Bicd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bicd2
Entrez Gene ID	306809
Full Name	BICD cargo adaptor 2
General protein information	Preferred Names BICD cargo adaptor 2 Names protein bicaudal D homolog 2 bicaudal D homolog 2 bicaudal D protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	This gene encodes a dynein-dynactin adaptor protein. In mouse, the protein primarily localizes to the Golgi complex as well as to microtubule plus ends through dynactin. Overexpression studies suggest that the N-terminus mediates the dynein-dynactin interaction, while the C-terminus is responsible for Golgi targeting. Knockout of this gene in mouse results in a defect in cerebellar granule cell migration. In human, mutations in this gene are associated with spinal muscular dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_198765.3	NP_942060.1	protein bicaudal D homolog 2 isoform 2
NM_001033674.2	NP_001028846.1	protein bicaudal D homolog 2 isoform 1

Pathways from BioSystems

Homologies

	BICD2	XP_001103763.1
Canis lupus familiaris (dog)	BICD2	XP_541330.2
Mus musculus (house mouse)	Bicd2	NP_001034268.1
Caenorhabditis elegans (roundworm)	bicd-1	NP_501001.1
Bos taurus (cattle)	BICD2	NP_001193404.1
Rattus norvegicus (Norway rat)	Bicd2	NP_001028846.1
Gallus gallus (chicken)	BICD2	XP_004944615.1
Danio rerio (zebrafish)	LOC557383	XP_005155947.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010206	XP_554113.3
Homo sapiens (human)	BICD2	NP_001003800.1
Pan troglodytes (chimpanzee)	BICD2	XP_520695.2
Drosophila melanogaster (fruit fly)	BicD	NP_001260531.1
Xenopus tropicalis (tropical clawed frog)	bicd2	XP_004914244.1

Gene Ontology
Bibliography

Related articles in PubMed

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Matsuto M, Kano F, Murata M
Biochimica et biophysica acta1853(10 Pt A)2592-609(2015 Oct)

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
Schroeder CM, Ostrem JM, Hertz NT, Vale RD
eLife3e03351(2014 Oct)

A role for Bicaudal-D2 in radial cerebellar granule cell migration.
Jaarsma D, van den Berg R, Wulf PS, van Erp S, Keijzer N, Schlager MA, de Graaff E, De Zeeuw CI, Pasterkamp RJ, Akhmanova A, Hoogenraad CC
Nature communications53411(2014 Mar)

Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy.
Neveling K, Martinez-Carrera LA, H?lker I, Heister A, Verrips A, Hosseini-Barkooie SM, Gilissen C, Vermeer S, Pennings M, Meijer R, te Riele M, Frijns CJ, Suchowersky O, MacLaren L, Rudnik-Sch?neborn S, Sinke RJ, Zerres K, Lowry RB, Lemmink HH, Garbes L, Veltman JA, Schelhaas HJ, Scheffer H, Wirth B
American journal of human genetics92(6)946-54(2013 Jun)

