Slc25a19 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc25a19
Entrez Gene ID	303676
Full Name	solute carrier family 25 member 19
General protein information	Preferred Names solute carrier family 25 member 19 Names mitochondrial thiamine pyrophosphate carrier solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_001007674.1	NP_001007675.1	mitochondrial thiamine pyrophosphate carrier

Pathways from BioSystems

Homologies

Saccharomyces cerevisiae (baker's yeast)	TPC1	NP_011610.3
Gallus gallus (chicken)	SLC25A19	XP_004946425.1
Caenorhabditis elegans (roundworm)	hpo-12	NP_001255632.1
Homo sapiens (human)	SLC25A19	NP_001119593.1
Canis lupus familiaris (dog)	SLC25A19	XP_005624165.1
Drosophila melanogaster (fruit fly)	Tpc1	NP_650034.1
Neurospora crassa	NCU07384	XP_958877.1
Bos taurus (cattle)	SLC25A19	NP_001039352.1
Rattus norvegicus (Norway rat)	Slc25a19	NP_001007675.1
Danio rerio (zebrafish)	slc25a19	NP_991278.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006806	XP_308941.4
Eremothecium gossypii	AGOS_AAR036W	NP_982577.1
Schizosaccharomyces pombe (fission yeast)	SPBC1604.04	NP_596636.2
Arabidopsis thaliana (thale cress)	AT3G21390	NP_566683.1
Oryza sativa (rice)	Os01g0934200	NP_001045309.1
Pan troglodytes (chimpanzee)	SLC25A19	NP_001233547.1
	SLC25A19	XP_001094462.2
Mus musculus (house mouse)	Slc25a19	NP_080347.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005113	XP_313991.3
Kluyveromyces lactis	KLLA0D15015g	XP_453726.1
Magnaporthe oryzae (rice blast fungus)	MGG_00489	XP_003718573.1
Arabidopsis thaliana (thale cress)	AT5G48970	NP_199708.1
Xenopus tropicalis (tropical clawed frog)	slc25a19	NP_001015953.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.
Lindhurst MJ, Fiermonte G, Song S, Struys E, De Leonardis F, Schwartzberg PL, Chen A, Castegna A, Verhoeven N, Mathews CK, Palmieri F, Biesecker LG
Proceedings of the National Academy of Sciences of the United States of America103(43)15927-32(2006 Oct)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

Mutant deoxynucleotide carrier is associated with congenital microcephaly.
Rosenberg MJ, Agarwala R, Bouffard G, Davis J, Fiermonte G, Hilliard MS, Koch T, Kalikin LM, Makalowska I, Morton DH, Petty EM, Weber JL, Palmieri F, Kelley RI, Sch?ffer AA, Biesecker LG
Nature genetics32(1)175-9(2002 Sep)

Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC).
Iacobazzi V, Ventura M, Fiermonte G, Prezioso G, Rocchi M, Palmieri F
Cytogenetics and cell genetics93(1-2)40-2(2001)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

mitochondria of Slc25a19(-/-) and Amish lethal microcephaly cells have undetectable and markedly reduced thiamine pyrophosphate content, respectively
Title: Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.

The following Slc25a19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc25a19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11546	NM_001007674.1 Latest version!	Rattus norvegicus solute carrier family 25 member 19 (Slc25a19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc25a19 ( NM_001007674.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007675.1 Rattus norvegicus solute carrier family 25 member 19 (Slc25a19), mRNA.

