Bcl6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcl6
Entrez Gene ID	303836
Full Name	B-cell CLL/lymphoma 6
General protein information	Preferred Names B-cell CLL/lymphoma 6 Names B-cell lymphoma 6 protein B-cell leukemia/lymphoma 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107084.1	NP_001100554.1	B-cell lymphoma 6 protein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BCL6	NP_001193379.1
Pan troglodytes (chimpanzee)	BCL6	XP_001158812.1
Canis lupus familiaris (dog)	BCL6	NP_001182333.1
Danio rerio (zebrafish)	bcl6a	NP_957028.1
Gallus gallus (chicken)	BCL6	NP_001012948.1
Homo sapiens (human)	BCL6	NP_001124317.1
	BCL6	XP_001103860.1
Mus musculus (house mouse)	Bcl6	NP_033874.1
Rattus norvegicus (Norway rat)	Bcl6	NP_001100554.1
Xenopus tropicalis (tropical clawed frog)	bcl6	NP_001116278.1

Gene Ontology
Bibliography

Related articles in PubMed

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.
Mathew R, Mao AP, Chiang AH, Bertozzi-Villa C, Bunker JJ, Scanlon ST, McDonald BD, Constantinides MG, Hollister K, Singer JD, Dent AL, Dinner AR, Bendelac A
The Journal of experimental medicine211(6)1137-51(2014 Jun)

ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells.
Tsuruoka N, Arima M, Yoshida N, Okada S, Sakamoto A, Hatano M, Satake H, Arguni E, Wang JY, Yang JH, Nishikura K, Sekiya S, Shozu M, Tokuhisa T
The Journal of biological chemistry288(2)826-36(2013 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BCL-6 expression tones down the unrestrained cytokine-induced proinflammatory response of beta-cells but it also favors gene networks leading to apoptosis.
Title: The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.

A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.
Title: A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.

Bcl6 and STAT5 binding are inversely coordinated by the endogenous pulses of pituitary GH release, suggesting this male-specific transcriptional repressor modulates hepatic GH signaling to select STAT5 target genes
Title: Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5.

The regulation of sPLA2-IIA gene transcription by PPARalpha/RXR and PPARgamma/RXR heterodimers requires an interaction with a PPAR response element (PPRE) of the sPLA2-IIA promoter.
Title: Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6.

The following Bcl6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcl6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02849	NM_001107084.1 Latest version!	Rattus norvegicus BCL6, transcription repressor (Bcl6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcl6 ( NM_001107084.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100554.1 Rattus norvegicus BCL6, transcription repressor (Bcl6), mRNA.

