Ppp1r15b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r15b
Entrez Gene ID	304799
Full Name	protein phosphatase 1, regulatory subunit 15B
General protein information	Preferred Names protein phosphatase 1, regulatory subunit 15B Names protein phosphatase 1 regulatory subunit 15B protein phosphatase 1, regulatory (inhibitor) subunit 15b
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107175.1	NP_001100645.1	protein phosphatase 1 regulatory subunit 15B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R15B	XP_545680.3
Bos taurus (cattle)	PPP1R15B	XP_002693950.1
Gallus gallus (chicken)	PPP1R15B	XP_003642789.2
Homo sapiens (human)	PPP1R15B	NP_116222.3
	PPP1R15B	XP_001097695.1
Pan troglodytes (chimpanzee)	PPP1R15B	XP_001159260.1
Mus musculus (house mouse)	Ppp1r15b	NP_598580.1
Rattus norvegicus (Norway rat)	Ppp1r15b	NP_001100645.1

Gene Ontology
Bibliography

Related articles in PubMed

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Kernohan KD, T?treault M, Liwak-Muir U, Geraghty MT, Qin W, Venkateswaran S, Davila J, , Holcik M, Majewski J, Richer J, Boycott KM
Human molecular genetics24(22)6293-300(2015 Nov)

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
Latreille M, Larose L
The Journal of biological chemistry281(36)26633-44(2006 Sep)

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.
Jousse C, Oyadomari S, Novoa I, Lu P, Zhang Y, Harding HP, Ron D
The Journal of cell biology163(4)767-75(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ppp1r15b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r15b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03041	NM_001107175.1 Latest version!	Rattus norvegicus protein phosphatase 1, regulatory subunit 15B (Ppp1r15b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r15b ( NM_001107175.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100645.1 Rattus norvegicus protein phosphatase 1, regulatory subunit 15B (Ppp1r15b), mRNA.

