Tiam1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tiam1
Entrez Gene ID	304109
Full Name	T-cell lymphoma invasion and metastasis 1
General protein information	Preferred Names T-cell lymphoma invasion and metastasis 1 Names T-lymphoma invasion and metastasis-inducing protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001100558.1	NP_001094028.1	T-lymphoma invasion and metastasis-inducing protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	TIAM1	NP_003244.2
Canis lupus familiaris (dog)	TIAM1	XP_005638879.1
Pan troglodytes (chimpanzee)	TIAM1	XP_531420.2
	TIAM1	XP_001098107.1
Danio rerio (zebrafish)	tiam1a	XP_005155445.1
Xenopus tropicalis (tropical clawed frog)	tiam1	XP_002938487.1
Mus musculus (house mouse)	Tiam1	NP_033410.2
Gallus gallus (chicken)	TIAM1	XP_416699.2
Danio rerio (zebrafish)	LOC100330358	XP_002664748.3
Bos taurus (cattle)	TIAM1	XP_003585664.2
Rattus norvegicus (Norway rat)	Tiam1	NP_001094028.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Blanco-Su?rez E, Fiuza M, Liu X, Chakkarapani E, Hanley JG
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism34(12)1898-906(2014 Dec)

miR-29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression and inhibiting epithelial-mesenchymal transition.
Wang B, Li W, Liu H, Yang L, Liao Q, Cui S, Wang H, Zhao L
Cell death & disease5e1335(2014 Jul)

Rho GTPases in insulin-stimulated glucose uptake.
Satoh T
Small GTPases5e28102(2014)

NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.
Xiao L, Hu C, Yang W, Guo D, Li C, Shen W, Liu X, Aijun H, Dan W, He C
Glia61(12)2078-99(2013 Dec)

Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han MH, Cheer JF, Dietz DM, Lobo MK
Frontiers in molecular neuroscience613(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We show that Rac1 and the Rac guanine nucleotide exchange factor (GEF) Tiam1 are differentially activated by oxygen-glucose deprivation in hippocampal and cortical neurons.
Title: Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.

our result suggests a critical role of NMDAR in regulation of oligodendrocyte precursor cells migration during CNS development by coupling to and activating the Tiam1/Rac1 pathway.
Title: NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.

MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1.
Title: The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.

Tiam1 mediates TrkA signaling and neurite outgrowth induced by NGF
Title: Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth.

siRNA-mediated knock-down of Tiam1 markedly inhibited glucose-induced membrane trafficking and activation of Rac1.
Title: Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.

The following Tiam1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tiam1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02903	NM_001100558.1 Latest version!	Rattus norvegicus TIAM Rac1 associated GEF 1 (Tiam1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tiam1 ( NM_001100558.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001094028.1 Rattus norvegicus TIAM Rac1 associated GEF 1 (Tiam1), mRNA.