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.
Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A
Molecular biology of the cell23(21)4226-41(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bicd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bicd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08534	NM_001033674.2 Latest version!	Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00
ORa04999	NM_198765.3 Latest version!	Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bicd2 ( NM_001033674.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001028846.1 Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa08534
Clone ID Related Accession (Same CDS sequence)	NM_001033674.2
Accession Version	NM_001033674.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2556bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-02-04
Organism	Rattus norvegicus(Norway rat)
Product	protein bicaudal D homolog 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC111847.6. On Mar 26, 2015 this sequence version replaced NM_001033674.1. Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC100660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906351 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGCGC CGTCGGAGGA GGAGGAGTAT GCGCGTCTGG TGATGGAGGC GCAGCCGGAG 
TGGCTGCGCG CCGAGGTGAA GCGACTGTCC CACGAGCTGG CCGAAACCAC GCGTGAGAAG 
ATCCAGGCGG CCGAGTATGG ACTGGCGGTG CTTGAGGAGA AGCACCAGCT CAAGCTGCAG 
TTCGAGGAGC TCGAGGTGGA CTATGAGGCC ATCCGCAGCG AGATGGAGCA GCTCAAAGAG 
GCATTTGGCC AGGCACACAC AAACCACAAG AAGGTGGCTG CTGATGGAGA GAGCCGGGAG 
GAGAGCCTGA TCCAGGAGTC CGCCTCTAAG GAGCAGTACT ATGTGCGGAA GGTGCTGGAG 
CTGCAGACAG AGCTGAAACA GCTGCGCAAT GTCCTTATCA ACACTCAGTC TGAGAATGAG 
CGCCTCACGT CTGTGGCCCA GGAGCTGAAA GAGATCAACC AGAATGTGGA GATTCAGCGT 
GGTCGCCTGC GAGATGACAT CAAGGAGTAC AAGTTCCGGG AGGCCCGTCT ACTTCAGGAC 
TACTCTGAGC TGGAGGAGGA GAACATTAGC CTGCAGAAAC AAGTGTCTGT GCTCAGGCAG 
AACCAGGTGG AATTTGAGGG CCTCAAGCAT GAAATCAAGC GTCTGGAGGA GGAGACAGAG 
TACCTTAACA GCCAGCTGGA GGATGCCATC CGGCTTAAGG AGATCTCTGA ACGGCAGTTG 
GAGGAAGCGC TGGAGACGTT GAAGACAGAG CGAGAGCAGA AGAACAACCT ACGTAAGGAG 
TTGTCGCACT ACATGAGCAT CAACGATTCC TTCTATACCA GCCACCTGCA GGTATCCTTA 
GATGGCCTCA AGTTCAGTGA TGATGCTGTC ACTGCTGAGC CCAACAACGA CGCCGAAGCC 
CTGGTCAATG GCTTTGAGCA CAGCGGCTTG GTCAAAGCGT CGTTGGACAA CAAGACATCC 