Price & Availability↑

CloneID	ORa02849
Clone ID Related Accession (Same CDS sequence)	NM_001107084.1
Accession Version	NM_001107084.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2124bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Rattus norvegicus(Norway rat)
Product	B-cell lymphoma 6 protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473999.2. On or before Oct 4, 2007 this sequence version replaced XM_001055978.1, XM_221333.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC166425.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCAC CGGCTGACAG CTGTATCCAG TTCACCCGCC ATGCTAGTGA TGTTCTTCTC 
AACCTTAACC GCCTCCGAAG TCGGGACATC TTGACCGACG TTGTCATCGT GGTGAGCCGT 
GAGCAGTTTA GAGCCCATAA GACAGTGCTC ATGGCCTGCA GTGGCCTGTT CTACAGCATC 
TTCACTGACC AGTTGAAATG CAACCTTAGT GTAATCAATC TGGATCCTGA GATCAGCCCT 
GAGGGGTTTT GCATCCTCTT GGACTTCATG TACACATCTA GGCTCAACCT GAGGGAAGGC 
AACATCATGG CCGTGATGGC CACAGCCATG TACCTGCAGA TGGAGCATGT TGTCGACACA 
TGCCGGAAGT TCATCAAGGC CAGTGAAGCA GAAATGGCCC CTGCACTTAA GCCTCCCCGT 
GAAGAGTTCC TGAACAGCCG GATGCTGATG CCCCATGACG TCATGGCCTA TCGAGGTCGT 
GAGGTTGTGG AGAACAATAT GCCACTAAGA AATACTCCCG GGTGTGAGAG TAGAGCTTTT 
GCCCCTCCCC TGTACAGTGG CCTGTCGACA CCACCAGCCT CTTATCCGAT GTATAGCCAT 
CTCCCGCTCA GCAGTTTCCT CTTCTCCGAC GAGGAACTAC GAGATGCCCC CCGAATGCCT 
GTGGCTAACC CTTTTCCCAA GGAGCGCGCC CTCCCCTGTG ACAGTGCCAG GCCAGTCCCT 
AATGAGTATA GCAGGCCAAC CATGGAGGTG TCCCCCAGCT TGTGCCACAG CAATATCTAC 
TCGCCCAAGG AGGCAGTCCC AGAGGAGGCT CGGAGTGACA TACACTACAG TGTGACTGAG 
GGCCCCAAGC CTGCTGCCCC TTCTGCTCGG CATGCCTCGT ACTTCCCCTG TGACAAAGCC 
AGCAAAGAAG AAGAGAGACC CTCTTCAGAG GACGAGATCG CCCTGCATTT CGAGCCCCCC 
AATGCACCCT TGAACCGGAA GGGTCTGGTT AGTCCCCAGA GTCCGCAGAA ATCCGACTGC 
CAGCCCAACT CACCCACAGA GTCCTCCAGC AGCAAGAACG CCTGCATCCT TCAGGCCTCT 
GGCTCTCCTC CAGCCAAGAG CCCCACTGAT CCGAAAGCCT GCAACTGGAA GAAGTATAAG 
TTCATCGTTC TCAACAGCCT CAATCAGAAT GCCAAGCCAG AGGGCTCTGA GCAGGCAGAG 
CTGGGCCGCC TCTCCCCACG AGCCTACCCT GCACCGCCGG CCTGCCAGCC GCCTATGGAG 
CCTGCGAACC TTGATCTCCA GTCTCCAACC AAGCTCAGTG CCAGTGGGGA GGACTCTACC 
ATCCCCCAAG CCAGCCGGCT CAATAACATC GTTAACAGGT CCCTGGCAGG CTCCCCCCGA 
AGCAGCAGCG AGAGCCACTC GCCACTCTAC ATGCACCCCC CGAAGTGCAC ATCCTGCGGC 
TCTCAGTCCC CACAGCATAC AGAGATGTGT CTCCATACTG CCGGGCCCAC ATTCCCGGAG 
GAGATGGGAG AGACCCAGTC AGAGTATTCG GATTCTAGCT GTGAGAATGG GGCCTTCTTC 
TGCAATGAAT GTGACTGCCG TTTTTCTGAG GAGGCCTCAC TCAAGAGGCA CACGCTGCAG 
ACGCACAGTG ACAAACCATA CAAATGTGAC CGCTGCCAGG CCTCCTTCCG CTACAAAGGC 
AACCTCGCCA GCCACAAGAC GGTCCACACA GGTGAAAAAC CCTACCGCTG TAACATTTGT 
GGAGCGCAGT TCAATCGGCC AGCCAACCTG AAGACCCACA CTCGAATTCA CTCTGGAGAA 
AAGCCCTACA AATGTGAAAC CTGTGGGGCC AGATTTGTGC AGGTGGCTCA CCTCCGTGCC 
CACGTGCTCA TCCACACTGG AGAGAAGCCG TACCCCTGTG AAATCTGTGG TACCCGCTTC 
AGGCACCTTC AGACTCTAAA GAGCCATCTG CGCATCCACA CAGGAGAGAA ACCGTACCAT 
TGTGAGAAGT GTAACCTGCA CTTTCGTCAC AAAAGCCAAC TGCGACTTCA TTTGCGTCAG 
AAACATGGCG CCATCACCAA CACCAAGGTG CAATACCGTG TGTCGGCCGC TGATTTGCCT 
CCGGAGCTCC CCAAAGCCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100554.1
CDS	192..2315
Translation	MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEISPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMAPALKPPREEFLNSRMLMPHDVMAYRGREVVENNMPLRNTPGCESRAFAPPLYSGLSTPPASYPMYSHLPLSSFLFSDEELRDAPRMPVANPFPKERALPCDSARPVPNEYSRPTMEVSPSLCHSNIYSPKEAVPEEARSDIHYSVTEGPKPAAPSARHASYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESSSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGSEQAELGRLSPRAYPAPPACQPPMEPANLDLQSPTKLSASGEDSTIPQASRLNNIVNRSLAGSPRSSSESHSPLYMHPPKCTSCGSQSPQHTEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSAADLPPELPKAC

Target ORF information:

RefSeq Version	NM_001107084.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCL6, transcription repressor (Bcl6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107084.1

ORF Insert Sequence:

ATGGCCTCAC CGGCTGACAG CTGTATCCAG TTCACCCGCC ATGCTAGTGA TGTTCTTCTC 
AACCTTAACC GCCTCCGAAG TCGGGACATC TTGACCGACG TTGTCATCGT GGTGAGCCGT 
GAGCAGTTTA GAGCCCATAA GACAGTGCTC ATGGCCTGCA GTGGCCTGTT CTACAGCATC 
TTCACTGACC AGTTGAAATG CAACCTTAGT GTAATCAATC TGGATCCTGA GATCAGCCCT 
GAGGGGTTTT GCATCCTCTT GGACTTCATG TACACATCTA GGCTCAACCT GAGGGAAGGC 
AACATCATGG CCGTGATGGC CACAGCCATG TACCTGCAGA TGGAGCATGT TGTCGACACA 
TGCCGGAAGT TCATCAAGGC CAGTGAAGCA GAAATGGCCC CTGCACTTAA GCCTCCCCGT 
GAAGAGTTCC TGAACAGCCG GATGCTGATG CCCCATGACG TCATGGCCTA TCGAGGTCGT 
GAGGTTGTGG AGAACAATAT GCCACTAAGA AATACTCCCG GGTGTGAGAG TAGAGCTTTT 
GCCCCTCCCC TGTACAGTGG CCTGTCGACA CCACCAGCCT CTTATCCGAT GTATAGCCAT 
CTCCCGCTCA GCAGTTTCCT CTTCTCCGAC GAGGAACTAC GAGATGCCCC CCGAATGCCT 
GTGGCTAACC CTTTTCCCAA GGAGCGCGCC CTCCCCTGTG ACAGTGCCAG GCCAGTCCCT 
AATGAGTATA GCAGGCCAAC CATGGAGGTG TCCCCCAGCT TGTGCCACAG CAATATCTAC 
TCGCCCAAGG AGGCAGTCCC AGAGGAGGCT CGGAGTGACA TACACTACAG TGTGACTGAG 
GGCCCCAAGC CTGCTGCCCC TTCTGCTCGG CATGCCTCGT ACTTCCCCTG TGACAAAGCC 
AGCAAAGAAG AAGAGAGACC CTCTTCAGAG GACGAGATCG CCCTGCATTT CGAGCCCCCC 
AATGCACCCT TGAACCGGAA GGGTCTGGTT AGTCCCCAGA GTCCGCAGAA ATCCGACTGC 
CAGCCCAACT CACCCACAGA GTCCTCCAGC AGCAAGAACG CCTGCATCCT TCAGGCCTCT 
GGCTCTCCTC CAGCCAAGAG CCCCACTGAT CCGAAAGCCT GCAACTGGAA GAAGTATAAG 
TTCATCGTTC TCAACAGCCT CAATCAGAAT GCCAAGCCAG AGGGCTCTGA GCAGGCAGAG 
CTGGGCCGCC TCTCCCCACG AGCCTACCCT GCACCGCCGG CCTGCCAGCC GCCTATGGAG 
CCTGCGAACC TTGATCTCCA GTCTCCAACC AAGCTCAGTG CCAGTGGGGA GGACTCTACC 
ATCCCCCAAG CCAGCCGGCT CAATAACATC GTTAACAGGT CCCTGGCAGG CTCCCCCCGA 
AGCAGCAGCG AGAGCCACTC GCCACTCTAC ATGCACCCCC CGAAGTGCAC ATCCTGCGGC 
TCTCAGTCCC CACAGCATAC AGAGATGTGT CTCCATACTG CCGGGCCCAC ATTCCCGGAG 
GAGATGGGAG AGACCCAGTC AGAGTATTCG GATTCTAGCT GTGAGAATGG GGCCTTCTTC 
TGCAATGAAT GTGACTGCCG TTTTTCTGAG GAGGCCTCAC TCAAGAGGCA CACGCTGCAG 
ACGCACAGTG ACAAACCATA CAAATGTGAC CGCTGCCAGG CCTCCTTCCG CTACAAAGGC 
AACCTCGCCA GCCACAAGAC GGTCCACACA GGTGAAAAAC CCTACCGCTG TAACATTTGT 
GGAGCGCAGT TCAATCGGCC AGCCAACCTG AAGACCCACA CTCGAATTCA CTCTGGAGAA 
AAGCCCTACA AATGTGAAAC CTGTGGGGCC AGATTTGTGC AGGTGGCTCA CCTCCGTGCC 
CACGTGCTCA TCCACACTGG AGAGAAGCCG TACCCCTGTG AAATCTGTGG TACCCGCTTC 
AGGCACCTTC AGACTCTAAA GAGCCATCTG CGCATCCACA CAGGAGAGAA ACCGTACCAT 
TGTGAGAAGT GTAACCTGCA CTTTCGTCAC AAAAGCCAAC TGCGACTTCA TTTGCGTCAG 
AAACATGGCG CCATCACCAA CACCAAGGTG CAATACCGTG TGTCGGCCGC TGATTTGCCT 
CCGGAGCTCC CCAAAGCCTG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.
The Journal of experimental medicine211(6)1137-51(2014 Jun)
Mathew R,Mao AP,Chiang AH,Bertozzi-Villa C,Bunker JJ,Scanlon ST,McDonald BD,Constantinides MG,Hollister K,Singer JD,Dent AL,Dinner AR,Bendelac A

ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells.
The Journal of biological chemistry288(2)826-36(2013 Jan)
Tsuruoka N,Arima M,Yoshida N,Okada S,Sakamoto A,Hatano M,Satake H,Arguni E,Wang JY,Yang JH,Nishikura K,Sekiya S,Shozu M,Tokuhisa T

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Bcl6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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