Price & Availability↑

CloneID	ORa02903
Clone ID Related Accession (Same CDS sequence)	NM_001100558.1
Accession Version	NM_001100558.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4773bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-16
Organism	Rattus norvegicus(Norway rat)
Product	T-lymphoma invasion and metastasis-inducing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CH473989.1. On or before Dec 19, 2009 this sequence version replaced XM_221672.4, XM_001072877.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGAAACG CAGAAAGCCA AAATGTAGAC CACGAGTTTT ATGGAGAAAA GCATGCCAGC 
CTGGGGCGGA AGCACACATC ACGCTCCCTG CGACTGTCAC ACAAGACCCG GAGGACGCGG 
CATGCTTCCT CTGGGAAGGC AATCCACAGG AACTCTGAAG TGAGCACGCG GTCCAGCAGC 
ACCCCTAGCA TCCCCCAGTC CCTGGCCGAA AATGGCTTGG AGCCCTTTTC CCAAGAAGGC 
GCCCTAGACG ACTTCGGGGA CCCCATCTGG GTGGACCGAG TGGATATGGG CTTGAGACCC 
GTGTCTTACA CGGATTCTTC TGTCACTCCC AGCGTAGACG GCAGCATCGT CCTCACGGCA 
GCCTCTGTGC AGAGCATGCC AGACTCGGAG GAGAGCCGGC TTTACGGGGA TGACGCTGCG 
TACTTGGCTG AGGGAGGCAG GAGGCAGCGT CCCTATACAT CCAACGGGCC CACGTTCATG 
GAGACAGCGA GCTTTAAGAA GAAACGCTCT AAATCTGCAG ACATCTGGCG GGAGGACAGC 
CTGGAGTTCT CACTCTCAGA TCTGAGCCAA GAACATTTAA CAAGCAACGA AGAAATCTTG 
GGCTCCGCGG AAGAGAAGGA TTGCGAGGAG GCTCGGGGGA TGGAAACAGG GGCGAGCCCC 
CGGCAGCTCA GCACCTGTCA GCGAGCCAAC TCCCTGGGTG ACTTGTATGC TCAGAAGAAC 
TCCGGGGTGA AGGCTAACGG AGGACCGAGA AACAGATTTT CGAGCTACTG CCGGAATTTG 
GTGTCGGATA TTCCCGATCT TGCAAAGCAT AAGATGCCAC CGGCTGCTGT AGAGACTCCG 
ACGTACAGTA ATTATAACAC GCTTCCCTGT AGGAAGTCGC ACTGTCTTTC CGAGGGTGCC 
ACCAACCCAC AAATTAGCCT TAGCAAGAGC ATGCAAGGCA GAAGAGCGAA AACCACCCAG 
GATGTTAACA CAGGCGAGGG CAGTGAGTTT GCAGACAGTG GGATCGAAGG GGCCACCACG 
GACACGGACC TCCTGTCCAG GAGATCCAAT GCCACCAACT CCAGCTACTC GCCTCCCACA 
GGCCGAGCCT TTGTGGGCAG CGACAGCGGC AGCAGTTCGA CTGGGGATGC TGCACGCCAG 
GGGGTGTACG AGAACTTCAG GCGGGAACTG GAGATGAGCA CCACCAACAG CGAGAGCCTG 
GAGGAGGCTG GCTCTGCGCA CAGCGACGAG CAGAGCAGCG GAACCCTCAG CTCCCCGGGC 
CAGTCGGACA TCCTGCTGAC GGCTGCGCAG GGCACTGTGC GGAAGGCTGG CGCGCTGGCA 
GTCAAGAACT TCCTGGTACA TAAGAAGAAT AAGAAGGTGG AGTCGGCTAC CCGGAGGAAG 
TGGAAGCACT ACTGGGTGTC CCTGAAAGGT TGCACGCTCT TTTTCTACGA GAGTGATGGC 
AGGTCTGGGA TAGACCACAA CAGTGTCCCC AAGCATGCTG TCTGGGTGGA GAACAGCATC 
GTGCAGGCCG TACCTGAGCA CCCCAAGAAA GATTTTGTCT TCTGCCTCAG CAACTCCCTG 
GGCGATGCCT TCCTCTTCCA GACCACCAGC CAGACAGAGC TGGAGAACTG GATCACGGCC 
ATCCACTCTG CCTGCGCAGC TGCGGTCGCA AGGCACCACC ACAAGGAAGA CACGCTCCGC 
CTCCTCAAGT CGGAAATCAA GAAGCTGGAG CAAAAGATTG ACATGGACGA GAAAATGAAG 
AAGATGGGCG AGATGCAGCT GTCCTCCGTC ACGGACGCGA AGAAGAAGAA GACCATACTT 
