Disc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Disc1
Entrez Gene ID	307940
Full Name	disrupted in schizophrenia 1
General protein information	Preferred Names disrupted in schizophrenia 1 Names disrupted in schizophrenia 1 homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12
Summary	interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_008772616.2	XP_008770838.1	disrupted in schizophrenia 1 homolog isoform X1
NM_175596.2	NP_783186.2	disrupted in schizophrenia 1 homolog

Pathways from BioSystems

Homologies

Homo sapiens (human)	DISC1	NP_001158009.1
Mus musculus (house mouse)	Disc1	NP_777279.2
Canis lupus familiaris (dog)	DISC1	XP_546088.3
Rattus norvegicus (Norway rat)	Disc1	NP_783186.2
Pan troglodytes (chimpanzee)	DISC1	XP_003308861.1
Bos taurus (cattle)	DISC1	XP_002698851.2
	DISC1	NP_001107827.1
Gallus gallus (chicken)	DISC1	XP_003641003.2

Gene Ontology
Bibliography

Related articles in PubMed

DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity.
Gancarz A, Jouroukhin Y, Saito A, Shevelkin A, Mueller LE, Kamiya A, Dietz DM, Pletnikov MV
Neuroscience research10570-4(2016 Apr)

DISC1 Protein Regulates ?-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons.
Wei J, Graziane NM, Gu Z, Yan Z
The Journal of biological chemistry290(46)27680-7(2015 Nov)

Half-life of DISC1 protein and its pathological significance under hypoxia stress.
Barodia SK, Park SK, Ishizuka K, Sawa A, Kamiya A
Neuroscience research971-6(2015 Aug)

Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome".
Owczarek S, Bang ML, Berezin V
Neural plasticity2015167308(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

evidence of a critical role of DISC1 in drug-induced behavioral neuroadaptations and sheds more light at the shared molecular pathology of drug abuse and other major psychiatric disorders.
Title: DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity.

The knowledge gained from this study would shed light on how DISC1 and the GABA system are linked mechanistically and how their interactions are critical for maintaining a normal mental state
Title: DISC1 Protein Regulates ?-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons.

Study determined the half-life of disrupted in schizophrenia 1 (DISC1). The half-life of DISC1 is diminished under hypoxia stress by increasing protein degradation of DISC1.
Title: Half-life of DISC1 protein and its pathological significance under hypoxia stress.

Study found that DISC1 influences APP C-terminal processing and Abeta peptide generation, affects surface expression and internalization of APP in neurons
Title: DISC1 regulates trafficking and processing of APP and A? generation.

This study observed a statistically significant (P < 0.05) decrease in the abundance of each of the three proteins (DISC1, PSD95, and NOS1) in ipsilateral traumatic brain injury tissues.
Title: A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury.

The following Disc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Disc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03865	NM_175596.2 Latest version!	Rattus norvegicus DISC1 scaffold protein (Disc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa03865	XM_008772616.2 Latest version!	Rattus norvegicus disrupted in schizophrenia 1 (Disc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Disc1 ( NM_175596.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_783186.2 Rattus norvegicus DISC1 scaffold protein (Disc1), mRNA.