Price & Availability↑

CloneID	ORa03041
Clone ID Related Accession (Same CDS sequence)	NM_001107175.1
Accession Version	NM_001107175.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	protein phosphatase 1 regulatory subunit 15B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473958.2. On or before Oct 4, 2007 this sequence version replaced XM_222633.4, XM_001060603.1. ##Evidence-Data-START## Transcript exon combination :: CB749751.1, CB759696.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGACGG GAACACACAG GGCTCGGAAG CGGCCTACCT CTCGGATGGG CTCCTGGTTC 
CGGCTGCCCT TCCTTCGGCG TTCGCACGCC TGCACTTCCG AGTTCCCGAA GCCTTCTTCT 
CGACCAAATC TCGAGGTCTC CGCCCGGCCC GAGCCTCGGA CCAGGTACTG GACCAAATTG 
CTTTCCCAGC TCCTTGCCCT GCTCCCTAGC TTGCTCCAGA AGCTGCTTAT TTGGAGTCAG 
CTTTTCGGTG GCATGATTCC GACCAGATGG TTAGATTTTT CAGCAAGTTA CAGCGCTCTA 
AGAGCTTTGA GAGGACGGGA GGAATCAGCC GCTCCCACAG TGCAGAAATC TTTGAATTCT 
CTGCGGCTGG ACTCTTCTTC GGAAGACTTG GTTGTCAGTT CTCTTGATTG GCTAGAGGAG 
GGACTCCAGG GGCAGTGCTC GTCCTCAGAC CTGGAATTGA AATTCAAGGC CCAGGAAAGA 
GCTTTAGACT CTACAGCGCA CACTTTCCTC TTGGAGCAGC AGCTGTGGGG AGTGGAGTTG 
CTGCCCGGTA GTCTTCAAAC CGGTCTAGTC TCCCACCGAG AACTTGGCTC TTCATCCTCT 
GGGCCTCTGA GTACTCAGAG CTTGGGCAAT TTCAAGGTAG TTTCCTATCT CCTGAACCCT 
TCCTACCTGG ACTGCCTTCC CCAGTTAGAG CTGCGCTGTC AGAACAGCGT CGGAGGTGGC 
CAACTTGTGG ATTTCCGAAC ACTATCCCCA GAGAGCTGCT ACCTTTCTGA AGATGCTTGT 
CACCCTCAGC CGCTGTGTGC TGAGATGTCG GCAACTGCCT GGCGGAGGTG TCCGCCCCTC 
TCTACAGAAG GCCTGCCAGA AATCCACCAC CTTCGGATGA AACGACTAGA ATTCCTTCAG 
GCAAACAAGG GGCAAGAGTT ACCCACCCCT GACCAAGACA ATGGCTATCA TAGCCTGGAG 
GAGGAGCACT GCCTTCTCCG GATGGATCCG CAACATTGCA CAGATAAGGC AGCACAGGCA 
GTCTCCCCTG CTGGAGCCAG CCCGCAGCCC ACTGAGAAAA AAGTAGAATT GGTGGTTGAG 
GAAGTTTTAC AGAGCCCCCA GGGAAGCAGT CTGTCTTGTG AGTTAAGTGT GCAAAAAGAA 
TGTGAAGACT ACTCAGACAT AGGGGGTAAC CTTCCAGTCT CTACCAGACC AGCTTGTACC 
AACAAACTGA TAGATTATAT TTTGGGAGGA GCCTCCAGTG ACTTGGACAC CAGCTCCGAT 
TCTGAAAGTG AGGATTGGGA TGAGGAACCT GAGGATGATG GTTTTGATAG TGATGGCTCC 
CTATCTGAAT CAGACAGGGA ACAAGACTCC GAAGGGCTTC ACCTTTGGAA CTCTTTCTAC 
AGTGTAGATC CTTACAACCC CCAGAACTTT ACAGCCACAA TTCAGACTGC TGCCAGAATT 
GCCCCCAGAG ACCCATCTGA TTCAGAGAAG TCCTGGTCTG GCAACTCTGA TGTAGGGAGT 
TCTCAGGCCA CACTCCTTCC CCAGACCCCT GACCAGAGTT CCGGGGAGGA GGATGACTGG 
GAATCCAGTG CAGATGAAGC AGAAAATCTT AGATTGTGGA ACTCTTTCTG TAATTCTGAG 
GACCCCTACA ACCTTTTAAA TTTTAAGGCT CCTTTCCAAA CGTCAGGGAA GAGCTGGAAA 
GGCAGTCAGG CATCCTCTGA GGCCACAGTG GTCTTTTCTG GGCATCAGAC CTTACTTTCT 
TGTGAGGCAC AACTGTTAGA GAGCCAAGAA GACAATTGTC CAGGCTGTGG GCTGGGTGAG 
GCACTTTCTG GAGAAAGATA CACCCATATC AAGAGAAAAA AGGTAACCTT CCTTGAAGAA 
GTTACTGAGT ATTATATAAG TGGTGATGAG GATCGCAAAG GACCATGGGA AGAATTTGCA 
AGGGATGGAT GCAGGTTCCA GAAACGAATT CAGGAAACAG AAGTCGCCAT TGGCTACTGC 
TTGACATTTG AGCATAGAGA AAGAGTGTTT AGTAGACTGC AAGACCACGT TTCAAAGGAC 
TTACTGTTGT ACAGCAGTGC TAAGCAGAGG GAGCAGCCTG CAGCCCTCAC CCACTCCATC 
TCTTACTTGA GAGGTTTCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100645.1
CDS	444..2567
Translation	METGTHRARKRPTSRMGSWFRLPFLRRSHACTSEFPKPSSRPNLEVSARPEPRTRYWTKLLSQLLALLPSLLQKLLIWSQLFGGMIPTRWLDFSASYSALRALRGREESAAPTVQKSLNSLRLDSSSEDLVVSSLDWLEEGLQGQCSSSDLELKFKAQERALDSTAHTFLLEQQLWGVELLPGSLQTGLVSHRELGSSSSGPLSTQSLGNFKVVSYLLNPSYLDCLPQLELRCQNSVGGGQLVDFRTLSPESCYLSEDACHPQPLCAEMSATAWRRCPPLSTEGLPEIHHLRMKRLEFLQANKGQELPTPDQDNGYHSLEEEHCLLRMDPQHCTDKAAQAVSPAGASPQPTEKKVELVVEEVLQSPQGSSLSCELSVQKECEDYSDIGGNLPVSTRPACTNKLIDYILGGASSDLDTSSDSESEDWDEEPEDDGFDSDGSLSESDREQDSEGLHLWNSFYSVDPYNPQNFTATIQTAARIAPRDPSDSEKSWSGNSDVGSSQATLLPQTPDQSSGEEDDWESSADEAENLRLWNSFCNSEDPYNLLNFKAPFQTSGKSWKGSQASSEATVVFSGHQTLLSCEAQLLESQEDNCPGCGLGEALSGERYTHIKRKKVTFLEEVTEYYISGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLTFEHRERVFSRLQDHVSKDLLLYSSAKQREQPAALTHSISYLRGFS

Target ORF information:

RefSeq Version	NM_001107175.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein phosphatase 1, regulatory subunit 15B (Ppp1r15b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107175.1

ORF Insert Sequence:

ATGGAGACGG GAACACACAG GGCTCGGAAG CGGCCTACCT CTCGGATGGG CTCCTGGTTC 
CGGCTGCCCT TCCTTCGGCG TTCGCACGCC TGCACTTCCG AGTTCCCGAA GCCTTCTTCT 
CGACCAAATC TCGAGGTCTC CGCCCGGCCC GAGCCTCGGA CCAGGTACTG GACCAAATTG 
CTTTCCCAGC TCCTTGCCCT GCTCCCTAGC TTGCTCCAGA AGCTGCTTAT TTGGAGTCAG 
CTTTTCGGTG GCATGATTCC GACCAGATGG TTAGATTTTT CAGCAAGTTA CAGCGCTCTA 
AGAGCTTTGA GAGGACGGGA GGAATCAGCC GCTCCCACAG TGCAGAAATC TTTGAATTCT 
CTGCGGCTGG ACTCTTCTTC GGAAGACTTG GTTGTCAGTT CTCTTGATTG GCTAGAGGAG 
GGACTCCAGG GGCAGTGCTC GTCCTCAGAC CTGGAATTGA AATTCAAGGC CCAGGAAAGA 
GCTTTAGACT CTACAGCGCA CACTTTCCTC TTGGAGCAGC AGCTGTGGGG AGTGGAGTTG 
CTGCCCGGTA GTCTTCAAAC CGGTCTAGTC TCCCACCGAG AACTTGGCTC TTCATCCTCT 
GGGCCTCTGA GTACTCAGAG CTTGGGCAAT TTCAAGGTAG TTTCCTATCT CCTGAACCCT 
TCCTACCTGG ACTGCCTTCC CCAGTTAGAG CTGCGCTGTC AGAACAGCGT CGGAGGTGGC 
CAACTTGTGG ATTTCCGAAC ACTATCCCCA GAGAGCTGCT ACCTTTCTGA AGATGCTTGT 
CACCCTCAGC CGCTGTGTGC TGAGATGTCG GCAACTGCCT GGCGGAGGTG TCCGCCCCTC 
TCTACAGAAG GCCTGCCAGA AATCCACCAC CTTCGGATGA AACGACTAGA ATTCCTTCAG 
GCAAACAAGG GGCAAGAGTT ACCCACCCCT GACCAAGACA ATGGCTATCA TAGCCTGGAG 
GAGGAGCACT GCCTTCTCCG GATGGATCCG CAACATTGCA CAGATAAGGC AGCACAGGCA 
GTCTCCCCTG CTGGAGCCAG CCCGCAGCCC ACTGAGAAAA AAGTAGAATT GGTGGTTGAG 
GAAGTTTTAC AGAGCCCCCA GGGAAGCAGT CTGTCTTGTG AGTTAAGTGT GCAAAAAGAA 
TGTGAAGACT ACTCAGACAT AGGGGGTAAC CTTCCAGTCT CTACCAGACC AGCTTGTACC 
AACAAACTGA TAGATTATAT TTTGGGAGGA GCCTCCAGTG ACTTGGACAC CAGCTCCGAT 
TCTGAAAGTG AGGATTGGGA TGAGGAACCT GAGGATGATG GTTTTGATAG TGATGGCTCC 
CTATCTGAAT CAGACAGGGA ACAAGACTCC GAAGGGCTTC ACCTTTGGAA CTCTTTCTAC 
AGTGTAGATC CTTACAACCC CCAGAACTTT ACAGCCACAA TTCAGACTGC TGCCAGAATT 
GCCCCCAGAG ACCCATCTGA TTCAGAGAAG TCCTGGTCTG GCAACTCTGA TGTAGGGAGT 
TCTCAGGCCA CACTCCTTCC CCAGACCCCT GACCAGAGTT CCGGGGAGGA GGATGACTGG 
GAATCCAGTG CAGATGAAGC AGAAAATCTT AGATTGTGGA ACTCTTTCTG TAATTCTGAG 
GACCCCTACA ACCTTTTAAA TTTTAAGGCT CCTTTCCAAA CGTCAGGGAA GAGCTGGAAA 
GGCAGTCAGG CATCCTCTGA GGCCACAGTG GTCTTTTCTG GGCATCAGAC CTTACTTTCT 
TGTGAGGCAC AACTGTTAGA GAGCCAAGAA GACAATTGTC CAGGCTGTGG GCTGGGTGAG 
GCACTTTCTG GAGAAAGATA CACCCATATC AAGAGAAAAA AGGTAACCTT CCTTGAAGAA 
GTTACTGAGT ATTATATAAG TGGTGATGAG GATCGCAAAG GACCATGGGA AGAATTTGCA 
AGGGATGGAT GCAGGTTCCA GAAACGAATT CAGGAAACAG AAGTCGCCAT TGGCTACTGC 
TTGACATTTG AGCATAGAGA AAGAGTGTTT AGTAGACTGC AAGACCACGT TTCAAAGGAC 
TTACTGTTGT ACAGCAGTGC TAAGCAGAGG GAGCAGCCTG CAGCCCTCAC CCACTCCATC 
TCTTACTTGA GAGGTTTCTC TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Human molecular genetics24(22)6293-300(2015 Nov)
Kernohan KD,T?treault M,Liwak-Muir U,Geraghty MT,Qin W,Venkateswaran S,Davila J,,Holcik M,Majewski J,Richer J,Boycott KM

Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
The Journal of biological chemistry281(36)26633-44(2006 Sep)
Latreille M,Larose L

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells.
The Journal of cell biology163(4)767-75(2003 Nov)
Jousse C,Oyadomari S,Novoa I,Lu P,Zhang Y,Harding HP,Ron D

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Ppp1r15b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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