GACCAGATCT TCGTTTGGGA GCAGAACCTC GAACAGTTCC AGATGGACCT TTTCCGGTTC 
CGCTGTTACC TTGCCAGCCT CCAGGGCGGG GAGCTGCCAA ACCCCAAACG ACTCCTAGGT 
TTTGCCAGCC GGCCCACCAA GGTGGCCATG GGCCGCCTTG GCATCTTTTC GGTATCATCT 
TTTCACGCCC TGGTGGCGGC CCGCACTGGC GAGATCGGGG TGAGAAGGCG TACTCAGGCT 
ATGTCCAGGT CTGCGAGCAA GCGGAGGAGC AGGTTTTCTT CTCTCTGGGG CCTAGACACT 
ACCTCCAAAA AGAAGCAGGG GCGCCCAACC ATCAACCAGG TGTTTGGAGA GGGGACCGAT 
GCTGTAAAGA GATCTTTAGA GGGAATATTT GATGACTCTG TTCCAGACGG CAAGAGGGAG 
AAGGAAGTGG TCTTACCCAG TGTCCACCAG CACAATCCTG ACTGTGACAT TTGGGTCCAT 
GAATATTTCA CTCCATCCTG GTTCTGTCTA CCCAATAATC AGCCAGCCTT GACGGTTGTC 
CGGCCGGGGG ACACTGCGAG GGACACCTTG GAGCTCATTT GCAAGGCGCA CCAACTGGAT 
CATTCTGCCC ATTACCTGCG CCTGAAATTT CTGATGGAGA ACAAGATGCA GTTCTATGTC 
CCGCAACCCG AGGAGGACAT TTACGAGCTG CTTTACAAAG AAATCGAAAT CTGTCCGAAA 
GTCACCCAGA ACATCCACAT TGAGAAGTCC GACGCGGCCG CCGATAATTA CGGGTTTTTG 
CTTTCTTCTG TGGACGAAGA TGGCGTTCGA AGGCTCTACG TGAACAGCGT CAAGGAAACC 
GGGCTAGCTT CCAAGAAAGG CCTGAAGGCG GGGGACGAGA TTCTTCAGAT CAATAACCGT 
GCCGCTGGTA CCCTGAACTC ATCTATGCTC AAAGATTTCC TCTCACAGCC CTCTCTGGGC 
CTCCTGGTGA GGACCTACCC TGAGCCAGAG GGAGGAGTGG AGCTGCTAGA GAACCCACCC 
CACCGAGTGG ACGGCCCTGT GGACCTTGGC GAGAGCCCCC TCACCTTCCT CACCAGCAAC 
CCAGGGCACA GCCTCTCCAG CGAGCAGGGC AGCAGTGCTG AGACAGCTCC GGAAGAGGGC 
GAAGGACCGG ACTTGGAGTC TTCCGATGAG ACAGATCACA GCAGCAAGAG CACAGAACAG 
GTCACAGCGT TTTGCCGGAG TCTGCACGAG ATGAGCCCCT CTGACTCGAG CCCGTCCCCT 
CAGGATGCCA CGAGCCCTCA GCTGGCAACC ACACGACAGC TATCGGACGC AGATAAACTG 
CGCAAGGTGA TCTGTGAGCT CCTAGAGACC GAACGCACCT ATGTGAAGGA CTTAAACTGC 
CTCATGGAGA GATACCTGAA GCCCCTTCAG AAGGAGACCT TTCTCACCCA GGATGAGCTC 
GATGTACTCT TTGGAAATTT AACCGAAATG GTGGAGTTTC AAGTTGAGTT CCTTAAAACT 
CTAGAAGATG GAGTTAGACT GGTCCCTGAC TTGGAAAAGC TTGAGAAGGT TGACCAGTTT 
AAGAAAGTGC TGTTCTCTCT GGGGGGATCC TTCCTGTACT ACGCGGACCG CTTCAAGCTC 
TACAGTGCCT TCTGTGCGAG CCATACGAAA GTCCCCAAGG TCCTGGTGAA AGCCAAGACG 
GACACAGCCT TCAAGGCATT CCTAGATGCC CAGAACCCGA GGCAGCAGCA CTCGTCCACA 
CTAGAGTCTT ACCTCATCAA GCCCATCCAG AGGGTCCTCA AGTACCCGCT TCTGCTCAGG 
GAGCTGTTTG CGCTGACCGA CGCGGAGAGT GAGGAGCATT ACCACCTGGA TGTGGCCATC 
AAGACTATGA ACAAGGTTGC CAGTCACATC AATGAGATGC AGAAGATCCA CGAAGAATTT 
GGTGCTGTGT TCGACCAGCT GATTGCTGAG CAGACAGGAG AGAAGAAAGA GGTCGCGGAT 
CTGAGCATGG GTGACCTGCT GTTGCACACC AGTGTCATCT GGCTGAACCC ACCCGCCTCG 
CTGGGAAAGT GGAAAAAGGA GCCGGAACTG GCAGCCTTCG TCTTCAAAAC TGCCGTGGTC 
CTTGTGTATA AAGATGGTTC CAAGCAGAAG AAGAAGCTCG TTGGCTCTCA CAGGCTGTCA 
ATCTACGAGG AGTGGGACCC TTTCCGGTTT CGCCACATGA TCCCTACCGA AGCTTTGCAA 
