Afg3l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Afg3l2
Entrez Gene ID	307350
Full Name	AFG3 like matrix AAA peptidase subunit 2
General protein information	Preferred Names AFG3 like matrix AAA peptidase subunit 2 Names AFG3-like protein 2 AFG3 ATPase family member 3-like 2 AFG3-like AAA ATPase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134864.1	NP_001128336.1	AFG3-like protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	AFG3L2	NP_006787.2
Pan troglodytes (chimpanzee)	AFG3L2	XP_512199.2
Saccharomyces cerevisiae (baker's yeast)	AFG3	NP_010933.1
Eremothecium gossypii	AGOS_AAR025C	NP_982566.2
Arabidopsis thaliana (thale cress)	ftsh10	NP_172231.2
Bos taurus (cattle)	AFG3L2	NP_001039676.1
Mus musculus (house mouse)	Afg3l2	NP_081406.1
Arabidopsis thaliana (thale cress)	ftsh3	NP_850129.1
	AFG3L2	XP_001094146.1
Gallus gallus (chicken)	AFG3L2	XP_419121.2
Drosophila melanogaster (fruit fly)	CG6512	NP_730248.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006949	XP_308807.4
Caenorhabditis elegans (roundworm)	spg-7	NP_491165.2
Danio rerio (zebrafish)	afg3l2	NP_001104667.1
Oryza sativa (rice)	Os05g0458400	NP_001055745.1
Canis lupus familiaris (dog)	AFG3L2	XP_547682.2
Rattus norvegicus (Norway rat)	Afg3l2	NP_001128336.1
Oryza sativa (rice)	Os01g0842600	NP_001044774.1
Xenopus tropicalis (tropical clawed frog)	afg3l2	NP_001072759.1

Gene Ontology
Bibliography

Related articles in PubMed

SCA28: Novel Mutation in the AFG3L2 Proteolytic Domain Causes a Mild Cerebellar Syndrome with Selective Type-1 Muscle Fiber Atrophy.
Svenstrup K, Nielsen TT, Aidt F, Rostgaard N, Duno M, Wibrand F, Vinther-Jensen T, Law I, Vissing J, Roos P, Hjermind LE, Nielsen JE
Cerebellum (London, England)16(1)62-67(2017 Feb)

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
K?nig T, Tr?der SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, M?hlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T
Molecular cell64(1)148-162(2016 Oct)

Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model.
Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young SM Jr, Drago I, Bahr BA, Puliti A, Codazzi F, Quattrini A, Casari G
The Journal of clinical investigation125(1)263-74(2015 Jan)

Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
Smets K, Deconinck T, Baets J, Sieben A, Martin JJ, Smouts I, Wang S, Taroni F, Di Bella D, Van Hecke W, Parizel PM, Jadoul C, De Potter R, Couvreur F, Rugarli E, De Jonghe P
Neurology82(23)2092-100(2014 Jun)

StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation.
Bahat A, Perlberg S, Melamed-Book N, Lauria I, Langer T, Orly J
Molecular endocrinology (Baltimore, Md.)28(2)208-24(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Afg3l2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Afg3l2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03694	NM_001134864.1 Latest version!	Rattus norvegicus AFG3 like matrix AAA peptidase subunit 2 (Afg3l2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Afg3l2 ( NM_001134864.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128336.1 Rattus norvegicus AFG3 like matrix AAA peptidase subunit 2 (Afg3l2), mRNA.