ACACCCAGAA AGGATGGCCT GGCTCCGCCC TCCCCCAGCC TTGTTTCCGA CCTGCTCAGT 
GAGCTCCACA TATCTGAGAT CCAGAAGCTG AAGCAGCAGC TGGTGCAGAT GGAGCGGGAG 
AAGGTGGGTC TGCTGGCGAC ATTACAGGAC ACACAGAAGC AGCTAGAGCA GGCTCGGGGA 
ACCCTCTCTG AGCAACATGA GAAGGTGAGT CGTCTCACAG AGAACCTTAG TGCCCTCCGG 
CGCCTGCAGG CTGGCAAGGA GCGACAGACT TCCCTGGATA ACGAAAAGGA CCGAGATAGC 
CATGAAGACG GTGACTACTA TGAGGTTGAC ATCAATGGGC CTGAGATCCT GTCCTGCAAG 
TACCATGTAG CTGTGGCCGA GGCTGGCGAG CTCCGGGAGC AGCTCAAGGC CCTGCACAGC 
ACACATGAAG CTCGGGAAGC CCAGCTTGCA GAAGAAAAGG GCCGCTATGA GGCTGAGGTC 
CAGGCTCTCA CTGAGAAGGT GTCACTGCTG GAGAAGGCTA GCCACCAGGA CCAAGAGCTG 
CTGGCCCAGC TGGAAAAGGA GCTGAGGAAG GTGAGTGACG TGGCTGGTGA GACCCAGGGC 
AGCCTGAATG TGGCTCAGGA TGAGTTGGTG ACCTTCAGCG AGGAGCTGGC CAATCTCTAC 
CACCATGTGT GCATGTGCAA CAACGAGACA CCCAACCGTG TCATGCTGGA CTATTACCGT 
GAGGGGCAGG GCAAGGCTGG CCGCACCAGC CCAGAAGGCC GCGGGCGCCG CTCGCCTGTC 
CTTTTGCCCA AGGGGCTGTT GTCGACAGAG ATCGGCCGAG CAGATGGTGG GACTGGGGAC 
AACAGCCCTT CACCCAGCTC TTCACTGCCA TCACCATTGA GTGACCCCCG CCGGGAACCT 
ATGAACATCT ACAACCTGAT CGCCATCATC CGAGACCAGA TCAAGCACCT GCAGGCAGCC 
GTAGATCGTA CAACCGAGCT GTCCCGGCAG CGGATTGCCT CACAGGAGCT GGGCCCTGCT 
GTGGATAAGG ACAAGGAAGC ACTCATGGAG GAGATCCTCA AGCTGAAGTC ACTGCTGAGT 
ACCAAGAGGG AACAGATCAC CACACTTCGT ACTGTGCTCA AGGCTAACAA GCAGACGGCA 
GAGGTGGCCC TCGCCAACCT GAAGAGCAAG TATGAGAATG AGAAGGCCAT GGTGACCGAG 
ACCATGATGA AGCTGCGGAA CGAGCTGAAG GCCCTCAAGG AGGACGCAGC CACCTTCTCC 
TCCCTGCGTG CCATGTTCGC CACCAGGTGT GATGAGTACA TCACGCAGCT GGATGAGATG 
CAGCGGCAGC TGGCGGCTGC CGAGGATGAG AAGAAGACTC TTAATTCCCT GCTGCGCATG 
GCCATCCAGC AGAAGCTGGC ACTCACCCAG CGGCTGGAGC TGCTGGAGCT GGACCATGAG 
CAGACCCGCA GGGGCCGTAA CAAGGCCACC TCCAAGGCCA AGCCAGCCAC ACCGAGCGTA 
AGTCACACCT GCGCCTGTGC CAGCGAGAGG GCGGAGGGCA CCGGGCTGGC CAACCAGGTG 
TTCTGCAGCG AGAAGCACAG CATTTACTGT GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028846.1
CDS	91..2646
Translation	MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLINTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDAVTAEPNNDAEALVNGFEHSGLVKASLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVSRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILSCKYHVAVAEAGELREQLKALHSTHEAREAQLAEEKGRYEAEVQALTEKVSLLEKASHQDQELLAQLEKELRKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLSTEIGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRNKATSKAKPATPSVSHTCACASERAEGTGLANQVFCSEKHSIYCD