GTCCGAGCTC TGCCCAGTGC AGATGCAGAG GCAAATGCCG TGTGTGAAAT TGTCCACGTG 
AAATCAGAGT CAGAGGGGAG GCCGGAGCGG GTTTTCCACC TCTGCTGCAG CTCCCCGGAG 
AGCCGAAAGG ATTTTCTGAA GTCTGTACAC TCCATCCTGC GAGATAAGCA CAGAAGGCAG 
CTCCTCAAAA CGGAAAGTCT TCCCTCAGCC CAGCAGTATG TCCCTTTTGG AGGCAAGAGA 
TTGTGTGCGC TTAAAGGCGC CAGGCCAGCC ATGAGCAGGG CAGTGTCTGC CCCAAGCAAG 
TCTCTTGGGA GGAGGAGGCG GCGACTGGCC CGAAACAGGT TTACCATTGA TTCAGACGCC 
ATCTCAGCCA GCAGCCCGGA GAAAGAGCCC CAGCAGCCCC CCGGTGGCGG GGACACTGAC 
CGATGGGTAG AGGAACAGTT TGATCTTGCT CAGTATGAGG AGCAGGATGA CATCAAGGAG 
ACAGACATCC TCAGTGACGA TGATGAATTC TGTGAGTCTG CGAAGGGCGC CTCAGTGGAC 
ATAGACCTGC AGGAGCAGCT TCAGGCTGCC TCTATCAGTC AGCGCGCCCG AGGCCGGAAA 
ACCCTTGATA GCCACGCCTC CCGCATGACA CAGCTCAAGA AGCAAGCGGC CCTTTCGGGC 
ATCAACGGAG GCCTGGAGAG TGCGAGCGAG GAGGTCATTT GGGTTAGGCG CGAAGACTTT 
GCCCCCTCCA GGAAACTGAA CACAGAGATA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001094028.1
CDS	182..4954
Translation	MGNAESQNVDHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKAIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQEGALDDFGDPIWVDRVDMGLRPVSYTDSSVTPSVDGSIVLTAASVQSMPDSEESRLYGDDAAYLAEGGRRQRPYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEEARGMETGASPRQLSTCQRANSLGDLYAQKNSGVKANGGPRNRFSSYCRNLVSDIPDLAKHKMPPAAVETPTYSNYNTLPCRKSHCLSEGATNPQISLSKSMQGRRAKTTQDVNTGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPPTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSPGQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSVPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAFLFQTTSQTELENWITAIHSACAAAVARHHHKEDTLRLLKSEIKKLEQKIDMDEKMKKMGEMQLSSVTDAKKKKTILDQIFVWEQNLEQFQMDLFRFRCYLASLQGGELPNPKRLLGFASRPTKVAMGRLGIFSVSSFHALVAARTGEIGVRRRTQAMSRSASKRRSRFSSLWGLDTTSKKKQGRPTINQVFGEGTDAVKRSLEGIFDDSVPDGKREKEVVLPSVHQHNPDCDIWVHEYFTPSWFCLPNNQPALTVVRPGDTARDTLELICKAHQLDHSAHYLRLKFLMENKMQFYVPQPEEDIYELLYKEIEICPKVTQNIHIEKSDAAADNYGFLLSSVDEDGVRRLYVNSVKETGLASKKGLKAGDEILQINNRAAGTLNSSMLKDFLSQPSLGLLVRTYPEPEGGVELLENPPHRVDGPVDLGESPLTFLTSNPGHSLSSEQGSSAETAPEEGEGPDLESSDETDHSSKSTEQVTAFCRSLHEMSPSDSSPSPQDATSPQLATTRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCASHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPIQRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGEKKEVADLSMGDLLLHTSVIWLNPPASLGKWKKEPELAAFVFKTAVVLVYKDGSKQKKKLVGSHRLSIYEEWDPFRFRHMIPTEALQVRALPSADAEANAVCEIVHVKSESEGRPERVFHLCCSSPESRKDFLKSVHSILRDKHRRQLLKTESLPSAQQYVPFGGKRLCALKGARPAMSRAVSAPSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPPGGGDTDRWVEEQFDLAQYEEQDDIKETDILSDDDEFCESAKGASVDIDLQEQLQAASISQRARGRKTLDSHASRMTQLKKQAALSGINGGLESASEEVIWVRREDFAPSRKLNTEI

