Atf6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Atf6
Entrez Gene ID	304962
Full Name	activating transcription factor 6
General protein information	Preferred Names activating transcription factor 6 Names cyclic AMP-dependent transcription factor ATF-6 alpha ATF6-alpha activating transcription factor 6 alpha cAMP-dependent transcription factor ATF-6 alpha
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598829.1	XP_017454318.1	cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1
XM_008769738.2	XP_008767960.1	cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2
NM_001107196.1	NP_001100666.1	cyclic AMP-dependent transcription factor ATF-6 alpha

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Atf6	NP_001074773.1
Gallus gallus (chicken)	ATF6	XP_422208.3
Danio rerio (zebrafish)	atf6	NP_001103989.1
Homo sapiens (human)	ATF6	NP_031374.2
	ATF6	XP_001118153.2
Bos taurus (cattle)	ATF6	XP_003585864.2
Xenopus tropicalis (tropical clawed frog)	atf6	XP_002933826.2
Pan troglodytes (chimpanzee)	ATF6	XP_001174215.1
Canis lupus familiaris (dog)	ATF6	XP_005640918.1
Rattus norvegicus (Norway rat)	Atf6	NP_001100666.1

Gene Ontology
Bibliography

Related articles in PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Sch?beler D, Vinson C, Taipale J
Science (New York, N.Y.)356(6337)(2017 05)

Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1? and PERK signaling activation.
Tang JY, Jin P, He Q, Lu LH, Ma JP, Gao WL, Bai HP, Yang J
Molecular and cellular biochemistry424(1-2)111-122(2017 Jan)

Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction.
Krawczyk KK, Ekman M, Rippe C, Grossi M, Nilsson BO, Albinsson S, Uvelius B, Sw?rd K
Scientific reports632449(2016 Sep)

Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury.
Jia W, Jian Z, Li J, Luo L, Zhao L, Zhou Y, Tang F, Xiao Y
International journal of molecular medicine37(5)1199-208(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results confirmed that ER stress-mediated apoptosis contributes to the protection effects of naringenin against H/R injury, which is potentially involved in ATF6, IRE1alpha and PERK signaling activation.
Title: Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1? and PERK signaling activation.

ATF6 upregulation is involved in the mechanism by which CIH attenuates myocardial I/R injury, possibly through upregulation of p-Akt, which is a key regulator of cardiomyocyte survival.
Title: Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury.

Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Title: ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.

ATF6beta is not essential for induction of most UPR genes, but is required to maintain cell survival in beta-cells undergoing chronic ER stress.
Title: ATF6? regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic ?-cells.

Study highlights that single-prolonged stress induced ATF6alpha-dependent endoplasmic reticulum stress and ER-related apoptosis in the prefrontal cortex neurons
Title: Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons.

The following Atf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Atf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13477	NM_001107196.1 Latest version!	Rattus norvegicus activating transcription factor 6 (Atf6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa46226	XM_008769738.2 Latest version!	Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa58086	XM_017598829.1 Latest version!	Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Atf6 ( NM_001107196.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100666.1 Rattus norvegicus activating transcription factor 6 (Atf6), mRNA.