Price & Availability↑

CloneID	ORa11546
Clone ID Related Accession (Same CDS sequence)	NM_001007674.1
Accession Version	NM_001007674.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 957bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-26
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial thiamine pyrophosphate carrier
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079002.1. On Nov 29, 2004 this sequence version replaced XM_221118.2. ##Evidence-Data-START## Transcript exon combination :: BC079002.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGTTGGCT ATGATGCCAA AGCAGATGCC AGGAGTAACT CCAAGTTGGA GGTGGCGGTG 
GCGGGATCAG TGTCAGGATT TGTCACTCGT GCCCTGATCA GCCCTTTGGA TGTCATCAAG 
ATCCGATTCC AGCTCCAGCT TGAACGCGTG TGTCCAAGTG ACCCCAATGC CAAATACCAC 
GGAATCCTCC AGGCGGCCAA GCAGATTCTG CAAGAAGAGG GCCCAAGAGC ATTCTGGAAA 
GGACATGTTC CAGCCCAGAT CCTGTCCATA GGCTATGGAG CCGTCCAATT TTTGGCCTTT 
GAAGAACTGA CTGAACTGCT TTACCAAGCC AACTTGTATC AAACCCACCA GTTCTCAGCG 
CACTTTGTAT GTGGTGGCCT GTCTGCCGGT ACAGCCACCC TCACCGTGCA CCCCGTGGAT 
GTCCTGCGCA CCCGCCTTGC AGCTCAGGGG GAGCCCAAGA TCTACAGCAA TCTGAGAGAG 
GCCATACGCA CCATGTATAG GACGGAGGGC CCTTTCGTCT TCTACAAAGG CTTGACTCCC 
ACTGTGATCG CCATCTTCCC ATACGCGGGC TTGCAGTTCT CCTGCTACCG TTCCTTGAAA 
CGCGCTTATG ACTGGATCAT GCCGCCAGAC GGAAAGCAAA CAGGGAACCT TAAAAACCTG 
CTTTGTGGCT GTGGATCTGG AGTCATCAGC AAGACCCTTA CGTATCCCCT GGACCTCTTC 
AAGAAGCGCC TGCAGGTGCG GGGCTTTGAA CATGCCCGAT CTGCCTTTGG CCAGGTTCGG 
AGCTACAGGG GCCTCTTGGA CCTCGCCCAG CAGGTGCTAC AACATGAAGG CACCCGGGGC 
TTCTTCAAGG GCCTGTCCCC CAGTCTGATG AAGGCTGCAC TCTCCACTGG CTTCATGTTC 
TTCTGGTATG AGCTCTTCTG TAACCTCTTC CATTGCATAA GGAGGGAAGA CAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007675.1
CDS	72..1028
Translation	MVGYDAKADARSNSKLEVAVAGSVSGFVTRALISPLDVIKIRFQLQLERVCPSDPNAKYHGILQAAKQILQEEGPRAFWKGHVPAQILSIGYGAVQFLAFEELTELLYQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKIYSNLREAIRTMYRTEGPFVFYKGLTPTVIAIFPYAGLQFSCYRSLKRAYDWIMPPDGKQTGNLKNLLCGCGSGVISKTLTYPLDLFKKRLQVRGFEHARSAFGQVRSYRGLLDLAQQVLQHEGTRGFFKGLSPSLMKAALSTGFMFFWYELFCNLFHCIRREDR

Target ORF information:

RefSeq Version	NM_001007674.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 25 member 19 (Slc25a19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007674.1

ORF Insert Sequence:

ATGGTTGGCT ATGATGCCAA AGCAGATGCC AGGAGTAACT CCAAGTTGGA GGTGGCGGTG 
GCGGGATCAG TGTCAGGATT TGTCACTCGT GCCCTGATCA GCCCTTTGGA TGTCATCAAG 
ATCCGATTCC AGCTCCAGCT TGAACGCGTG TGTCCAAGTG ACCCCAATGC CAAATACCAC 
GGAATCCTCC AGGCGGCCAA GCAGATTCTG CAAGAAGAGG GCCCAAGAGC ATTCTGGAAA 
GGACATGTTC CAGCCCAGAT CCTGTCCATA GGCTATGGAG CCGTCCAATT TTTGGCCTTT 
GAAGAACTGA CTGAACTGCT TTACCAAGCC AACTTGTATC AAACCCACCA GTTCTCAGCG 
CACTTTGTAT GTGGTGGCCT GTCTGCCGGT ACAGCCACCC TCACCGTGCA CCCCGTGGAT 
GTCCTGCGCA CCCGCCTTGC AGCTCAGGGG GAGCCCAAGA TCTACAGCAA TCTGAGAGAG 
GCCATACGCA CCATGTATAG GACGGAGGGC CCTTTCGTCT TCTACAAAGG CTTGACTCCC 
ACTGTGATCG CCATCTTCCC ATACGCGGGC TTGCAGTTCT CCTGCTACCG TTCCTTGAAA 
CGCGCTTATG ACTGGATCAT GCCGCCAGAC GGAAAGCAAA CAGGGAACCT TAAAAACCTG 
CTTTGTGGCT GTGGATCTGG AGTCATCAGC AAGACCCTTA CGTATCCCCT GGACCTCTTC 
AAGAAGCGCC TGCAGGTGCG GGGCTTTGAA CATGCCCGAT CTGCCTTTGG CCAGGTTCGG 
AGCTACAGGG GCCTCTTGGA CCTCGCCCAG CAGGTGCTAC AACATGAAGG CACCCGGGGC 
TTCTTCAAGG GCCTGTCCCC CAGTCTGATG AAGGCTGCAC TCTCCACTGG CTTCATGTTC 
TTCTGGTATG AGCTCTTCTG TAACCTCTTC CATTGCATAA GGAGGGAAGA CAGATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia.
Proceedings of the National Academy of Sciences of the United States of America103(43)15927-32(2006 Oct)
Lindhurst MJ,Fiermonte G,Song S,Struys E,De Leonardis F,Schwartzberg PL,Chen A,Castegna A,Verhoeven N,Mathews CK,Palmieri F,Biesecker LG

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

Mutant deoxynucleotide carrier is associated with congenital microcephaly.
Nature genetics32(1)175-9(2002 Sep)
Rosenberg MJ,Agarwala R,Bouffard G,Davis J,Fiermonte G,Hilliard MS,Koch T,Kalikin LM,Makalowska I,Morton DH,Petty EM,Weber JL,Palmieri F,Kelley RI,Sch?ffer AA,Biesecker LG

Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC).
Cytogenetics and cell genetics93(1-2)40-2(2001)
Iacobazzi V,Ventura M,Fiermonte G,Prezioso G,Rocchi M,Palmieri F

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Slc25a19 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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