Price & Availability↑

CloneID	ORa03694
Clone ID Related Accession (Same CDS sequence)	NM_001134864.1
Accession Version	NM_001134864.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2409bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	AFG3-like protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07032372.1. On Sep 10, 2008 this sequence version replaced XM_225866.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCTCACC GCTGCCTGCT GCTGTGGGGT CGGGGCGGCT GCCGTCGCGG CCTTCCTCCC 
CTGCTCGTGC CCAGCGGCTG CCTGGGTCCC GGCCGGCGGC CCTGCCTCCG TACGCTTTAT 
CAGTACGCTA CGGTCCAAAC AGCAAACAGC AGAAGTTCTC TTCTAAGGGA TGTAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCTCCC AAAGGATTTG AAAAATACTT TCCTAATGGG 
AAAAATGGAA AAAAGGCCAG CGAATCTAAG GAAGCTGTTG GAGAAAAAAA AGAATCACAA 
CTCTCCGGTC CCCAGTCTTC TGGAGGTGCA AGTGGTGGGG GAGGGAAGCG CCGTGGCAAG 
AAAGAAGATT CTCACTGGTG GTCCAGGTTC CAGAAGGGTG ACTTTCCATG GGATGACAAG 
GATTTCAGGA TGTACTTTCT CTGGACTGCT CTTTTTTGGA GTGGAGTCAT GATTTACTTC 
CTGTTCAAGA GCTCTGGGAG AGAAATCACA TGGAAAGACT TTGTCAATAA CTATCTTTCT 
AAAGGAGTGG TGGACAGACT AGAAGTTGTC AACAAACGTT TTGTTCGTGT GACCTTTACT 
CCAGGAAAAA CTCCAGTTGA TGGGCAATAC GTCTGGTTTA ATATTGGCAG TGTTGACACA 
TTTGAGCGGA ATCTGGAGAC TTTGCAGCAA GAATTGGGCA TAGAAGGGGA GAACCGGGTG 
CCTGTGGTTT ACATTGCTGA AAGCGATGGC TCCTTCCTGC TGAGCATGTT GCCCACGGTA 
CTCATTATTG CTTTTCTACT CTACACCATA AGAAGAGGGC CCGCTGGCAT TGGTCGGACC 
GGTCGGGGAA TGGGTGGACT CTTCAGTGTT GGGGAAACGA CAGCCAAGGT CTTAAAGGAT 
GAGATAGATG TGAAGTTTAA AGATGTGGCT GGCTGTGAGG AGGCCAAGCT AGAAATAATG 
GAATTTGTGA ATTTCTTGAA AAATCCAAAG CAGTATCAAG ACCTAGGAGC AAAAATCCCA 
AAGGGTGCCA TTCTCACTGG TCCCCCAGGT ACTGGGAAGA CACTGCTAGC TAAGGCCACA 
GCTGGAGAAG CCAATGTCCC CTTCATCACT GTCAGTGGAT CTGAGTTTCT GGAGATGTTT 
GTCGGTGTTG GTCCAGCCAG GGTCCGAGAC TTATTTGCCC TTGCACGGAA GAATGCTCCT 
TGCATTCTCT TCATTGACGA GATTGATGCT GTGGGAAGGA AGCGTGGTAG AGGCAACTTT 
GGAGGACAGA GTGAGCAGGA GAACACACTC AATCAGCTGC TCGTGGAGAT GGACGGCTTC 
AACACCACCA CCAACGTGGT CATCCTGGCA GGCACAAATC GACCAGACAT CCTTGATCCA 
GCTCTGCTGA GACCAGGCCG CTTTGACAGG CAGATCTTCA TTGGACCCCC AGACATAAAA 
GGACGAGCTT CAATCTTCAA AGTTCACCTT CGACCATTGA AACTAGACAG TGCCTTGGAA 
AAAGATAAAT TGGCCAGAAA ACTGGCGTCC TTGACTCCAG GGTTTTCAGG CGCTGATGTT 
GCCAATGTCT GTAATGAAGC TGCTTTGATT GCTGCCAGAC ACCTTTCAGA TGCCATTAAC 
GAGAAGCACT TCGAACAAGC GATTGAGCGA GTGATTGGAG GCTTGGAGAA AAAAACCCAA 
GTTCTGCAAC CCGAGGAGAA GAAGACTGTG GCTTACCACG AAGCAGGCCA CGCAGTCGCC 
GGCTGGTATC TGGAGCATGC AGACCCACTC TTAAAGGTGT CCATCATCCC GCGTGGAAAG 
GGGCTGGGCT ATGCTCAGTA CTTGCCCAAG GAGCAGTATC TGTACACAAA GGAGCAGCTG 
CTGGACAGGA TGTGCATGAC TCTGGGTGGC CGTGTCTCCG AGGAGATCTT CTTTGGAAGA 
ATTACGACCG GTGCCCAGGA TGACTTGAGG AAGGTTACCC AGAGTGCCTA TGCCCAGATT 
GTTCAGTTTG GCATGAATGA GAAAGTGGGG CAGATCTCCT TTGACCTCCC ACGACAGGGG 
GACATGGTAT TAGAGAAGCC TTACAGTGAA GCCACTGCAA GAATGATAGA CGATGAAGTG 
AGGATACTCA TTAGTGAAGC CTATAAAAGA ACTGTGGCTC TTCTCACAGA GAAGAAGGCT 
GACGTGGAGA AGGTTGCTCT CCTACTGTTA GAGAAAGAAG TATTAGACAA GAACGACATG 
GTTGAACTTC TGGGTCCCAG ACCATTTACA GAAAAATCCA CATATGAAGA ATTTGTGGAA 
GGCACTGGCA GCTTAGATGA GGACACTTCT CTTCCTGAAG GCCTTCAGGA TTGGAACAAG 
GAGCGGGAGA AGGAGAAGAA GGAGAAGAAG GAGAAGGAGG AGCCCGTGAA TGAGAAGGTG 
GTCAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128336.1
CDS	176..2584
Translation	MAHRCLLLWGRGGCRRGLPPLLVPSGCLGPGRRPCLRTLYQYATVQTANSRSSLLRDVIAAYQRFCSRPPKGFEKYFPNGKNGKKASESKEAVGEKKESQLSGPQSSGGASGGGGKRRGKKEDSHWWSRFQKGDFPWDDKDFRMYFLWTALFWSGVMIYFLFKSSGREITWKDFVNNYLSKGVVDRLEVVNKRFVRVTFTPGKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDGSFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTAKVLKDEIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSALEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLPKEQYLYTKEQLLDRMCMTLGGRVSEEIFFGRITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPRQGDMVLEKPYSEATARMIDDEVRILISEAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELLGPRPFTEKSTYEEFVEGTGSLDEDTSLPEGLQDWNKEREKEKKEKKEKEEPVNEKVVS