Target ORF information:

RefSeq Version	NM_001033674.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033674.2

ORF Insert Sequence:

ATGTCCGCGC CGTCGGAGGA GGAGGAGTAT GCGCGTCTGG TGATGGAGGC GCAGCCGGAG 
TGGCTGCGCG CCGAGGTGAA GCGACTGTCC CACGAGCTGG CCGAAACCAC GCGTGAGAAG 
ATCCAGGCGG CCGAGTATGG ACTGGCGGTG CTTGAGGAGA AGCACCAGCT CAAGCTGCAG 
TTCGAGGAGC TCGAGGTGGA CTATGAGGCC ATCCGCAGCG AGATGGAGCA GCTCAAAGAG 
GCATTTGGCC AGGCACACAC AAACCACAAG AAGGTGGCTG CTGATGGAGA GAGCCGGGAG 
GAGAGCCTGA TCCAGGAGTC CGCCTCTAAG GAGCAGTACT ATGTGCGGAA GGTGCTGGAG 
CTGCAGACAG AGCTGAAACA GCTGCGCAAT GTCCTTATCA ACACTCAGTC TGAGAATGAG 
CGCCTCACGT CTGTGGCCCA GGAGCTGAAA GAGATCAACC AGAATGTGGA GATTCAGCGT 
GGTCGCCTGC GAGATGACAT CAAGGAGTAC AAGTTCCGGG AGGCCCGTCT ACTTCAGGAC 
TACTCTGAGC TGGAGGAGGA GAACATTAGC CTGCAGAAAC AAGTGTCTGT GCTCAGGCAG 
AACCAGGTGG AATTTGAGGG CCTCAAGCAT GAAATCAAGC GTCTGGAGGA GGAGACAGAG 
TACCTTAACA GCCAGCTGGA GGATGCCATC CGGCTTAAGG AGATCTCTGA ACGGCAGTTG 
GAGGAAGCGC TGGAGACGTT GAAGACAGAG CGAGAGCAGA AGAACAACCT ACGTAAGGAG 
TTGTCGCACT ACATGAGCAT CAACGATTCC TTCTATACCA GCCACCTGCA GGTATCCTTA 
GATGGCCTCA AGTTCAGTGA TGATGCTGTC ACTGCTGAGC CCAACAACGA CGCCGAAGCC 
CTGGTCAATG GCTTTGAGCA CAGCGGCTTG GTCAAAGCGT CGTTGGACAA CAAGACATCC 
ACACCCAGAA AGGATGGCCT GGCTCCGCCC TCCCCCAGCC TTGTTTCCGA CCTGCTCAGT 
GAGCTCCACA TATCTGAGAT CCAGAAGCTG AAGCAGCAGC TGGTGCAGAT GGAGCGGGAG 
AAGGTGGGTC TGCTGGCGAC ATTACAGGAC ACACAGAAGC AGCTAGAGCA GGCTCGGGGA 
ACCCTCTCTG AGCAACATGA GAAGGTGAGT CGTCTCACAG AGAACCTTAG TGCCCTCCGG 
CGCCTGCAGG CTGGCAAGGA GCGACAGACT TCCCTGGATA ACGAAAAGGA CCGAGATAGC 
CATGAAGACG GTGACTACTA TGAGGTTGAC ATCAATGGGC CTGAGATCCT GTCCTGCAAG 
TACCATGTAG CTGTGGCCGA GGCTGGCGAG CTCCGGGAGC AGCTCAAGGC CCTGCACAGC 
ACACATGAAG CTCGGGAAGC CCAGCTTGCA GAAGAAAAGG GCCGCTATGA GGCTGAGGTC 
CAGGCTCTCA CTGAGAAGGT GTCACTGCTG GAGAAGGCTA GCCACCAGGA CCAAGAGCTG 
CTGGCCCAGC TGGAAAAGGA GCTGAGGAAG GTGAGTGACG TGGCTGGTGA GACCCAGGGC 
AGCCTGAATG TGGCTCAGGA TGAGTTGGTG ACCTTCAGCG AGGAGCTGGC CAATCTCTAC 
CACCATGTGT GCATGTGCAA CAACGAGACA CCCAACCGTG TCATGCTGGA CTATTACCGT 
GAGGGGCAGG GCAAGGCTGG CCGCACCAGC CCAGAAGGCC GCGGGCGCCG CTCGCCTGTC 
CTTTTGCCCA AGGGGCTGTT GTCGACAGAG ATCGGCCGAG CAGATGGTGG GACTGGGGAC 
AACAGCCCTT CACCCAGCTC TTCACTGCCA TCACCATTGA GTGACCCCCG CCGGGAACCT 
ATGAACATCT ACAACCTGAT CGCCATCATC CGAGACCAGA TCAAGCACCT GCAGGCAGCC 
GTAGATCGTA CAACCGAGCT GTCCCGGCAG CGGATTGCCT CACAGGAGCT GGGCCCTGCT 
GTGGATAAGG ACAAGGAAGC ACTCATGGAG GAGATCCTCA AGCTGAAGTC ACTGCTGAGT 
