Efnb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Efnb2
Entrez Gene ID	306636
Full Name	ephrin B2
General protein information	Preferred Names ephrin B2 Names ephrin-B2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107328.2	NP_001100798.1	ephrin-B2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Efnb2	NP_001100798.1
Bos taurus (cattle)	EFNB2	XP_002692032.2
Danio rerio (zebrafish)	efnb2a	NP_571098.1
Danio rerio (zebrafish)	LOC100333671	XP_002660391.1
Homo sapiens (human)	EFNB2	NP_004084.1
Danio rerio (zebrafish)	efnb2b	NP_571883.1
Xenopus tropicalis (tropical clawed frog)	efnb2	NP_001093709.1
	EFNB2	XP_001100069.1
Pan troglodytes (chimpanzee)	EFNB2	XP_001134800.1
Canis lupus familiaris (dog)	EFNB2	NP_001107768.1
Mus musculus (house mouse)	Efnb2	NP_034241.2
Gallus gallus (chicken)	EFNB2	NP_990155.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.
Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
Molecular biology of the cell28(24)3532-3541(2017 Nov)

RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth.
Li Y, Chen Y, Tan L, Pan JY, Lin WW, Wu J, Hu W, Chen X, Wang XD
CNS neuroscience & therapeutics23(10)779-789(2017 Oct)

Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland.
Yoshida S, Kato T, Kanno N, Nishimura N, Nishihara H, Horiguchi K, Kato Y
Cell and tissue research370(1)99-112(2017 10)

p75(NTR)-dependent activation of NF-?B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia.
Caporali A, Meloni M, Nailor A, Miti? T, Shantikumar S, Riu F, Sala-Newby GB, Rose L, Besnier M, Katare R, Voellenkle C, Verkade P, Martelli F, Madeddu P, Emanueli C
Nature communications68024(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

elevated GluA2 trafficking induced by activated EphB2/ephrinB2 reverse signaling likely contributes to Retinal Ganglion Cell apoptosis in Chronic Ocular Hypertension rats.
Title: GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model.

These findings suggest the involvement of cell-cell EphA4 and ephrin-B2 signaling in establishing order in the developing inferior colliculus
Title: EphA4 and ephrin-B2 expression patterns during inferior colliculus projection shaping prior to experience.

Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.
Title: Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1.

EphB-ephrinB interactions play an important role in NMDA-dependent, activity-dependent synaptic plasticity in the adult spinal cord, inducing the phosphorylation of the NR2B subunit via Src family kinases, thus contributing to chronic pain states.
Title: EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia.

The data raise the possibility that PTH or PTHrP might regulate ephrinB2 to act in a paracrine or autocrine manner on EphB4 or EphB2 in the osteoblast, contributing as a local event to the anabolic action of PTH or PTHrP.
Title: EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts.

The following Efnb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efnb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05297	NM_001107328.2 Latest version!	Rattus norvegicus ephrin B2 (Efnb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Efnb2 ( NM_001107328.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100798.1 Rattus norvegicus ephrin B2 (Efnb2), mRNA.

Price & Availability↑

CloneID	ORa05297
Clone ID Related Accession (Same CDS sequence)	NM_001107328.2
Accession Version	NM_001107328.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	ephrin-B2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ011669.1. On Apr 13, 2008 this sequence version replaced NM_001107328.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ011669.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCATGG CCCGGTCCAG GAGGGACTCT GTGTGGAAGT ACTGTTGGGG ACTTTTGATG 
GTTTTGTGCA GAACTGCGAT CTCCAGATCG ATAGTTCTAG AGCCTATCTA CTGGAATTCC 
TCGAACTCCA AATTTCTACC CGGACAAGGC CTGGTACTAT ACCCACAGAT AGGAGACAAA 
TTGGATATTA TTTGCCCCAA AGTGGACTCT AAAACTGTTG GCCAGTATGA ATATTATAAA 
GTTTATATGG TTGATAAAGA GCAAGCCGAC AGATGCACTA TTAAGAAGGA AAATACCCCA 
CTGCTCAACT GTGCCAGACC AGACCAAGAT GTGAAATTCA CCATCAAGTT CCAAGAATTC 
AGCCCTAACC TCTGGGGTCT AGAGTTTCAG AAGAACAAAG ATTACTACAT TATATCTACA 
TCAAATGGGT CTTTGGAGGG CCTGGATAAC CAGGAGGGAG GGGTGTGCCA GACAAGAGCC 
ATGAAGATCC TCATGAAAGT TGGACAAGAT GCAAGTTCTG CTGGATCAAC CAGGAATAAT 
GATCCAACAA GACGTCCAGA GCTAGAAGCT GGTACGAATG GGAGAAGTTC AACAACAAGT 
CCCTTTGTGA AGCCAAATCC AGGTTCTAGC ACCGATGGCA ACAGCGCGGG GCATTCCGGG 
AACAATCTCC TGGGTTCCGA AGTGGCCTTA TTCGCAGGGA TTGCATCAGG ATGCATCATC 
TTCATCGTCA TCATCATCAC TTTGGTGGTG CTGCTGCTCA AGTACCGCAG GAGACACCGC 
AAACACTCTC CACAGCACAC GACCACGCTG TCTCTCAGCA CACTGGCCAC GCCCAAGCGA 
GGTGGCAACA ACAATGGCTC GGAGCCCAGT GACGTTATCA TACCGCTAAG GACTGCAGAC 
AGTGTCTTCT GCCCACACTA CGAGAAGGTC AGCGGGGACT ATGGGCACCC GGTGTACATC 
GTGCAGGAGA TGCCCCCACA GAGTCCTGCC AACATTTACT ACAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100798.1
CDS	10..1020
Translation	MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKEQADRCTIKKENTPLLNCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNNDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV

Target ORF information:

RefSeq Version	NM_001107328.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ephrin B2 (Efnb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107328.2

ORF Insert Sequence:

ATGGCCATGG CCCGGTCCAG GAGGGACTCT GTGTGGAAGT ACTGTTGGGG ACTTTTGATG 
GTTTTGTGCA GAACTGCGAT CTCCAGATCG ATAGTTCTAG AGCCTATCTA CTGGAATTCC 
TCGAACTCCA AATTTCTACC CGGACAAGGC CTGGTACTAT ACCCACAGAT AGGAGACAAA 
TTGGATATTA TTTGCCCCAA AGTGGACTCT AAAACTGTTG GCCAGTATGA ATATTATAAA 
GTTTATATGG TTGATAAAGA GCAAGCCGAC AGATGCACTA TTAAGAAGGA AAATACCCCA 
CTGCTCAACT GTGCCAGACC AGACCAAGAT GTGAAATTCA CCATCAAGTT CCAAGAATTC 
AGCCCTAACC TCTGGGGTCT AGAGTTTCAG AAGAACAAAG ATTACTACAT TATATCTACA 
TCAAATGGGT CTTTGGAGGG CCTGGATAAC CAGGAGGGAG GGGTGTGCCA GACAAGAGCC 
ATGAAGATCC TCATGAAAGT TGGACAAGAT GCAAGTTCTG CTGGATCAAC CAGGAATAAT 
GATCCAACAA GACGTCCAGA GCTAGAAGCT GGTACGAATG GGAGAAGTTC AACAACAAGT 
CCCTTTGTGA AGCCAAATCC AGGTTCTAGC ACCGATGGCA ACAGCGCGGG GCATTCCGGG 
AACAATCTCC TGGGTTCCGA AGTGGCCTTA TTCGCAGGGA TTGCATCAGG ATGCATCATC 
TTCATCGTCA TCATCATCAC TTTGGTGGTG CTGCTGCTCA AGTACCGCAG GAGACACCGC 
AAACACTCTC CACAGCACAC GACCACGCTG TCTCTCAGCA CACTGGCCAC GCCCAAGCGA 
GGTGGCAACA ACAATGGCTC GGAGCCCAGT GACGTTATCA TACCGCTAAG GACTGCAGAC 
AGTGTCTTCT GCCCACACTA CGAGAAGGTC AGCGGGGACT ATGGGCACCC GGTGTACATC 
GTGCAGGAGA TGCCCCCACA GAGTCCTGCC AACATTTACT ACAAGGTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.
Molecular biology of the cell28(24)3532-3541(2017 Nov)
Okumura F,Joo-Okumura A,Obara K,Petersen A,Nishikimi A,Fukui Y,Nakatsukasa K,Kamura T

RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth.
CNS neuroscience & therapeutics23(10)779-789(2017 Oct)
Li Y,Chen Y,Tan L,Pan JY,Lin WW,Wu J,Hu W,Chen X,Wang XD

Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland.
Cell and tissue research370(1)99-112(2017 10)
Yoshida S,Kato T,Kanno N,Nishimura N,Nishihara H,Horiguchi K,Kato Y

p75(NTR)-dependent activation of NF-?B regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia.
Nature communications68024(2015 Aug)
Caporali A,Meloni M,Nailor A,Miti? T,Shantikumar S,Riu F,Sala-Newby GB,Rose L,Besnier M,Katare R,Voellenkle C,Verkade P,Martelli F,Madeddu P,Emanueli C

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Efnb2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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