Slc39a14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc39a14
Entrez Gene ID	306009
Full Name	solute carrier family 39 member 14
General protein information	Preferred Names solute carrier family 39 member 14 Names zinc transporter ZIP14 solute carrier family 39 (zinc transporter), member 14
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p11

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252270.2	XP_006252332.1	zinc transporter ZIP14 isoform X1
NM_001107275.1	NP_001100745.1	zinc transporter ZIP14 precursor
XM_017599703.1	XP_017455192.1	zinc transporter ZIP14 isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	SLC39A14	NP_001128625.1
Caenorhabditis elegans (roundworm)	Y55F3BL.2	NP_499995.2
Pan troglodytes (chimpanzee)	SLC39A14	XP_531112.3
Canis lupus familiaris (dog)	SLC39A14	XP_005635776.1
Bos taurus (cattle)	SLC39A14	NP_001091505.1
Mus musculus (house mouse)	Slc39a14	NP_659057.2
Rattus norvegicus (Norway rat)	Slc39a14	NP_001100745.1
Danio rerio (zebrafish)	LOC799782	XP_005171823.1
Caenorhabditis elegans (roundworm)	tag-140	NP_505904.2
	LOC716112	XP_001106660.2
Gallus gallus (chicken)	SLC39A14	XP_004950914.1
Xenopus tropicalis (tropical clawed frog)	slc39a14	NP_001090864.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.
Aburto-Luna V, Trevi?o S, Santos-L?pez G, Moroni-Gonz?lez D, Calva-Cruz O, Aguilar-Alonso P, Le?n-Ch?vez BA, Brambila E
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(2)167-175(2017 Feb)

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Tuschl K, Meyer E, Valdivia LE, Zhao N, Dadswell C, Abdul-Sada A, Hung CY, Simpson MA, Chong WK, Jacques TS, Woltjer RL, Eaton S, Gregory A, Sanford L, Kara E, Houlden H, Cuno SM, Prokisch H, Valletta L, Tiranti V, Younis R, Maher ER, Spencer J, Straatman-Iwanowska A, Gissen P, Selim LA, Pintos-Morell G, Coroleu-Lletget W, Mohammad SS, Yoganathan S, Dale RC, Thomas M, Rihel J, Bodamer OA, Enns CA, Hayflick SJ, Clayton PT, Mills PB, Kurian MA, Wilson SW
Nature communications711601(2016 May)

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y
Trends in biochemical sciences41(3)274-86(2016 Mar)

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

After tissue is damaged in abdominal surgery, cytokines are released to the circulation, IL-6, the main mediator of acute phase response induces the expression of MT and Zip14, and the increase of transporter Zip14 promotes the uptake of zinc by liver at the expense of serum zinc
Title: Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.

Nuclear localization for Zip8 and Zip14 transporters as well as TfR1 was observed in the inner ear of rats.
Title: Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats.

Data suggest magnesium deficiency enhances liver zinc uptake by up-regulating expression of Zip14/Slc39a14 (solute carrier family 39, member 14); increased liver content of zinc leads to up-regulation of expression of metallothioneins (Mt1 and Mt2).
Title: Magnesium and calcium deficiencies additively increase zinc concentrations and metallothionein expression in the rat liver.

The following Slc39a14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc39a14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05267	NM_001107275.1 Latest version!	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa05267	XM_017599703.1 Latest version!	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa36832	XM_006252270.2 Latest version!	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc39a14 ( NM_001107275.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100745.1 Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), mRNA.

Price & Availability↑

CloneID	ORa05267
Clone ID Related Accession (Same CDS sequence)	NM_001107275.1 , XM_017599703.1
Accession Version	NM_001107275.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP14 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473951.1. On or before Oct 4, 2007 this sequence version replaced XM_224332.4, XM_001070144.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01906353, SAMN01906354 [ECO:0000348] ##Evidence-Data-END##

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTGTGGG GCTTTGGGTT CCTCAGTGTC 
TCACTGATTA ACCTGGCCTC GCTCCTGGGA GTCCTGGTCC TGCCATGCAC GGAGAAAGCG 
TTTTTCAGCC GTGTGCTCAC TTACTTCATC GCCTTGTCCA TTGGAACGCT GCTCTCTAAC 
GCACTTTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100745.1
CDS	233..1705
Translation	MVTMERLHPAFPSYLLLVLFGIWRTVPQIHASSTGLLPLSATSFLEELMKRYGENDSLTLPQLKTLLNSVGVGRDNVSLPKEAHRNLSTCFSSGDLFAAHNFSERSRIGKSEFQEFCPTILQQLDSRACTPENQENKENEQTEEGKPSAIEVWGFGFLSVSLINLASLLGVLVLPCTEKAFFSRVLTYFIALSIGTLLSNALFQLIPEAFGFNPQDNYVSKSAVVFGGFYLFFFTEKILKMLLKQKNEHHHGHNHFTSETLPSKKDQEEGVTEKLQNGDLDHMIPQHCNNDLDGKAPSTDEKVIVGSMSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYVGLAFGILAGSHFSANWIFALAGGMFLYIALADMFPEMNEVCQEDEKKDSFLVPFVIQNLGLLTGFSIMLVLTMYSGQIQIG