ACCAAGAGGG AACAGATCAC CACACTTCGT ACTGTGCTCA AGGCTAACAA GCAGACGGCA 
GAGGTGGCCC TCGCCAACCT GAAGAGCAAG TATGAGAATG AGAAGGCCAT GGTGACCGAG 
ACCATGATGA AGCTGCGGAA CGAGCTGAAG GCCCTCAAGG AGGACGCAGC CACCTTCTCC 
TCCCTGCGTG CCATGTTCGC CACCAGGTGT GATGAGTACA TCACGCAGCT GGATGAGATG 
CAGCGGCAGC TGGCGGCTGC CGAGGATGAG AAGAAGACTC TTAATTCCCT GCTGCGCATG 
GCCATCCAGC AGAAGCTGGC ACTCACCCAG CGGCTGGAGC TGCTGGAGCT GGACCATGAG 
CAGACCCGCA GGGGCCGTAA CAAGGCCACC TCCAAGGCCA AGCCAGCCAC ACCGAGCGTA 
AGTCACACCT GCGCCTGTGC CAGCGAGAGG GCGGAGGGCA CCGGGCTGGC CAACCAGGTG 
TTCTGCAGCG AGAAGCACAG CATTTACTGT GATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bicd2 ( NM_198765.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_942060.1 Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa04999
Clone ID Related Accession (Same CDS sequence)	NM_198765.3
Accession Version	NM_198765.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2463bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-02-05
Organism	Rattus norvegicus(Norway rat)
Product	protein bicaudal D homolog 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC111847.6. On Mar 26, 2015 this sequence version replaced NM_198765.2. Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter C-terminus than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AJ250312.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906351 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGCGC CGTCGGAGGA GGAGGAGTAT GCGCGTCTGG TGATGGAGGC GCAGCCGGAG 
TGGCTGCGCG CCGAGGTGAA GCGACTGTCC CACGAGCTGG CCGAAACCAC GCGTGAGAAG 
ATCCAGGCGG CCGAGTATGG ACTGGCGGTG CTTGAGGAGA AGCACCAGCT CAAGCTGCAG 
TTCGAGGAGC TCGAGGTGGA CTATGAGGCC ATCCGCAGCG AGATGGAGCA GCTCAAAGAG 
GCATTTGGCC AGGCACACAC AAACCACAAG AAGGTGGCTG CTGATGGAGA GAGCCGGGAG 
GAGAGCCTGA TCCAGGAGTC CGCCTCTAAG GAGCAGTACT ATGTGCGGAA GGTGCTGGAG 
CTGCAGACAG AGCTGAAACA GCTGCGCAAT GTCCTTATCA ACACTCAGTC TGAGAATGAG 
CGCCTCACGT CTGTGGCCCA GGAGCTGAAA GAGATCAACC AGAATGTGGA GATTCAGCGT 
GGTCGCCTGC GAGATGACAT CAAGGAGTAC AAGTTCCGGG AGGCCCGTCT ACTTCAGGAC 
TACTCTGAGC TGGAGGAGGA GAACATTAGC CTGCAGAAAC AAGTGTCTGT GCTCAGGCAG 
AACCAGGTGG AATTTGAGGG CCTCAAGCAT GAAATCAAGC GTCTGGAGGA GGAGACAGAG 
TACCTTAACA GCCAGCTGGA GGATGCCATC CGGCTTAAGG AGATCTCTGA ACGGCAGTTG 
GAGGAAGCGC TGGAGACGTT GAAGACAGAG CGAGAGCAGA AGAACAACCT ACGTAAGGAG 
TTGTCGCACT ACATGAGCAT CAACGATTCC TTCTATACCA GCCACCTGCA GGTATCCTTA 