Price & Availability↑

CloneID	ORa13477
Clone ID Related Accession (Same CDS sequence)	NM_001107196.1
Accession Version	NM_001107196.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1971bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cyclic AMP-dependent transcription factor ATF-6 alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473958.2. On or before Oct 4, 2007 this sequence version replaced XM_222871.4, XM_001076843.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168890.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG GTGAAGACTG GGAGTCCACG 
TTGTTTGCTG AGCTTGGCTA TTTCACAGAC ACGGATGATG TCCAGTTTGA TGCAGCACAT 
GAGACTTACG AAAATAATTT TGATCATCTT AATTTTGATT TGGATTTGAT GCCTTGGGAG 
TCAGACATAT GGAGCCCCAG CAGCCACTTC TGCTCAGACA TTAAGGCAGA GCCCCAGCCT 
CTTTCTCCGG CTTCCTCCAG TTGTTCTGTC TCTTCTCCTC GGTCCACAGA CTCCTGTTCT 
TCAACTCAGC ACGTTCCTGA GGAGTTGGAC TTGTTGTCTA GTTCTCAGTC TCCCCTTTCC 
TTGTATGGCG ACAGCTGTCA CAGCCCCTCC TCAGCAGAGC CACTGAAGGA AGAGAAGCCT 
GTCACTGGTC CTGGAAACAA AACGGAACAT GGACTGACTC CAAAGAAAAA AATCCAGATG 
AGTTCAAAAC CTTCAGTTCA GCCCAAGCCT TTGTTACTTC CAGCAGCACC CAAGACTCCA 
GCAAACGCCA GTGTCCCAGC AAAGACCATC ATCATTCAGA CACTGCCAGC CCTGATGCCA 
CTGGCAAAGC AGCAGTCGAT TATCAGTATA CAGCCTGCGC CCACCAAAGG TCAGACTGTT 
TTGCTCTCTC AGCCTGCTGT GGTTCAACTT CAGACCCCTG GAGTTCTGCC CTCTGCTCAG 
CCAGTACTTG CTGTCACTGG CGGAGCCACA CAGCTACCTA ACCATGTGGT GAATGTGGTG 
CCAGCCCCGG TGGTGAACAG CCCGGTGAAC GGAAAACTGT GTGTGACTAA ACCTGTTCTA 
CAAAGCAGCA CCAGAAGCAC GGGTTCAGAT ATTGCCGTAC TGAGGAGACA GCAGCGTATG 
ATCAAGAACC GAGAGTCTGC TTGTCAGTCA CGAAAGAAGA AGAAAGAGTA TATGCTAGGC 
CTGGAGGCCA GGTTGAAGGC CGCCCTCTCC GAGAATGAGC AGCTGAAGAA GGAGAATGGG 
TCCCTGAAGC GACAGCTGGA CCAGGTGGTG TCAGAGAACC AGAGGCTCAA AGTCCCAAGT 
CCAAAGCGCA GAGCTGTCTG TGTGATGATA GTATTAGCAT TTATCATGCT GAACTATGGG 
CCCATGAGCA TGCTGGAGCA AGATTCCAGG AGAGTGAAAC CTAGTGTGAG CCCTGCCAAT 
CAAAGGAGGC ATCTTTTAGA GTTTTCAGCA AAAGAAGTTA AAGACACGTC AGATGGTGAC 
AACCAGAAAA ACAGTTACAG ATATGATCAT TCTGTGTCCA ATGACAAAGC CTTAATGGTG 
CTAAGTGAAG AACCATTACT TTATATCCCT CCACCTCCAT GTCAGCCCCT CATTAACACG 
ACAGAGTCTC TCAGGTTGAA CCATGAACTT CGAGGCTGGG TTCATAGACA TGAAGTGGAA 
AGGACCAAAT CGAGAAGAAT GACAAATAGC CAGCAGAAAA CCCGCATTCT CCAGGGTGCT 
CTGGAACAGG GCTCGAATTC TCAGCTGATG GCTGTCCAGT ACACAGAAAC CACTAGCATC 
AGTAGGAATT CTGGGAGTGA GCTGCAGGTG TATTACGCTT CGCCTGGAAG TTACCAAGGC 
TTCTTTGACG CCATCCGCAG GAGGGGAGAT ACATTTTACG TCGTATCATT TCGAAGGGAT 
CACCTGCTAT TACCAGCTAC CACCCATAAC AAGACCACAA GACCGAAGAT GTCCATTGTG 
TTACCAGCAA TAAACATAAA TGATAACGTG ATCAATGGGC AGGATTATGA AGTAATGATG 
CAGATTGACT GTCAGGTCAT GGACACCAGG ATCCTCCACA TCAAAAGCTC CTCGGTTCCC 
CCGTATCTCC GAGATCATCA GAGAAACCAA ACCAGCACCT TCTTCGGTTC CCCTCCCACA 
GCCACAGAGA CGACCCATGT GGTCAGCACC CTCCCTGAGT CGGTACAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100666.1
CDS	71..2041
Translation	MESPFSPVLPHGPGEDWESTLFAELGYFTDTDDVQFDAAHETYENNFDHLNFDLDLMPWESDIWSPSSHFCSDIKAEPQPLSPASSSCSVSSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPAVVQLQTPGVLPSAQPVLAVTGGATQLPNHVVNVVPAPVVNSPVNGKLCVTKPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDQVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQDSRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKNSYRYDHSVSNDKALMVLSEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTATETTHVVSTLPESVQ

Target ORF information:

RefSeq Version	NM_001107196.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activating transcription factor 6 (Atf6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107196.1

ORF Insert Sequence:

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG GTGAAGACTG GGAGTCCACG 
TTGTTTGCTG AGCTTGGCTA TTTCACAGAC ACGGATGATG TCCAGTTTGA TGCAGCACAT 
GAGACTTACG AAAATAATTT TGATCATCTT AATTTTGATT TGGATTTGAT GCCTTGGGAG 
TCAGACATAT GGAGCCCCAG CAGCCACTTC TGCTCAGACA TTAAGGCAGA GCCCCAGCCT 
CTTTCTCCGG CTTCCTCCAG TTGTTCTGTC TCTTCTCCTC GGTCCACAGA CTCCTGTTCT 
TCAACTCAGC ACGTTCCTGA GGAGTTGGAC TTGTTGTCTA GTTCTCAGTC TCCCCTTTCC 
TTGTATGGCG ACAGCTGTCA CAGCCCCTCC TCAGCAGAGC CACTGAAGGA AGAGAAGCCT 
GTCACTGGTC CTGGAAACAA AACGGAACAT GGACTGACTC CAAAGAAAAA AATCCAGATG 
AGTTCAAAAC CTTCAGTTCA GCCCAAGCCT TTGTTACTTC CAGCAGCACC CAAGACTCCA 
GCAAACGCCA GTGTCCCAGC AAAGACCATC ATCATTCAGA CACTGCCAGC CCTGATGCCA 
CTGGCAAAGC AGCAGTCGAT TATCAGTATA CAGCCTGCGC CCACCAAAGG TCAGACTGTT 
TTGCTCTCTC AGCCTGCTGT GGTTCAACTT CAGACCCCTG GAGTTCTGCC CTCTGCTCAG 
CCAGTACTTG CTGTCACTGG CGGAGCCACA CAGCTACCTA ACCATGTGGT GAATGTGGTG 
CCAGCCCCGG TGGTGAACAG CCCGGTGAAC GGAAAACTGT GTGTGACTAA ACCTGTTCTA 
CAAAGCAGCA CCAGAAGCAC GGGTTCAGAT ATTGCCGTAC TGAGGAGACA GCAGCGTATG 
ATCAAGAACC GAGAGTCTGC TTGTCAGTCA CGAAAGAAGA AGAAAGAGTA TATGCTAGGC 
CTGGAGGCCA GGTTGAAGGC CGCCCTCTCC GAGAATGAGC AGCTGAAGAA GGAGAATGGG 
TCCCTGAAGC GACAGCTGGA CCAGGTGGTG TCAGAGAACC AGAGGCTCAA AGTCCCAAGT 
CCAAAGCGCA GAGCTGTCTG TGTGATGATA GTATTAGCAT TTATCATGCT GAACTATGGG 
CCCATGAGCA TGCTGGAGCA AGATTCCAGG AGAGTGAAAC CTAGTGTGAG CCCTGCCAAT 
CAAAGGAGGC ATCTTTTAGA GTTTTCAGCA AAAGAAGTTA AAGACACGTC AGATGGTGAC 
AACCAGAAAA ACAGTTACAG ATATGATCAT TCTGTGTCCA ATGACAAAGC CTTAATGGTG 
CTAAGTGAAG AACCATTACT TTATATCCCT CCACCTCCAT GTCAGCCCCT CATTAACACG 
ACAGAGTCTC TCAGGTTGAA CCATGAACTT CGAGGCTGGG TTCATAGACA TGAAGTGGAA 
AGGACCAAAT CGAGAAGAAT GACAAATAGC CAGCAGAAAA CCCGCATTCT CCAGGGTGCT 
CTGGAACAGG GCTCGAATTC TCAGCTGATG GCTGTCCAGT ACACAGAAAC CACTAGCATC 
AGTAGGAATT CTGGGAGTGA GCTGCAGGTG TATTACGCTT CGCCTGGAAG TTACCAAGGC 
TTCTTTGACG CCATCCGCAG GAGGGGAGAT ACATTTTACG TCGTATCATT TCGAAGGGAT 
CACCTGCTAT TACCAGCTAC CACCCATAAC AAGACCACAA GACCGAAGAT GTCCATTGTG 
TTACCAGCAA TAAACATAAA TGATAACGTG ATCAATGGGC AGGATTATGA AGTAATGATG 
CAGATTGACT GTCAGGTCAT GGACACCAGG ATCCTCCACA TCAAAAGCTC CTCGGTTCCC 
CCGTATCTCC GAGATCATCA GAGAAACCAA ACCAGCACCT TCTTCGGTTC CCCTCCCACA 
GCCACAGAGA CGACCCATGT GGTCAGCACC CTCCCTGAGT CGGTACAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atf6 ( XM_008769738.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008767960.1 Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa46226
Clone ID Related Accession (Same CDS sequence)	XM_008769738.2
Accession Version	XM_008769738.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1959bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008769738.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG AGTCCACGTT GTTTGCTGAG 