Price & Availability↑

CloneID	ORa03865
Clone ID Related Accession (Same CDS sequence)	XM_008772616.2 , NM_175596.2
Accession Version	NM_175596.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2475bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Rattus norvegicus(Norway rat)
Product	disrupted in schizophrenia 1 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY177674.2. On May 18, 2003 this sequence version replaced NM_175596.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY177674.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGCAGGGCG CGGGTTCCCG GGGCGCTTGG ATCCACAGTC CGAGCCACTG CCCAGGCAAT 
GGGCATGGCT CGCCGCCTGC AGTAGCCCCT CAGAGGCGGC GGCTGACACG GAGACCAGGC 
TACATGAGAA GCACAGCCAG TCCTGGGATC GGGTTCCTGT CTCCAGCAGT GGGCATGCCA 
CGTCCGATCT CAGCGGGGCT GACAGGCCAG GAGTTCTACC CCTCACAGTC CAAGGCTAGA 
CAGTGCAGCC TTGACCTCAG AAGCCACTGC CAAGACTCAT TGGTGGGCAA CCCTTTTCTC 
AAGGGCTCCC TTGGCCCTGC TGTGACCTCT GTGGGCCACC TGCACCCAGC CCAGGGCTCT 
ATGAGAGAAA GGATGGTGCA CTCTGGGGTT CATTCCGGGA ATGACAGAAG ACAATCCGAG 
AGGCTGACTG GGGACAGTGG TTGTCGGCAA GAATTTTTAT CTTCAGACAG CTCTAAGTCT 
CTGGCTTCTA GCCTTGATGT AGCTTGGAGC AAGGGATCGA GGGGCCTGAA GACTGTGAGG 
CCTCTGGTAT CACCGGCGTC GAATGGCCCC GTTGACATCC CATCCCTTCC TGGGTTCCAA 
GACACCTTTA CTTCCAACTT CAGCTTCATC CGACTCTCCC TCGGTGCTGC TGGAGAACGC 
GGAGAAGCAG AAGGTTGCCT GCCATCCAGA GAGGCCGAAC CCCTGCATCA GAGCCCCCAA 
GAGATGGCAG CTGAAGGATC CGGCTCAGAC AGGCCCCACG GGGAGCCTCG GCATCTCTGG 
ACCTTCAGTC TTCACGCTGC TCCGGGCTTG GTGGACTTGG CTCAGGGGAC GAGGAGCAAC 
AGGCAACCAG AATGTGGCAT GGTCTCCTCC TCCGATGCTG GCTTCTCTTC CCAGGATGCA 
TCCCCCGCTG GAGGGCGGAG CGACCAGGAC GGAGGCTGGG CGGATGCCCA TGGATGGCAC 
GCTCTGCTCA GGGAATGGGA GCCTATGCTG CAGGACTACC TACTGAGCAA CCGCAGGCAG 
CTGGAGGTCA CTTCCTTGAT TTTAAAGCTT CAGAAACTTC AAGAAAAAGC GGTCGAGGAT 
GGCGATTACG ACATGGCAGA GACACTGAGA CAGAGATTGG AAGACCTGGA ACAGGAGAAA 
GGCCGCCTGC CCTGGGCTCT GCCCTCACAG CAACCAGCCC TTCGCAGCTT CTTGGGGTAC 
CTGGCAACAC AGACACACGC GGCCTTGCAT GGAGCCCCCC AAAGGGCTGG CAGCGATGAC 
CCAGAAGCCC CACTTGAGGG ACAGCGGAGG ACCACCGCCC AGGATAGCCT GCCGGGACTA 
GCCGTCACCA GGCGGGACTG GCTGATGCGA GAGAAAGAGC AATTGCAGAA GGAAATCGAA 
GCTCTCCGGG CAAGGGTGTC TGTGCTGGAG GCGAAGGAAC AACGGCTGAG CCAAGAGTTG 