Target ORF information:

RefSeq Version	NM_001100558.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus TIAM Rac1 associated GEF 1 (Tiam1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001100558.1

ORF Insert Sequence:

ATGGGAAACG CAGAAAGCCA AAATGTAGAC CACGAGTTTT ATGGAGAAAA GCATGCCAGC 
CTGGGGCGGA AGCACACATC ACGCTCCCTG CGACTGTCAC ACAAGACCCG GAGGACGCGG 
CATGCTTCCT CTGGGAAGGC AATCCACAGG AACTCTGAAG TGAGCACGCG GTCCAGCAGC 
ACCCCTAGCA TCCCCCAGTC CCTGGCCGAA AATGGCTTGG AGCCCTTTTC CCAAGAAGGC 
GCCCTAGACG ACTTCGGGGA CCCCATCTGG GTGGACCGAG TGGATATGGG CTTGAGACCC 
GTGTCTTACA CGGATTCTTC TGTCACTCCC AGCGTAGACG GCAGCATCGT CCTCACGGCA 
GCCTCTGTGC AGAGCATGCC AGACTCGGAG GAGAGCCGGC TTTACGGGGA TGACGCTGCG 
TACTTGGCTG AGGGAGGCAG GAGGCAGCGT CCCTATACAT CCAACGGGCC CACGTTCATG 
GAGACAGCGA GCTTTAAGAA GAAACGCTCT AAATCTGCAG ACATCTGGCG GGAGGACAGC 
CTGGAGTTCT CACTCTCAGA TCTGAGCCAA GAACATTTAA CAAGCAACGA AGAAATCTTG 
GGCTCCGCGG AAGAGAAGGA TTGCGAGGAG GCTCGGGGGA TGGAAACAGG GGCGAGCCCC 
CGGCAGCTCA GCACCTGTCA GCGAGCCAAC TCCCTGGGTG ACTTGTATGC TCAGAAGAAC 
TCCGGGGTGA AGGCTAACGG AGGACCGAGA AACAGATTTT CGAGCTACTG CCGGAATTTG 
GTGTCGGATA TTCCCGATCT TGCAAAGCAT AAGATGCCAC CGGCTGCTGT AGAGACTCCG 
ACGTACAGTA ATTATAACAC GCTTCCCTGT AGGAAGTCGC ACTGTCTTTC CGAGGGTGCC 
ACCAACCCAC AAATTAGCCT TAGCAAGAGC ATGCAAGGCA GAAGAGCGAA AACCACCCAG 
GATGTTAACA CAGGCGAGGG CAGTGAGTTT GCAGACAGTG GGATCGAAGG GGCCACCACG 
GACACGGACC TCCTGTCCAG GAGATCCAAT GCCACCAACT CCAGCTACTC GCCTCCCACA 
GGCCGAGCCT TTGTGGGCAG CGACAGCGGC AGCAGTTCGA CTGGGGATGC TGCACGCCAG 
GGGGTGTACG AGAACTTCAG GCGGGAACTG GAGATGAGCA CCACCAACAG CGAGAGCCTG 
GAGGAGGCTG GCTCTGCGCA CAGCGACGAG CAGAGCAGCG GAACCCTCAG CTCCCCGGGC 
CAGTCGGACA TCCTGCTGAC GGCTGCGCAG GGCACTGTGC GGAAGGCTGG CGCGCTGGCA 
GTCAAGAACT TCCTGGTACA TAAGAAGAAT AAGAAGGTGG AGTCGGCTAC CCGGAGGAAG 
TGGAAGCACT ACTGGGTGTC CCTGAAAGGT TGCACGCTCT TTTTCTACGA GAGTGATGGC 
AGGTCTGGGA TAGACCACAA CAGTGTCCCC AAGCATGCTG TCTGGGTGGA GAACAGCATC 
GTGCAGGCCG TACCTGAGCA CCCCAAGAAA GATTTTGTCT TCTGCCTCAG CAACTCCCTG 
GGCGATGCCT TCCTCTTCCA GACCACCAGC CAGACAGAGC TGGAGAACTG GATCACGGCC 
ATCCACTCTG CCTGCGCAGC TGCGGTCGCA AGGCACCACC ACAAGGAAGA CACGCTCCGC 
CTCCTCAAGT CGGAAATCAA GAAGCTGGAG CAAAAGATTG ACATGGACGA GAAAATGAAG 