CTTGGCTATT TCACAGACAC GGATGATGTC CAGTTTGATG CAGCACATGA GACTTACGAA 
AATAATTTTG ATCATCTTAA TTTTGATTTG GATTTGATGC CTTGGGAGTC AGACATATGG 
AGCCCCAGCA GCCACTTCTG CTCAGACATT AAGGCAGAGC CCCAGCCTCT TTCTCCGGCT 
TCCTCCAGTT GTTCTGTCTC TTCTCCTCGG TCCACAGACT CCTGTTCTTC AACTCAGCAC 
GTTCCTGAGG AGTTGGACTT GTTGTCTAGT TCTCAGTCTC CCCTTTCCTT GTATGGCGAC 
AGCTGTCACA GCCCCTCCTC AGCAGAGCCA CTGAAGGAAG AGAAGCCTGT CACTGGTCCT 
GGAAACAAAA CGGAACATGG ACTGACTCCA AAGAAAAAAA TCCAGATGAG TTCAAAACCT 
TCAGTTCAGC CCAAGCCTTT GTTACTTCCA GCAGCACCCA AGACTCCAGC AAACGCCAGT 
GTCCCAGCAA AGACCATCAT CATTCAGACA CTGCCAGCCC TGATGCCACT GGCAAAGCAG 
CAGTCGATTA TCAGTATACA GCCTGCGCCC ACCAAAGGTC AGACTGTTTT GCTCTCTCAG 
CCTGCTGTGG TTCAACTTCA GACCCCTGGA GTTCTGCCCT CTGCTCAGCC AGTACTTGCT 
GTCACTGGCG GAGCCACACA GCTACCTAAC CATGTGGTGA ATGTGGTGCC AGCCCCGGTG 
GTGAACAGCC CGGTGAACGG AAAACTGTGT GTGACTAAAC CTGTTCTACA AAGCAGCACC 
AGAAGCACGG GTTCAGATAT TGCCGTACTG AGGAGACAGC AGCGTATGAT CAAGAACCGA 
GAGTCTGCTT GTCAGTCACG AAAGAAGAAG AAAGAGTATA TGCTAGGCCT GGAGGCCAGG 
TTGAAGGCCG CCCTCTCCGA GAATGAGCAG CTGAAGAAGG AGAATGGGTC CCTGAAGCGA 
CAGCTGGACC AGGTGGTGTC AGAGAACCAG AGGCTCAAAG TCCCAAGTCC AAAGCGCAGA 
GCTGTCTGTG TGATGATAGT ATTAGCATTT ATCATGCTGA ACTATGGGCC CATGAGCATG 
CTGGAGCAAG ATTCCAGGAG AGTGAAACCT AGTGTGAGCC CTGCCAATCA AAGGAGGCAT 
CTTTTAGAGT TTTCAGCAAA AGAAGTTAAA GACACGTCAG ATGGTGACAA CCAGAAAAAC 
AGTTACAGAT ATGATCATTC TGTGTCCAAT GACAAAGCCT TAATGGTGCT AAGTGAAGAA 
CCATTACTTT ATATCCCTCC ACCTCCATGT CAGCCCCTCA TTAACACGAC AGAGTCTCTC 
AGGTTGAACC ATGAACTTCG AGGCTGGGTT CATAGACATG AAGTGGAAAG GACCAAATCG 
AGAAGAATGA CAAATAGCCA GCAGAAAACC CGCATTCTCC AGGGTGCTCT GGAACAGGGC 
TCGAATTCTC AGCTGATGGC TGTCCAGTAC ACAGAAACCA CTAGCATCAG TAGGAATTCT 
GGGAGTGAGC TGCAGGTGTA TTACGCTTCG CCTGGAAGTT ACCAAGGCTT CTTTGACGCC 
ATCCGCAGGA GGGGAGATAC ATTTTACGTC GTATCATTTC GAAGGGATCA CCTGCTATTA 
CCAGCTACCA CCCATAACAA GACCACAAGA CCGAAGATGT CCATTGTGTT ACCAGCAATA 
AACATAAATG ATAACGTGAT CAATGGGCAG GATTATGAAG TAATGATGCA GATTGACTGT 
CAGGTCATGG ACACCAGGAT CCTCCACATC AAAAGCTCCT CGGTTCCCCC GTATCTCCGA 
GATCATCAGA GAAACCAAAC CAGCACCTTC TTCGGTTCCC CTCCCACAGC CACAGAGACG 
ACCCATGTGG TCAGCACCCT CCCTGAGTCG GTACAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008767960.1
CDS	142..2100
Translation	MESPFSPVLPHGPESTLFAELGYFTDTDDVQFDAAHETYENNFDHLNFDLDLMPWESDIWSPSSHFCSDIKAEPQPLSPASSSCSVSSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPAVVQLQTPGVLPSAQPVLAVTGGATQLPNHVVNVVPAPVVNSPVNGKLCVTKPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDQVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQDSRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKNSYRYDHSVSNDKALMVLSEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKTRILQGALEQGSNSQLMAVQYTETTSISRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTATETTHVVSTLPESVQ

Target ORF information:

RefSeq Version	XM_008769738.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008769738.2

ORF Insert Sequence:

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG AGTCCACGTT GTTTGCTGAG 
CTTGGCTATT TCACAGACAC GGATGATGTC CAGTTTGATG CAGCACATGA GACTTACGAA 
AATAATTTTG ATCATCTTAA TTTTGATTTG GATTTGATGC CTTGGGAGTC AGACATATGG 
AGCCCCAGCA GCCACTTCTG CTCAGACATT AAGGCAGAGC CCCAGCCTCT TTCTCCGGCT 
TCCTCCAGTT GTTCTGTCTC TTCTCCTCGG TCCACAGACT CCTGTTCTTC AACTCAGCAC 
GTTCCTGAGG AGTTGGACTT GTTGTCTAGT TCTCAGTCTC CCCTTTCCTT GTATGGCGAC 
AGCTGTCACA GCCCCTCCTC AGCAGAGCCA CTGAAGGAAG AGAAGCCTGT CACTGGTCCT 
GGAAACAAAA CGGAACATGG ACTGACTCCA AAGAAAAAAA TCCAGATGAG TTCAAAACCT 
TCAGTTCAGC CCAAGCCTTT GTTACTTCCA GCAGCACCCA AGACTCCAGC AAACGCCAGT 
GTCCCAGCAA AGACCATCAT CATTCAGACA CTGCCAGCCC TGATGCCACT GGCAAAGCAG 
CAGTCGATTA TCAGTATACA GCCTGCGCCC ACCAAAGGTC AGACTGTTTT GCTCTCTCAG 
CCTGCTGTGG TTCAACTTCA GACCCCTGGA GTTCTGCCCT CTGCTCAGCC AGTACTTGCT 
GTCACTGGCG GAGCCACACA GCTACCTAAC CATGTGGTGA ATGTGGTGCC AGCCCCGGTG 
GTGAACAGCC CGGTGAACGG AAAACTGTGT GTGACTAAAC CTGTTCTACA AAGCAGCACC 
AGAAGCACGG GTTCAGATAT TGCCGTACTG AGGAGACAGC AGCGTATGAT CAAGAACCGA 
GAGTCTGCTT GTCAGTCACG AAAGAAGAAG AAAGAGTATA TGCTAGGCCT GGAGGCCAGG 
TTGAAGGCCG CCCTCTCCGA GAATGAGCAG CTGAAGAAGG AGAATGGGTC CCTGAAGCGA 
CAGCTGGACC AGGTGGTGTC AGAGAACCAG AGGCTCAAAG TCCCAAGTCC AAAGCGCAGA 
GCTGTCTGTG TGATGATAGT ATTAGCATTT ATCATGCTGA ACTATGGGCC CATGAGCATG 
CTGGAGCAAG ATTCCAGGAG AGTGAAACCT AGTGTGAGCC CTGCCAATCA AAGGAGGCAT 
CTTTTAGAGT TTTCAGCAAA AGAAGTTAAA GACACGTCAG ATGGTGACAA CCAGAAAAAC 
AGTTACAGAT ATGATCATTC TGTGTCCAAT GACAAAGCCT TAATGGTGCT AAGTGAAGAA 
CCATTACTTT ATATCCCTCC ACCTCCATGT CAGCCCCTCA TTAACACGAC AGAGTCTCTC 
AGGTTGAACC ATGAACTTCG AGGCTGGGTT CATAGACATG AAGTGGAAAG GACCAAATCG 
AGAAGAATGA CAAATAGCCA GCAGAAAACC CGCATTCTCC AGGGTGCTCT GGAACAGGGC 
TCGAATTCTC AGCTGATGGC TGTCCAGTAC ACAGAAACCA CTAGCATCAG TAGGAATTCT 
