Mpo cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mpo
Entrez Gene ID	303413
Full Name	myeloperoxidase
General protein information	Preferred Names myeloperoxidase Names myeloperoxidase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	myeloperoxidase family member that may contribute to hyperoxia-mediated lung injury via nitration of proteins, resulting in reactive nitrogen species [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107036.1	NP_001100506.1	myeloperoxidase precursor
XM_006247096.3	XP_006247158.1	myeloperoxidase isoform X1
XM_006247095.2	XP_006247157.1	myeloperoxidase isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
Zhu ML, Zhao JP, Cui N, Gon?alves-Rizzi VH, Possomato-Vieira JS, Nascimento RA, Dias-Junior CA
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban37(6)904-909(2017 Dec)

Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.
Gellhaar S, Sunnemark D, Eriksson H, Olson L, Galter D
Cell and tissue research(2017 May)

Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.
Tian R, Ding Y, Peng YY, Lu N
Biochemical and biophysical research communications484(3)572-578(2017 03)

Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving ?-catenin signaling in hyperlipidemia.
Liu WQ, Zhang YZ, Wu Y, Zhang JJ, Li TB, Jiang T, Xiong XM, Luo XJ, Ma QL, Peng J
Biochemical and biophysical research communications467(4)859-65(2015 Nov)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases.
Title: Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.

Upregulation of MPO concomitant with endothelial senescence and dysfunction in hyperlipidemic rats.
Title: Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving ?-catenin signaling in hyperlipidemia.

While myocardial TLR4, MPO and ADMA levels increased in the MIR group, these parameters were found to be decreased significantly in the group treated with apocynin.
Title: Effects of apocynin, an NADPH oxidase inhibitor, on levels of ADMA, MPO, iNOS and TLR4 induced by myocardial ischemia reperfusion.

the role of leukocyte activation, leukocyte-derived MPO and MPO-generated oxidants on BBB function
Title: Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.

MPO has dual functionality under rotenone-exposed conditions, playing a critical regulatory role in modulating pathological and protective events in the brain
Title: Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells.

The following Mpo gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mpo cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05137	NM_001107036.1 Latest version!	Rattus norvegicus myeloperoxidase (Mpo), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00
ORa33560	XM_006247096.3 Latest version!	Rattus norvegicus myeloperoxidase (Mpo), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa33560	XM_006247095.2 Latest version!	Rattus norvegicus myeloperoxidase (Mpo), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mpo ( NM_001107036.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100506.1 Rattus norvegicus myeloperoxidase (Mpo), mRNA.

Price & Availability↑

CloneID	ORa05137
Clone ID Related Accession (Same CDS sequence)	NM_001107036.1
Accession Version	NM_001107036.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1377bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-29
Organism	Rattus norvegicus(Norway rat)
Product	myeloperoxidase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On or before Oct 4, 2007 this sequence version replaced XM_220830.4, XM_001081173.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100506.1
CDS	487..1863
Translation	MKLFLALAGLLAPLAMLQTSTGATPALPGEVANSVVLDCMEEAKRLVNKAYKERRESIKQSLRSGSASPMELLSYFKQPVAGTRTAVRAADYLHVALDLLKRKLQPLWPRPFNVTGDMRSSEMPELTSMHTLFVREHNRLATELKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYLPQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNQYRSTGPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALATISLPRIICDNTGITTVSKNNIFMSNSHPRDFVSCNTLPKLNLASWKET

Target ORF information:

RefSeq Version	NM_001107036.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myeloperoxidase (Mpo), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107036.1

ORF Insert Sequence:

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpo ( XM_006247096.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247158.1 Rattus norvegicus myeloperoxidase (Mpo), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa33560
Clone ID Related Accession (Same CDS sequence)	XM_006247096.3 , XM_006247095.2
Accession Version	XM_006247096.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	myeloperoxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006247096.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGACGT GTTGACGCCT 
GCTCAGCTGA ATCTGTTGTC CGTGTCAAGT GGCTGCGCCT ATCAGGATGT GGGGGTGACA 
TGCCCACCGC AGGACAAGTA TCGAACCATC ACTGGACACT GCAACAACAG ACGCAGCCCC 
ACTCTGGGGG CCTCCAACCG AGCCTTTGTG CGCTGGCTGC CTGCAGAATA TGAGGATGGC 
ATCTCCTTGC CTTTTGGCTG GACGCCCAAG GTCAATCGCA GTGGCTTCAA GGTGCCCTTG 
GCTCGCCAGG TCTCCAACGC CATCGTACGC TTCCCCAACG ATCAGCTGAC CAAGGACCAG 
GAGCGTGCAC TCATGTTCAT GCAGTGGGGC CAGTTTCTGG ACCATGATAT CACCTTGACT 
CCAGAGCCAG CTACCCGGTT CTCCTTCCTC ACTGGACTCA ACTGTGAGAC CAGCTGCCTG 
CAGCAGCAAC CCTGCTTTCC CCTCAAGATC CCACCCAATG ACCCTCGAAT CAAGAACCAA 
AAGGACTGCA TCCCCTTCTT CCGTTCCTGC CCGGCATGCA CCGGGAGCAA CATTACCATT 
CGCAACCAGA TCAACGCGCT CACTTCCTTC GTGGATGCCA GCGGGGTGTA TGGCAGCGAG 
GACCCCCTGG CCAGGAGATT GCGAAACCTC ACCAACCAGC TGGGGCTGTT GGCTGTCAAT 
ACACGCTTCC AAGACAATGG CAGGGCCCTG TTGCCCTTTG ACAGCCTGCA TGATGACCCA 
TGCCTCCTTA CCAACCGCTC GGCCCGCATT CCTTGTTTTC TGGCAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247158.1
CDS	165..2321
Translation	MKLFLALAGLLAPLAMLQTSTGATPALPGEVANSVVLDCMEEAKRLVNKAYKERRESIKQSLRSGSASPMELLSYFKQPVAGTRTAVRAADYLHVALDLLKRKLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVGVTCPPQDKYRTITGHCNNRRSPTLGASNRAFVRWLPAEYEDGISLPFGWTPKVNRSGFKVPLARQVSNAIVRFPNDQLTKDQERALMFMQWGQFLDHDITLTPEPATRFSFLTGLNCETSCLQQQPCFPLKIPPNDPRIKNQKDCIPFFRSCPACTGSNITIRNQINALTSFVDASGVYGSEDPLARRLRNLTNQLGLLAVNTRFQDNGRALLPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRLATELKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYLPQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNQYRSTGPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALATISLPRIICDNTGITTVSKNNIFMSNSHPRDFVSCNTLPKLNLASWKET

Target ORF information:

RefSeq Version	XM_006247096.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myeloperoxidase (Mpo), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247096.3

ORF Insert Sequence:

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGACGT GTTGACGCCT 
GCTCAGCTGA ATCTGTTGTC CGTGTCAAGT GGCTGCGCCT ATCAGGATGT GGGGGTGACA 
TGCCCACCGC AGGACAAGTA TCGAACCATC ACTGGACACT GCAACAACAG ACGCAGCCCC 
ACTCTGGGGG CCTCCAACCG AGCCTTTGTG CGCTGGCTGC CTGCAGAATA TGAGGATGGC 
ATCTCCTTGC CTTTTGGCTG GACGCCCAAG GTCAATCGCA GTGGCTTCAA GGTGCCCTTG 
GCTCGCCAGG TCTCCAACGC CATCGTACGC TTCCCCAACG ATCAGCTGAC CAAGGACCAG 
GAGCGTGCAC TCATGTTCAT GCAGTGGGGC CAGTTTCTGG ACCATGATAT CACCTTGACT 
CCAGAGCCAG CTACCCGGTT CTCCTTCCTC ACTGGACTCA ACTGTGAGAC CAGCTGCCTG 
CAGCAGCAAC CCTGCTTTCC CCTCAAGATC CCACCCAATG ACCCTCGAAT CAAGAACCAA 
AAGGACTGCA TCCCCTTCTT CCGTTCCTGC CCGGCATGCA CCGGGAGCAA CATTACCATT 
CGCAACCAGA TCAACGCGCT CACTTCCTTC GTGGATGCCA GCGGGGTGTA TGGCAGCGAG 
GACCCCCTGG CCAGGAGATT GCGAAACCTC ACCAACCAGC TGGGGCTGTT GGCTGTCAAT 
ACACGCTTCC AAGACAATGG CAGGGCCCTG TTGCCCTTTG ACAGCCTGCA TGATGACCCA 
TGCCTCCTTA CCAACCGCTC GGCCCGCATT CCTTGTTTTC TGGCAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpo ( XM_006247095.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247157.1 Rattus norvegicus myeloperoxidase (Mpo), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33560
Clone ID Related Accession (Same CDS sequence)	XM_006247096.3 , XM_006247095.2
Accession Version	XM_006247095.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2157bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	myeloperoxidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006247095.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGACGT GTTGACGCCT 
GCTCAGCTGA ATCTGTTGTC CGTGTCAAGT GGCTGCGCCT ATCAGGATGT GGGGGTGACA 
TGCCCACCGC AGGACAAGTA TCGAACCATC ACTGGACACT GCAACAACAG ACGCAGCCCC 
ACTCTGGGGG CCTCCAACCG AGCCTTTGTG CGCTGGCTGC CTGCAGAATA TGAGGATGGC 
ATCTCCTTGC CTTTTGGCTG GACGCCCAAG GTCAATCGCA GTGGCTTCAA GGTGCCCTTG 
GCTCGCCAGG TCTCCAACGC CATCGTACGC TTCCCCAACG ATCAGCTGAC CAAGGACCAG 
GAGCGTGCAC TCATGTTCAT GCAGTGGGGC CAGTTTCTGG ACCATGATAT CACCTTGACT 
CCAGAGCCAG CTACCCGGTT CTCCTTCCTC ACTGGACTCA ACTGTGAGAC CAGCTGCCTG 
CAGCAGCAAC CCTGCTTTCC CCTCAAGATC CCACCCAATG ACCCTCGAAT CAAGAACCAA 
AAGGACTGCA TCCCCTTCTT CCGTTCCTGC CCGGCATGCA CCGGGAGCAA CATTACCATT 
CGCAACCAGA TCAACGCGCT CACTTCCTTC GTGGATGCCA GCGGGGTGTA TGGCAGCGAG 
GACCCCCTGG CCAGGAGATT GCGAAACCTC ACCAACCAGC TGGGGCTGTT GGCTGTCAAT 
ACACGCTTCC AAGACAATGG CAGGGCCCTG TTGCCCTTTG ACAGCCTGCA TGATGACCCA 
TGCCTCCTTA CCAACCGCTC GGCCCGCATT CCTTGTTTTC TGGCAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247157.1
CDS	164..2320
Translation	MKLFLALAGLLAPLAMLQTSTGATPALPGEVANSVVLDCMEEAKRLVNKAYKERRESIKQSLRSGSASPMELLSYFKQPVAGTRTAVRAADYLHVALDLLKRKLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVGVTCPPQDKYRTITGHCNNRRSPTLGASNRAFVRWLPAEYEDGISLPFGWTPKVNRSGFKVPLARQVSNAIVRFPNDQLTKDQERALMFMQWGQFLDHDITLTPEPATRFSFLTGLNCETSCLQQQPCFPLKIPPNDPRIKNQKDCIPFFRSCPACTGSNITIRNQINALTSFVDASGVYGSEDPLARRLRNLTNQLGLLAVNTRFQDNGRALLPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRLATELKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYLPQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNQYRSTGPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALATISLPRIICDNTGITTVSKNNIFMSNSHPRDFVSCNTLPKLNLASWKET

Target ORF information:

RefSeq Version	XM_006247095.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myeloperoxidase (Mpo), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247095.2

ORF Insert Sequence:

ATGAAGCTTT TTTTGGCCTT GGCAGGCCTC CTGGCCCCCC TGGCCATGCT TCAGACTTCC 
ACTGGTGCCA CTCCAGCGCT CCCGGGGGAA GTGGCGAACT CAGTGGTGCT GGACTGCATG 
GAGGAGGCCA AGCGGCTGGT GAACAAAGCC TACAAGGAGC GGAGAGAAAG CATCAAGCAG 
AGTCTTCGAA GTGGCTCCGC CAGCCCTATG GAACTCCTAT CGTATTTCAA GCAGCCGGTG 
GCGGGCACCA GGACAGCTGT GAGGGCTGCC GACTATCTGC ACGTGGCCCT GGACCTGCTG 
AAGAGGAAGC TGCAGCCCCT GTGGCCACGG CCTTTCAATG TCACAGACGT GTTGACGCCT 
GCTCAGCTGA ATCTGTTGTC CGTGTCAAGT GGCTGCGCCT ATCAGGATGT GGGGGTGACA 
TGCCCACCGC AGGACAAGTA TCGAACCATC ACTGGACACT GCAACAACAG ACGCAGCCCC 
ACTCTGGGGG CCTCCAACCG AGCCTTTGTG CGCTGGCTGC CTGCAGAATA TGAGGATGGC 
ATCTCCTTGC CTTTTGGCTG GACGCCCAAG GTCAATCGCA GTGGCTTCAA GGTGCCCTTG 
GCTCGCCAGG TCTCCAACGC CATCGTACGC TTCCCCAACG ATCAGCTGAC CAAGGACCAG 
GAGCGTGCAC TCATGTTCAT GCAGTGGGGC CAGTTTCTGG ACCATGATAT CACCTTGACT 
CCAGAGCCAG CTACCCGGTT CTCCTTCCTC ACTGGACTCA ACTGTGAGAC CAGCTGCCTG 
CAGCAGCAAC CCTGCTTTCC CCTCAAGATC CCACCCAATG ACCCTCGAAT CAAGAACCAA 
AAGGACTGCA TCCCCTTCTT CCGTTCCTGC CCGGCATGCA CCGGGAGCAA CATTACCATT 
CGCAACCAGA TCAACGCGCT CACTTCCTTC GTGGATGCCA GCGGGGTGTA TGGCAGCGAG 
GACCCCCTGG CCAGGAGATT GCGAAACCTC ACCAACCAGC TGGGGCTGTT GGCTGTCAAT 
ACACGCTTCC AAGACAATGG CAGGGCCCTG TTGCCCTTTG ACAGCCTGCA TGATGACCCA 
TGCCTCCTTA CCAACCGCTC GGCCCGCATT CCTTGTTTTC TGGCAGGGGA CATGCGCTCC 
AGCGAGATGC CAGAGCTCAC CTCCATGCAC ACCCTCTTCG TGCGAGAGCA TAACCGTCTG 
GCCACAGAGC TCAAGCGCCT GAATCCTCGC TGGAATGGGG AGAAGCTTTA CCAGGAGGCC 
CGGAAGATTG TGGGGGCCAT GGTCCAGATC ATCACATACC GAGACTACCT GCCCTTGGTG 
TTGGGGCCAG CAGCCATGAA GAAGTACCTA CCCCAGTACC GATCCTACAA TGACTCAGTA 
GACCCTCGGA TCGCCAATGT CTTCACCAAC GCTTTCCGTT ACGGCCACAC CCTCATCCAA 
CCCTTCATGT TCCGCCTGGA CAATCAGTAC CGGTCCACAG GACCCAACCC CCGTGTCCCA 
CTCAGCAGGG TCTTTTTTGC CAGCTGGAGA GTTGTGCTGG AAGGTGGCAT TGACCCCATC 
CTCCGAGGCC TCATGGCTAC TCCTGCCAAA CTGAATCGCC AGAACCAAAT TGCGGTGGAT 
GAGATCCGGG AGCGACTGTT TGAGCAGGTC ATGAGGATAG GTCTTGACTT ACCTGCCCTT 
AACATGCAGC GCAGCCGGGA TCATGGCCTC CCGGGATACA ATGCCTGGAG ACGCTTCTGT 
GGGCTTCCAC AGCCCAGCAC AGTGGGTGAG CTCGGCACGG TGCTGAAGAA CCTGGAGCTG 
GCACGGAAGC TGATGGCACA GTATGGCACG CCCAACAACA TTGACATCTG GATGGGCGGT 
GTGTCCGAGC CCCTAGAGCC CAATGGCCGC GTAGGCCAGC TCCTTGCCTG CCTCATTGGC 
ACTCAGTTTA GGAAGCTACG GGATGGCGAT AGGTTTTGGT GGGAGAACCC GGGTGTGTTC 
AGTAAACAGC AGAGACAGGC CTTGGCTACC ATCTCCTTGC CCCGCATCAT CTGTGACAAC 
ACTGGCATCA CTACCGTGTC TAAGAACAAC ATCTTCATGT CCAACTCACA CCCCCGAGAC 
TTTGTGAGCT GTAACACCCT TCCTAAACTG AATCTGGCTT CCTGGAAGGA GACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban37(6)904-909(2017 Dec)
Zhu ML,Zhao JP,Cui N,Gon?alves-Rizzi VH,Possomato-Vieira JS,Nascimento RA,Dias-Junior CA

Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease.
Cell and tissue research(2017 May)
Gellhaar S,Sunnemark D,Eriksson H,Olson L,Galter D

Myeloperoxidase amplified high glucose-induced endothelial dysfunction in vasculature: Role of NADPH oxidase and hypochlorous acid.
Biochemical and biophysical research communications484(3)572-578(2017 03)
Tian R,Ding Y,Peng YY,Lu N

Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving ?-catenin signaling in hyperlipidemia.
Biochemical and biophysical research communications467(4)859-65(2015 Nov)
Liu WQ,Zhang YZ,Wu Y,Zhang JJ,Li TB,Jiang T,Xiong XM,Luo XJ,Ma QL,Peng J

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

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Mpo cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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