GAGGATCAGG AGATGCTGCT CCGGTGGCAG GGCTGTGACC AGATGGCACT GGTGGCACAG 
CTGTCCCCAG GCCAGCTGCA GGAGGTCAGC AAGGCCTTGG GAGAGACTCT GACCTCTGCC 
AGATGGGCTC CCTTCCGCGT GGAGCCACCC GAAACCCTCA GGAGCCTCCG GGAAAGGACA 
AAGTCACTCG ACCTGGCTGT TAGAGAACTC ACTGAGCAGG TATGCTCAGG TGAGAAGCTA 
TGCAGCTCTC TGAGGAAGAG ACTCGCTGAC CTTGACACCA GGCTGCCTGC CTTGCTGGAA 
GCCAAGATGC TGGCCCTATC AGGAAGCTGC TTCTCTACAG CCAAGGAGCT CGCAGAGGAG 
ATTTGGGCCG TGTCATCGGA GCGGGAAGGG CTAGAGATGT TCCTGGGCAG GCTGCTGGCC 
CTCAGCTCCA GGAACACGAG AAGACTGGGC AGCGTCAAAG AGGACTACCT CAGGTGCAGG 
CAGGACCTGG CCCTCCAGGA AGCCGCCCAC AAAACACGCG TGAAGGCAAA CACTGTGAAG 
TGCACGGAAG TGTTGGAGGG TCAGCTGAGC TGCTGCAGGT GCCCGCTGCT TGAGAGAGTG 
TGGAAAGCGG ACTTGGAGGC GTGTCAGTTG CTGATGCAGA GCCTAGAGAT CCAGGAAGCA 
GGCAGCAGCT CACATGTGGA GGATGAGAAG CAGGTGCACA GCACAGGAGA GGCGGCTCAG 
ACAGCTGCCC TGGCTGTCCC TAGAACACCC CACCCCGAAG AGGAAAAGTC CCCCTTGCAG 
GAATCTCATG TCGTTTTTGC TGAAGTTGGA GACAAATGCG AAGCCATAGG CATGAGGCTC 
CTGCACCTGG AAGACCAGCT TCTCGGCGCC ATGCACGGTC ACGATGAAGC TCTCTTTCAG 
TCTCTCCAGG GGGAGCTCCA GATGGTTAAG GAAACACTAC AGACCATGTT CCTGCAGCTC 
CAGCCAGCAA AGGAGGCAGG AGGAGAGGCC TCAGCTTCCT ATTCGACAGC TGGTGCTCAG 
GAAGCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_783186.2
CDS	1..2475
Translation	MQGAGSRGAWIHSPSHCPGNGHGSPPAVAPQRRRLTRRPGYMRSTASPGIGFLSPAVGMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKGSLGPAVTSVGHLHPAQGSMRERMVHSGVHSGNDRRQSERLTGDSGCRQEFLSSDSSKSLASSLDVAWSKGSRGLKTVRPLVSPASNGPVDIPSLPGFQDTFTSNFSFIRLSLGAAGERGEAEGCLPSREAEPLHQSPQEMAAEGSGSDRPHGEPRHLWTFSLHAAPGLVDLAQGTRSNRQPECGMVSSSDAGFSSQDASPAGGRSDQDGGWADAHGWHALLREWEPMLQDYLLSNRRQLEVTSLILKLQKLQEKAVEDGDYDMAETLRQRLEDLEQEKGRLPWALPSQQPALRSFLGYLATQTHAALHGAPQRAGSDDPEAPLEGQRRTTAQDSLPGLAVTRRDWLMREKEQLQKEIEALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQEVSKALGETLTSARWAPFRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRKRLADLDTRLPALLEAKMLALSGSCFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSRNTRRLGSVKEDYLRCRQDLALQEAAHKTRVKANTVKCTEVLEGQLSCCRCPLLERVWKADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAAQTAALAVPRTPHPEEEKSPLQESHVVFAEVGDKCEAIGMRLLHLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFLQLQPAKEAGGEASASYSTAGAQEAED