GGGAGTGAGC TGCAGGTGTA TTACGCTTCG CCTGGAAGTT ACCAAGGCTT CTTTGACGCC 
ATCCGCAGGA GGGGAGATAC ATTTTACGTC GTATCATTTC GAAGGGATCA CCTGCTATTA 
CCAGCTACCA CCCATAACAA GACCACAAGA CCGAAGATGT CCATTGTGTT ACCAGCAATA 
AACATAAATG ATAACGTGAT CAATGGGCAG GATTATGAAG TAATGATGCA GATTGACTGT 
CAGGTCATGG ACACCAGGAT CCTCCACATC AAAAGCTCCT CGGTTCCCCC GTATCTCCGA 
GATCATCAGA GAAACCAAAC CAGCACCTTC TTCGGTTCCC CTCCCACAGC CACAGAGACG 
ACCCATGTGG TCAGCACCCT CCCTGAGTCG GTACAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Atf6 ( XM_017598829.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454318.1 Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58086
Clone ID Related Accession (Same CDS sequence)	XM_017598829.1
Accession Version	XM_017598829.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG GTGAAGACTG GGAGTCCACG 
TTGTTTGCTG AGCTTGGCTA TTTCACAGAC ACGGATGATG TCCAGTTTGA TGCAGCACAT 
GAGACTTACG AAAATAATTT TGATCATCTT AATTTTGATT TGGATTTGAT GCCTTGGGAG 
TCAGACATAT GGAGCCCCAG CAGCCACTTC TGCTCAGACA TTAAGGCAGA GCCCCAGCCT 
CTTTCTCCGG CTTCCTCCAG TTGTTCTGTC TCTTCTCCTC GGTCCACAGA CTCCTGTTCT 
TCAACTCAGC ACGTTCCTGA GGAGTTGGAC TTGTTGTCTA GTTCTCAGTC TCCCCTTTCC 
TTGTATGGCG ACAGCTGTCA CAGCCCCTCC TCAGCAGAGC CACTGAAGGA AGAGAAGCCT 
GTCACTGGTC CTGGAAACAA AACGGAACAT GGACTGACTC CAAAGAAAAA AATCCAGATG 
AGTTCAAAAC CTTCAGTTCA GCCCAAGCCT TTGTTACTTC CAGCAGCACC CAAGACTCCA 
GCAAACGCCA GTGTCCCAGC AAAGACCATC ATCATTCAGA CACTGCCAGC CCTGATGCCA 
CTGGCAAAGC AGCAGTCGAT TATCAGTATA CAGCCTGCGC CCACCAAAGG TCAGACTGTT 
TTGCTCTCTC AGCCTGCTGT GGTTCAACTT CAGACCCCTG GAGTTCTGCC CTCTGCTCAG 
CCAGTACTTG CTGTCACTGG CGGAGCCACA CAGCTACCTA ACCATGTGGT GAATGTGGTG 
CCAGCCCCGG TGGTGAACAG CCCGGTGAAC GGAAAACTGT GTGTGACTAA ACCTGTTCTA 
CAAAGCAGCA CCAGAAGCAC GGGTTCAGAT ATTGCCGTAC TGAGGAGACA GCAGCGTATG 
ATCAAGAACC GAGAGTCTGC TTGTCAGTCA CGAAAGAAGA AGAAAGAGTA TATGCTAGGC 