AAGATGGGCG AGATGCAGCT GTCCTCCGTC ACGGACGCGA AGAAGAAGAA GACCATACTT 
GACCAGATCT TCGTTTGGGA GCAGAACCTC GAACAGTTCC AGATGGACCT TTTCCGGTTC 
CGCTGTTACC TTGCCAGCCT CCAGGGCGGG GAGCTGCCAA ACCCCAAACG ACTCCTAGGT 
TTTGCCAGCC GGCCCACCAA GGTGGCCATG GGCCGCCTTG GCATCTTTTC GGTATCATCT 
TTTCACGCCC TGGTGGCGGC CCGCACTGGC GAGATCGGGG TGAGAAGGCG TACTCAGGCT 
ATGTCCAGGT CTGCGAGCAA GCGGAGGAGC AGGTTTTCTT CTCTCTGGGG CCTAGACACT 
ACCTCCAAAA AGAAGCAGGG GCGCCCAACC ATCAACCAGG TGTTTGGAGA GGGGACCGAT 
GCTGTAAAGA GATCTTTAGA GGGAATATTT GATGACTCTG TTCCAGACGG CAAGAGGGAG 
AAGGAAGTGG TCTTACCCAG TGTCCACCAG CACAATCCTG ACTGTGACAT TTGGGTCCAT 
GAATATTTCA CTCCATCCTG GTTCTGTCTA CCCAATAATC AGCCAGCCTT GACGGTTGTC 
CGGCCGGGGG ACACTGCGAG GGACACCTTG GAGCTCATTT GCAAGGCGCA CCAACTGGAT 
CATTCTGCCC ATTACCTGCG CCTGAAATTT CTGATGGAGA ACAAGATGCA GTTCTATGTC 
CCGCAACCCG AGGAGGACAT TTACGAGCTG CTTTACAAAG AAATCGAAAT CTGTCCGAAA 
GTCACCCAGA ACATCCACAT TGAGAAGTCC GACGCGGCCG CCGATAATTA CGGGTTTTTG 
CTTTCTTCTG TGGACGAAGA TGGCGTTCGA AGGCTCTACG TGAACAGCGT CAAGGAAACC 
GGGCTAGCTT CCAAGAAAGG CCTGAAGGCG GGGGACGAGA TTCTTCAGAT CAATAACCGT 
GCCGCTGGTA CCCTGAACTC ATCTATGCTC AAAGATTTCC TCTCACAGCC CTCTCTGGGC 
CTCCTGGTGA GGACCTACCC TGAGCCAGAG GGAGGAGTGG AGCTGCTAGA GAACCCACCC 
CACCGAGTGG ACGGCCCTGT GGACCTTGGC GAGAGCCCCC TCACCTTCCT CACCAGCAAC 
CCAGGGCACA GCCTCTCCAG CGAGCAGGGC AGCAGTGCTG AGACAGCTCC GGAAGAGGGC 
GAAGGACCGG ACTTGGAGTC TTCCGATGAG ACAGATCACA GCAGCAAGAG CACAGAACAG 
GTCACAGCGT TTTGCCGGAG TCTGCACGAG ATGAGCCCCT CTGACTCGAG CCCGTCCCCT 
CAGGATGCCA CGAGCCCTCA GCTGGCAACC ACACGACAGC TATCGGACGC AGATAAACTG 
CGCAAGGTGA TCTGTGAGCT CCTAGAGACC GAACGCACCT ATGTGAAGGA CTTAAACTGC 
CTCATGGAGA GATACCTGAA GCCCCTTCAG AAGGAGACCT TTCTCACCCA GGATGAGCTC 
GATGTACTCT TTGGAAATTT AACCGAAATG GTGGAGTTTC AAGTTGAGTT CCTTAAAACT 
CTAGAAGATG GAGTTAGACT GGTCCCTGAC TTGGAAAAGC TTGAGAAGGT TGACCAGTTT 
AAGAAAGTGC TGTTCTCTCT GGGGGGATCC TTCCTGTACT ACGCGGACCG CTTCAAGCTC 
TACAGTGCCT TCTGTGCGAG CCATACGAAA GTCCCCAAGG TCCTGGTGAA AGCCAAGACG 
GACACAGCCT TCAAGGCATT CCTAGATGCC CAGAACCCGA GGCAGCAGCA CTCGTCCACA 
CTAGAGTCTT ACCTCATCAA GCCCATCCAG AGGGTCCTCA AGTACCCGCT TCTGCTCAGG 
GAGCTGTTTG CGCTGACCGA CGCGGAGAGT GAGGAGCATT ACCACCTGGA TGTGGCCATC 