Target ORF information:

RefSeq Version	NM_175596.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DISC1 scaffold protein (Disc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175596.2

ORF Insert Sequence:

ATGCAGGGCG CGGGTTCCCG GGGCGCTTGG ATCCACAGTC CGAGCCACTG CCCAGGCAAT 
GGGCATGGCT CGCCGCCTGC AGTAGCCCCT CAGAGGCGGC GGCTGACACG GAGACCAGGC 
TACATGAGAA GCACAGCCAG TCCTGGGATC GGGTTCCTGT CTCCAGCAGT GGGCATGCCA 
CGTCCGATCT CAGCGGGGCT GACAGGCCAG GAGTTCTACC CCTCACAGTC CAAGGCTAGA 
CAGTGCAGCC TTGACCTCAG AAGCCACTGC CAAGACTCAT TGGTGGGCAA CCCTTTTCTC 
AAGGGCTCCC TTGGCCCTGC TGTGACCTCT GTGGGCCACC TGCACCCAGC CCAGGGCTCT 
ATGAGAGAAA GGATGGTGCA CTCTGGGGTT CATTCCGGGA ATGACAGAAG ACAATCCGAG 
AGGCTGACTG GGGACAGTGG TTGTCGGCAA GAATTTTTAT CTTCAGACAG CTCTAAGTCT 
CTGGCTTCTA GCCTTGATGT AGCTTGGAGC AAGGGATCGA GGGGCCTGAA GACTGTGAGG 
CCTCTGGTAT CACCGGCGTC GAATGGCCCC GTTGACATCC CATCCCTTCC TGGGTTCCAA 
GACACCTTTA CTTCCAACTT CAGCTTCATC CGACTCTCCC TCGGTGCTGC TGGAGAACGC 
GGAGAAGCAG AAGGTTGCCT GCCATCCAGA GAGGCCGAAC CCCTGCATCA GAGCCCCCAA 
GAGATGGCAG CTGAAGGATC CGGCTCAGAC AGGCCCCACG GGGAGCCTCG GCATCTCTGG 
ACCTTCAGTC TTCACGCTGC TCCGGGCTTG GTGGACTTGG CTCAGGGGAC GAGGAGCAAC 
AGGCAACCAG AATGTGGCAT GGTCTCCTCC TCCGATGCTG GCTTCTCTTC CCAGGATGCA 
TCCCCCGCTG GAGGGCGGAG CGACCAGGAC GGAGGCTGGG CGGATGCCCA TGGATGGCAC 
GCTCTGCTCA GGGAATGGGA GCCTATGCTG CAGGACTACC TACTGAGCAA CCGCAGGCAG 
CTGGAGGTCA CTTCCTTGAT TTTAAAGCTT CAGAAACTTC AAGAAAAAGC GGTCGAGGAT 
GGCGATTACG ACATGGCAGA GACACTGAGA CAGAGATTGG AAGACCTGGA ACAGGAGAAA 
GGCCGCCTGC CCTGGGCTCT GCCCTCACAG CAACCAGCCC TTCGCAGCTT CTTGGGGTAC 
CTGGCAACAC AGACACACGC GGCCTTGCAT GGAGCCCCCC AAAGGGCTGG CAGCGATGAC 
CCAGAAGCCC CACTTGAGGG ACAGCGGAGG ACCACCGCCC AGGATAGCCT GCCGGGACTA 
GCCGTCACCA GGCGGGACTG GCTGATGCGA GAGAAAGAGC AATTGCAGAA GGAAATCGAA 
GCTCTCCGGG CAAGGGTGTC TGTGCTGGAG GCGAAGGAAC AACGGCTGAG CCAAGAGTTG 
GAGGATCAGG AGATGCTGCT CCGGTGGCAG GGCTGTGACC AGATGGCACT GGTGGCACAG 
CTGTCCCCAG GCCAGCTGCA GGAGGTCAGC AAGGCCTTGG GAGAGACTCT GACCTCTGCC 
AGATGGGCTC CCTTCCGCGT GGAGCCACCC GAAACCCTCA GGAGCCTCCG GGAAAGGACA 
AAGTCACTCG ACCTGGCTGT TAGAGAACTC ACTGAGCAGG TATGCTCAGG TGAGAAGCTA 
TGCAGCTCTC TGAGGAAGAG ACTCGCTGAC CTTGACACCA GGCTGCCTGC CTTGCTGGAA 
GCCAAGATGC TGGCCCTATC AGGAAGCTGC TTCTCTACAG CCAAGGAGCT CGCAGAGGAG 
ATTTGGGCCG TGTCATCGGA GCGGGAAGGG CTAGAGATGT TCCTGGGCAG GCTGCTGGCC 
CTCAGCTCCA GGAACACGAG AAGACTGGGC AGCGTCAAAG AGGACTACCT CAGGTGCAGG 
CAGGACCTGG CCCTCCAGGA AGCCGCCCAC AAAACACGCG TGAAGGCAAA CACTGTGAAG 