GATGGCCTCA AGTTCAGTGA TGATGCTGTC ACTGCTGAGC CCAACAACGA CGCCGAAGCC 
CTGGTCAATG GCTTTGAGCA CAGCGGCTTG GTCAAAGCGT CGTTGGACAA CAAGACATCC 
ACACCCAGAA AGGATGGCCT GGCTCCGCCC TCCCCCAGCC TTGTTTCCGA CCTGCTCAGT 
GAGCTCCACA TATCTGAGAT CCAGAAGCTG AAGCAGCAGC TGGTGCAGAT GGAGCGGGAG 
AAGGTGGGTC TGCTGGCGAC ATTACAGGAC ACACAGAAGC AGCTAGAGCA GGCTCGGGGA 
ACCCTCTCTG AGCAACATGA GAAGGTGAGT CGTCTCACAG AGAACCTTAG TGCCCTCCGG 
CGCCTGCAGG CTGGCAAGGA GCGACAGACT TCCCTGGATA ACGAAAAGGA CCGAGATAGC 
CATGAAGACG GTGACTACTA TGAGGTTGAC ATCAATGGGC CTGAGATCCT GTCCTGCAAG 
TACCATGTAG CTGTGGCCGA GGCTGGCGAG CTCCGGGAGC AGCTCAAGGC CCTGCACAGC 
ACACATGAAG CTCGGGAAGC CCAGCTTGCA GAAGAAAAGG GCCGCTATGA GGCTGAGGTC 
CAGGCTCTCA CTGAGAAGGT GTCACTGCTG GAGAAGGCTA GCCACCAGGA CCAAGAGCTG 
CTGGCCCAGC TGGAAAAGGA GCTGAGGAAG GTGAGTGACG TGGCTGGTGA GACCCAGGGC 
AGCCTGAATG TGGCTCAGGA TGAGTTGGTG ACCTTCAGCG AGGAGCTGGC CAATCTCTAC 
CACCATGTGT GCATGTGCAA CAACGAGACA CCCAACCGTG TCATGCTGGA CTATTACCGT 
GAGGGGCAGG GCAAGGCTGG CCGCACCAGC CCAGAAGGCC GCGGGCGCCG CTCGCCTGTC 
CTTTTGCCCA AGGGGCTGTT GTCGACAGAG ATCGGCCGAG CAGATGGTGG GACTGGGGAC 
AACAGCCCTT CACCCAGCTC TTCACTGCCA TCACCATTGA GTGACCCCCG CCGGGAACCT 
ATGAACATCT ACAACCTGAT CGCCATCATC CGAGACCAGA TCAAGCACCT GCAGGCAGCC 
GTAGATCGTA CAACCGAGCT GTCCCGGCAG CGGATTGCCT CACAGGAGCT GGGCCCTGCT 
GTGGATAAGG ACAAGGAAGC ACTCATGGAG GAGATCCTCA AGCTGAAGTC ACTGCTGAGT 
ACCAAGAGGG AACAGATCAC CACACTTCGT ACTGTGCTCA AGGCTAACAA GCAGACGGCA 
GAGGTGGCCC TCGCCAACCT GAAGAGCAAG TATGAGAATG AGAAGGCCAT GGTGACCGAG 
ACCATGATGA AGCTGCGGAA CGAGCTGAAG GCCCTCAAGG AGGACGCAGC CACCTTCTCC 
TCCCTGCGTG CCATGTTCGC CACCAGGTGT GATGAGTACA TCACGCAGCT GGATGAGATG 
CAGCGGCAGC TGGCGGCTGC CGAGGATGAG AAGAAGACTC TTAATTCCCT GCTGCGCATG 
GCCATCCAGC AGAAGCTGGC ACTCACCCAG CGGCTGGAGC TGCTGGAGCT GGACCATGAG 
CAGACCCGCA GGGGCCGTAA CAAGGCCACC TCCAAGGCCA AGCCAGCCAC ACCGAGCCTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_942060.1
CDS	91..2553
Translation	MSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLINTQSENERLTSVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLDGLKFSDDAVTAEPNNDAEALVNGFEHSGLVKASLDNKTSTPRKDGLAPPSPSLVSDLLSELHISEIQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVSRLTENLSALRRLQAGKERQTSLDNEKDRDSHEDGDYYEVDINGPEILSCKYHVAVAEAGELREQLKALHSTHEAREAQLAEEKGRYEAEVQALTEKVSLLEKASHQDQELLAQLEKELRKVSDVAGETQGSLNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGRRSPVLLPKGLLSTEIGRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLELLELDHEQTRRGRNKATSKAKPATPSL