AAGACTATGA ACAAGGTTGC CAGTCACATC AATGAGATGC AGAAGATCCA CGAAGAATTT 
GGTGCTGTGT TCGACCAGCT GATTGCTGAG CAGACAGGAG AGAAGAAAGA GGTCGCGGAT 
CTGAGCATGG GTGACCTGCT GTTGCACACC AGTGTCATCT GGCTGAACCC ACCCGCCTCG 
CTGGGAAAGT GGAAAAAGGA GCCGGAACTG GCAGCCTTCG TCTTCAAAAC TGCCGTGGTC 
CTTGTGTATA AAGATGGTTC CAAGCAGAAG AAGAAGCTCG TTGGCTCTCA CAGGCTGTCA 
ATCTACGAGG AGTGGGACCC TTTCCGGTTT CGCCACATGA TCCCTACCGA AGCTTTGCAA 
GTCCGAGCTC TGCCCAGTGC AGATGCAGAG GCAAATGCCG TGTGTGAAAT TGTCCACGTG 
AAATCAGAGT CAGAGGGGAG GCCGGAGCGG GTTTTCCACC TCTGCTGCAG CTCCCCGGAG 
AGCCGAAAGG ATTTTCTGAA GTCTGTACAC TCCATCCTGC GAGATAAGCA CAGAAGGCAG 
CTCCTCAAAA CGGAAAGTCT TCCCTCAGCC CAGCAGTATG TCCCTTTTGG AGGCAAGAGA 
TTGTGTGCGC TTAAAGGCGC CAGGCCAGCC ATGAGCAGGG CAGTGTCTGC CCCAAGCAAG 
TCTCTTGGGA GGAGGAGGCG GCGACTGGCC CGAAACAGGT TTACCATTGA TTCAGACGCC 
ATCTCAGCCA GCAGCCCGGA GAAAGAGCCC CAGCAGCCCC CCGGTGGCGG GGACACTGAC 
CGATGGGTAG AGGAACAGTT TGATCTTGCT CAGTATGAGG AGCAGGATGA CATCAAGGAG 
ACAGACATCC TCAGTGACGA TGATGAATTC TGTGAGTCTG CGAAGGGCGC CTCAGTGGAC 
ATAGACCTGC AGGAGCAGCT TCAGGCTGCC TCTATCAGTC AGCGCGCCCG AGGCCGGAAA 
ACCCTTGATA GCCACGCCTC CCGCATGACA CAGCTCAAGA AGCAAGCGGC CCTTTCGGGC 
ATCAACGGAG GCCTGGAGAG TGCGAGCGAG GAGGTCATTT GGGTTAGGCG CGAAGACTTT 
GCCCCCTCCA GGAAACTGAA CACAGAGATA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism34(12)1898-906(2014 Dec)
Blanco-Su?rez E,Fiuza M,Liu X,Chakkarapani E,Hanley JG

miR-29b suppresses tumor growth and metastasis in colorectal cancer via downregulating Tiam1 expression and inhibiting epithelial-mesenchymal transition.
Cell death & disease5e1335(2014 Jul)
Wang B,Li W,Liu H,Yang L,Liao Q,Cui S,Wang H,Zhao L

Rho GTPases in insulin-stimulated glucose uptake.
Small GTPases5e28102(2014)
Satoh T

NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.
Glia61(12)2078-99(2013 Dec)
Xiao L,Hu C,Yang W,Guo D,Li C,Shen W,Liu X,Aijun H,Dan W,He C

Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Frontiers in molecular neuroscience613(2013)
Chandra R,Lenz JD,Gancarz AM,Chaudhury D,Schroeder GL,Han MH,Cheer JF,Dietz DM,Lobo MK

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Tiam1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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