TGCACGGAAG TGTTGGAGGG TCAGCTGAGC TGCTGCAGGT GCCCGCTGCT TGAGAGAGTG 
TGGAAAGCGG ACTTGGAGGC GTGTCAGTTG CTGATGCAGA GCCTAGAGAT CCAGGAAGCA 
GGCAGCAGCT CACATGTGGA GGATGAGAAG CAGGTGCACA GCACAGGAGA GGCGGCTCAG 
ACAGCTGCCC TGGCTGTCCC TAGAACACCC CACCCCGAAG AGGAAAAGTC CCCCTTGCAG 
GAATCTCATG TCGTTTTTGC TGAAGTTGGA GACAAATGCG AAGCCATAGG CATGAGGCTC 
CTGCACCTGG AAGACCAGCT TCTCGGCGCC ATGCACGGTC ACGATGAAGC TCTCTTTCAG 
TCTCTCCAGG GGGAGCTCCA GATGGTTAAG GAAACACTAC AGACCATGTT CCTGCAGCTC 
CAGCCAGCAA AGGAGGCAGG AGGAGAGGCC TCAGCTTCCT ATTCGACAGC TGGTGCTCAG 
GAAGCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Disc1 ( XM_008772616.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008770838.1 Rattus norvegicus disrupted in schizophrenia 1 (Disc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa03865
Clone ID Related Accession (Same CDS sequence)	XM_008772616.2 , NM_175596.2
Accession Version	XM_008772616.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2475bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	disrupted in schizophrenia 1 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008772616.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGGCG CGGGTTCCCG GGGCGCTTGG ATCCACAGTC CGAGCCACTG CCCAGGCAAT 
GGGCATGGCT CGCCGCCTGC AGTAGCCCCT CAGAGGCGGC GGCTGACACG GAGACCAGGC 
TACATGAGAA GCACAGCCAG TCCTGGGATC GGGTTCCTGT CTCCAGCAGT GGGCATGCCA 
CGTCCGATCT CAGCGGGGCT GACAGGCCAG GAGTTCTACC CCTCACAGTC CAAGGCTAGA 
CAGTGCAGCC TTGACCTCAG AAGCCACTGC CAAGACTCAT TGGTGGGCAA CCCTTTTCTC 
AAGGGCTCCC TTGGCCCTGC TGTGACCTCT GTGGGCCACC TGCACCCAGC CCAGGGCTCT 
ATGAGAGAAA GGATGGTGCA CTCTGGGGTT CATTCCGGGA ATGACAGAAG ACAATCCGAG 
AGGCTGACTG GGGACAGTGG TTGTCGGCAA GAATTTTTAT CTTCAGACAG CTCTAAGTCT 
CTGGCTTCTA GCCTTGATGT AGCTTGGAGC AAGGGATCGA GGGGCCTGAA GACTGTGAGG 
CCTCTGGTAT CACCGGCGTC GAATGGCCCC GTTGACATCC CATCCCTTCC TGGGTTCCAA 
GACACCTTTA CTTCCAACTT CAGCTTCATC CGACTCTCCC TCGGTGCTGC TGGAGAACGC 
GGAGAAGCAG AAGGTTGCCT GCCATCCAGA GAGGCCGAAC CCCTGCATCA GAGCCCCCAA 
GAGATGGCAG CTGAAGGATC CGGCTCAGAC AGGCCCCACG GGGAGCCTCG GCATCTCTGG 
ACCTTCAGTC TTCACGCTGC TCCGGGCTTG GTGGACTTGG CTCAGGGGAC GAGGAGCAAC 
AGGCAACCAG AATGTGGCAT GGTCTCCTCC TCCGATGCTG GCTTCTCTTC CCAGGATGCA 
TCCCCCGCTG GAGGGCGGAG CGACCAGGAC GGAGGCTGGG CGGATGCCCA TGGATGGCAC 
GCTCTGCTCA GGGAATGGGA GCCTATGCTG CAGGACTACC TACTGAGCAA CCGCAGGCAG 
CTGGAGGTCA CTTCCTTGAT TTTAAAGCTT CAGAAACTTC AAGAAAAAGC GGTCGAGGAT 
GGCGATTACG ACATGGCAGA GACACTGAGA CAGAGATTGG AAGACCTGGA ACAGGAGAAA 