Target ORF information:

RefSeq Version	NM_001134864.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus AFG3 like matrix AAA peptidase subunit 2 (Afg3l2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134864.1

ORF Insert Sequence:

ATGGCTCACC GCTGCCTGCT GCTGTGGGGT CGGGGCGGCT GCCGTCGCGG CCTTCCTCCC 
CTGCTCGTGC CCAGCGGCTG CCTGGGTCCC GGCCGGCGGC CCTGCCTCCG TACGCTTTAT 
CAGTACGCTA CGGTCCAAAC AGCAAACAGC AGAAGTTCTC TTCTAAGGGA TGTAATTGCT 
GCTTATCAAA GATTCTGTTC TCGACCTCCC AAAGGATTTG AAAAATACTT TCCTAATGGG 
AAAAATGGAA AAAAGGCCAG CGAATCTAAG GAAGCTGTTG GAGAAAAAAA AGAATCACAA 
CTCTCCGGTC CCCAGTCTTC TGGAGGTGCA AGTGGTGGGG GAGGGAAGCG CCGTGGCAAG 
AAAGAAGATT CTCACTGGTG GTCCAGGTTC CAGAAGGGTG ACTTTCCATG GGATGACAAG 
GATTTCAGGA TGTACTTTCT CTGGACTGCT CTTTTTTGGA GTGGAGTCAT GATTTACTTC 
CTGTTCAAGA GCTCTGGGAG AGAAATCACA TGGAAAGACT TTGTCAATAA CTATCTTTCT 
AAAGGAGTGG TGGACAGACT AGAAGTTGTC AACAAACGTT TTGTTCGTGT GACCTTTACT 
CCAGGAAAAA CTCCAGTTGA TGGGCAATAC GTCTGGTTTA ATATTGGCAG TGTTGACACA 
TTTGAGCGGA ATCTGGAGAC TTTGCAGCAA GAATTGGGCA TAGAAGGGGA GAACCGGGTG 
CCTGTGGTTT ACATTGCTGA AAGCGATGGC TCCTTCCTGC TGAGCATGTT GCCCACGGTA 
CTCATTATTG CTTTTCTACT CTACACCATA AGAAGAGGGC CCGCTGGCAT TGGTCGGACC 
GGTCGGGGAA TGGGTGGACT CTTCAGTGTT GGGGAAACGA CAGCCAAGGT CTTAAAGGAT 
GAGATAGATG TGAAGTTTAA AGATGTGGCT GGCTGTGAGG AGGCCAAGCT AGAAATAATG 
GAATTTGTGA ATTTCTTGAA AAATCCAAAG CAGTATCAAG ACCTAGGAGC AAAAATCCCA 
AAGGGTGCCA TTCTCACTGG TCCCCCAGGT ACTGGGAAGA CACTGCTAGC TAAGGCCACA 
GCTGGAGAAG CCAATGTCCC CTTCATCACT GTCAGTGGAT CTGAGTTTCT GGAGATGTTT 
GTCGGTGTTG GTCCAGCCAG GGTCCGAGAC TTATTTGCCC TTGCACGGAA GAATGCTCCT 
TGCATTCTCT TCATTGACGA GATTGATGCT GTGGGAAGGA AGCGTGGTAG AGGCAACTTT 
GGAGGACAGA GTGAGCAGGA GAACACACTC AATCAGCTGC TCGTGGAGAT GGACGGCTTC 
AACACCACCA CCAACGTGGT CATCCTGGCA GGCACAAATC GACCAGACAT CCTTGATCCA 
GCTCTGCTGA GACCAGGCCG CTTTGACAGG CAGATCTTCA TTGGACCCCC AGACATAAAA 
GGACGAGCTT CAATCTTCAA AGTTCACCTT CGACCATTGA AACTAGACAG TGCCTTGGAA 
AAAGATAAAT TGGCCAGAAA ACTGGCGTCC TTGACTCCAG GGTTTTCAGG CGCTGATGTT 
GCCAATGTCT GTAATGAAGC TGCTTTGATT GCTGCCAGAC ACCTTTCAGA TGCCATTAAC 
GAGAAGCACT TCGAACAAGC GATTGAGCGA GTGATTGGAG GCTTGGAGAA AAAAACCCAA 
GTTCTGCAAC CCGAGGAGAA GAAGACTGTG GCTTACCACG AAGCAGGCCA CGCAGTCGCC 
GGCTGGTATC TGGAGCATGC AGACCCACTC TTAAAGGTGT CCATCATCCC GCGTGGAAAG 