Target ORF information:

RefSeq Version	NM_198765.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BICD cargo adaptor 2 (Bicd2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198765.3

ORF Insert Sequence:

ATGTCCGCGC CGTCGGAGGA GGAGGAGTAT GCGCGTCTGG TGATGGAGGC GCAGCCGGAG 
TGGCTGCGCG CCGAGGTGAA GCGACTGTCC CACGAGCTGG CCGAAACCAC GCGTGAGAAG 
ATCCAGGCGG CCGAGTATGG ACTGGCGGTG CTTGAGGAGA AGCACCAGCT CAAGCTGCAG 
TTCGAGGAGC TCGAGGTGGA CTATGAGGCC ATCCGCAGCG AGATGGAGCA GCTCAAAGAG 
GCATTTGGCC AGGCACACAC AAACCACAAG AAGGTGGCTG CTGATGGAGA GAGCCGGGAG 
GAGAGCCTGA TCCAGGAGTC CGCCTCTAAG GAGCAGTACT ATGTGCGGAA GGTGCTGGAG 
CTGCAGACAG AGCTGAAACA GCTGCGCAAT GTCCTTATCA ACACTCAGTC TGAGAATGAG 
CGCCTCACGT CTGTGGCCCA GGAGCTGAAA GAGATCAACC AGAATGTGGA GATTCAGCGT 
GGTCGCCTGC GAGATGACAT CAAGGAGTAC AAGTTCCGGG AGGCCCGTCT ACTTCAGGAC 
TACTCTGAGC TGGAGGAGGA GAACATTAGC CTGCAGAAAC AAGTGTCTGT GCTCAGGCAG 
AACCAGGTGG AATTTGAGGG CCTCAAGCAT GAAATCAAGC GTCTGGAGGA GGAGACAGAG 
TACCTTAACA GCCAGCTGGA GGATGCCATC CGGCTTAAGG AGATCTCTGA ACGGCAGTTG 
GAGGAAGCGC TGGAGACGTT GAAGACAGAG CGAGAGCAGA AGAACAACCT ACGTAAGGAG 
TTGTCGCACT ACATGAGCAT CAACGATTCC TTCTATACCA GCCACCTGCA GGTATCCTTA 
GATGGCCTCA AGTTCAGTGA TGATGCTGTC ACTGCTGAGC CCAACAACGA CGCCGAAGCC 
CTGGTCAATG GCTTTGAGCA CAGCGGCTTG GTCAAAGCGT CGTTGGACAA CAAGACATCC 
ACACCCAGAA AGGATGGCCT GGCTCCGCCC TCCCCCAGCC TTGTTTCCGA CCTGCTCAGT 
GAGCTCCACA TATCTGAGAT CCAGAAGCTG AAGCAGCAGC TGGTGCAGAT GGAGCGGGAG 
AAGGTGGGTC TGCTGGCGAC ATTACAGGAC ACACAGAAGC AGCTAGAGCA GGCTCGGGGA 
ACCCTCTCTG AGCAACATGA GAAGGTGAGT CGTCTCACAG AGAACCTTAG TGCCCTCCGG 
CGCCTGCAGG CTGGCAAGGA GCGACAGACT TCCCTGGATA ACGAAAAGGA CCGAGATAGC 
CATGAAGACG GTGACTACTA TGAGGTTGAC ATCAATGGGC CTGAGATCCT GTCCTGCAAG 
TACCATGTAG CTGTGGCCGA GGCTGGCGAG CTCCGGGAGC AGCTCAAGGC CCTGCACAGC 
ACACATGAAG CTCGGGAAGC CCAGCTTGCA GAAGAAAAGG GCCGCTATGA GGCTGAGGTC 
CAGGCTCTCA CTGAGAAGGT GTCACTGCTG GAGAAGGCTA GCCACCAGGA CCAAGAGCTG 
CTGGCCCAGC TGGAAAAGGA GCTGAGGAAG GTGAGTGACG TGGCTGGTGA GACCCAGGGC 
AGCCTGAATG TGGCTCAGGA TGAGTTGGTG ACCTTCAGCG AGGAGCTGGC CAATCTCTAC 
CACCATGTGT GCATGTGCAA CAACGAGACA CCCAACCGTG TCATGCTGGA CTATTACCGT 
GAGGGGCAGG GCAAGGCTGG CCGCACCAGC CCAGAAGGCC GCGGGCGCCG CTCGCCTGTC 
CTTTTGCCCA AGGGGCTGTT GTCGACAGAG ATCGGCCGAG CAGATGGTGG GACTGGGGAC 
AACAGCCCTT CACCCAGCTC TTCACTGCCA TCACCATTGA GTGACCCCCG CCGGGAACCT 
ATGAACATCT ACAACCTGAT CGCCATCATC CGAGACCAGA TCAAGCACCT GCAGGCAGCC 
GTAGATCGTA CAACCGAGCT GTCCCGGCAG CGGATTGCCT CACAGGAGCT GGGCCCTGCT 
GTGGATAAGG ACAAGGAAGC ACTCATGGAG GAGATCCTCA AGCTGAAGTC ACTGCTGAGT 
ACCAAGAGGG AACAGATCAC CACACTTCGT ACTGTGCTCA AGGCTAACAA GCAGACGGCA 
GAGGTGGCCC TCGCCAACCT GAAGAGCAAG TATGAGAATG AGAAGGCCAT GGTGACCGAG 
ACCATGATGA AGCTGCGGAA CGAGCTGAAG GCCCTCAAGG AGGACGCAGC CACCTTCTCC 
TCCCTGCGTG CCATGTTCGC CACCAGGTGT GATGAGTACA TCACGCAGCT GGATGAGATG 
CAGCGGCAGC TGGCGGCTGC CGAGGATGAG AAGAAGACTC TTAATTCCCT GCTGCGCATG 
GCCATCCAGC AGAAGCTGGC ACTCACCCAG CGGCTGGAGC TGCTGGAGCT GGACCATGAG 
CAGACCCGCA GGGGCCGTAA CAAGGCCACC TCCAAGGCCA AGCCAGCCAC ACCGAGCCTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.
Biochimica et biophysica acta1853(10 Pt A)2592-609(2015 Oct)
Matsuto M,Kano F,Murata M

