gRNAs
The following Kat6a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kat6a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa46428 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001100570.2 | |
| Accession Version | NM_001100570.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5997bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone acetyltransferase KAT6A | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07026361.1 and AB195309.1. On Sep 23, 2014 this sequence version replaced NM_001100570.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB195309.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTAAAGC TCGCTAACCC GCTGTACACG CAGTGGATTT TGGAGGCCAT CAAAAAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001094040.1 |
| CDS | 314..6310 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001100570.2 |
1 | ATGGTAAAGC TCGCTAACCC GCTGTACACG CAGTGGATTT TGGAGGCCAT CAAAAAAGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancer. |
The leucine twenty homeobox (LEUTX) gene, which lacks a histone acetyltransferase domain, is fused to KAT6A in therapy-related acute myeloid leukemia with t(8;19)(p11;q13). |
MOZ increases p53 acetylation and premature senescence through its complex formation with PML. |
MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. |
Physical and functional HAT/HDAC interplay regulates protein acetylation balance. |