GGCCGCCTGC CCTGGGCTCT GCCCTCACAG CAACCAGCCC TTCGCAGCTT CTTGGGGTAC 
CTGGCAACAC AGACACACGC GGCCTTGCAT GGAGCCCCCC AAAGGGCTGG CAGCGATGAC 
CCAGAAGCCC CACTTGAGGG ACAGCGGAGG ACCACCGCCC AGGATAGCCT GCCGGGACTA 
GCCGTCACCA GGCGGGACTG GCTGATGCGA GAGAAAGAGC AATTGCAGAA GGAAATCGAA 
GCTCTCCGGG CAAGGGTGTC TGTGCTGGAG GCGAAGGAAC AACGGCTGAG CCAAGAGTTG 
GAGGATCAGG AGATGCTGCT CCGGTGGCAG GGCTGTGACC AGATGGCACT GGTGGCACAG 
CTGTCCCCAG GCCAGCTGCA GGAGGTCAGC AAGGCCTTGG GAGAGACTCT GACCTCTGCC 
AGATGGGCTC CCTTCCGCGT GGAGCCACCC GAAACCCTCA GGAGCCTCCG GGAAAGGACA 
AAGTCACTCG ACCTGGCTGT TAGAGAACTC ACTGAGCAGG TATGCTCAGG TGAGAAGCTA 
TGCAGCTCTC TGAGGAAGAG ACTCGCTGAC CTTGACACCA GGCTGCCTGC CTTGCTGGAA 
GCCAAGATGC TGGCCCTATC AGGAAGCTGC TTCTCTACAG CCAAGGAGCT CGCAGAGGAG 
ATTTGGGCCG TGTCATCGGA GCGGGAAGGG CTAGAGATGT TCCTGGGCAG GCTGCTGGCC 
CTCAGCTCCA GGAACACGAG AAGACTGGGC AGCGTCAAAG AGGACTACCT CAGGTGCAGG 
CAGGACCTGG CCCTCCAGGA AGCCGCCCAC AAAACACGCG TGAAGGCAAA CACTGTGAAG 
TGCACGGAAG TGTTGGAGGG TCAGCTGAGC TGCTGCAGGT GCCCGCTGCT TGAGAGAGTG 
TGGAAAGCGG ACTTGGAGGC GTGTCAGTTG CTGATGCAGA GCCTAGAGAT CCAGGAAGCA 
GGCAGCAGCT CACATGTGGA GGATGAGAAG CAGGTGCACA GCACAGGAGA GGCGGCTCAG 
ACAGCTGCCC TGGCTGTCCC TAGAACACCC CACCCCGAAG AGGAAAAGTC CCCCTTGCAG 
GAATCTCATG TCGTTTTTGC TGAAGTTGGA GACAAATGCG AAGCCATAGG CATGAGGCTC 
CTGCACCTGG AAGACCAGCT TCTCGGCGCC ATGCACGGTC ACGATGAAGC TCTCTTTCAG 
TCTCTCCAGG GGGAGCTCCA GATGGTTAAG GAAACACTAC AGACCATGTT CCTGCAGCTC 
CAGCCAGCAA AGGAGGCAGG AGGAGAGGCC TCAGCTTCCT ATTCGACAGC TGGTGCTCAG 
GAAGCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008770838.1
CDS	1423..3897
Translation	MQGAGSRGAWIHSPSHCPGNGHGSPPAVAPQRRRLTRRPGYMRSTASPGIGFLSPAVGMPRPISAGLTGQEFYPSQSKARQCSLDLRSHCQDSLVGNPFLKGSLGPAVTSVGHLHPAQGSMRERMVHSGVHSGNDRRQSERLTGDSGCRQEFLSSDSSKSLASSLDVAWSKGSRGLKTVRPLVSPASNGPVDIPSLPGFQDTFTSNFSFIRLSLGAAGERGEAEGCLPSREAEPLHQSPQEMAAEGSGSDRPHGEPRHLWTFSLHAAPGLVDLAQGTRSNRQPECGMVSSSDAGFSSQDASPAGGRSDQDGGWADAHGWHALLREWEPMLQDYLLSNRRQLEVTSLILKLQKLQEKAVEDGDYDMAETLRQRLEDLEQEKGRLPWALPSQQPALRSFLGYLATQTHAALHGAPQRAGSDDPEAPLEGQRRTTAQDSLPGLAVTRRDWLMREKEQLQKEIEALRARVSVLEAKEQRLSQELEDQEMLLRWQGCDQMALVAQLSPGQLQEVSKALGETLTSARWAPFRVEPPETLRSLRERTKSLDLAVRELTEQVCSGEKLCSSLRKRLADLDTRLPALLEAKMLALSGSCFSTAKELAEEIWAVSSEREGLEMFLGRLLALSSRNTRRLGSVKEDYLRCRQDLALQEAAHKTRVKANTVKCTEVLEGQLSCCRCPLLERVWKADLEACQLLMQSLEIQEAGSSSHVEDEKQVHSTGEAAQTAALAVPRTPHPEEEKSPLQESHVVFAEVGDKCEAIGMRLLHLEDQLLGAMHGHDEALFQSLQGELQMVKETLQTMFLQLQPAKEAGGEASASYSTAGAQEAED