Target ORF information:

RefSeq Version	NM_001107275.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107275.1

ORF Insert Sequence:

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTGTGGG GCTTTGGGTT CCTCAGTGTC 
TCACTGATTA ACCTGGCCTC GCTCCTGGGA GTCCTGGTCC TGCCATGCAC GGAGAAAGCG 
TTTTTCAGCC GTGTGCTCAC TTACTTCATC GCCTTGTCCA TTGGAACGCT GCTCTCTAAC 
GCACTTTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc39a14 ( XM_017599703.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455192.1 Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa05267
Clone ID Related Accession (Same CDS sequence)	NM_001107275.1 , XM_017599703.1
Accession Version	XM_017599703.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP14 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTGTGGG GCTTTGGGTT CCTCAGTGTC 
TCACTGATTA ACCTGGCCTC GCTCCTGGGA GTCCTGGTCC TGCCATGCAC GGAGAAAGCG 
TTTTTCAGCC GTGTGCTCAC TTACTTCATC GCCTTGTCCA TTGGAACGCT GCTCTCTAAC 
GCACTTTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455192.1
CDS	342..1814
Translation	MVTMERLHPAFPSYLLLVLFGIWRTVPQIHASSTGLLPLSATSFLEELMKRYGENDSLTLPQLKTLLNSVGVGRDNVSLPKEAHRNLSTCFSSGDLFAAHNFSERSRIGKSEFQEFCPTILQQLDSRACTPENQENKENEQTEEGKPSAIEVWGFGFLSVSLINLASLLGVLVLPCTEKAFFSRVLTYFIALSIGTLLSNALFQLIPEAFGFNPQDNYVSKSAVVFGGFYLFFFTEKILKMLLKQKNEHHHGHNHFTSETLPSKKDQEEGVTEKLQNGDLDHMIPQHCNNDLDGKAPSTDEKVIVGSMSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYVGLAFGILAGSHFSANWIFALAGGMFLYIALADMFPEMNEVCQEDEKKDSFLVPFVIQNLGLLTGFSIMLVLTMYSGQIQIG

Target ORF information:

RefSeq Version	XM_017599703.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017599703.1

ORF Insert Sequence:

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTGTGGG GCTTTGGGTT CCTCAGTGTC 
TCACTGATTA ACCTGGCCTC GCTCCTGGGA GTCCTGGTCC TGCCATGCAC GGAGAAAGCG 
TTTTTCAGCC GTGTGCTCAC TTACTTCATC GCCTTGTCCA TTGGAACGCT GCTCTCTAAC 
GCACTTTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc39a14 ( XM_006252270.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252332.1 Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa36832
Clone ID Related Accession (Same CDS sequence)	XM_006252270.2
Accession Version	XM_006252270.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	zinc transporter ZIP14 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005114.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006252270.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTATGGG GGTACGGTCT CCTCTGCGTT 
ACCGTCATCT CCCTCTGCTC CCTCATGGGG GCCAGCGTGG TGCCCTTCAT GAAGAAGACA 
TTTTACAAGA GACTGCTGCT CTACTTCATA GCCTTGGCGA TTGGAACCCT CTACTCCAAT 
GCCCTCTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252332.1
CDS	258..1730
Translation	MVTMERLHPAFPSYLLLVLFGIWRTVPQIHASSTGLLPLSATSFLEELMKRYGENDSLTLPQLKTLLNSVGVGRDNVSLPKEAHRNLSTCFSSGDLFAAHNFSERSRIGKSEFQEFCPTILQQLDSRACTPENQENKENEQTEEGKPSAIEVWGYGLLCVTVISLCSLMGASVVPFMKKTFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPQDNYVSKSAVVFGGFYLFFFTEKILKMLLKQKNEHHHGHNHFTSETLPSKKDQEEGVTEKLQNGDLDHMIPQHCNNDLDGKAPSTDEKVIVGSMSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFTVSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYVGLAFGILAGSHFSANWIFALAGGMFLYIALADMFPEMNEVCQEDEKKDSFLVPFVIQNLGLLTGFSIMLVLTMYSGQIQIG

Target ORF information:

RefSeq Version	XM_006252270.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 39 member 14 (Slc39a14), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252270.2

ORF Insert Sequence:

ATGGTCACCA TGGAGCGGCT ACACCCAGCC TTCCCTAGCT ACCTCCTGTT GGTGCTGTTT 
GGTATATGGA GAACTGTCCC CCAGATTCAT GCCTCATCTA CTGGCCTGCT GCCCCTCAGT 
GCCACCTCTT TCCTGGAAGA GCTTATGAAA CGCTACGGAG AGAATGACAG CCTTACCTTG 
CCACAGCTGA AGACTCTGCT CAACAGCGTG GGCGTGGGCC GGGATAATGT TTCCCTGCCC 
AAAGAAGCAC ACAGGAACCT CTCCACGTGC TTTAGCTCTG GAGATCTCTT TGCGGCCCAC 
AACTTCAGTG AGCGATCTCG TATTGGGAAG AGTGAATTCC AGGAGTTCTG CCCCACCATT 
CTCCAGCAGT TGGATTCCCG GGCTTGCACC CCAGAAAACC AGGAGAATAA GGAAAATGAG 
CAGACAGAGG AGGGGAAGCC AAGCGCCATT GAAGTATGGG GGTACGGTCT CCTCTGCGTT 
ACCGTCATCT CCCTCTGCTC CCTCATGGGG GCCAGCGTGG TGCCCTTCAT GAAGAAGACA 
TTTTACAAGA GACTGCTGCT CTACTTCATA GCCTTGGCGA TTGGAACCCT CTACTCCAAT 
GCCCTCTTCC AGCTCATCCC AGAGGCTTTT GGTTTCAACC CTCAGGACAA TTATGTCTCC 
AAGTCTGCTG TGGTCTTTGG GGGTTTCTAC CTTTTCTTTT TCACAGAAAA GATCCTGAAG 
ATGCTCCTGA AGCAGAAAAA CGAGCACCAT CACGGACATA ACCATTTTAC CTCCGAAACG 
CTTCCTTCCA AGAAGGACCA GGAGGAGGGT GTCACGGAGA AGCTACAGAA TGGGGACCTG 
GATCATATGA TTCCTCAGCA CTGCAACAAT GATCTGGATG GCAAGGCACC CAGCACAGAC 
GAGAAGGTCA TCGTAGGCTC CATGTCTGTG CAGGACCTGC AGGCATCCCA GAGTGCTTGC 
TACTGGCTCA AAGGGGTTCG ATATTCTGAT ATTGGTACCT TGGCCTGGAT GATCACCCTG 
AGCGATGGTC TCCACAATTT CATCGATGGC CTGGCTATCG GTGCCTCCTT CACTGTGTCT 
GTCTTCCAAG GCATTAGCAC GTCGGTGGCC ATTCTCTGTG AGGAATTTCC TCACGAGCTG 
GGAGACTTCG TTATCCTGCT CAATGCTGGT ATGAGTATCC AGCAGGCCCT CTTCTTCAAC 
TTCCTCTCTG CTTGCTGCTG CTATGTGGGT CTGGCCTTTG GTATCCTGGC TGGCAGTCAC 
TTCTCTGCAA ACTGGATTTT TGCACTGGCT GGAGGAATGT TCTTGTATAT TGCTCTAGCC 
GATATGTTCC CTGAGATGAA TGAGGTGTGC CAGGAGGATG AGAAGAAGGA CAGCTTTTTG 
GTCCCCTTCG TCATCCAGAA TCTTGGCCTC CTAACTGGCT TCTCCATCAT GCTGGTTCTC 
ACCATGTATT CAGGGCAGAT TCAGATCGGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic mobilization of zinc after an experimental surgery, and its relationship with inflammatory cytokines release, and expression of metallothionein and Zip14 transporter.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(2)167-175(2017 Feb)
Aburto-Luna V,Trevi?o S,Santos-L?pez G,Moroni-Gonz?lez D,Calva-Cruz O,Aguilar-Alonso P,Le?n-Ch?vez BA,Brambila E

Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia.
Nature communications711601(2016 May)
Tuschl K,Meyer E,Valdivia LE,Zhao N,Dadswell C,Abdul-Sada A,Hung CY,Simpson MA,Chong WK,Jacques TS,Woltjer RL,Eaton S,Gregory A,Sanford L,Kara E,Houlden H,Cuno SM,Prokisch H,Valletta L,Tiranti V,Younis R,Maher ER,Spencer J,Straatman-Iwanowska A,Gissen P,Selim LA,Pintos-Morell G,Coroleu-Lletget W,Mohammad SS,Yoganathan S,Dale RC,Thomas M,Rihel J,Bodamer OA,Enns CA,Hayflick SJ,Clayton PT,Mills PB,Kurian MA,Wilson SW

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.
Trends in biochemical sciences41(3)274-86(2016 Mar)
Bogdan AR,Miyazawa M,Hashimoto K,Tsuji Y

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

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Slc39a14 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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