CTGGAGGCCA GGTTGAAGGC CGCCCTCTCC GAGAATGAGC AGCTGAAGAA GGAGAATGGG 
TCCCTGAAGC GACAGCTGGA CCAGGTGGTG TCAGAGAACC AGAGGCTCAA AGTCCCAAGT 
CCAAAGCGCA GAGCTGTCTG TGTGATGATA GTATTAGCAT TTATCATGCT GAACTATGGG 
CCCATGAGCA TGCTGGAGCA AGATTCCAGG AGAGTGAAAC CTAGTGTGAG CCCTGCCAAT 
CAAAGGAGGC ATCTTTTAGA GTTTTCAGCA AAAGAAGTTA AAGACACGTC AGATGGTGAC 
AACCAGAAAA ACAGTTACAG ATATGATCAT TCTGTGTCCA ATGACAAAGC CTTAATGGTG 
CTAAGTGAAG AACCATTACT TTATATCCCT CCACCTCCAT GTCAGCCCCT CATTAACACG 
ACAGAGTCTC TCAGGTTGAA CCATGAACTT CGAGGCTGGG TTCATAGACA TGAAGTGGAA 
AGGACCAAAT CGAGAAGAAT GACAAATAGC CAGCAGAAAA CCCGCATTCT CCAGGGTGCT 
CTGGAACAGG GCTCGAATTC TCAGCTGATG GCTGTCCAGT ACACAGAAAC CACTAGCATC 
AGGAATTCTG GGAGTGAGCT GCAGGTGTAT TACGCTTCGC CTGGAAGTTA CCAAGGCTTC 
TTTGACGCCA TCCGCAGGAG GGGAGATACA TTTTACGTCG TATCATTTCG AAGGGATCAC 
CTGCTATTAC CAGCTACCAC CCATAACAAG ACCACAAGAC CGAAGATGTC CATTGTGTTA 
CCAGCAATAA ACATAAATGA TAACGTGATC AATGGGCAGG ATTATGAAGT AATGATGCAG 
ATTGACTGTC AGGTCATGGA CACCAGGATC CTCCACATCA AAAGCTCCTC GGTTCCCCCG 
TATCTCCGAG ATCATCAGAG AAACCAAACC AGCACCTTCT TCGGTTCCCC TCCCACAGCC 
ACAGAGACGA CCCATGTGGT CAGCACCCTC CCTGAGTCGG TACAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454318.1
CDS	142..2109
Translation	MESPFSPVLPHGPGEDWESTLFAELGYFTDTDDVQFDAAHETYENNFDHLNFDLDLMPWESDIWSPSSHFCSDIKAEPQPLSPASSSCSVSSPRSTDSCSSTQHVPEELDLLSSSQSPLSLYGDSCHSPSSAEPLKEEKPVTGPGNKTEHGLTPKKKIQMSSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPAVVQLQTPGVLPSAQPVLAVTGGATQLPNHVVNVVPAPVVNSPVNGKLCVTKPVLQSSTRSTGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLKRQLDQVVSENQRLKVPSPKRRAVCVMIVLAFIMLNYGPMSMLEQDSRRVKPSVSPANQRRHLLEFSAKEVKDTSDGDNQKNSYRYDHSVSNDKALMVLSEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNSQQKTRILQGALEQGSNSQLMAVQYTETTSIRNSGSELQVYYASPGSYQGFFDAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININDNVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDHQRNQTSTFFGSPPTATETTHVVSTLPESVQ

