT GCTCATTTAC AACTCAGTGG AGACAGCATA 
GCTGAAAGGA GTCATAGAGG TGAAGGAGAA GAAGATCACG AATCACCATC TTCTGGTAGA 
GTACCAGATA CGTCCACTGA AGAAACAGAG TCGGATGCCA GTAGTGATAT TGAGGATGCC 
CCTGTGGTGG TTGCACAGCA CTCCTTGACC CAACAGAGAC TTTTGGTTTC AAGTGCAAAT 
CAGACAGTAG CTGAACGGTC TGACCGACCA GTTGCAGGGG GTGGGACCAT GAGTGTCAAT 
GTCAGATCCA GAAGGCCTGA CGGACAGTGC ACAGTGACAG AGGTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia-ischemia.
Neuroscience34674-80(2017 Mar)
Yang X,Cheng J,Gao Y,Ding J,Ni X

Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes.
British journal of pharmacology172(20)4817-32(2015 Oct)
Gero D,Szabo C

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.
Molecular cell58(6)935-46(2015 Jun)
Barkauskaite E,Jankevicius G,Ahel I

Modulation of poly(ADP-ribose) polymerase-1 (PARP-1)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes.
Molecular medicine (Cambridge, Mass.)20313-28(2014 Jul)
Ger? D,Szoleczky P,Chatzianastasiou A,Papapetropoulos A,Szabo C

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Nature cell biology13(5)623-9(2011 May)
Zhang Y,Liu S,Mickanin C,Feng Y,Charlat O,Michaud GA,Schirle M,Shi X,Hild M,Bauer A,Myer VE,Finan PM,Porter JA,Huang SM,Cong F

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Rnf146 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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