Klf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klf2
Entrez Gene ID	306330
Full Name	Kruppel-like factor 2
Synonyms	Lklf
General protein information	Preferred Names Kruppel-like factor 2 Names Krueppel-like factor 2 Kruppel-like factor 2 (lung) lung Kruppel-like factor lung krueppel-like factor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007684.1	NP_001007685.1	Krueppel-like factor 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KLF2	XP_003316222.1
Mus musculus (house mouse)	Klf2	NP_032478.2
Rattus norvegicus (Norway rat)	Klf2	NP_001007685.1
Homo sapiens (human)	KLF2	NP_057354.1

Gene Ontology
Bibliography

Related articles in PubMed

KLF2 attenuates bleomycin-induced pulmonary fibrosis and inflammation with regulation of AP-1.
Shi J, Zhou LR, Wang XS, Du JF, Jiang MM, Song Z, Han GC, Mai ZT
Biochemical and biophysical research communications495(1)20-26(2018 Jan)

Experimental Lung Injury Reduces Kr?ppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.
Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y
American journal of respiratory and critical care medicine195(5)639-651(2017 Mar)

MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.
Lee DY, Lin TE, Lee CI, Zhou J, Huang YH, Lee PL, Shih YT, Chien S, Chiu JJ
Proceedings of the National Academy of Sciences of the United States of America114(8)2072-2077(2017 02)

KLF2 and caveolin-1 as early indicators of acute lung injury induced by paraquat.
Qiaoli S, Yi S, Jie Z, Deyun C
European review for medical and pharmacological sciences20(1)138-45(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KLF2 was remarkably downregulated in bleomycin-treated rats, both in mRNA and protein levels. Additionally, overexpression of KLF2 attenuated the destruction of the alveolar space and pulmonary interstitial collagen hyperplasia.
Title: KLF2 attenuates bleomycin-induced pulmonary fibrosis and inflammation with regulation of AP-1.

Transcription factor Kruppel-like factor 2 (KLF2) of the zinc finger family of DNA-binding proteins has recently emerged as a major molecular switch that controls endothelial homeostasis
Title: Experimental Lung Injury Reduces Kr?ppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.

lung tissue expression of KLF2 and Cav-1 is modulated early in the pathogenesis of acute lung injury.
Title: KLF2 and caveolin-1 as early indicators of acute lung injury induced by paraquat.

Cirrhotic rats treated with simvastatin showed hepatic up regulation in KLF2 protein and reduction in liver fibrosis.
Title: KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins.

High-glucose-induced, FOXO1-mediated KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction.
Title: FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2.

The following Klf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11592	NM_001007684.1 Latest version!	Rattus norvegicus Kruppel-like factor 2 (Klf2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klf2 ( NM_001007684.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007685.1 Rattus norvegicus Kruppel-like factor 2 (Klf2), mRNA.

Price & Availability↑

CloneID	ORa11592
Clone ID Related Accession (Same CDS sequence)	NM_001007684.1
Accession Version	NM_001007684.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	Krueppel-like factor 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF181251.1. On Nov 29, 2004 this sequence version replaced XM_224722.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906348, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCTCA GCGAGCCTAT CTTGCCGTCC TTTGCCACTT TCGCCAGCCC CTGCGAGCGC 
GGCCTCCAGG AGCGCTGGCC GCGAAATGAG CCCGAGGCGG GCAGCACGGA TGAGGACCTA 
AACAGCGTGC TGGACTTCAT CCTGTCCATG GGACTGGACG GCCTGGGCGC CGAGAACCCT 
CCCGAGCCCC CACCGCAGCC CCCGCCTCCT GCGTTCTACT ACCCGGAGCC GGGTGCCCCT 
CCGCCCTATG GCACCCCGGC GGCTGGCCTG GGAACGGAGC TGCTGCGCCC GGATCTGGAT 
GCGCCTCAGG GGCCGGCTCT ACACGGCCGC TTCCTCCTCG CGCCTCCCGG GCGGCTGGTG 
AAAGCCGAGC CCCCGGAGGT GGACGGCGGC GGCTACGGGT GCGCAGCCGG CTTGGCTCGC 
GGACCGCGCG GGCTGAAGCT CGAGGGCGCC CTGGGAGCGA CAGGTGCATG CATGCGGGGT 
CCTGCTGGCC GTCCCCCACC GCCCTCCGAC ACGCCGCCGC TCAGCCCCGA CGGCCCCCCG 
CGCCTCCCGG CGCCCGGTCC CCGCAACCCG TTCCCGCCAC CCTTCGGCCC CGGCCCCAGC 
TTCGGCGGCC CCGGCCCCGC GTTGCACTAC GGGCCGCCCG CTCCCGGCGC TTTCGGTCTC 
TTCGACGACG CGGCGGCGGC TCTGGGTCTT GCTCCCCCTG CCACGCGCGG TCTCCTCACG 
CCGCCCTCGT CCCCGCTGGA GCTGTTGGAG GCCAAGCCCA AGCGCGGCCG CCGCTCCTGG 
CCCCGCAAGC GCGCCGCCAC GCACACTTGC AGCTACACCA ACTGCGGCAA GACCTACACC 
AAGAGTTCGC ACCTAAAGGC GCATCTGAGG ACGCACACAG GTGAGAAGCC TTATCATTGC 
AACTGGGACG GCTGCGGCTG GAAGTTCGCG CGCTCTGACG AGCTTACCCG CCACTACCGC 
AAGCACACGG GTCACAGGCC CTTCCAGTGC CACTTGTGCG ACCGGGCCTT CTCCAGGTCC 
GACCACCTGG CTCTGCACAT GAAGCGACAC ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007685.1
CDS	1..1056
Translation	MALSEPILPSFATFASPCERGLQERWPRNEPEAGSTDEDLNSVLDFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYGTPAAGLGTELLRPDLDAPQGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAAGLARGPRGLKLEGALGATGACMRGPAGRPPPPSDTPPLSPDGPPRLPAPGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAFGLFDDAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM

Target ORF information:

RefSeq Version	NM_001007684.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Kruppel-like factor 2 (Klf2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007684.1

ORF Insert Sequence:

ATGGCGCTCA GCGAGCCTAT CTTGCCGTCC TTTGCCACTT TCGCCAGCCC CTGCGAGCGC 
GGCCTCCAGG AGCGCTGGCC GCGAAATGAG CCCGAGGCGG GCAGCACGGA TGAGGACCTA 
AACAGCGTGC TGGACTTCAT CCTGTCCATG GGACTGGACG GCCTGGGCGC CGAGAACCCT 
CCCGAGCCCC CACCGCAGCC CCCGCCTCCT GCGTTCTACT ACCCGGAGCC GGGTGCCCCT 
CCGCCCTATG GCACCCCGGC GGCTGGCCTG GGAACGGAGC TGCTGCGCCC GGATCTGGAT 
GCGCCTCAGG GGCCGGCTCT ACACGGCCGC TTCCTCCTCG CGCCTCCCGG GCGGCTGGTG 
AAAGCCGAGC CCCCGGAGGT GGACGGCGGC GGCTACGGGT GCGCAGCCGG CTTGGCTCGC 
GGACCGCGCG GGCTGAAGCT CGAGGGCGCC CTGGGAGCGA CAGGTGCATG CATGCGGGGT 
CCTGCTGGCC GTCCCCCACC GCCCTCCGAC ACGCCGCCGC TCAGCCCCGA CGGCCCCCCG 
CGCCTCCCGG CGCCCGGTCC CCGCAACCCG TTCCCGCCAC CCTTCGGCCC CGGCCCCAGC 
TTCGGCGGCC CCGGCCCCGC GTTGCACTAC GGGCCGCCCG CTCCCGGCGC TTTCGGTCTC 
TTCGACGACG CGGCGGCGGC TCTGGGTCTT GCTCCCCCTG CCACGCGCGG TCTCCTCACG 
CCGCCCTCGT CCCCGCTGGA GCTGTTGGAG GCCAAGCCCA AGCGCGGCCG CCGCTCCTGG 
CCCCGCAAGC GCGCCGCCAC GCACACTTGC AGCTACACCA ACTGCGGCAA GACCTACACC 
AAGAGTTCGC ACCTAAAGGC GCATCTGAGG ACGCACACAG GTGAGAAGCC TTATCATTGC 
AACTGGGACG GCTGCGGCTG GAAGTTCGCG CGCTCTGACG AGCTTACCCG CCACTACCGC 
AAGCACACGG GTCACAGGCC CTTCCAGTGC CACTTGTGCG ACCGGGCCTT CTCCAGGTCC 
GACCACCTGG CTCTGCACAT GAAGCGACAC ATGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KLF2 attenuates bleomycin-induced pulmonary fibrosis and inflammation with regulation of AP-1.
Biochemical and biophysical research communications495(1)20-26(2018 Jan)
Shi J,Zhou LR,Wang XS,Du JF,Jiang MM,Song Z,Han GC,Mai ZT

Experimental Lung Injury Reduces Kr?ppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling.
American journal of respiratory and critical care medicine195(5)639-651(2017 Mar)
Huang RT,Wu D,Meliton A,Oh MJ,Krause M,Lloyd JA,Nigdelioglu R,Hamanaka RB,Jain MK,Birukova A,Kress JP,Birukov KG,Mutlu GM,Fang Y

MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.
Proceedings of the National Academy of Sciences of the United States of America114(8)2072-2077(2017 02)
Lee DY,Lin TE,Lee CI,Zhou J,Huang YH,Lee PL,Shih YT,Chien S,Chiu JJ

KLF2 and caveolin-1 as early indicators of acute lung injury induced by paraquat.
European review for medical and pharmacological sciences20(1)138-45(2016)
Qiaoli S,Yi S,Jie Z,Deyun C

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Klf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報