Target ORF information:

RefSeq Version	XM_017598829.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activating transcription factor 6 (Atf6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598829.1

ORF Insert Sequence:

ATGGAGTCGC CTTTTAGTCC GGTTCTTCCT CATGGACCAG GTGAAGACTG GGAGTCCACG 
TTGTTTGCTG AGCTTGGCTA TTTCACAGAC ACGGATGATG TCCAGTTTGA TGCAGCACAT 
GAGACTTACG AAAATAATTT TGATCATCTT AATTTTGATT TGGATTTGAT GCCTTGGGAG 
TCAGACATAT GGAGCCCCAG CAGCCACTTC TGCTCAGACA TTAAGGCAGA GCCCCAGCCT 
CTTTCTCCGG CTTCCTCCAG TTGTTCTGTC TCTTCTCCTC GGTCCACAGA CTCCTGTTCT 
TCAACTCAGC ACGTTCCTGA GGAGTTGGAC TTGTTGTCTA GTTCTCAGTC TCCCCTTTCC 
TTGTATGGCG ACAGCTGTCA CAGCCCCTCC TCAGCAGAGC CACTGAAGGA AGAGAAGCCT 
GTCACTGGTC CTGGAAACAA AACGGAACAT GGACTGACTC CAAAGAAAAA AATCCAGATG 
AGTTCAAAAC CTTCAGTTCA GCCCAAGCCT TTGTTACTTC CAGCAGCACC CAAGACTCCA 
GCAAACGCCA GTGTCCCAGC AAAGACCATC ATCATTCAGA CACTGCCAGC CCTGATGCCA 
CTGGCAAAGC AGCAGTCGAT TATCAGTATA CAGCCTGCGC CCACCAAAGG TCAGACTGTT 
TTGCTCTCTC AGCCTGCTGT GGTTCAACTT CAGACCCCTG GAGTTCTGCC CTCTGCTCAG 
CCAGTACTTG CTGTCACTGG CGGAGCCACA CAGCTACCTA ACCATGTGGT GAATGTGGTG 
CCAGCCCCGG TGGTGAACAG CCCGGTGAAC GGAAAACTGT GTGTGACTAA ACCTGTTCTA 
CAAAGCAGCA CCAGAAGCAC GGGTTCAGAT ATTGCCGTAC TGAGGAGACA GCAGCGTATG 
ATCAAGAACC GAGAGTCTGC TTGTCAGTCA CGAAAGAAGA AGAAAGAGTA TATGCTAGGC 
CTGGAGGCCA GGTTGAAGGC CGCCCTCTCC GAGAATGAGC AGCTGAAGAA GGAGAATGGG 
TCCCTGAAGC GACAGCTGGA CCAGGTGGTG TCAGAGAACC AGAGGCTCAA AGTCCCAAGT 
CCAAAGCGCA GAGCTGTCTG TGTGATGATA GTATTAGCAT TTATCATGCT GAACTATGGG 
CCCATGAGCA TGCTGGAGCA AGATTCCAGG AGAGTGAAAC CTAGTGTGAG CCCTGCCAAT 
CAAAGGAGGC ATCTTTTAGA GTTTTCAGCA AAAGAAGTTA AAGACACGTC AGATGGTGAC 
AACCAGAAAA ACAGTTACAG ATATGATCAT TCTGTGTCCA ATGACAAAGC CTTAATGGTG 
CTAAGTGAAG AACCATTACT TTATATCCCT CCACCTCCAT GTCAGCCCCT CATTAACACG 
ACAGAGTCTC TCAGGTTGAA CCATGAACTT CGAGGCTGGG TTCATAGACA TGAAGTGGAA 
AGGACCAAAT CGAGAAGAAT GACAAATAGC CAGCAGAAAA CCCGCATTCT CCAGGGTGCT 
CTGGAACAGG GCTCGAATTC TCAGCTGATG GCTGTCCAGT ACACAGAAAC CACTAGCATC 
AGGAATTCTG GGAGTGAGCT GCAGGTGTAT TACGCTTCGC CTGGAAGTTA CCAAGGCTTC 
TTTGACGCCA TCCGCAGGAG GGGAGATACA TTTTACGTCG TATCATTTCG AAGGGATCAC 
CTGCTATTAC CAGCTACCAC CCATAACAAG ACCACAAGAC CGAAGATGTC CATTGTGTTA 
CCAGCAATAA ACATAAATGA TAACGTGATC AATGGGCAGG ATTATGAAGT AATGATGCAG 
ATTGACTGTC AGGTCATGGA CACCAGGATC CTCCACATCA AAAGCTCCTC GGTTCCCCCG 
TATCTCCGAG ATCATCAGAG AAACCAAACC AGCACCTTCT TCGGTTCCCC TCCCACAGCC 
ACAGAGACGA CCCATGTGGT CAGCACCCTC CCTGAGTCGG TACAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Science (New York, N.Y.)356(6337)(2017 05)
Yin Y,Morgunova E,Jolma A,Kaasinen E,Sahu B,Khund-Sayeed S,Das PK,Kivioja T,Dave K,Zhong F,Nitta KR,Taipale M,Popov A,Ginno PA,Domcke S,Yan J,Sch?beler D,Vinson C,Taipale J

Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1? and PERK signaling activation.
Molecular and cellular biochemistry424(1-2)111-122(2017 Jan)
Tang JY,Jin P,He Q,Lu LH,Ma JP,Gao WL,Bai HP,Yang J

Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction.
Scientific reports632449(2016 Sep)
Krawczyk KK,Ekman M,Rippe C,Grossi M,Nilsson BO,Albinsson S,Uvelius B,Sw?rd K

Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury.
International journal of molecular medicine37(5)1199-208(2016 May)
Jia W,Jian Z,Li J,Luo L,Zhao L,Zhou Y,Tang F,Xiao Y

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Atf6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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