GGGCTGGGCT ATGCTCAGTA CTTGCCCAAG GAGCAGTATC TGTACACAAA GGAGCAGCTG 
CTGGACAGGA TGTGCATGAC TCTGGGTGGC CGTGTCTCCG AGGAGATCTT CTTTGGAAGA 
ATTACGACCG GTGCCCAGGA TGACTTGAGG AAGGTTACCC AGAGTGCCTA TGCCCAGATT 
GTTCAGTTTG GCATGAATGA GAAAGTGGGG CAGATCTCCT TTGACCTCCC ACGACAGGGG 
GACATGGTAT TAGAGAAGCC TTACAGTGAA GCCACTGCAA GAATGATAGA CGATGAAGTG 
AGGATACTCA TTAGTGAAGC CTATAAAAGA ACTGTGGCTC TTCTCACAGA GAAGAAGGCT 
GACGTGGAGA AGGTTGCTCT CCTACTGTTA GAGAAAGAAG TATTAGACAA GAACGACATG 
GTTGAACTTC TGGGTCCCAG ACCATTTACA GAAAAATCCA CATATGAAGA ATTTGTGGAA 
GGCACTGGCA GCTTAGATGA GGACACTTCT CTTCCTGAAG GCCTTCAGGA TTGGAACAAG 
GAGCGGGAGA AGGAGAAGAA GGAGAAGAAG GAGAAGGAGG AGCCCGTGAA TGAGAAGGTG 
GTCAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SCA28: Novel Mutation in the AFG3L2 Proteolytic Domain Causes a Mild Cerebellar Syndrome with Selective Type-1 Muscle Fiber Atrophy.
Cerebellum (London, England)16(1)62-67(2017 Feb)
Svenstrup K,Nielsen TT,Aidt F,Rostgaard N,Duno M,Wibrand F,Vinther-Jensen T,Law I,Vissing J,Roos P,Hjermind LE,Nielsen JE

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
Molecular cell64(1)148-162(2016 Oct)
K?nig T,Tr?der SE,Bakka K,Korwitz A,Richter-Dennerlein R,Lampe PA,Patron M,M?hlmeister M,Guerrero-Castillo S,Brandt U,Decker T,Lauria I,Paggio A,Rizzuto R,Rugarli EI,De Stefani D,Langer T

Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model.
The Journal of clinical investigation125(1)263-74(2015 Jan)
Maltecca F,Baseggio E,Consolato F,Mazza D,Podini P,Young SM Jr,Drago I,Bahr BA,Puliti A,Codazzi F,Quattrini A,Casari G

Partial deletion of AFG3L2 causing spinocerebellar ataxia type 28.
Neurology82(23)2092-100(2014 Jun)
Smets K,Deconinck T,Baets J,Sieben A,Martin JJ,Smouts I,Wang S,Taroni F,Di Bella D,Van Hecke W,Parizel PM,Jadoul C,De Potter R,Couvreur F,Rugarli E,De Jonghe P

StAR enhances transcription of genes encoding the mitochondrial proteases involved in its own degradation.
Molecular endocrinology (Baltimore, Md.)28(2)208-24(2014 Feb)
Bahat A,Perlberg S,Melamed-Book N,Lauria I,Langer T,Orly J

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Afg3l2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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