Target ORF information:

RefSeq Version	XM_008772616.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus disrupted in schizophrenia 1 (Disc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008772616.2

ORF Insert Sequence:

ATGCAGGGCG CGGGTTCCCG GGGCGCTTGG ATCCACAGTC CGAGCCACTG CCCAGGCAAT 
GGGCATGGCT CGCCGCCTGC AGTAGCCCCT CAGAGGCGGC GGCTGACACG GAGACCAGGC 
TACATGAGAA GCACAGCCAG TCCTGGGATC GGGTTCCTGT CTCCAGCAGT GGGCATGCCA 
CGTCCGATCT CAGCGGGGCT GACAGGCCAG GAGTTCTACC CCTCACAGTC CAAGGCTAGA 
CAGTGCAGCC TTGACCTCAG AAGCCACTGC CAAGACTCAT TGGTGGGCAA CCCTTTTCTC 
AAGGGCTCCC TTGGCCCTGC TGTGACCTCT GTGGGCCACC TGCACCCAGC CCAGGGCTCT 
ATGAGAGAAA GGATGGTGCA CTCTGGGGTT CATTCCGGGA ATGACAGAAG ACAATCCGAG 
AGGCTGACTG GGGACAGTGG TTGTCGGCAA GAATTTTTAT CTTCAGACAG CTCTAAGTCT 
CTGGCTTCTA GCCTTGATGT AGCTTGGAGC AAGGGATCGA GGGGCCTGAA GACTGTGAGG 
CCTCTGGTAT CACCGGCGTC GAATGGCCCC GTTGACATCC CATCCCTTCC TGGGTTCCAA 
GACACCTTTA CTTCCAACTT CAGCTTCATC CGACTCTCCC TCGGTGCTGC TGGAGAACGC 
GGAGAAGCAG AAGGTTGCCT GCCATCCAGA GAGGCCGAAC CCCTGCATCA GAGCCCCCAA 
GAGATGGCAG CTGAAGGATC CGGCTCAGAC AGGCCCCACG GGGAGCCTCG GCATCTCTGG 
ACCTTCAGTC TTCACGCTGC TCCGGGCTTG GTGGACTTGG CTCAGGGGAC GAGGAGCAAC 
AGGCAACCAG AATGTGGCAT GGTCTCCTCC TCCGATGCTG GCTTCTCTTC CCAGGATGCA 
TCCCCCGCTG GAGGGCGGAG CGACCAGGAC GGAGGCTGGG CGGATGCCCA TGGATGGCAC 
GCTCTGCTCA GGGAATGGGA GCCTATGCTG CAGGACTACC TACTGAGCAA CCGCAGGCAG 
CTGGAGGTCA CTTCCTTGAT TTTAAAGCTT CAGAAACTTC AAGAAAAAGC GGTCGAGGAT 
GGCGATTACG ACATGGCAGA GACACTGAGA CAGAGATTGG AAGACCTGGA ACAGGAGAAA 
GGCCGCCTGC CCTGGGCTCT GCCCTCACAG CAACCAGCCC TTCGCAGCTT CTTGGGGTAC 
CTGGCAACAC AGACACACGC GGCCTTGCAT GGAGCCCCCC AAAGGGCTGG CAGCGATGAC 
CCAGAAGCCC CACTTGAGGG ACAGCGGAGG ACCACCGCCC AGGATAGCCT GCCGGGACTA 
GCCGTCACCA GGCGGGACTG GCTGATGCGA GAGAAAGAGC AATTGCAGAA GGAAATCGAA 
GCTCTCCGGG CAAGGGTGTC TGTGCTGGAG GCGAAGGAAC AACGGCTGAG CCAAGAGTTG 
GAGGATCAGG AGATGCTGCT CCGGTGGCAG GGCTGTGACC AGATGGCACT GGTGGCACAG 