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
eLife3e03351(2014 Oct)
Schroeder CM,Ostrem JM,Hertz NT,Vale RD

A role for Bicaudal-D2 in radial cerebellar granule cell migration.
Nature communications53411(2014 Mar)
Jaarsma D,van den Berg R,Wulf PS,van Erp S,Keijzer N,Schlager MA,de Graaff E,De Zeeuw CI,Pasterkamp RJ,Akhmanova A,Hoogenraad CC

Mutations in BICD2, which encodes a golgin and important motor adaptor, cause congenital autosomal-dominant spinal muscular atrophy.
American journal of human genetics92(6)946-54(2013 Jun)
Neveling K,Martinez-Carrera LA,H?lker I,Heister A,Verrips A,Hosseini-Barkooie SM,Gilissen C,Vermeer S,Pennings M,Meijer R,te Riele M,Frijns CJ,Suchowersky O,MacLaren L,Rudnik-Sch?neborn S,Sinke RJ,Zerres K,Lowry RB,Lemmink HH,Garbes L,Veltman JA,Schelhaas HJ,Scheffer H,Wirth B

BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.
Molecular biology of the cell23(21)4226-41(2012 Nov)
Splinter D,Razafsky DS,Schlager MA,Serra-Marques A,Grigoriev I,Demmers J,Keijzer N,Jiang K,Poser I,Hyman AA,Hoogenraad CC,King SJ,Akhmanova A

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Bicd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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