CTGTCCCCAG GCCAGCTGCA GGAGGTCAGC AAGGCCTTGG GAGAGACTCT GACCTCTGCC 
AGATGGGCTC CCTTCCGCGT GGAGCCACCC GAAACCCTCA GGAGCCTCCG GGAAAGGACA 
AAGTCACTCG ACCTGGCTGT TAGAGAACTC ACTGAGCAGG TATGCTCAGG TGAGAAGCTA 
TGCAGCTCTC TGAGGAAGAG ACTCGCTGAC CTTGACACCA GGCTGCCTGC CTTGCTGGAA 
GCCAAGATGC TGGCCCTATC AGGAAGCTGC TTCTCTACAG CCAAGGAGCT CGCAGAGGAG 
ATTTGGGCCG TGTCATCGGA GCGGGAAGGG CTAGAGATGT TCCTGGGCAG GCTGCTGGCC 
CTCAGCTCCA GGAACACGAG AAGACTGGGC AGCGTCAAAG AGGACTACCT CAGGTGCAGG 
CAGGACCTGG CCCTCCAGGA AGCCGCCCAC AAAACACGCG TGAAGGCAAA CACTGTGAAG 
TGCACGGAAG TGTTGGAGGG TCAGCTGAGC TGCTGCAGGT GCCCGCTGCT TGAGAGAGTG 
TGGAAAGCGG ACTTGGAGGC GTGTCAGTTG CTGATGCAGA GCCTAGAGAT CCAGGAAGCA 
GGCAGCAGCT CACATGTGGA GGATGAGAAG CAGGTGCACA GCACAGGAGA GGCGGCTCAG 
ACAGCTGCCC TGGCTGTCCC TAGAACACCC CACCCCGAAG AGGAAAAGTC CCCCTTGCAG 
GAATCTCATG TCGTTTTTGC TGAAGTTGGA GACAAATGCG AAGCCATAGG CATGAGGCTC 
CTGCACCTGG AAGACCAGCT TCTCGGCGCC ATGCACGGTC ACGATGAAGC TCTCTTTCAG 
TCTCTCCAGG GGGAGCTCCA GATGGTTAAG GAAACACTAC AGACCATGTT CCTGCAGCTC 
CAGCCAGCAA AGGAGGCAGG AGGAGAGGCC TCAGCTTCCT ATTCGACAGC TGGTGCTCAG 
GAAGCCGAGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DISC1 signaling in cocaine addiction: Towards molecular mechanisms of co-morbidity.
Neuroscience research10570-4(2016 Apr)
Gancarz A,Jouroukhin Y,Saito A,Shevelkin A,Mueller LE,Kamiya A,Dietz DM,Pletnikov MV

DISC1 Protein Regulates ?-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons.
The Journal of biological chemistry290(46)27680-7(2015 Nov)
Wei J,Graziane NM,Gu Z,Yan Z

Half-life of DISC1 protein and its pathological significance under hypoxia stress.
Neuroscience research971-6(2015 Aug)
Barodia SK,Park SK,Ishizuka K,Sawa A,Kamiya A

Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome".
Neural plasticity2015167308(2015)
Owczarek S,Bang ML,Berezin V

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Disc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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